P.3.f.004 Total antioxidant status, malondialdehyde and reduced glutathione serum levels in chronic paranoid schizophrenia

2008 ◽  
Vol 18 ◽  
pp. S476
Author(s):  
A.L. Morera ◽  
A. Intxausti ◽  
P. Abreu-Gonzalez ◽  
M. Henry ◽  
A. Orozco-Sanmartin ◽  
...  
Keyword(s):  
Antioxidant Status ◽  
Reduced Glutathione ◽  
Paranoid Schizophrenia ◽  
Total Antioxidant Status ◽  
Serum Levels ◽  
Total Antioxidant

Serum oxidizability, total antioxidant status and albumin serum levels in patients with aneurysmal or arterial occlusive disease

2008 ◽  
Vol 41 (9) ◽  
pp. 706-711 ◽  
Author(s):  
Ioannis Delimaris ◽  
Sotiris Georgopoulos ◽  
Christos Kroupis ◽  
Ariadni Zachari ◽  
Maria Liberi ◽  
...  
Keyword(s):  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Serum Levels ◽  
Arterial Occlusive Disease ◽  
Occlusive Disease ◽  
Total Antioxidant

scholarly journals Attenuation of Oxidative Stress and Inflammation by Portulaca oleracea in Streptozotocin-Induced Diabetic Rats

2017 ◽  
Vol 22 (4) ◽  
pp. 562-566 ◽  
Author(s):  
Saeed Samarghandian ◽  
Abasalt Borji ◽  
Tahereh Farkhondeh
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Serum Levels ◽  
Diabetic Rats ◽  
Portulaca Oleracea ◽  
Tnf Α ◽  
Total Antioxidant ◽  
Factor Α ◽  
Necrosis Factor

The present study was designed to investigate the protective effect of the aqueous extract of Portulaca oleracea against hyperglycemic, oxidative damage and inflammation in the serum of streptozotocin (STZ)-induced diabetic rats. In the present study, the rats were divided into the following groups of 8 animals each: control, untreated diabetic, 3 Portulaca oleracea (100, 200, 400 mg/kg/d)–treated diabetic groups. At the end of the 4-week period, glucose, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA), glutathione (GSH), and total antioxidant status (TAS) levels were measured. STZ caused an elevation in the serum levels of glucose, MDA, IL-6, and TNF-α with reduction in the levels of GSH and TAS ( P < .01). Portulaca oleracea ameliorated glucose, MDA, IL-6, TNF-α, GSH, and TAS levels in diabetic groups versus to the untreated groups ( P < .05). Taken together, Portulaca oleracea prevented hyperglycemia by preventing the oxidative stress and inflammation.

P.871Relationship between therapeutic compliance with antipsychotics and total antioxidant status in acute paranoid schizophrenia

2020 ◽  
Vol 40 ◽  
pp. S484
Author(s):  
E. Diaz- Mesa ◽  
A. Fumero-Morera ◽  
P. Abreu-Gonzalez ◽  
E. Hernandez-Padron ◽  
F.J. Garcia Gomez-Pamo ◽  
...  
Keyword(s):  
Antioxidant Status ◽  
Paranoid Schizophrenia ◽  
Total Antioxidant Status ◽  
Total Antioxidant

The effect of diet on total antioxidant status, ceruloplasmin, transferrin and ferritin serum levels in phenylketonuric children

2010 ◽  
Vol 99 (10) ◽  
pp. 1565-1570 ◽  
Author(s):  
Kleopatra H Schulpis ◽  
Maria Papastamataki ◽  
Helen Stamou ◽  
Ioannis Papassotiriou ◽  
Alexandra Margeli
Keyword(s):  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Serum Levels ◽  
Total Antioxidant

scholarly journals Effect of Boron Supplementation on Bone Mineralization and Antioxidant Status in Broiler Chicken

2021 ◽  
Author(s):  
Sanjay K. Pradhan ◽  
B. Kumar ◽  
Kantesh B. Banakara ◽  
R.R. Singh ◽  
V.B. Kharadi ◽  
...  
Keyword(s):  
Trace Element ◽  
Antioxidant Status ◽  
Defense Mechanism ◽  
Reduced Glutathione ◽  
Bone Mineralization ◽  
Total Antioxidant Status ◽  
Broiler Chicks ◽  
Bone Ash ◽  
Total Antioxidant ◽  
Poultry Diets

Background: Functionality and requirement of Boron as a trace element in livestock feeding has not been well established. Limited research conducted worldwide suggests B is a trace element known to influence various physiological functions specifically the metabolism of minerals, hormones, immunity and antioxidant defense mechanism; thereby the performance of the birds. The whole grains widely used in poultry diets contain very little boron and currently, there is no definitive information regarding the boron requirement for any class of poultry and inclusion levels are far from standardized. Therefore, the present experiment has been conducted to study the influence of boron on bone mineralization and antioxidant status in broiler.Methods: A total of 240 day-old broiler chicks (Vencob) of mixed sex (avg. BW 47.50±0.26 g) were distributed in a completely randomized design into five treatments each with four replicates of 12 birds (6 of each sex). The dietary treatments involved supplementation of boron at 0 (B-0), 25 (B-25), 50 (B-50), 75 (B-75) and 100 (B-100) mg/kg diet. The birds were offered starter (d 1 to 21) and finisher (d 22 to 42) diet in mash form. At d 42, Whole blood (2 ml) sample was collected for the estimation of total antioxidant status and reduced glutathione by FRAP and DTNB method, respectively. Two birds per replication were selected randomly; sacrificed and right femur bone was collected to measure the bone ash and mineral content.Result: Boron supplementation enhanced the bone ash, calcium and phosphorus content but decreased the manganese and iron content in bone. Supplementation of Boron significantly enhanced (P less than 0.05) the total antioxidant capacity but lowered the plasma reduced glutathione level.

scholarly journals Antioxidant Properties of Orally Administered of Aqueous Extracts of Selected Medicinal Plants and Paracetamol in Human Volunteers: In vivo

2021 ◽  
Vol 7 (3) ◽  
Keyword(s):  
Superoxide Dismutase ◽  
Blood Cell ◽  
Oral Administration ◽  
Red Blood Cell ◽  
Antioxidant Status ◽  
Reduced Glutathione ◽  
Total Antioxidant Status ◽  
Zingiber Officinale ◽  
Aqueous Extracts ◽  
Total Antioxidant

Objectives: In the current study, we used the herbal plant extracts and studied antioxidative value against the well-known drug Paracetamol. Methods: 54 Healthy volunteers were grouped into six groups, 5 groups drinking 200-250ml of aqueous extract from selected medicinal plants daily for 5 days and group six received 2 tablets of paracetamol (each tablet, 500 mg) daily for five days. Blood samples were taken before and 1 hr after the administration (samples 1 and 2, respectively) and then one day after the last dose of day five (sample 3). Serum total antioxidant status (TAS), red blood cell reduced glutathione (GSH), red blood cell malonyldialdehyde (MDA, and red blood cell superoxide dismutase (SOD) were used as assays. Results: Oral administration of aqueous extracts of studied plants increased significantly the serum total antioxidant status and red blood cell reduced glutathione after 5 days of administration compared to 0 time of administration. Data also showed that red blood cell superoxide dismutase increased significantly after five days of aqueous extracts of Zingiber officinale, Rosmarinus officinalis & Saliva triloba administration compared to 0 time of administration. Oral administration of aqueous extracts of Zingiber officinale, Rosmarinus officinalis, Verbena triphylla, caused a significant decrease in red blood cell malonyldialdehyde. Oral administration of Paracetamol for 5 days did not affect total antioxidant status red blood cell malonyldialdehyde, red blood cell reduced glutathione and red blood cell superoxide dismutase.

scholarly journals Androgen Deprivation Therapy in Patients With Prostate Cancer Increases Serum Levels of Thromboxane A2: Cardiovascular Implications

2021 ◽  
Vol 8 ◽  
Author(s):  
Mario Álvarez-Maestro ◽  
Aritz Eguibar ◽  
Patricia Chanca ◽  
Mercedes Klett-Mingo ◽  
Juan Gómez Rivas ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vascular Function ◽  
Healthy Subjects ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Serum Levels ◽  
Androgen Deprivation ◽  
Male Rats ◽  
Total Antioxidant ◽  
Cox 2

Introduction: Androgens have been described as important players in the regulation of vascular function/structure through their action on the release and effect of vasoactive factors, such as prostanoids. Patients with prostate cancer (PCa) under androgen deprivation therapies (ADTs) present increased risk of cardiovascular mortality. Since thromboxane A2 (TXA2) is one of the most studied prostanoids and its involvement in different cardiovascular diseases has been described, the aim of this study was to investigate: (i) the effect of ADT on the serum levels of TXA2 in PCa patients and its possible link to the redox status and (ii) the effect of the non-hydrolyzable TXA2 analog U-46619 on the function of the aorta of male rats.Methods: The levels of TXA2 and total antioxidant status in 50 healthy subjects, 54 PCa patients, and 57 PCa under ADT were evaluated. These determinations were accompanied by levels of testosterone and C-reactive protein as an inflammation marker. In aortic segments from male rats, the U46619-induced effects on: (i) the vasomotor responses to acetylcholine (ACh), to the NO donor sodium nitroprusside (SNP), to the carbon monoxide-releasing molecule-3 (CORM-3), and to noradrenaline (NA) and (ii) the expression of cyclooxygenase-2 (COX-2), heme oxygenase-1 (HO-1), and phosphorylated ERK1/2 were analyzed.Results: The serum level of TXA2 in patients with PCa was increased with respect to healthy subjects, which was further increased by ADT. There was no modification in the total antioxidant status among the three experimental groups. In aortic segments from male rats, the TXA2 analog decreased the endothelium-dependent relaxation and the sensitivity of smooth muscle cells to NO, while it increased the vasoconstriction induced by NA; the expression of COX-2, HO-1, and pERK1/2 was also increased.Conclusions: ADT increased, along with other inflammatory/oxidative markers, the serum levels of TXA2. The fact that TXA2 negatively impacts the vascular function of the aorta of healthy male rats suggests that inhibition of TXA2-mediated events could be considered a potential strategy to protect the cardiovascular system.

scholarly journals DNA Methylation Is Correlated with Oxidative Stress in Myelodysplastic Syndrome—Relevance as Complementary Prognostic Biomarkers

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3138
Author(s):  
Ana Cristina Gonçalves ◽  
Raquel Alves ◽  
Inês Baldeiras ◽  
Bárbara Marques ◽  
Bárbara Oliveiros ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Methylation ◽  
Antioxidant Status ◽  
Reduced Glutathione ◽  
Total Antioxidant Status ◽  
Prognostic Biomarkers ◽  
Healthy Individuals ◽  
Total Antioxidant ◽  
Gene Promotor ◽  
Dna Methylations

Oxidative stress and abnormal DNA methylation have been implicated in cancer, including myelodysplastic syndromes (MDSs). This fact leads us to investigate whether oxidative stress is correlated with localized and global DNA methylations in the peripheral blood of MDS patients. Sixty-six MDS patients and 26 healthy individuals were analyzed. Several oxidative stress and macromolecule damage parameters were analyzed. Localized (gene promotor) and global DNA methylations (5-mC and 5-hmC levels; LINE-1 methylation) were assessed. MDS patients had lower levels of reduced glutathione and total antioxidant status (TAS) and higher levels of peroxides, nitric oxide, peroxides/TAS, and 8-hydroxy-2-deoxyguanosine compared with controls. These patients had higher 5-mC levels and lower 5-hmC/5-mC ratio and LINE-1 methylation and increased methylation frequency of at least one methylated gene. Peroxide levels and peroxide/TAS ratio were higher in patients with methylated genes than those without methylation and negatively correlated with LINE-1 methylation and positively with 5-mC levels. The 5-hmC/5-mC ratio was significantly associated with progression to acute leukemia and peroxide/TAS ratio with overall survival. This study points to a relationship between oxidative stress and DNA methylation, two common pathogenic mechanisms involved in MDS, and suggests the relevance of 5-hmC/5-mC and peroxide/TAS ratios as complementary prognostic biomarkers.

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