TRANSCATHETER PDA CLOSURE IN NEONATES UP TO 3 KILOGRAMS IMPROVES RESPIRATORY STATUS AND GROWTH VELOCITY

Objective:Cobalamin (B12) deficiency has been reported in infants born to mothers with low cobalamin intake. Early diagnosis of vitamin B12 deficiency in infants is critical for the prevention of neurobehavioral disorders. We investigated the relationship between serum vitamin B12 level in newborns and in their healthy mothers who consumed an omnivorous diet. Anthropometry was studied longitudinally to assess the growth velocity of the infants. Urinary methylmalonic acid (MMA) excretion of 6-month old infants was compared retrospectively as the biomarker correlated with the initial serum vitamin B12 concentrations. Methods: Serum cobalamin and blood hemoglobin were determined in 84 pairs of newborns and their mothers. Urinary MMA excretion was measured in the same subjects during the first 6 months of the post partum period. Results: At birth, median serum cobalamin levels were 152.0 pmol/L in the mothers and 296.6 pmol/L in the newborns. Maternal and neonatal serum cobalamin levels had no effect on growth velocity during the first six months of postnatal life. Serum maternal and neonatal cobalamin levels were inversely associated with urinary MMA excretion. Conclusion: Early diagnosis of vitamin B12 status in neonates and infants is crucial, particularly in nutritionally deprived areas. Biochemical measurement of plasma cobalamin or its metabolic marker MMA is highly recommended. Urinary MMA measurement in cobalamin diagnostics provides an advantage in that blood sampling is not required. A vitamin B12 taskforce should be created to alleviate vitamin deficiency and its negative consequences.

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Ki-67 antigen expression in non-functioning pituitary adenomas is correlated to growth velocity but not to invasiveness

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-2003-817548 ◽

2003 ◽

Vol 111 (06) ◽

Author(s):

J Honegger ◽

C Prettin ◽

F Feuerhake ◽

M Petrick ◽

M Reincke

Keyword(s):

Growth Velocity ◽

Pituitary Adenomas ◽

Antigen Expression ◽

Ki 67 ◽

Non Functioning Pituitary Adenomas

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Treatment with growth hormone-releasing hormone (GHRH) 1-44 stimulates growth velocity in growth hormone-deficient children

Acta Endocrinologica ◽

10.1530/acta.0.120s085 ◽

1989 ◽

Vol 120 (3_Suppl) ◽

pp. S85-S86

Author(s):

Y.-F. SHI ◽

X.-L. BAO ◽

R. Liu ◽

J.-Y. DENG ◽

W. REINHARDT ◽

...

Keyword(s):

Growth Hormone ◽

Growth Velocity ◽

Growth Hormone Releasing Hormone ◽

Releasing Hormone

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Growth and development in girls with Turner's syndrome during early therapy with low doses of estradiol

Acta Endocrinologica ◽

10.1530/acta.0.112s157 ◽

1986 ◽

Vol 113 (4_Suppl) ◽

pp. S157-S163 ◽

Cited By ~ 8

Author(s):

K.W. KASTRUP ◽

_ _

Keyword(s):

Growth Velocity ◽

Final Height ◽

Bone Age ◽

Growth Spurt ◽

First Year ◽

Turner's Syndrome ◽

Turner’S Syndrome ◽

Early Therapy ◽

Group I ◽

Group Ii

Abstract Early therapy with a low dose of estrogen (estradiol-17β) was given to 33 girls with Turner's syndrome (T.s.) for a period of 4 years. The dose (0.25-2 mg/day) was adjusted every 3 months to maintain plasma estradiol in the normal concentration range for bone age. Growth velocity was compared with that of untreated girls with T.s. All girls were above age 10 years. Bone age was below 10 years in 11 girls (group I) and above 10 years in 22 girls (group II). Growth velocity in the first year of treatment in group I 7.5 ± 1.3 cm (SD) with mean SD score (SDS) of +4.3 and in group II 4.9 ± 1.3 with mean SDS of +3.5. Growth velocity decreased in the following years to 1.6 ± 1.0 cm, SDS -1.44 in group I and 0.9 ± 0.6cm, SDS -2.34 in group II during the fourth year. Withdrawal bleeding occurred in 16 girls of group II after the mean of 23 (range 15-33) months and in 3 girls of group I after 15 to 51 months of treatment. The treatment did not cause an inappropriate acceleration of pubertal development. Breast development appeared in most girls by 3 months of treatment. Pubic hair appeared by 12 months of treatment in group I; it was present in most girls in group II at start of treatment. Final height is known for 12 girls of group II; it was 144.2 ± 4.5 cm. The final height as predicted at the start of therapy was 142.2 ± 5.3 cm. Bone age advanced in the first year of treatment by 2 years. Early treatment with small doses of estrogens induces a growth spurt and normalizes the events of puberty. This will presumably decrease the psychological risks associated with abnormally delayed development.

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