SERUM THYROID-STIMULATING HORMONE MEASUREMENT FOR ASSESSMENT OF THYROID FUNCTION AND DISEASE

Abstract Background As the incidence of secretory osteoporosis has increased, bone loss, osteoporosis and their relationships with thyroid-stimulating hormone (TSH) have received increased attention. In this study, the role of TSH in bone metabolism and its possible underlying mechanisms were investigated. Methods We analyzed the serum levels of free triiodothyronine (FT3), free thyroxine (FT4), and TSH and the bone mineral density (BMD) levels of 114 men with normal thyroid function. In addition, osteoblasts from rat calvarial samples were treated with different doses of TSH for different lengths of time. The related gene and protein expression levels were investigated. Results A comparison of the BMD between the high-level and low-level serum TSH groups showed that the TSH serum concentration was positively correlated with BMD. TSH at concentrations of 10 mU/mL and 100 mU/mL significantly increased the mRNA levels of ALP, COI1 and Runx2 compared with those of the control (P < 0.05, P < 0.01). Bone morphogenetic protein (BMP)2 activity was enhanced with both increased TSH concentration and increased time. The protein levels of Runx2 and osterix were increased in a dose-dependent manner. Conclusions The circulating concentrations of TSH and BMD were positively correlated with normal thyroid function in males. TSH promoted osteoblast proliferation and differentiation in rat primary osteoblasts.

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Management of thyroid disease in pregnancy – Room for improvement in the first trimester

Obstetric Medicine ◽

10.1177/1753495x16629773 ◽

2016 ◽

Vol 9 (3) ◽

pp. 126-129 ◽

Cited By ~ 1

Author(s):

Helen Robinson ◽

Philip Robinson ◽

Michael D’Emden ◽

Kassam Mahomed

Keyword(s):

General Practitioner ◽

Thyroid Function ◽

Thyroid Disease ◽

Thyroid Dysfunction ◽

First Trimester ◽

Antenatal Clinic ◽

Thyroid Stimulating Hormone ◽

Thyroid Function Tests ◽

In Pregnancy ◽

Stimulating Hormone

Background First-trimester care of maternal thyroid dysfunction has previously been shown to be poor. This study evaluates early management of thyroid dysfunction in pregnancy in Australia. Methods Patients reviewed by the Obstetric Medicine team for thyroid dysfunction from 1 January 2012 to 30 June 2013 were included. Data were collected on gestation at referral from the patient’s general practitioner to the antenatal clinic, information provided in the referral letter, thyroid function tests and thyroid medications. Results Eighty-five women were included in the study. At the time of general practitioner referral to antenatal services, 19% of women with preexisting thyroid disease had no thyroid function tested. Forty-three percent had an abnormal thyroid-stimulating hormone defined as being outside the laboratory-specific pregnancy reference range if available, or outside the level of 0.1–2.5 mIu/L in the first trimester, 0.2–3.0 mIu/L in the second trimester and 0.3–3.0 mIu/L in the third trimester. Only 21% of women increased their thyroxine dose prior to their first antenatal clinic review. Conclusion This study highlights that a significant proportion of women with known thyroid disease either have untested thyroid function in the first trimester or a thyroid-stimulating hormone outside of levels recommended by guidelines.

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Association of altered thyroid function and prolactin level in polycystic ovarian syndrome

Bangladesh Medical Journal ◽

10.3329/bmj.v45i1.28957 ◽

2016 ◽

Vol 45 (1) ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Marufa Mustari ◽

MA Hasanat ◽

Qamrul Hasan ◽

Sadiqa Tuqan ◽

Md Shah Emran ◽

...

Keyword(s):

Thyroid Function ◽

Prolactin Level ◽

Polycystic Ovarian Syndrome ◽

Density Lipoprotein ◽

Serum Testosterone ◽

Thyroid Stimulating Hormone ◽

Primary Infertility ◽

Altered Thyroid ◽

Ovarian Syndrome ◽

Stimulating Hormone

Polycystic ovarian syndrome (PCOS) is a common disorder for female with fertile age. Along with other clinical and biochemical manifestations, thyroid function and prolactin level may be altered in patients with PCOS. This study aimed to evaluate the clinical and biochemical status, as well as alteration of thyroid stimulating hormone (TSH), prolactin (PRL) level in patients with PCOS. Present study comprised of 100 diagnosed PCOS patients according to revised Rotterdem Consensus criteria. All patients were studied for serum testosterone, LH (lutenizing hormone), FSH (follicle stimulating hormone), blood glucose, lipid profile as well as TSH, FT4 (free thyroxin) and prolactin level. Out of 100 PCOS patients 97 had hirsutism, 64 had acanthosis nigricans, where menstrual irregularities were in 94 patients. Diastolic blood pressure (74±1.1 vs. 77±0.9, mmHg; p=0.017), total cholesterol (163±5.3 vs. 193±6.2 mg/dl; p<0.001), low density lipoprotein (LDL, 104±3.7 vs. 124±4.9 mg/dl; p=0.002) and frequency of acanthosis (25% vs. 75%; p<0.001) were significantly higher among the patients having BMI>25 Kg/m2 than those of have ? 25 Kg/m2. Among the fertile women (n=53), 47% had primary and 41.5% had secondary infertility; whereas of the total patients, 21% had altered thyroid function and 6.1% had raised prolactin (PRL, ng/ml) level. Differences of TSH (4.1±3.6 vs. 3.5±6.8, mIU/L; p=0.725) was not significant; whereas level of PRL (13.87±6.9vs. 9.4±5.2 ng/ml; p=0.018) was significantly higher in the group of primary infertility. Hirsutism, menstrual disturbance and acanthosis were very common in PCOS. Both primary and secondary sterility were also commonly observed and PRL was higher in primary infertility. About one fifth of PCOS had altered thyroid function.Bangladesh Med J. 2016 Jan; 45 (1): 1-5

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Thyroid Function and Release of Thyroid-stimulating Hormone and Prolactin from the Pituitary in Human Obesity

Journal of International Medical Research ◽

10.1177/030006059101900505 ◽

1991 ◽

Vol 19 (5) ◽

pp. 389-394 ◽

Cited By ~ 7

Author(s):

R. Scaglione ◽

M.R. Averna ◽

M.A. Dichiara ◽

C.M. Barbagallo ◽

G. Mazzola ◽

...

Keyword(s):

Thyroid Function ◽

Thyroid Stimulating Hormone ◽

Human Obesity ◽

Stimulating Hormone

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Thyroid function in preterm infants and neurodevelopment at 2 years

Archives of Disease in Childhood - Fetal and Neonatal Edition ◽

10.1136/archdischild-2018-316742 ◽

2020 ◽

Vol 105 (5) ◽

pp. 504-509 ◽

Cited By ~ 1

Author(s):

Fiona L R Williams ◽

Alice Lindgren ◽

Jennifer Watson ◽

Anita Boelen ◽

Timothy Cheetham

Keyword(s):

Preterm Infants ◽

Thyroid Function ◽

Thyroid Dysfunction ◽

Cohort Analysis ◽

Dried Blood Spots ◽

Thyroid Stimulating Hormone ◽

Composite Score ◽

Fine Motor ◽

The Relationship ◽

Stimulating Hormone

ObjectivesPostnatal thyroid dysfunction is common in preterm infants but the relationship between mild dysfunction and neurodevelopment is unclear. Our aim is to describe the relationship between thyroid function and neurodevelopment.DesignCohort analysis.Patients1275 infants born under 31 weeks’ gestation; there were no exclusion criteria.SettingThe infants were part of a UK daily iodine supplementation trial.Main outcomesThyroid-stimulating hormone, thyroid-binding globulin and total thyroxine levels were measured in dried blood spots on postnatal days 7, 14, 28 and the equivalent of 34 weeks’ gestation. Neurodevelopment was measured using the Bayley-III Scales of infant development at 2 years of age.ResultsNo infant was identified as hypothyroid through routine screening. The 3% of infants consistently in the top decile of gestationally age-adjusted thyroid-stimulating hormone levels had a reduction in cognitive score of 7 Bayley units when compared with those not in the top decile (95% CI –13 to –1). A reduction in motor composite score of 6 units (95% CI −12 to <−0.1) and fine motor score of 1 unit (95% CI –2 to –0.1) was also identified. The 0.7% of infants consistently in the bottom decile of age-adjusted thyroxine levels had a reduction in motor composite score of 14 units (95% CI –25 to –2) and its two subset scores, fine and gross motor, of 2 units (95% CI respectively −4.5 to <−0.1 and –4.3 to –0.3).ConclusionsPreterm infants with consistent ‘mild’ thyroid dysfunction score less on neurodevelopmental tests at 2 years of age. Many of these infants will not be detected by current clinical protocols or screening programmes.

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Prevalence of abnormal thyroid stimulating hormone and thyroid peroxidase antibody-positive results in a population of pregnant women in the Samara region of the Russian Federation

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm.2005.212 ◽

2005 ◽

Vol 43 (11) ◽

Cited By ~ 11

Author(s):

Frank A. Quinn ◽

Gennady N. Gridasov ◽

Sergey A. Vdovenko ◽

Natalia A. Krasnova ◽

Nadezhda V. Vodopianova ◽

...

Keyword(s):

Pregnant Women ◽

Thyroid Function ◽

Russian Federation ◽

Gestational Age ◽

Thyroid Stimulating Hormone ◽

Thyroid Peroxidase ◽

The Russian Federation ◽

Maternal Thyroid ◽

Positive Results ◽

Stimulating Hormone

AbstractUndiagnosed thyroid disease is a common problem with significant public health implications. This is especially true during pregnancy, when the health of both the mother and the developing child can be adversely affected by abnormal maternal thyroid function. Measurement of serum thyroid stimulating hormone (TSH) and thyroid peroxidase antibodies (TPO-Ab) are two common ways to assess maternal thyroid status. The objective of our study was to determine the prevalence of abnormal TSH and TPO-Ab tests in a population of pregnant women in the Samara region of the Russian Federation. Serum samples were obtained from 1588 pregnant women as part of their routine antenatal care. TSH and TPO-Ab were measured, and trimester-specific reference values for TSH (2.5–97.5 percentiles) were calculated using TPO-Ab-negative women. TSH results outside these ranges were considered abnormal; TPO-Ab levels outside the manufacturer's reference range (>12IU/mL) were considered abnormal. Overall, the prevalence of abnormal results was 6.3% for TSH and 10.7% for TPO-Ab. High TSH (>97.5 trimester-specific percentile) and TPO-Ab-positive results were most common in the first trimester (5.7% and 13.8%, respectively). TSH levels were associated with gestational age and TPO-Ab status, and with maternal age in TPO-Ab-negative women. TPO-Ab status was associated with both maternal and gestational age. Women with TSH >2.5mIU/L had a significantly increased risk of being TPO-Ab-positive, and this risk increased with age. Based on our data, we conclude that abnormal TSH and TPO-Ab are common in pregnant women of the Samara region. Given the association of thyroid dysfunction to adverse pregnancy outcomes, screening of this population for abnormal thyroid function should be considered.

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THE EFFECT OF PROLONGED FEEDING OF GOITROGENS ON THYROID FUNCTION IN RATS

Journal of Endocrinology ◽

10.1677/joe.0.0320341 ◽

1965 ◽

Vol 32 (3) ◽

pp. 341-351 ◽

Cited By ~ 7

Author(s):

G. D. BROADHEAD ◽

I. B. PEARSON ◽

G. M. WILSON

Keyword(s):

Thyroid Function ◽

Iodine Content ◽

Close Correlation ◽

Potassium Thiocyanate ◽

Thyroid Stimulating Hormone ◽

Size Reduction ◽

Potassium Perchlorate ◽

Prolonged Feeding ◽

Stimulating Hormone

SUMMARY Graded doses of propylthiouracil, carbimazole, sulphadiazine, potassium perchlorate and potassium thiocyanate were fed to groups of rats under standardized conditions for 2 months. The rats were given 131I 24 hr. before they were killed, and the thyroid weight, the proportions of labelled iodoaminoacids, and the thyroidal iodine content were determined. All the goitrogens produced increase in thyroid size, reduction of thyroidal iodine content, and an elevation of the monoiodotyrosine: di-iodotyrosine (MIT:DIT) ratio. The tri-iodothyronine: thyroxine (T3: T4) ratio was usually increased. Irrespective of the antithyroid compound used, there was a close correlation between the decrease in thyroidal iodine content and the rise in the MIT:DIT ratio. In further experiments, either thyroid stimulating hormone (TSH) or thyroxine were injected s.c. twice daily for 5 days. TSH decreased the MIT:DIT ratio and increased the amount of labelled T3. Thyroxine increased the MIT:DIT ratio and decreased the amount of T4. It is suggested that when goitrogens were administered for a prolonged period, the pattern of 131I-labelling of iodoaminoacids was dependent on a balance between inhibition of synthesis caused by the goitrogen and stimulation due to TSH. There was increased production of the physiologically more economical T3 in an attempt to compensate for decreased thyroxine formation.

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Obesity and hypothyroidism

Obesity and metabolism ◽

10.14341/2071-8713-4826 ◽

2013 ◽

Vol 10 (2) ◽

pp. 54-58 ◽

Cited By ~ 1

Author(s):

S M Zakharova ◽

L V Savelieva ◽

M I Fadeeva

Keyword(s):

Weight Loss ◽

Energy Expenditure ◽

Thyroid Function ◽

Thyroid Dysfunction ◽

Thyroid Stimulating Hormone ◽

Overt Hypothyroidism ◽

Obese Patients ◽

Common Diseases ◽

The Relationship ◽

Stimulating Hormone

Obesity and hypothyroidism are common diseases, and consequently clinicians should be particularly alert to the possibility of thyroid dysfunction in obese patients. The relationship between thyroid function and obesity is likely to be bidirectional, with hypothyroidism affecting weight, but obesity also influencing thyroid function. Both serum thyroid-stimulating hormone and fT3 are typically increased in obese individuals, an effect likely mediated by leptin. Following L-T4 treatment for overt hypothyroidism, weight loss appears to be modest and mediated primarily by loss of water weight rather than fat. Selected thyroid analogs might be a means by which to improve weight loss by increasing energy expenditure in obese patients during continued caloric deprivation

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The effect of iodine in patients using povidone-iodine mouth wash on thyroid function

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20194927 ◽

2019 ◽

Vol 5 (6) ◽

pp. 1562 ◽

Cited By ~ 1

Author(s):

Gowri Shankar Murugesan ◽

Manju Priya Venkat

Keyword(s):

Thyroid Gland ◽

Thyroid Function ◽

Povidone Iodine ◽

Endocrine System ◽

Thyroid Stimulating Hormone ◽

Increased Risk ◽

Before And After ◽

Mouth Wash ◽

Serum Tsh ◽

Stimulating Hormone

Background: Thyroid gland is a key part of endocrine system and it performs its functions via two most important thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroid gland is mainly regulated by thyroid-stimulating hormone (TSH). Povidone-iodine (polyvinylpyrrolidone-iodine, PVP-I) mouthwash is commonly used to treat infections of the oral cavity and oropharynx and iodine released from PVP-I can interfere with thyroid function. In this study the effect of brief treatment with povidone-iodine mouth wash on thyroid function was assessed. The aim of the present study was to assess whether iodine is absorbed through oral transmucosal route and interfere with TSH in serum.Methods: Fifty one patients with acute and chronic pharyngitis and tonsillitis were recruited and out of which forty-seven patients were treated with 20 ml of PVP-I mouthwash twice daily for 3 weeks and blood was collected from the respective patients before and after treatment with PVP-I. Serum thyroid stimulating hormone concentration was measured from the collected blood samples of the patients.Results: In the present study there was a small increase in serum TSH concentration during the therapy with PVP-I but the concentration determined was within the normal range.Conclusions: Based on the results of this study we conclude that the use of PVP-I for a brief period transiently increase TSH value and prolonged use should be avoided in people with an increased risk of thyroid dysfunction and other autoimmune disorders.

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