Are serum thyroid hormone changes in rats a reliable indicator for human neurodevelopmental effects? -Evaluation of different cases

2021 ◽  
Vol 350 ◽  
pp. S140-S141
Author(s):  
P. Botham ◽  
A. Charlton ◽  
D. Guignard ◽  
B. Hannas ◽  
S. Jacobi ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Reliable Indicator ◽  
Serum Thyroid Hormone ◽  
Neurodevelopmental Effects

scholarly journals Effects of Daily Kelp (Laminaria japonica) Intake on Body Composition, Serum Lipid Levels, and Thyroid Hormone Levels in Healthy Japanese Adults: A Randomized, Double-Blind Study

Marine Drugs ◽  
2021 ◽  
Vol 19 (7) ◽  
pp. 352
Author(s):  
Seiichiro Aoe ◽  
Chiemi Yamanaka ◽  
Hirofumi Ohtoshi ◽  
Fumiko Nakamura ◽  
Suguru Fujiwara
Keyword(s):  
Thyroid Hormone ◽  
Body Fat ◽  
Laminaria Japonica ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Double Blind ◽  
Serum Thyroid Hormone ◽  
Thyroid Hormone Levels ◽  
Male Subjects ◽  
Japanese Subjects

To investigate whether supplementation with iodine-reduced kelp (Laminaria japonica) powder decreases body fat composition in overweight Japanese subjects, a randomized, double-blind, placebo-controlled intervention study was conducted in 50 Japanese subjects with body mass index (BMI) ≥25 and <30 kg/m2. Subjects were randomly assigned to consume thirty tablets/d (10 tablets orally, 3 times/d) containing either iodine-reduced kelp powder (test, 6 g kelp powder corresponding to 3 g alginate/d) or kelp-free powder (placebo) for 8 weeks. Anthropometric measurements, blood lipids, and serum thyroid hormone levels were obtained before and after the trial. Body fat percentage was significantly decreased in male subjects from the test group compared with the placebo group. The same tendency was observed for body weight (p = 0.065) and BMI (p = 0.072) in male subjects. No significant changes in anthropometric measurements or visceral fat area were observed in female subjects. Serum thyroid hormone concentrations did not increase after 1.03 mg/d of iodine supplementation through kelp intake. The intake of iodine-reduced kelp powder led to significant and safe reductions in body fat percentage in overweight male subjects. The consumption of kelp high in alginate may contribute to preventing obesity without influencing thyroid function in Japanese subjects with a relatively high intake of iodine from seaweed.

scholarly journals Very rare case of Graves’ disease with resistance to methimazole: a case report and literature review

2021 ◽  
Vol 49 (3) ◽  
pp. 030006052199619
Author(s):  
Yusaku Mori ◽  
Munenori Hiromura ◽  
Michishige Terasaki ◽  
Hideki Kushima ◽  
Makoto Ohara ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Rare Case ◽  
Therapeutic Option ◽  
Lithium Carbonate ◽  
Graves Disease ◽  
High Dose ◽  
Hormone Concentration ◽  
Thyroid Hormone Concentration ◽  
Serum Thyroid Hormone ◽  
Inorganic Iodine

Background Methimazole (MMI) is used to treat hyperthyroidism in Graves’ disease. It is rare to encounter patients in whom hyperthyroidism cannot be controlled using high doses of MMI. Case presentation: A 21-year-old woman was referred to our hospital because of MMI-resistant Graves’ disease. Although her MMI dose had been increased to 120 mg/day, her serum thyroid hormone concentration was too high to be measured. Additional therapy with lithium carbonate, and then with dexamethasone and inorganic iodine, was initiated. After 14 days, the patient’s serum thyroid hormone concentration normalized, while she was taking 150 mg/day MMI, 800 mg/day lithium carbonate, 6 mg/day dexamethasone and 306 mg/day inorganic iodine, and total thyroidectomy was then performed. The patient was discharged 8 days after the thyroidectomy and experienced no major complications. Conclusions We have presented a rare case of Graves’ disease that was resistant to high-dose MMI. Combination therapy of MMI with lithium carbonate, dexamethasone and inorganic iodine may represent a therapeutic option for the preoperative preparation of patients with MMI-resistant Graves’ disease.

Body temperature regulation and oxygen consumption in young chicks fed thyroid hormone

1991 ◽  
Vol 69 (7) ◽  
pp. 1842-1847 ◽  
Author(s):  
Gregory K. Snyder ◽  
Joseph R. Coelho ◽  
Dalan R. Jensen
Keyword(s):  
Oxygen Consumption ◽  
Thyroid Hormone ◽  
Body Temperature ◽  
Ambient Temperature ◽  
Cold Exposure ◽  
Elevated Serum ◽  
Body Temperatures ◽  
Serum Thyroid Hormone ◽  
Regulate Body Temperature ◽  
Young Chicks

In chicks the ability to regulate body temperature to adult levels develops during the first 2 weeks of life. We examined whether the ability of young chicks to regulate body temperature is increased by elevated levels of the thyroid hormone 3,3′5-triiodothyronine. By 13 days following hatch, body temperatures of chicks were not significantly different from those expected for adult birds. Furthermore, at an ambient temperature of 10 °C, 13-day-old control chicks were able to maintain body temperature, and elevated serum thyroid hormone levels did not increase rates of oxygen consumption or body temperature above control values. Six-day-old chicks had body temperatures that were significantly lower than those of the 13-day-old chicks and were not able to regulate body temperature when exposed to an ambient temperature of 10 °C. On the other hand, 6-day-old chicks with elevated serum thyroid hormone had significantly higher rates of oxygen consumption than 6-day-old control chicks, and were able to maintain constant body temperatures during cold exposure. The increased oxygen consumption rates and improved ability to regulate body temperature during cold exposure were correlated with increased citrate synthase activity in skeletal muscle. Our results support the argument that thyroid hormones play an important role in the development of thermoregulatory ability in neonate birds by stimulating enzyme activities associated with aerobic metabolism.

scholarly journals NADPH Oxidase Inhibitor Apocynin Attenuates PCB153-Induced Thyroid Injury in Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Ablikim Abliz ◽  
Chen Chen ◽  
Wenhong Deng ◽  
Weixing Wang ◽  
Rongze Sun
Keyword(s):  
Thyroid Hormone ◽  
Nadph Oxidase ◽  
Inflammatory Cytokines ◽  
Thyroid Dysfunction ◽  
Thyroid Tissue ◽  
Oxidase Inhibitor ◽  
Control Group ◽  
Ros Generation ◽  
Sprague Dawley ◽  
Serum Thyroid Hormone

PCBs, widespread endocrine disruptors, cause the disturbance of thyroid hormone (TH) homeostasis in humans and animals. However, the exact mechanism of thyroid dysfunction caused by PCBs is still unknown. In order to clarify the hypotheses that NADPH oxidase (NOX) and subsequent NF-κB pathway may play roles in thyroid dysfunction, sixty Sprague-Dawley rats were randomly divided into four groups: control group, PCB153 treated (PCB) group, received apocynin with PCB153 treatment (APO + PCB) group, and drug control (APO) group. Serum thyroid hormone levels were evaluated. The morphological change of thyroid tissue was analyzed under the light and transmission electron microscopy. NOX2, 8-OHdG, and NF-κB expression in the thyroid tissue was evaluated by immune-histochemical staining. Oxidative stress and inflammatory cytokines were detected. The following results were reduced after apocynin treatment: (1) serum thyroid hormone, (2) thyroid pathological injuries, (3) thyroid MDA, (4) thyroid ultrastructural change, (5) serum inflammatory cytokines, and (6) thyroid expression of NOX2, 8-OHdG, and NF-κB. These results suggested that NOX inhibition attenuates thyroid dysfunction induced by PCB in rats, presumably because of its role in preventing ROS generation and inhibiting the activation of NF-κB pathway. Our findings may provide new therapeutic targets for PCBs induced thyroid dysfunction.

Effect of Halofenate on Serum Thyroid Hormone Determinationsin Vitro

1976 ◽  
Vol 43 (1) ◽  
pp. 26-31 ◽  
Author(s):  
FRED E. KARCH ◽  
JOHN P. MORGAN ◽  
NORMAN P. KUBASIK ◽  
H. E. SINE
Keyword(s):  
Thyroid Hormone ◽  
Serum Thyroid Hormone

scholarly journals Serum Thyroid Hormone Values for African Spurred Tortoises (Centrochelys [Formerly Geochelone] sulcata)

2009 ◽  
Vol 19 (2) ◽  
pp. 47-49 ◽  
Author(s):  
Keri H. Franco ◽  
Daniel J. Famini ◽  
John P. Hoover ◽  
Mark E. Payton
Keyword(s):  
Thyroid Hormone ◽  
Serum Thyroid Hormone

Seasonal changes in serum thyroid hormone levels in ruffed grouse maintained under natural conditions of temperature and photoperiod

1979 ◽  
Vol 57 (10) ◽  
pp. 2022-2027 ◽  
Author(s):  
A. Garbutt ◽  
J. F. Leatherland ◽  
A. L. A. Middleton
Keyword(s):  
Thyroid Hormone ◽  
Seasonal Changes ◽  
Gonadal Development ◽  
Early Spring ◽  
Light Period ◽  
Ruffed Grouse ◽  
Natural Conditions ◽  
Blood Samples ◽  
Serum Thyroid Hormone ◽  
Thyroid Hormone Levels

Serum triiodothyronine (T3) and thyroxine (T4) concentrations were measured in a population of ruffed grouse, held outdoors under natural conditions of photoperiod and temperature. Blood samples were collected at monthly intervals, and at the solstices and equinoxes to test for variation through the light period. No changes in T4 or T3 levels were found during the light period but levels of T3 and T4 showed marked seasonal changes. Lowest T4 and T3 levels were found in birds during the winter months, with an increase in the concentration of both hormones in early spring concomitant with gonadal development in the adults. A lowering of serum T4 and T3 values was associated with the period of molt.

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