Social functioning and cognition in patients with schizophrenia, their unaffected siblings and healthy controls: impact on quality of life

2011 ◽  
Vol 26 (S2) ◽  
pp. 1398-1398
Author(s):  
D.D. Achaval ◽  
K. Buglioni ◽  
J. Lopez ◽  
J. Douer ◽  
E. Costanzo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Social Skills ◽  
Social Cognition ◽  
Social Functioning ◽  
Social Performance ◽  
Adaptive Behaviour ◽  
Healthy Controls ◽  
Cognitive Screening ◽  
Intermediate Phenotypes

BackgroundPatients with schizophrenia show deficits in many cognitive domains and social functioning, social skills, and self management skills in their daily life activities.ObjectiveTo evaluate the relationship between general-social cognition, mental state and social functioning, and impact on quality of life.MethodsTwenty patients with chronic disorder of schizophrenia were evaluated and compared with 20 siblings and 20 healthy controls regarding performance in a series of tests: Cognitive Screening: Word Accentuation Test, MCCB (Matrics Consensus Cognitive Battery) Social Functioning: UPSA (University of California Performance Skills Assessment), TABS (Test of Adaptive Behaviour in Schizophrenia), SSPA (Social Skills Performance Assessment), Beck and Hamilton depression scales, Scale for Positive and Negative Syndrome of Schizophrenia, and SF-36 as indicator of quality of life.ResultsPatients showed significant differences from controls and siblings in MCCB total score (p < 0.001), whereas siblings showed significant differences compared to controls in MCCB total score (p = 0.053). Siblings performed differently from patients (p < 0.001) and controls (p = 0.019) in social functioning measured with TABS. A series of correlations between general cognition and social functioning were demonstrated for patients and their unaffected siblings (not shown).ConclusionResults suggest that the performance of nonpsychotic siblings is located between patients and healthy controls, suggesting that social performance measures are (or associated with) intermediate phenotypes of the disease. General and social cognition have a complex relationship with social functioning and quality of life.

scholarly journals Quality of life of people with schizophrenia compared to controls: A case-control study

2019 ◽  
Author(s):  
Abraha Gosh Woldemariam ◽  
Haftom Desta Kahsay
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Social Functioning ◽  
Physical Component Summary ◽  
Mental Component Summary ◽  
Case Control Study ◽  
Case Control ◽  
Healthy Controls ◽  
Control Study

Abstract Objective: purpose of this study was to compare the quality of life of people with schizophrenia to healthy controls. Results: the present study demonstrated that respondents with schizophrenia have significantly lower scores in Physical component summary ( U=70.5, z=-8.695, p<..001, r=-.734 ), mental component summary ( U=79.0,z= -8.634 p<.001, r=-.730 ), Physical functioning ( U=310, z-9.553, p<.001, r=-.808 ), Role Physical ( U=419, z=-8.975, p<.001, r=-.759 ), Body pain ( U=1395.5, z=-3.501, p<.001, r=-.296 ), General health ( U=320,z=-7.514, p<.001, r=-.635 ), Vitality ( U=353, z=-7.398, p=.001, r=-.625 ), Social functioning ( U=213.5, z=-9.398, p<.001, r=-.794 ), Role emotion ( U=144.5, z=-985, p<.001, r=-.844 ) and Mental health ( U=178, z=-8.199, p<.001, r=-.693 ) compared with healthy controls. Key words: Quality of life, Schizophrenia, Controls, Case-Control

scholarly journals Impact on Quality of Life 3 Years After Diagnosis of Prostate Cancer Patients Below 75 At Diagnosis: An Observational Case-Control Study

2020 ◽  
Author(s):  
Nadine Houédé ◽  
Xavier Rébillard ◽  
Sophie Bouvet ◽  
Sarah Kabani ◽  
Pascale Fabbro-Peray ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Multivariate Analysis ◽  
Social Functioning ◽  
Cancer Patients ◽  
Case Control ◽  
Healthy Controls ◽  
Global Quality Of Life

Abstract Background: Prostate cancer patients are known to suffer from poor sexual and urinary long-term side-effects following treatment, potentially impacting quality of life. The purpose of our study was to compare health-related quality of life at 3 years between prostate cancer patients and healthy controls according to key life-style characteristics. Secondary objectives were to compare urological dysfunction, sexual function, anxiety and depression. Methods: Multicentric, case-control, observational prospective, open, follow-up study including 819 prostate cancer patients < 75 years old from the EPICAP cohort, newly diagnosed from 1 December 2011 to 31 March 2014 and 879 healthy controls. Participants were excluded if they experienced a relapse. Controls from the same geographical region were age-matched and were excluded if they were diagnosed with prostate cancer. Patients received one of the following treatments: active surveillance (AS), radical prostatectomy (RP), external beam radiotherapy (EBRT), High-intensity Focused Ultrasound (HIFU), chemotherapy (CT), or androgen deprivation therapy (ADT) as appropriate. The primary outcome was the quality of life as evaluated by the QLQ-C30 questionnaire. Scores were analyzed by multivariate analysis to adjust for predefined socio-demographic confounding effects. Results: In total, 564 participants were included (mean age 67.9 years): 376 patients and 188 controls. Treatment breakdown was: 258 underwent RP, 90 received EBRT, 52 brachytherapy or HIFU, 15 CT, 26 ADT and 61 AS. There was no difference in median global quality of life between patients and controls (94.87 vs 94.15, p=0.71). Multivariate analysis showed poorer social functioning in patients (24.3% vs. 16.3%, p=0.0209), more dyspnea (22% vs. 12.4%, p=0.0078), and yet less current pain (23% vs 33%, p=0.0151). Conclusions: Global health status score at 3 years after diagnosis was similar between patients and controls, though patients showed a significantly worse social functioning. Prostate cancer diagnosis per se does not impact the quality of life of patients <75 years at diagnosis. However, the therapeutic option that will be chosen following diagnosis should be carefully discussed with the medical staff in terms of benefit-risk ratios as it could have a long-term impact on urinary or erectile dysfunction.Trial registration: clinicaltrials.gov, NCT02854982. Registered 4 August 2016 – retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02854982

Neuro-cognition and social cognition elements of social functioning and social quality of life

2017 ◽  
Vol 258 ◽  
pp. 538-543 ◽  
Author(s):  
Ilanit Hasson-Ohayon ◽  
Michal Mashiach-Eizenberg ◽  
Nitzan Arnon-Ribenfeld ◽  
Shlomo Kravetz ◽  
David Roe
Keyword(s):  
Quality Of Life ◽  
Social Cognition ◽  
Social Functioning ◽  
Social Quality ◽  
Social Quality Of Life

Social skills training for chronic psychotic patients: A French study

1996 ◽  
Vol 11 (S2) ◽  
pp. 77s-84s ◽  
Author(s):  
O Chambon ◽  
M Marie-Cardine ◽  
A Dazord
Keyword(s):  
Quality Of Life ◽  
Social Skills ◽  
Social Functioning ◽  
Social Skills Training ◽  
Skills Training ◽  
Rehabilitation Program ◽  
Problem Solving Skills ◽  
Schizophrenic Patients ◽  
The Impact

SummaryThe aim of this article is to describe the cognitive-behavioral methods for social rehabilitation and psychotherapy of chronic psychotic patients which are nowadays available in French-speaking countries, then to propose a theoretical framework to help integrate these various methods for use in our duly pratice and, finally, to expose our research in this field, especially concerning the topic of quality of life and social skills training programs. We present a study we designed in order to assess the impact of a comprehensive social skills training program upon quality of life of chronic schizophrenic patients. Starting from the point of view that a good psychosocial rehabilitation program is one that improves social skills and social functioning without negative effects on quality of life, we tried to show such qualities in a quite comprehensive rehabilitation program using social skills training methods corresponding to the social readaptative “modules” from Liberman and Wallace's Social and Independant Living Skills Program — “medication management module” — followed by “basic conversational skills module”, and finally, a brief adapted version of “interpersonal problem solving skills module”. We were able to observe the evolution of social skills and functioning of eight schizophrenic patients having benefited from this program, over a one year period, and we compared results regarding quality of life with two control groups made of schizophrenic patients, one of them having benefited from a supportive group therapy in order to study the impact of non-specific factors. The results indicate a clear dissociation between direct benefits of social skills training (knowledge, social skills, social functioning and symptomatology) which all showed a significant improvement in the experimental group, and subjective benefits (self-esteem, sense of self-efficacy, quality of life) which showed no change, as well when consider no intra-group as well as between group comparisons.

scholarly journals Impact on Quality of Life 3 Years After Diagnosis of Prostate Cancer Patients Below 75 At Diagnosis: An Observational Case-Control Study

2020 ◽  
Author(s):  
Nadine Houédé ◽  
Xavier Rébillard ◽  
Sophie Bouvet ◽  
Sarah Kabani ◽  
Pascale Fabbro-Peray ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Multivariate Analysis ◽  
Social Functioning ◽  
Cancer Patients ◽  
Case Control ◽  
Healthy Controls ◽  
Global Quality Of Life

Abstract Background: Prostate cancer patients are known to suffer from poor sexual and urinary long-term side-effects following treatment, potentially impacting quality of life. The purpose of our study was to compare health-related quality of life at 3 years between prostate cancer patients and healthy controls according to key life-style characteristics. Secondary objectives were to compare urological dysfunction, sexual function, anxiety and depression. Methods: Multicentric, case-control, observational prospective, open, follow-up study including 819 prostate cancer patients < 75 years old from the EPICAP cohort, newly diagnosed from 1 December 2011 to 31 March 2014 and 879 healthy controls. Participants were excluded if they experienced a relapse. Controls from the same geographical region were age-matched and were excluded if they were diagnosed with prostate cancer. Patients received one of the following treatments: active surveillance (AS), radical prostatectomy (RP), external beam radiotherapy (EBRT), High-intensity Focused Ultrasound (HIFU), chemotherapy (CT), or androgen deprivation therapy (ADT) as appropriate. The primary outcome was the quality of life as evaluated by the QLQ-C30 questionnaire. Scores were analyzed by multivariate analysis to adjust for predefined socio-demographic confounding effects. Results: In total, 564 participants were included (mean age 67.9 years): 376 patients and 188 controls. Treatment breakdown was: 258 underwent RP, 90 received EBRT, 52 brachytherapy or HIFU, 15 CT, 26 ADT and 61 AS. There was no difference in median global quality of life between patients and controls (94.87 vs 94.15, p=0.71). Multivariate analysis showed poorer social functioning in patients (24.3% vs. 16.3%, p=0.0209), more dyspnea (22% vs. 12.4%, p=0.0078), and yet less current pain (23% vs 33%, p=0.0151). Conclusions: Global health status score at 3 years after diagnosis was similar between patients and controls, though patients showed a significantly worse social functioning. Prostate cancer diagnosis per se does not seem to impact the quality of life of patients <75 years at diagnosis. However, the therapeutic option that will be chosen following diagnosis should be carefully discussed with the medical staff in terms of benefit-risk ratios as it could have a long-term impact on urinary or erectile dysfunction.Trial registration: clinicaltrials.gov, NCT02854982. Registered 4 August 2016, retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02854982

scholarly journals Multivariate predictors of social skills performance in middle-aged and older out-patients with schizophrenia spectrum disorders

2007 ◽  
Vol 38 (5) ◽  
pp. 755-763 ◽  
Author(s):  
D. I. Sitzer ◽  
E. W. Twamley ◽  
T. L. Patterson ◽  
D. V. Jeste
Keyword(s):  
Quality Of Life ◽  
Cognitive Impairment ◽  
Social Skills ◽  
Social Functioning ◽  
Negative Symptoms ◽  
Rating Scale ◽  
Social Contact ◽  
Schizophrenia Spectrum Disorders ◽  
Middle Aged

BackgroundCognitive impairment and negative symptoms are two of the primary features of schizophrenia associated with poor social functioning. We examined the relationships between clinical characteristics, specific cognitive abilities and social skills performance in middle-aged and older out-patients with schizophrenia and normal comparison subjects.MethodOne hundred and ninety-four middle-aged and older schizophrenia out-patients and 60 normal comparison subjects were administered a standardized, performance-based measure of social skills using role-plays of various social situations [Social Skills Performance Assessment (SSPA)] and measures of current level of social contact (the Lehman Quality of Life Interview), psychiatric symptom severity [the Positive and Negative Syndrome Scale (PANSS) and the Hamilton Depression Rating Scale (HAMD)], insight [the Birchwood Insight Scale (IS)] and cognitive functioning [the Mattis Dementia Rating Scale (DRS)].ResultsPatients demonstrated worse social skills compared with normal subjects. Better performance on the SSPA was associated with having less severe positive and negative symptoms, fewer social contacts, and better attention, initiation/freedom from perseveration, visuospatial ability, abstraction ability and memory. After controlling for demographic, clinical and insight-related factors, abstraction ability was the strongest predictor of social skills performance, followed by frequency of social contact.ConclusionsSocial functioning (as measured through direct observation of social skills performance) was related to cognitive ability in out-patients with schizophrenia. Addressing such cognitive impairment may help to improve social functioning and result in greater overall quality of life.

scholarly journals Creating Live Interactions to Mitigate Barriers (CLIMB): A Mobile Intervention to Improve Social Functioning in People With Chronic Psychotic Disorders

2016 ◽  
Vol 3 (4) ◽  
pp. e52 ◽  
Author(s):  
Bruno Biagianti ◽  
Danielle Schlosser ◽  
Mor Nahum ◽  
Josh Woolley ◽  
Sophia Vinogradov
Keyword(s):  
Quality Of Life ◽  
Social Cognition ◽  
Group Therapy ◽  
Social Functioning ◽  
Mobile Devices ◽  
Psychotic Disorders ◽  
Positive Effects ◽  
Randomized Controlled Studies ◽  
Therapy Sessions

Background Numerous psychosocial interventions for individuals with chronic psychotic disorders (CPD) have shown positive effects on social cognitive and functional outcome measures. However, access to and engagement with these interventions remains limited. This is partly because these interventions require specially trained therapists, are not available in all clinical settings, and have a high scheduling burden for participants, usually requiring a commitment of several weeks. Delivering interventions remotely via mobile devices may facilitate access, improve scheduling flexibility, and decrease participant burden, thus improving adherence to intervention requirements. To address these needs, we designed the Creating Live Interactions to Mitigate Barriers (CLIMB) digital intervention, which aims to enhance social functioning in people with CPD. CLIMB consists of two treatment components: a computerized social cognition training (SCT) program and optimized remote group therapy (ORGT). ORGT is an innovative treatment that combines remote group therapy with group texting (short message service, SMS). Objectives The objectives of this single-arm study were to investigate the feasibility of delivering 6 weeks of CLIMB to people with CPD and explore the initial effects on outcomes. Methods Participants were recruited, screened and enrolled via the Internet, and delivered assessments and interventions remotely using provided tablets (iPads). Participants were asked to complete 18 hours of SCT and to attend 6 remote group therapy sessions. To assess feasibility, adherence to study procedures, attrition rates, engagement metrics, and acceptability of the intervention were evaluated. Changes on measures of social cognition, quality of life, and symptoms were also explored. Results In total, 27 participants were enrolled over 12 months. Remote assessments were completed successfully on 96% (26/27) of the enrolled participants. Retention in the 6-week trial was 78% (21/27). Of all the iPads used, 95% (22/23) were returned undamaged at the end of the intervention. Participants on average attended 84% of the group therapy sessions, completed a median of 9.5 hours of SCT, and posted a median of 5.2 messages per week on the group text chat. Participants rated CLIMB in the medium range in usability, acceptability, enjoyment, and perceived benefit. Participants showed significant improvements in emotion identification abilities for prosodic happiness (P=.001), prosodic happiness intensity (P=.04), and facial anger (P=.04), with large within-group effect sizes (d=.60 to d=.86). Trend-level improvements were observed on aspects of quality of life (P values less than .09). No improvements were observed for symptoms. Conclusions It is feasible and acceptable to remotely deliver an intervention aimed at enhancing social functioning in people with CPD using mobile devices. This approach may represent a scalable method to increase treatment access and adherence. Our pilot data also demonstrate within-group gains in some aspects of social cognition after 6 weeks of CLIMB. Future randomized controlled studies in larger samples should evaluate the extent to which CLIMB significantly improves social cognition, symptoms, and quality of life in CPD.

scholarly journals Impact on Quality of Life 3 Years After Diagnosis of Prostate Cancer Patients: An Observational Case-Control Study

2020 ◽  
Author(s):  
Nadine Houédé ◽  
Xavier Rébillard ◽  
Sophie Bouvet ◽  
Sarah Kabani ◽  
Pascale Fabbro-Peray ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Multivariate Analysis ◽  
Social Functioning ◽  
Cancer Patients ◽  
Case Control ◽  
Healthy Controls ◽  
Global Quality Of Life

Abstract Background Prostate cancer patients are known to suffer from poor sexual and urinary long-term side-effects following treatment, potentially impacting quality of life. The purpose of our study was to compare health-related quality of life at 3 years between prostate cancer patients and healthy controls according to key life-style characteristics. Secondary objectives were to compare urological dysfunction, sexual function, anxiety and depression.Methods Multicentric, case-control, observational prospective, open, follow-up study including 819 prostate cancer patients < 75 years old from the EPICAP cohort newly diagnosed from 1 December 2011 to 31 March 2014 and 879 healthy controls. Participants were excluded if they experienced a relapse. Controls from the same geographical region were age-matched and were excluded if they were diagnosed with prostate cancer. Patients received one of the following treatments: active surveillance (AS), radical prostatectomy (RP), external beam radiotherapy (EBRT), High-intensity Focused Ultrasound (HIFU), chemotherapy (CT), or androgen deprivation therapy (ADT) as appropriate. The primary outcome was the quality of life as evaluated by the QLQ-C30 questionnaire. Scores were analyzed by multivariate analysis to adjust for predefined socio-demographic confounding effects.Results In total, 564 participants were included (mean age 67.9 years): 376 patients and 188 controls. Treatment breakdown was: 258 underwent RP, 90 received EBRT, 52 brachytherapy or HIFU, 15 CT, 26 ADT and 61 AS. There was no difference in median global quality of life between patients and controls (94.87 vs 94.15, p = 0.71). Multivariate analysis showed poorer social functioning in patients (24.3% vs. 16.3%, p = 0.0209), more dyspnea (22% vs. 12.4%, p = 0.0078), and yet less current pain (23% vs 33%, p = 0.0151).Conclusions Global health status score at 3 years after diagnosis was similar between patients and controls, though patients showed a significantly worse social functioning. Prostate cancer diagnosis per se does not impact the quality of life of patients. However, the therapeutic option that will be chosen following diagnosis should be carefully discussed with the medical staff in terms of benefit-risk ratios as it could have a long-term impact on urinary or erectile dysfunction.Trial registration: clinicaltrials.gov, NCT02854982. Registered 4 August 2016 – retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02854982

scholarly journals Physical Activity and Quality of Life in Hemodialysis Patients and Healthy Controls: A Cross-Sectional Study

2021 ◽  
Vol 18 (4) ◽  
pp. 1978
Author(s):  
Tjaša Filipčič ◽  
Špela Bogataj ◽  
Jernej Pajek ◽  
Maja Pajek
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Everyday Life ◽  
Habitual Physical Activity ◽  
Healthy Controls ◽  
Age And Gender ◽  
Comorbidity Score ◽  
Sf 36 ◽  
And Gender

Hemodialysis (HD) patients have lower functional abilities compared to healthy people, and this is associated with lower physical activity in everyday life. This may affect their quality of life, but research on this topic is limited. Therefore, the present study aimed to determine the relationship between habitual physical activity and quality of life in HD patients and healthy controls. Ninety-three HD patients and 140 controls participated in the study. Quality of life was assessed using a 36-item medical outcomes study short-form health survey (SF-36). Human Activity Profile (HAP) was used to assess habitual physical activity. The adjusted activity score (AAS) from HAP, age, gender, fat tissue index (FTI), lean tissue index (LTI), and Davies comorbidity score were analyzed as possible predictors of the Physical Component Summary (PCS) of the SF-36. Three sequential linear models were used to model PCS. In Model 1, PCS was regressed by gender and age; in Model 2 the LTI, FTI, and Davies comorbidity scores were added. Model 3 also included AAS. After controlling for age and gender (ModelHD 1: p = 0.056), LTI, FTI, and Davies comorbidity score effects (ModelHD 2: p = 0.181), the AAS accounted for 32% of the variation in PCS of HD patients (ModelHD 3: p < 0.001). Consequently, the PCS of HD patients would increase by 0.431 points if the AAS increased by one point. However, in healthy controls, AAS had a lower impact than in the HD sample (B = 0.359 vs. 0.431), while the corresponding effects of age and gender (ModelH 1: p < 0.001), LTI, FTI, and Davies comorbidity score (ModelH 2: p < 0.001) were adjusted for. The proportion of variation in PCS attributed to AAS was 14.9% (ModelH 3: p < 0.001). The current study results showed that physical activity in everyday life as measured by the HAP questionnaire is associated to a higher degree with the quality of life of HD patients than in healthy subjects. Routine physical activity programs are therefore highly justified, and the nephrology community should play a leading role in this effort.

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