BDNF Val66Met modulates 5-HTTLPR for develop neuroticism in borderline personality disorder

2011 ◽  
Vol 26 (S2) ◽  
pp. 822-822
Author(s):  
J. Villarroel Garrido ◽  
H. Silva Ibarra ◽  
P. Iturra Constant ◽  
S. Jerez Concha ◽  
C. Montes Aguirre ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Correlation Method ◽  
Borderline Personality ◽  
Transporter Gene ◽  
Bdnf Gene ◽  
Serotonin System ◽  
Increased Risk ◽  
Genetic Level ◽  
Axis I

Brain derived neurotrophic factor (BDNF) is the most widely distributed and highly expressed neurotrophin in the CNS. BDNF gene have been associated with increased risk psychiatric disorders. It has been described interaction between BDNF and serotonin system at a neural and genetic level. Neuroticism as a personality trait relevant in borderline personality disorder (BPD) has genetic inheritance and is associated with serotonergic dysfunction. Has been reported that BDNF Val66Met variant is associated with neuroticism in general population. The aim of this study is to test the association between Val66Met and neuroticism and evaluate if the presence of Val66Met allele interacts with polymorphism in promoter region of serotonin transporter gene (5-HTTLPR) for develop neuroticism in BPD. We evaluate personality with NEO PI R in 104 BPD subjects that did not meet criteria for axis I diagnoses and other personality disorders. Genetic analysis of BDNF was performed determining the presence of Val/Val Val/Met and Met/Met BDNF variants. 5-HTTLPR was performed determining the presence of L and S 5-HTTLPR alleles. Statistical analysis were tested with parametric and correlation method with Stata10. We did not found differences in neuroticism between BDNF variants, but when controlled by BDNF alleles we found that Met/Met modulate the expression of 5-HTTLPR, with S-carriers (LS+SS) having higher neuroticism than LL (F = 6.36, p = 0.0031). We found no differences in expression of 5-HTTLPR in other BDNF variants. We conclude that BDNF have a differential modulating effect of 5-HTTLPR in neuroticism in BPD.

Association between 5-HTTLPR and neuroticism in borderline personality disorder

2011 ◽  
Vol 26 (S2) ◽  
pp. 816-816
Author(s):  
H. Silva Ibarra ◽  
J. Villarroel Garrido ◽  
P. Iturra Constant ◽  
S. Jerez Concha ◽  
M.L. Bustamante Calderon ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Promoter Region ◽  
Correlation Method ◽  
Borderline Personality ◽  
Transporter Gene ◽  
Emotional Instability ◽  
Personality Dimension ◽  
Significant Difference ◽  
Axis I

Neuroticism is characterized by emotional instability and the tendency to experience negative emotions such as anger, anxiety and depressed mood. Subjects with borderline personality disorder (BPD) present this personality dimension as a temperamental core trait. There has been proposed that neuroticism can appropriately describe the most important characteristics of BPD. The polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) has been implicated in depression, anxiety and suicide. It is estimated that 5-HTTLPR polymorphism account to 7 to 9% of inherited variance of neuroticism in personality. The aim of this study is to evaluate the association between neuroticism and 5-HTTLPR polymorphism in BPD. We evaluate personality with NEO PI R inventory in 104 BPD subjects (76 female/28 male) that did not meet criteria for axis I diagnoses and other personality disorders. The genetic analysis of 5-HTTLPR were performed determining the presence of long and short alleles, subjects were grouped in long/long (LL) and S-carriers (LS+SS). Statistical analysis were tested with parametric and correlation method with Stata10. We found significant difference in neuroticism between the genotype groups (F = 8.57, p = 0.0004) and lower levels of neuroticism in LL than S-carriers. Female have higher neuroticism than male. 5-HTTLPR polymorphism explains 18.02% of inherited variance in neuroticism. The S-carriers had 11.9 times higher risk of presenting elevated neuroticism compared with LL. We conclude that there are relation between 5-HTTLPR polymorphism and neuroticism in BPD. These results should contribute to the genetic study of BPD.

scholarly journals Prospective study of family adversity and maladaptive parenting in childhood and borderline personality disorder symptoms in a non-clinical population at 11 years

2012 ◽  
Vol 42 (11) ◽  
pp. 2405-2420 ◽  
Author(s):  
C. Winsper ◽  
M. Zanarini ◽  
D. Wolke
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Borderline Personality ◽  
Family Adversity ◽  
Increased Risk ◽  
Axis I ◽  
Dsm Iv ◽  
Parent Conflict ◽  
Prospective Longitudinal ◽  
Maladaptive Parenting

BackgroundRetrospective studies have consistently indicated an association between maladaptive parenting and borderline personality disorder (BPD). This requires corroboration with prospective, longitudinal designs. We investigated the association between suboptimal parenting and parent conflict in childhood and BPD symptoms in late childhood using a prospective sample.MethodA community sample of 6050 mothers and their children (born between April 1991 and December 1992) were assessed. Mothers' family adversity was assessed during pregnancy and parenting behaviours such as hitting, shouting, hostility and parent conflict across childhood. Intelligence quotient (IQ) and DSM-IV Axis I diagnoses were assessed at 7–8 years. Trained psychologists interviewed children at 11 years (mean age 11.74 years) to ascertain BPD symptoms.ResultsAfter adjustment for confounders, family adversity in pregnancy predicted BPD probable 1 to 2 adversities: odds ratio (OR)=1.34 [95% confidence interval (CI) 1.01–1.77]; >2 adversities: OR 1.99 (95% CI 1.34–2.94) and definite 1 to 2 adversities: OR 2.48 (95% CI 1.01–6.08) symptoms. Each point increase in the suboptimal parenting index predicted BPD probable: OR 1.13 (95% CI 1.05–1.23) and definite: OR 1.28 (95% CI 1.03–1.60) symptoms. Parent conflict predicted BPD probable: OR 1.19 (95% CI 1.06–1.34) and definite: OR 1.42 (95% CI 1.06–1.91) symptoms. Within the path analysis, the association between suboptimal parenting and BPD outcome was partially mediated by DSM-IV diagnoses and IQ at 7–8 years.ConclusionsChildren from adverse family backgrounds, who experience suboptimal parenting and more conflict between parents, have poor cognitive abilities and a DSM-IV diagnosis, are at increased risk of BPD symptoms at 11 years.

Axis I Dissociative Disorder Comorbidity in Borderline Personality Disorder and Reports of Childhood Trauma

2006 ◽  
Vol 67 (10) ◽  
pp. 1583-1590 ◽  
Author(s):  
Vedat Sar ◽  
Gamze Akyuz ◽  
Nesim Kugu ◽  
Erdinc Ozturk ◽  
Hayriye Ertem-Vehid
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Childhood Trauma ◽  
Borderline Personality ◽  
Dissociative Disorder ◽  
Axis I

scholarly journals Family History Study of the Familial Coaggregation of Borderline Personality Disorder With Axis I and Nonborderline Dramatic Cluster Axis II Disorders

2009 ◽  
Vol 23 (4) ◽  
pp. 357-369 ◽  
Author(s):  
Mary C. Zanarini ◽  
Leah K. Barison ◽  
Frances R. Frankenburg ◽  
D. Bradford Reich ◽  
James I. Hudson
Keyword(s):  
Borderline Personality Disorder ◽  
Family History ◽  
Personality Disorder ◽  
Borderline Personality ◽  
Axis Ii ◽  
Axis I

Suicidal and Nonsuicidal Self-Injury in Borderline Personality Disorder

2017 ◽  
Author(s):  
Margaret S. Andover ◽  
Heather T. Schatten ◽  
Blair W. Morris
Keyword(s):  
Risk Factors ◽  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Attempted Suicide ◽  
Borderline Personality ◽  
Modifiable Risk Factors ◽  
Self Injury ◽  
Increased Risk ◽  
Suicide Attempted ◽  
Nonsuicidal Self Injury

Individuals diagnosed with borderline personality disorder (BPD) are at an elevated risk for engaging in self-injurious behaviors, including suicide, attempted suicide, and nonsuicidal self-injury (NSSI). The purpose of this chapter is to provide an overview of research on self-injurious behaviors among individuals with BPD. Definitions and prevalence rates are provided for NSSI, suicide, and attempted suicide. Clinical correlates of and risk factors for the behaviors, as well as associations between specific BPD criteria and self-injurious behaviors, are discussed, and a brief overview of treatments focused on reducing self-injurious behaviors among BPD patients is provided. By understanding risk factors for attempted suicide and NSSI in BPD, we can better identify patients who are at increased risk and focus treatment efforts on addressing modifiable risk factors.

scholarly journals Recent developments in psychosocial interventions for borderline personality disorder

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 561
Author(s):  
Christina M Temes ◽  
Mary C Zanarini
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Treatment Options ◽  
Specific Treatment ◽  
Psychosocial Interventions ◽  
Borderline Personality ◽  
Post Traumatic Stress ◽  
Treatment Needs ◽  
Specific Patient ◽  
Increased Risk

Borderline personality disorder (BPD) is a serious psychiatric disorder that affects multiple symptomatic domains and is associated with an increased risk of suicidality. Several empirically supported treatments for BPD have been developed in recent years for adults with BPD. More recent work has focused on tailoring or applying (or both) these existing treatments to specific patient populations, including patients with certain types of comorbidity (for example, BPD and post-traumatic stress disorder or antisocial personality disorder) and younger patients. Other work has involved developing treatments and models of treatment delivery that address concerns related to access of care. Relatedly, new adjunctive and technology-assisted interventions have been developed, adding to the growing repertoire of treatment options for these patients. Advances in the last several years address specific treatment needs and offer cost-efficient options for this diverse patient population.

scholarly journals Axis I-Axis II comorbidity of borderline personality disorder: gender-related differences

2008 ◽  
Vol 7 (S1) ◽  
Author(s):  
Ioannis Pantoularis ◽  
George Garyfallos ◽  
Martha Lobtzianidou ◽  
Aristidis Livanos ◽  
Ioannis Dasoukis ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Borderline Personality ◽  
Axis Ii ◽  
Axis I
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