Manufacturing factors affecting the drug delivery function of thermo-responsive membrane prepared by adsorption of binary liquid crystals

The pharmaceutical industry has faced several marked challenges in order to bring new chemical entities (NCEs) into the market over the past few decades. Various novel drug delivery approaches have been used as a part of life cycle management from which Osmotic drug delivery systems look the most promising one. After discussing the history of osmotic pump development, this article looks at the principles, advantages and disadvantages of osmotic drug delivery systems. Then, the basic components of osmotic pump and factors affecting the design of oral osmotic drug delivery systems are discussed in detail. In the later part of the manuscript, various types of osmotic pumps available in the market and evaluation methods for osmotic drug delivery systems are discussed in detail.

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Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review

Polymers ◽

10.3390/polym13081272 ◽

2021 ◽

Vol 13 (8) ◽

pp. 1272

Author(s):

Anita Ioana Visan ◽

Gianina Popescu-Pelin ◽

Gabriel Socol

Keyword(s):

Drug Delivery ◽

Degradation Mechanism ◽

Degradation Behavior ◽

Polymeric Coatings ◽

Degradation Mechanisms ◽

Coating Materials ◽

Factors Affecting ◽

Existing Problems ◽

Future Performance ◽

Measuring Techniques

The purpose of the work was to emphasize the main differences and similarities in the degradation mechanisms in the case of polymeric coatings compared with the bulk ones. Combined with the current background, this work reviews the properties of commonly utilized degradable polymers in drug delivery, the factors affecting degradation mechanism, testing methods while offering a retrospective on the evolution of the controlled release of biodegradable polymeric coatings. A literature survey on stability and degradation of different polymeric coatings, which were thoroughly evaluated by different techniques, e.g., polymer mass loss measurements, surface, structural and chemical analysis, was completed. Moreover, we analyzed some shortcomings of the degradation behavior of biopolymers in form of coatings and briefly proposed some solving directions to the main existing problems (e.g., improving measuring techniques resolution, elucidation of complete mathematical analysis of the different degradation mechanisms). Deep studies are still necessary on the dynamic changes which occur to biodegradable polymeric coatings which can help to envisage the future performance of synthesized films designed to be used as medical devices with application in drug delivery.

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Liquid Crystals and Their Application in the Field of Drug Delivery

Colloids in Drug Delivery - Surfactant Science ◽

10.1201/9781439818268-c13 ◽

2010 ◽

pp. 311-336 ◽

Cited By ~ 3

Author(s):

Rakesh Patel ◽

Tanmay Patel

Keyword(s):

Drug Delivery ◽

Liquid Crystals

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Cubic lyotropic liquid crystals as drug delivery carriers: Physicochemical and morphological studies

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2018.08.003 ◽

2018 ◽

Vol 550 (1-2) ◽

pp. 57-70 ◽

Cited By ~ 11

Author(s):

Maria Chountoulesi ◽

Natassa Pippa ◽

Stergios Pispas ◽

Evangelia D. Chrysina ◽

Aleksander Forys ◽

...

Keyword(s):

Drug Delivery ◽

Liquid Crystals ◽

Lyotropic Liquid Crystals ◽

Morphological Studies

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Physiological Factors Affecting Oral Drug Delivery

Encyclopedia of Pharmaceutical Science and Technology, Fourth Edition ◽

10.1081/e-ept4-120050332 ◽

2013 ◽

pp. 2716-2726

Keyword(s):

Drug Delivery ◽

Oral Drug Delivery ◽

Oral Drug ◽

Physiological Factors ◽

Factors Affecting

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Stability of Engineered Micro or Nanobubbles for Biomedical Applications

Pharmaceutics ◽

10.3390/pharmaceutics12111089 ◽

2020 ◽

Vol 12 (11) ◽

pp. 1089

Author(s):

Beomjin Park ◽

Semi Yoon ◽

Yonghyun Choi ◽

Jaehee Jang ◽

Soomin Park ◽

...

Keyword(s):

Drug Delivery ◽

Biomedical Applications ◽

Ultrasonic Field ◽

Nanometer Scale ◽

Factors Affecting ◽

The Core ◽

Bubble Structure ◽

The Stability ◽

The Relationship

A micro/nanobubble (MNB) refers to a bubble structure sized in a micrometer or nanometer scale, in which the core is separated from the external environment and is normally made of gas. Recently, it has been confirmed that MNBs can be widely used in angiography, drug delivery, and treatment. Thus, MNBs are attracting attention as they are capable of constructing a new contrast agent or drug delivery system. Additionally, in order to effectively use an MNB, the method of securing its stability is also being studied. This review highlights the factors affecting the stability of an MNB and the stability of the MNB within the ultrasonic field. It also discusses the relationship between the stability of the bubble and its applicability in vivo.

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