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2021 ◽  
Alexander Stepanov ◽  
Svetlana Usharova ◽  
Kristina Malsagova ◽  
Larisa Moshetova ◽  
Ksenia Turkina ◽  

Abstract Tear samples were collected from 88 subjects and analyzed using absolute quantitative and comparative proteomic approach. We found a large proportion (505 proteins) of tear proteome between healthy donors and subjects with retinal vein occlusion (RVO). Comparative proteomic analysis revealed 30 proteins (p<0.05) significantly differed in their quantitative property. Among them S100A6 (3.7 fmoles/ng, p<0.001), S100A8 (0.68 fmoles/ng, p<0.001), and S100A9 (2.06 fmoles/ng, p<0.001) are the most overrepresented proteins. Mesothelin was found as tear-specific protein with significant increase (1.08 fmoles/ng versus 0.54 fmoles/ng in the control, p<0.001) in the RVO group. The selected altered proteins were combined to reconstruct the customized map of protein-protein interactions with the burden of quantitating property and the context of RVO-related association. The customized interactions map (FDR<0.01) emerged inflammation and impartment of retinal hemostasis as the main RVO-associated processes. The semantic analysis of customized map encouraged the prevalence of core biological processes encompassing dysregulation of mitochondrial organization and utilization of topologically incorrect folded proteins as a consequence of oxidative stress and inflammation caused by the retinal ischemic condition. Significantly differed proteins (S100A6, S100A8, S100A9, MSL, B2M) were applied for the ROC plotting with AUC varied from 0.772 to 0.952 suggesting their association with the CRVO.

Faizah Mughal ◽  
Ashok Kumar ◽  
Jai Dev Maheshwari ◽  
Ali Nawaz Bijarani ◽  
Tayyaba Kazmi ◽  

Background: The menstrual cycle describes the healthy reproductive system of the women which is controlled by different hormones. Aim: The goal of the study is to evaluate the prevalence of irregular menstruation in different endocrine changes and to identify their association with the age of women in reproductive life. Methodology: It was a cross-sectional study conducted on women attending the gynecological clinic of Karachi from March 2019 to June 2019. Of the 165 women with different hormonal changes 100 presented with menstrual cycle abnormality. Results: Among the women with menstrual irregularities 51% women presented with insulin resistance, 23% with hyperandrogenism, 19% with hypothyroidism and 7% hyperprolactinemia. Age-related association was observed in menstrual irregularities women with insulin resistant and hyperandrogenism. Conclusion: Menstrual cycle is a physiological process, any irregularities in cycle can be caused by  even  minimal  hormonal  imbalance.  As  a  result,  it  is  critical  to  address  endocrine abnormalities in order to improve women's reproductive health.

2021 ◽  
pp. 432-436
Mette Vestergaard Elbæk ◽  
Gabrielle Randskov Vinding ◽  
Gregor Borut Ernst Jemec

Darier’s disease is a rare genodermatosis characterized clinically by dyskeratotic papules in the seborrheic and intertriginous areas and nail abnormalities. Dyskeratosis and acantholysis are typical histological findings. Darier’s disease is not known to be inflammatory by nature as inflammation occurs primarily due to local infections, and it may therefore differ from inflammatory dermatoses such as psoriasis and cutaneous lupus in response to antigen stimulation. Known triggers of Darier’s disease primarily include exogenous factors such as sun exposure, friction, or infection. We present a case of a 47-year-old white female with a flare of Darier’s disease 2 days following her first vaccination with COVID-19 vaccine (ChAdOx1-s [recombinant]) (Vaxzevria<sup>®</sup> [previously known as COVID-19 vaccine AstraZeneca]). In this case report, we discuss possible mechanisms linking the vaccination and the flare of Darier’s disease. We consider inflammatory mechanisms as well as a random co-occurrence. Due to the close time-related association between the disease flare and the COVID-19 vaccination, we find an urge to make other clinicians aware of a possible association.

2021 ◽  
pp. 1-10
Wei Qin ◽  
Wenwen Li ◽  
Qi Wang ◽  
Min Gong ◽  
Tingting Li ◽  

Background: The global race-dependent association of Alzheimer’s disease (AD) and apolipoprotein E (APOE) genotype is not well understood. Transethnic analysis of APOE could clarify the role of genetics in AD risk across populations. Objective: This study aims to determine how race and APOE genotype affect the risks for AD. Methods: We performed a systematic search of PubMed, Embase, Web of Science, and the Cochrane Library since 1993 to Aug 25, 2020. A total of 10,395 reports were identified, and 133 were eligible for analysis with data on 77,402 participants. Studies contained AD clinical diagnostic and APOE genotype data. Homogeneous data sets were pooled in case-control analyses. Odds ratios and 95% confidence intervals for developing AD were calculated for populations of different races and APOE genotypes. Results: The proportion of APOE genotypes and alleles differed between populations of different races. Results showed that APOE ɛ4 was a risk factor for AD, whereas APOE ɛ2 protected against it. The effects of APOE ɛ4 and ɛ2 on AD risk were distinct in various races, they were substantially attenuated among Black people. Sub-group analysis found a higher frequency of APOE ɛ4/ɛ4 and lower frequency of APOE ɛ3/ɛ3 among early-onset AD than late-onset AD in a combined group and different races. Conclusion: Our meta-analysis suggests that the association of APOE genotypes and AD differ between races. These results enhance our understanding of APOE-related risk for AD across race backgrounds and provide new insights into precision medicine for AD.

2020 ◽  
Vol 10 (6) ◽  
pp. 135-140
Dr. Naina Hasija

To run the euro-region economy easily (saving from the awful impacts of crown), the European Central Bank (ECB) has reported countless measures since the start of the COVID-19 emergency. This reaction has set off apprehensions of a future expansion in swelling. We presume that the measures presented by the ECB during the emergency and the subsequent expansion in the size of its asset report, regardless of whether it were to be lasting, may prompt inflation. Central banks have found a way to keep their economies above water during the COVID-19 lockdowns. In the euro region, the European Central Bank (ECB) has facilitated essentially the states of its renegotiating activities and has reported another resource buy program to guarantee that its financial approach keeps on being very much communicated to all nations of the money related association. The European Central Bank worked by making cash and proficiently supplanting the credit framework by subbing cash for credit which may get terrible impacts the since quite a while ago run.

2020 ◽  
pp. 1-10
Juliane Sonntag ◽  
Mandy Vogel ◽  
Mandy Geserick ◽  
Felix Eckelt ◽  
Antje Körner ◽  

<b><i>Introduction:</i></b> The thyroid parafollicular hormone calcitonin (CT) shows particularly high blood levels in early childhood, a period of high bone turnover, which decrease with increasing age. Data about the physiological role of CT during infancy, childhood, and adolescence are contradictory or lacking. <b><i>Objective:</i></b> We hypothesize that CT demonstrates age-related correlations with parameters of bone growth and turnover as well as with parameters of calcium homeostasis. <b><i>Methods:</i></b> 5,410 measurements of anthropometric data and venous blood samples were collected from 2,636 participants of the LIFE Child study, aged 2 months–18 years. Univariate correlations and multiple regression analysis were performed between serum CT and anthropometric indicators (height standard deviation scores [SDS] and BMI-SDS), markers of calcium (Ca) homeostasis (Ca, parathyroid hormone, 25-OH vitamin D, and phosphate [P]), bone formation (procollagen type 1 N-terminal propeptide [P1NP], osteocalcin), and bone resorption (β-CrossLaps). <b><i>Results:</i></b> CT was significantly associated with Ca (β = 0.26, <i>p</i> &#x3c; 0.05) and P1NP/100 (β = 0.005, <i>p</i> &#x3c; 0.05) in children aged 2 months–1.1 years. These relations were independent of age and sex and could not be confirmed in children aged 1.1–8 years. Independent of age, sex, puberty, P, and height SDS CT showed a significant positive relation to Ca (β = 0.26; <i>p</i> &#x3c; 0.001) in children aged 8–18 years. <b><i>Conclusions:</i></b> Our findings suggest a unique association between CT and Ca in periods of rapid bone growth and point to a possible involvement of CT in promoting bone formation during the first year of life.

Mathematics ◽  
2020 ◽  
Vol 8 (10) ◽  
pp. 1776
Manuel Franco ◽  
Juana-María Vivo ◽  
Debasis Kundu

In 2020, El-Morshedy et al. introduced a bivariate extension of the Burr type X generator (BBX-G) of distributions, and Muhammed presented a bivariate generalized inverted Kumaraswamy (BGIK) distribution. In this paper, we propose a more flexible generator of bivariate distributions based on the maximization process from an arbitrary three-dimensional baseline distribution vector, which is of interest for maintenance and stress models, and expands the BBX-G and BGIK distributions, among others. This proposed generator allows one to generate new bivariate distributions by combining non-identically distributed baseline components. The bivariate distributions belonging to the proposed family have a singular part due to the latent component which makes them suitable for modeling two-dimensional data sets with ties. Several distributional and stochastic properties are studied for such bivariate models, as well as for its marginals, conditional distributions, and order statistics. Furthermore, we analyze its copula representation and some related association measures. The EM algorithm is proposed to compute the maximum likelihood estimations of the unknown parameters, which is illustrated by using two particular distributions of this bivariate family for modeling two real data sets.

Conor Philpott ◽  
Brian Donovan ◽  
Sarahjane Belton ◽  
Diarmuid Lester ◽  
Michael Duncan ◽  

Irish adolescents have been found to possess high perceptions of motor competence. However, there is an evidential value to investigating the strength of the relationship between adolescent perceptions of motor competence and their low levels of actual motor competence. The purpose of this research was to gather data on the fundamental, functional, and perceived motor competence in adolescents, differentiated by year group, to discern if participants could assess their perceptions of ability. Data were collected on adolescents (N = 373; mean age: 14.38 ± 0.87 years; 47.7% female) across six second-level schools in Ireland, including measurements of fundamental movement skills, functional movement, and perceived motor competence. Poor levels of fundamental and functional movement were observed, with significant differences between year groups detected. Participants in 1st year scored the highest in overall fundamental movement skills; however, for overall functional movement, 3rd-year participants scored highest. High levels of perceived motor competence were reported across the entire sample. These scores did not align with actual motor competence, nor did any alignment between these measurements improve with aging, countering theorized age-related associations. Future research should target low levels of actual motor competence while emphasizing the cognitive aspects of movement to ensure greater accuracy between actual and perceived motor competence.

Anavil Lou G. Balanon

Responses in terms of semantic association including paradigmatic and syntagmatic association, non semantic association including clang (phonological-related) and orthographical (spelling-related) association and random or other types of association of the freshman students in the College of Arts and Communication, University of Eastern Philippines was determined in this study. Secondly, this finds out whether AB LLT students which are the screened students in the college of arts and communication produce other types of responses besides the commonly known semantic responses. The instrument and stimuli was patterned after the study of Lan Wang of Indiana University of Pennsylvania, USA., entitled Word Association: Second Language Vocabulary Acquisition and Instruction. Modification was just made according to the locale of the study. Overall result of this study, the AB LLT respondents produced more semantic associations than the BSCrim, BSDevCom, ABPolSci, BSCD, ABPubAd and ABSocio respondents while the BSCrim,  BSDevCom, ABPolSci, BSCD, ABPubAd and ABSocio respondents produced more nonsemantic and random or other types of associations than the AB LLT respondents.

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