FRI-449-Complex ATP7B mutation patterns in Wilson disease and a evaluation of a yeast model for functional analysis of the individual variant

A internet exerce grande influência nas relações sociais, portanto, os relacionamentos afetivos também são modificados, logo, dentre esta categoria surge o relacionamento virtual, possibilitando variadas formas de interação, inclusive a criação de perfis falsos. Para descrever o indivíduo que forja sua identidade ao entrar em um relacionamento, por meio da internet, utiliza-se o termo “catfish”. Com base na Análise do Comportamento se objetivou apresentar uma análise funcional do comportamento do “catfish”, identificar suas características e detectar possíveis funções da classe de respostas, a partir de cinco episódios da série com o mesmo nome. A pesquisa é de caráter bibliográfico e documental, foram utilizados livros, artigos e episódios, disponibilizados pelo canal de televisão a cabo MTV e em sites especializados em séries, para a devida análise. Através da análise funcional foram obtidas informações de antecedentes – respostas – consequências (imediatas e atrasadas), possibilitando a identificação de funções para respostas apresentadas em cada episódio. O resultado da pesquisa aponta que a maioria dos “catfish” apresenta baixo contato com reforçadores sociais (antecedente), o que forneceu uma condição para a criação do perfil falso nas redes sociais (resposta) e obteve como consequência a atenção e suporte social (reforço) indicando, assim, que o comportamento do “catfish” é mantido por reforçamento positivo.Palavras-chaves: Relacionamento Virtual, Catfish, Análise Funcional, Análise do Comportamento.AbstractThe internet exerts a great influence on social relationships, therefore, affective relationships are also modified, thus, within this category emerges the virtual relationship, allowing various forms of interaction, including the creation of fake profiles. To describe the individual who forges their identity when entering into a relationship via the internet, the term “catfish” is used. Based on the Behavior Analysis, it was aimed to present a functional analysis of the “catfish”’s behavior, identify its characteristics and detect possible functions of the class of responses from six episodes of the series with the same name. The research is of bibliographical and documentary character, books, articles and episodes, made available by the cable television channel MTV were used and in sites specialized in series, for the due analysis. Through the functional analysis information about antecedent- responses – consequences were obtained (immediate and delayed), allowing the identification of functions for responses presented in each episode. The result of the research indicates that most catfish have low contact with social reinforcers (antecedent) which provided a condition for creating the false profile in social networks (response) and obtained as a consequence attention and social support (reinforcement), thus indicating that the catfish’s behavior is maintained by positive reinforcement.Keywords: Virtual relationship, Catfish, Functional analysis, Behavior Analysis

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Functional characterization of new mutations in Wilson disease gene (ATP7B) using the yeast model

Journal of Trace Elements in Medicine and Biology ◽

10.1016/j.jtemb.2015.02.006 ◽

2015 ◽

Vol 31 ◽

pp. 33-36 ◽

Cited By ~ 5

Author(s):

Ozlenen Simsek Papur ◽

Orhan Terzioglu ◽

Ahmet Koc

Keyword(s):

Wilson Disease ◽

Disease Gene ◽

Functional Characterization ◽

New Mutations ◽

Yeast Model

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Pilot Evaluation of the Impact of Lottery-Based Incentives on Engagement Levels of Male Low SES Vocational Students With an mHealth App

Frontiers in Digital Health ◽

10.3389/fdgth.2021.748588 ◽

2022 ◽

Vol 3 ◽

Author(s):

Raoul Nuijten ◽

Pieter Van Gorp ◽

Juup Hietbrink ◽

Pascale Le Blanc ◽

Astrid Kemperman ◽

...

Keyword(s):

Experimental Design ◽

Digital Health ◽

Health Promotion Program ◽

Vocational Students ◽

Anticipated Regret ◽

Physically Active ◽

The Social ◽

Individual Variant ◽

The Individual ◽

The Impact

In general, individuals with lower socioeconomic status (SES) are less physically active and adhere to poorer diets than higher SES individuals. To promote healthier lifestyles in lower SES populations, we hosted a digital health promotion program among male vocational students at a school in The Netherlands. In a pilot study, we evaluated whether this target audience could be engaged with an mHealth app using lottery-based incentives that trigger feelings of anticipated regret. Especially, we studied the social and interpersonal aspects of regret lotteries in a within-subject experimental design. In this design, subjects either participated in a social variant (i.e., with students competing against their peers for a chance at a regret lottery), or an individual variant (i.e., with subjects solely individually engaged in a lottery). Additionally, we studied the impact of different payout schedules in a between-subject experimental design. In this design, participants were assigned to either a short-term, low-value payout schedule, or a long-term, high-value payout schedule. From a population of 72 male students, only half voluntarily participated in our 10-week program. From interviews, we learned that the main reason for neglecting the program was not related to the lottery-based incentives, nor to the prizes that were awarded. Instead, non-enrolled subjects did not join the program, because their peers were not joining. Paradoxically, it was suggested that students withheld their active participation until a larger portion of the sample was actively participating. From the subjects that enrolled in the program (N = 36, males, between 15 and 25 years of age), we found that a large proportion stopped interacting with the program over time (e.g., after roughly 4 weeks). Our results also indicated that students performed significantly more health-related activities when assigned to the social regret lottery, as opposed to the individual variant. This result was supported by interview responses from active participants: They mainly participated to compete against their peers, and not so much for the prizes. Hence, from this study, we obtained initial evidence on the impact of social and competitive aspects in lottery-based incentives to stimulate engagement levels in lower SES students with an mHealth app.

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Toward Data-Based Case Conceptualization: A Functional Analysis Approach With Ecological Momentary Assessment

10.31234/osf.io/prg7n ◽

2020 ◽

Author(s):

Saskia Scholten ◽

Tanja Lischetzke ◽

Julia Glombiewski

Keyword(s):

Functional Analysis ◽

Treatment Planning ◽

Emotional Disorders ◽

Ecological Momentary Assessment ◽

Psychotherapy Research ◽

Case Conceptualization ◽

Network Analyses ◽

The Individual ◽

Ecological Momentary ◽

Momentary Assessment

Network analyses and process-based approaches to psychotherapy are thrilling developments for psychotherapy research and practice, but they lack a therapeutic rationale for the individual selection of treatment modules. Conceptualizing the conditional relations around human responses using functional analysis could guide case conceptualization and treatment planning. In a pilot study with four participants (a 30- and a 25-year-old man; a 19- and a 44-year-old woman), we developed and tested the feasibility and acceptance of an assessment that comprises elements of functional analysis for participants with emotional disorders. We assessed an individualized set of items three times per day, for a period of 30 days, with ecological momentary assessment while participants were waiting for psychotherapy. The implementation proved to be both feasible and accepted; participants did not report any side effects. Three datasets were included in the analysis; one had to be excluded because the minimum response rate of 80% (out of 90 data points) was not met. P-factor and network analyses revealed meaningful behavioral clusters (e.g., participant 1: hopelessness, procrastination, coping, avoidance). The assessment is a promising diagnostic tool that helps participants and therapists identify and systemize relevant behavior patterns and to draw conclusions for treatment planning.

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Assessment and Management of ID in Childhood

10.4018/978-1-6684-3542-7.ch004 ◽

2022 ◽

pp. 50-72

Author(s):

Sumita P. Chowhan ◽

Plabita Patowary

Keyword(s):

Functional Analysis ◽

Adaptive Functioning ◽

Daily Life ◽

Challenging Behaviors ◽

Management Strategies ◽

Signs And Symptoms ◽

Intellectual Deficiency ◽

Community Settings ◽

Efficient Management ◽

The Individual

Intellectual disability is a neurodevelopment disorder that affects the intellectual and adaptive functioning. The individual fails to meet standards of personal independence and social responsibility in one or more aspects of daily life, including communication, social participation, academic or occupational functioning, and personal independence at home or in community settings. There is an immense need to understand and be aware of the signs and symptoms of the disorder. This chapter focuses on the process of the assessment which is necessary to identify intellectual deficiency and also the issues that should be taken care of during the process. The various principles and tools of assessment, which can be used to measure IQ, are mentioned. It also focuses on the various challenging behaviors and functional analysis. It also focuses on recent and efficient management strategies that can be used to help the affected person cope and acquire new skills.

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Functional analysis of mutations in the ATP loop of the Wilson disease copper transporter, ATP7B

Human Mutation ◽

10.1002/humu.21228 ◽

2010 ◽

Vol 31 (5) ◽

pp. 569-577 ◽

Cited By ~ 20

Author(s):

Leiah M. Luoma ◽

Taha M.M. Deeb ◽

Georgina Macintyre ◽

Diane W. Cox

Keyword(s):

Functional Analysis ◽

Wilson Disease ◽

Copper Transporter

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Studies in functional and analytical graniology. 3. The Breviarcuate skull and its analysis.

Australian Journal of Zoology ◽

10.1071/zo9540399 ◽

1954 ◽

Vol 2 (3) ◽

pp. 399 ◽

Cited By ~ 2

Author(s):

R Tucker

Keyword(s):

Functional Analysis ◽

Zygomatic Arch ◽

Alveolar Process ◽

Its Analysis ◽

Triangular Structure ◽

Structural Importance ◽

Flow Through ◽

The Individual ◽

Palatine Bone

The functional analysis of the breviarcuate skull is based on the cranium of the dog. The tri-triangular structure of the breviarcuate skull is exposed on the level of the palatine bone to the stresses initiated by the masseter. The morphofunctional relations of the palatine bone to the zygomatic arch are discussed and analysed in detail. The most important functional crossroads of the stresses in the breviarcuate skull are the temporal, maxillary, premaxillary, supraorbital, and interparieto-occipital nodes. The vectors which originate directly or indirectly from the masticatory musculature flow through the bony tracts whose pattern bears no relation to that of the individual bones which make up the skull. The following tracts are described: maxillo-premaxillary (the alveolar process), premaxillo-supraorbital, supraorbito-squamosal, interparieto-occipitosquamosal and occipito-interparieto-supraorbital. The morphofunctional connections of this skull and its functional and structural importance are described and discussed.

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Using Functional Analysis Techniques to Develop Educational Support Plans for Students with High Support Needs

Australasian Journal of Special Education ◽

10.1017/s1030011200024477 ◽

1999 ◽

Vol 23 (1) ◽

pp. 5-14

Author(s):

Mark F. O’Reilly ◽

Stephanie M. Peck ◽

Jessica Webster ◽

Sally Jo Baird ◽

Kristen Plowman ◽

...

Keyword(s):

Functional Analysis ◽

School Setting ◽

Severe Disabilities ◽

Individual Characteristics ◽

Challenging Behaviour ◽

Classroom Context ◽

Educational Support ◽

Students With Severe Disabilities ◽

The Individual ◽

High Support

We examined the use of functional analysis methodologies to identify the environmental determinants of challenging behaviour for two students with severe disabilities. With one student the functional analysis was conducted in an outpatient clinic which was removed from the school setting. The functional analysis was conducted in the classroom setting with the other student. These assessments produced clear hypotheses regarding the controlling contingencies for challenging behaviour with both students. Individualised support plans were then developed and were successfully implemented by classroom personnel. The results of this study are discussed in terms of using a flexible approach to functional assessment in schools based on the individual characteristics of the student and the classroom context.

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Unipept CLI 2.0: adding support for visualizations and functional annotations

Bioinformatics ◽

10.1093/bioinformatics/btaa553 ◽

2020 ◽

Vol 36 (14) ◽

pp. 4220-4221 ◽

Cited By ~ 1

Author(s):

Pieter Verschaffelt ◽

Philippe Van Thienen ◽

Tim Van Den Bossche ◽

Felix Van der Jeugt ◽

Caroline De Tender ◽

...

Keyword(s):

Functional Analysis ◽

Web Application ◽

Application Programming Interface ◽

Supplementary Information ◽

Functional Annotations ◽

New Information ◽

Interactive Visualizations ◽

Application Programming ◽

Version 2.0 ◽

The Individual

Abstract Summary Unipept is an ecosystem of tools developed for fast metaproteomics data-analysis consisting of a web application, a set of web services (application programming interface, API) and a command-line interface (CLI). After the successful introduction of version 4 of the Unipept web application, we here introduce version 2.0 of the API and CLI. Next to the existing taxonomic analysis, version 2.0 of the API and CLI provides access to Unipept’s powerful functional analysis for metaproteomics samples. The functional analysis pipeline supports retrieval of Enzyme Commission numbers, Gene Ontology terms and InterPro entries for the individual peptides in a metaproteomics sample. This paves the way for other applications and developers to integrate these new information sources into their data processing pipelines, which greatly increases insight into the functions performed by the organisms in a specific environment. Both the API and CLI have also been expanded with the ability to render interactive visualizations from a list of taxon ids. These visualizations are automatically made available on a dedicated website and can easily be shared by users. Availability and implementation The API is available at http://api.unipept.ugent.be. Information regarding the CLI can be found at https://unipept.ugent.be/clidocs. Both interfaces are freely available and open-source under the MIT license. Contact [email protected] Supplementary information Supplementary data are available at Bioinformatics online.

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