P.8.a.007 Association between individual differences in slow wave sleep, slow wave activity and sleep continuity in young, middle-aged and older men and women

Slow-wave activity in the electroencephalogram is thought to reflect the depth or intensity of sleep. This hypothesis is primarily derived from studies of rats or humans. However, some characteristics of sleep of rabbits differ from those of rats or humans. To determine whether slow-wave activity (power density in the delta frequency band of 0.5-5.0 Hz) correlates with arousability in rabbits, we presented auditory stimuli (72-90 dB) to control or sleep-deprived animals during slow-wave sleep. The resulting behavioral responses, defined by changes in eye state and body posture, and the latency to return to sleep were used as measures of arousability. Behavioral responsiveness to auditory stimuli increased with increasing stimulus intensity in both control and sleep-deprived animals. Overall, however, sleep-deprived animals exhibited fewer postural changes and eye openings than did control rabbits. Sleep-deprived rabbits also more rapidly returned to sleep after the stimulus presentation than did control animals. Latency to return to sleep was correlated with delta power before stimulus presentation, but behavioral responsiveness was not. These data suggest that, in this rabbit model, delta power may not be predictive of behavioral arousability but may reflect sleep propensity.

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Changes in electromyographic activity, muscle fibre and force production characteristics during heavy resistance/power strength training in middle-aged and older men and women

Acta Physiologica Scandinavica ◽

10.1046/j.1365-201x.2001.171001051.x ◽

2001 ◽

Vol 171 (1) ◽

pp. 51-62 ◽

Cited By ~ 23

Author(s):

K. Hakkinen ◽

W. J. Kraemer ◽

R. U. Newton ◽

M. Alen

Keyword(s):

Strength Training ◽

Muscle Fibre ◽

Force Production ◽

Older Men ◽

Electromyographic Activity ◽

Middle Aged ◽

Men And Women ◽

Older Men And Women ◽

Production Characteristics

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Validity of muscle thickness-based prediction equation for quadriceps femoris volume in middle-aged and older men and women

European Journal of Applied Physiology ◽

10.1007/s00421-016-3464-1 ◽

2016 ◽

Vol 116 (11-12) ◽

pp. 2125-2133 ◽

Cited By ~ 6

Author(s):

Miyuki Nakatani ◽

Yohei Takai ◽

Ryota Akagi ◽

Taku Wakahara ◽

Norihide Sugisaki ◽

...

Keyword(s):

Muscle Thickness ◽

Older Men ◽

Prediction Equation ◽

Quadriceps Femoris ◽

Middle Aged ◽

Men And Women ◽

Older Men And Women

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The Validity of the Sit-and-Reach Test and the Modified Sit-and-Reach Test in Middle-Aged to Older Men and Women

Research Quarterly for Exercise and Sport ◽

10.1080/02701367.2003.10609099 ◽

2003 ◽

Vol 74 (3) ◽

pp. 331-336 ◽

Cited By ~ 54

Author(s):

Koen A. P. M. Lemmink ◽

Han C. G. Kemper ◽

Mathieu H. G. Greef ◽

Piet Rispens ◽

Martin Stevens

Keyword(s):

Older Men ◽

Middle Aged ◽

Men And Women ◽

Older Men And Women

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Inter-individual Differences In Physical Function Responses To Exercise Training Among Older Men And Women

Medicine & Science in Sports & Exercise ◽

10.1249/00005768-200505001-00509 ◽

2005 ◽

Vol 37 (Supplement) ◽

pp. S96

Author(s):

Justin W. Johnson ◽

Tongjian You ◽

Stephen Messier ◽

Gary Miller ◽

Barbara Nicklas

Keyword(s):

Individual Differences ◽

Exercise Training ◽

Physical Function ◽

Older Men ◽

Men And Women ◽

Older Men And Women

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Scalp EEG interictal high frequency oscillations as an objective EEG biomarker of infantile spasms

10.1101/2020.05.31.126573 ◽

2020 ◽

Author(s):

Hiroki Nariai ◽

Shaun A. Hussain ◽

Danilo Bernardo ◽

Hirotaka Motoi ◽

Masaki Sonoda ◽

...

Keyword(s):

Slow Wave ◽

High Frequency ◽

Slow Wave Sleep ◽

Wave Activity ◽

Infantile Spasms ◽

Slow Wave Activity ◽

List Type ◽

Normal Children ◽

High Frequency Oscillations ◽

Epileptic Spasms

ABSTRACTObjectiveTo investigate the diagnostic utility of high frequency oscillations (HFOs) via scalp electroencephalogram (EEG) in infantile spasms.MethodsWe retrospectively analyzed interictal slow-wave sleep EEGs sampled at 2,000 Hz recorded from 30 consecutive patients who were suspected of having infantile spasms. We measured the rate of HFOs (80-500 Hz) and the strength of the cross-frequency coupling between HFOs and slow-wave activity (SWA) at 3-4 Hz and 0.5-1 Hz as quantified with modulation indices (MIs).ResultsTwenty-three patients (77%) exhibited active spasms during the overnight EEG recording. Although the HFOs were detected in all children, increased HFO rate and MIs correlated with the presence of active spasms (p < 0.001 by HFO rate; p < 0.01 by MIs at 3-4 Hz; p = 0.02 by MIs at 0.5-1 Hz). The presence of active spasms was predicted by the logistic regression models incorporating HFO-related metrics (AUC: 0.80-0.98) better than that incorporating hypsarrhythmia (AUC: 0.61). The predictive performance of the best model remained favorable (87.5% accuracy) after a cross-validation procedure.ConclusionsIncreased rate of HFOs and coupling between HFOs and SWA are associated with active epileptic spasms.SignificanceScalp-recorded HFOs may serve as an objective EEG biomarker for active epileptic spasms.HighlightsObjective analyses of scalp high frequency oscillations and its coupling with slow-wave activity in infantile spasms were feasible.Increased rate of high frequency oscillations and its coupling with slow-wave activity correlated with active epileptic spasms.The scalp high frequency oscillations were also detected in neurologically normal children (although at the low rate).

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