Decreased levels of the brain specific 24S-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients

2003 ◽  
Vol 347 (3) ◽  
pp. 159-162 ◽  
Author(s):  
C.E Teunissen ◽  
C.D Dijkstra ◽  
C.H Polman ◽  
E.L.J Hoogervorst ◽  
K von Bergmann ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Multiple Sclerosis Patients ◽  
Cholesterol Precursors ◽  
The Brain

Clinical Features Neuropsychological Disorders in Multiple Sclerosis Patients in Aspect Comorbidity

2016 ◽  
pp. 112-116
Author(s):  
Hennadii Chupryna ◽  
Nataliia Svyrydova ◽  
Tetiana Parnikoza
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Evoked Potentials ◽  
Somatosensory Evoked Potentials ◽  
Clinical Manifestations ◽  
Seizure Threshold ◽  
Eeg Mapping ◽  
Neuropsychological Disorders ◽  
Multiple Sclerosis Patients ◽  
The Brain

The objective: to investigate the relationship between clinical manifestations of neuropsychological disorders and neuroimaging data (MRI) and electrophysiological (EEG mapping, somatosensory evoked potentials) methods of diagnosis in patients with multiple sclerosis (MS) in the aspect of comorbidity. Patients and methods. Achieved the clinical, neuropsychological, instrumental study 216 MS patients with the presence of (107) or absence (109) comorbid pathology. Spend a numerical score of neurological deficit symptoms (the FS scale) with the total score counting, defined EDSS level evaluated symptoms of fatigue (the FSS), pain (VAS), depression (BDI-II), the degree of cognitive impairment (MMSE). Implemented neyrovizualizuatsionnoe (MRI) study of the brain and spinal cord and EEG mapping study of electrical activity (EA) of the brain., somatosensory evoked potentials (SSEP). Results. It is found that the presence of foci of demyelination in the brain stem in both groups correlated with the severity of the manifestations of depression BDI-II data. It also shows that about 65% of both groups of MS patients had signs of decrease ascending activating effects on the cortex from the reticular formation of the brainstem. It was found that 70% of MS patients in both groups there are irritative and hypersynchronous types EA brain, reducing the symptoms of seizure threshold, with the presence of a strong direct correlation between them and multimodal pain. Conclusions. In the presence of comorbid disease in MS patients observed clinically deeper and more frequent manifestations of NPM, which is confirmed by the results of neuropsychological testing conducted. The presence of foci of demyelination in the cervical spinal cord was significantly more frequent in the MS group with comorbidity (p<0.05), and both groups of patients clinically directly correlates with the severity of pain according to VAS.

CX3CR1 drives cytotoxic CD4+CD28− T cells into the brain of multiple sclerosis patients

2012 ◽  
Vol 38 (1) ◽  
pp. 10-19 ◽  
Author(s):  
Bieke Broux ◽  
Kim Pannemans ◽  
Xin Zhang ◽  
Silva Markovic-Plese ◽  
Tom Broekmans ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cells ◽  
Multiple Sclerosis Patients ◽  
The Brain

scholarly journals Migraine in Multiple Sclerosis Patients Affects Functional Connectivity of the Brain Circuitry Involved in Pain Processing

2021 ◽  
Vol 12 ◽  
Author(s):  
Emanuele Pravatà ◽  
Gianna C. Riccitelli ◽  
Carlo Sestieri ◽  
Rosaria Sacco ◽  
Alessandro Cianfoni ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Functional Connectivity ◽  
Pain Perception ◽  
Brain Regions ◽  
Daily Activities ◽  
Control Group ◽  
Resting State Functional Connectivity ◽  
Brain Circuitry ◽  
Multiple Sclerosis Patients ◽  
The Brain

Migraine is particularly common in patients with multiple sclerosis (MS) and has been linked to the dysfunction of the brain circuitry modulating the peripheral nociceptive stimuli. Using MRI, we explored whether changes in the resting state-functional connectivity (RS-FC) may characterize the occurrence of migraine in patients with MS. The RS-FC characteristics in concerned brain regions were explored in 20 MS patients with migraine (MS+M) during the interictal phase, and compared with 19 MS patients without migraine (MS-M), which served as a control group. Functional differences were correlated to the frequency and severity of previous migraine attacks, and with the resulting impact on daily activities. In MS+M, the loss of periaqueductal gray matter (PAG) positive connectivity with the default mode network and the left posterior cranial pons was associated with an increase of migraine attacks frequency. In contrast, the loss of PAG negative connectivity with sensorimotor and visual network was linked to migraine symptom severity and related daily activities impact. Finally, a PAG negative connection was established with the prefrontal executive control network. Migraine in MS+M patients and its impact on daily activities, underlies RS-FC rearrangements between brain regions involved in pain perception and modulation.

Eyes are mirror of the brain: comparison of multiple sclerosis patients and healthy controls using OCT

2019 ◽  
Vol 129 (9) ◽  
pp. 848-855 ◽  
Author(s):  
Ümit Doğan ◽  
Fatih Ulaş ◽  
Şule Aydın Türkoğlu ◽  
Muhammed Nur Ögün ◽  
Sümeyra Ağca
Keyword(s):  
Multiple Sclerosis ◽  
Healthy Controls ◽  
Multiple Sclerosis Patients ◽  
The Brain

Swallowing and Speaking Challenges for the MS Patient

2000 ◽  
Vol 2 (3) ◽  
pp. 4-14 ◽  
Author(s):  
Shirley A. Brown
Keyword(s):  
Multiple Sclerosis ◽  
Brain Stem ◽  
Brain Area ◽  
Diagnosis And Treatment ◽  
Team Approach ◽  
Swallowing Difficulty ◽  
Multiple Sclerosis Patients ◽  
The Brain

Abstract The therapeutic team approach helps multiple sclerosis patients meet the challenges of dysphagia (swallowing difficulty) and dysarthria (speech problems). Both stem either from plaques (or lesions) in the brain area responsible for these functions or from demyelination of the nerves in the brain stem. This article addresses diagnosis and treatment.

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