437 THE ASSOCIATION BETWEEN HEBERDEN'S NODES AND FEMOROTIBIAL CARTILAGE LOSS IN SUBJECTS WITH PREVALENT OR AT HIGH RISK OF KNEE OSTEOARTHRITIS USING MR IMAGING – DATA FROM OAI

Meniscal injury has been found to leave patients at high risk for the development of knee osteoarthritis (OA). Partial meniscectomy is often used to treat meniscal tears, and while this procedure adequately addresses pain and the restoration of function, it does not prevent the progression of OA in the injured knee. Often during arthroscopy, surgeons identify areas of “softened” cartilage, which do not always correlate with visible signs of surface damage or cartilage loss. This softening has been related to changes in the cartilage matrix, which could represent early structural damage that can lead to irreversible cartilage damage and OA.

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Abstract WP420: Clopidogrel with Aspirin May be More Effective in Decreasing One-year Stroke Recurrence for Acute Minor Stroke with Watershed Infarcts: Subgroup Analysis of Chance

Stroke ◽

10.1161/str.48.suppl_1.wp420 ◽

2017 ◽

Vol 48 (suppl_1) ◽

Author(s):

Yuehua Pu ◽

Liping Liu ◽

Yilong Wang ◽

Jing Jing ◽

Anxin Wang ◽

...

Keyword(s):

High Risk ◽

Mr Imaging ◽

Antiplatelet Therapy ◽

Dual Antiplatelet Therapy ◽

Minor Stroke ◽

Stroke Recurrence ◽

Imaging Data ◽

Stroke Patients ◽

One Year ◽

Watershed Infarcts

Background and Objective: In symptomatic cerebral large artery disease, watershed infarcts may result from hemodynamic impairment or microembolism. Such patients often have a high risk of recurrence or deterioration. It is still not clear whether dual antiplatelet therapy reduce the risk of stroke recurrence. The aim of this subgroup analysis is to discuss whether dual antiplatelet therapy could decrease the one year stroke recurrence more effectively for minor stroke patients with watershed infarcts. Methods: Patients enrolled in Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events (CHANCE) trial and have magnetic resonance (MR) imaging data were included in this study. Diffusion-weighted imaging was obtained for detection of watershed infarcts. We assessed the interaction of the treatment effects of clopidogrel plus aspirin versus aspirin alone among patients with watershed infarcts or not. Results: Of the 1089 patients with MR imaging data enrolled in the CHANCE trial, 831 (76.3%) patients with acute infarcts. Among patients with acute infarcts, 93 (11.19%) were watershed infarcts, 55 (59.14%) received dual antiplatelet therapy. Patients with watershed infarcts had higher rates of recurrent stroke (17.20% vs 10.70%, p=0.063) at 1 year. For patients with watershed infarcts, one-year stroke recurrence was 6 (10.91%) in clopidogrel plus aspirin group and 10 (26.32%) in placebo plus aspirin group. There was interaction between antiplatelet therapy and presence of watershed infarcts on the primary outcome of any stroke (p=0.0933). (Kaplan-Meier curves were showed in the figure). Conclusions: For minor stroke patients with watershed infarcts, clopidogrel with aspirin may be more effective in decreasing 1-year stroke recurrence attributed to its potential mechanism of microembolism. Studies in other populations and subsequent analysis with adequate power are warranted to further verify such findings.

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Faculty Opinions recommendation of Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13901.471406 ◽

2006 ◽

Author(s):

Elizabeth Arner

Keyword(s):

Magnetic Resonance Imaging ◽

Bone Marrow ◽

Magnetic Resonance ◽

Knee Osteoarthritis ◽

Imaging Study ◽

Cartilage Loss ◽

Magnetic Resonance Imaging Study ◽

Resonance Imaging ◽

Bone Marrow Lesions

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Audio-guided self-hypnosis for reduction of claustrophobia during MR imaging: results of an observational 2-group study

European Radiology ◽

10.1007/s00330-021-07887-w ◽

2021 ◽

Author(s):

Adriane E. Napp ◽

Torsten Diekhoff ◽

Olf Stoiber ◽

Judith Enders ◽

Gerd Diederichs ◽

...

Keyword(s):

High Risk ◽

Mr Imaging ◽

Odds Ratio ◽

Control Group ◽

Waiting Room ◽

High Risk Patients ◽

Imaging Results ◽

Before And After ◽

Risk Patients ◽

And Coping

Abstract Objectives To evaluate the influence of audio-guided self-hypnosis on claustrophobia in a high-risk cohort undergoing magnetic resonance (MR) imaging. Methods In this prospective observational 2-group study, 55 patients (69% female, mean age 53.6 ± 13.9) used self-hypnosis directly before imaging. Claustrophobia included premature termination, sedation, and coping actions. The claustrophobia questionnaire (CLQ) was completed before self-hypnosis and after MR imaging. Results were compared to a control cohort of 89 patients examined on the same open MR scanner using logistic regression for multivariate analysis. Furthermore, patients were asked about their preferences for future imaging. Results There was significantly fewer claustrophobia in the self-hypnosis group (16%; 9/55), compared with the control group (43%; 38/89; odds ratio .14; p = .001). Self-hypnosis patients also needed less sedation (2% vs 16%; 1/55 vs 14/89; odds ratio .1; p = .008) and non-sedation coping actions (13% vs 28%; 7/55 vs 25/89; odds ratio .3; p = .02). Self-hypnosis did not influence the CLQ results measured before and after MR imaging (p = .79). Self-hypnosis reduced the frequency of claustrophobia in the subgroup of patients above an established CLQ cut-off of .33 from 47% (37/78) to 18% (9/49; p = .002). In the subgroup below the CLQ cut-off of 0.33, there were no significant differences (0% vs 9%, 0/6 vs 1/11; p = 1.0). Most patients (67%; 35/52) preferred self-hypnosis for future MR examinations. Conclusions Self-hypnosis reduced claustrophobia in high-risk patients undergoing imaging in an open MR scanner and might reduce the need for sedation and non-sedation coping actions. Key Points • Forty percent of the patients at high risk for claustrophobia may also experience a claustrophobic event in an open MR scanner. • Self-hypnosis while listening to an audio in the waiting room before the examination may reduce claustrophobic events in over 50% of patients with high risk for claustrophobia. • Self-hypnosis may also reduce the need for sedation and other time-consuming non-sedation coping actions and is preferred by high-risk patients for future examinations.

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Machine learning based estimates of medial knee contact force are associated with cartilage loss over 2.5 years in knee osteoarthritis patients

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2020.02.369 ◽

2020 ◽

Vol 28 ◽

pp. S226

Author(s):

N.M. Brisson ◽

A.A. Gatti ◽

P. Damm ◽

G.N. Duda ◽

M.R. Maly

Keyword(s):

Machine Learning ◽

Knee Osteoarthritis ◽

Contact Force ◽

Cartilage Loss ◽

Medial Knee

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T2 Relaxation Time of Cartilage at MR Imaging: Comparison with Severity of Knee Osteoarthritis

Radiology ◽

10.1148/radiol.2322030976 ◽

2004 ◽

Vol 232 (2) ◽

pp. 592-598 ◽

Cited By ~ 359

Author(s):

Timothy C. Dunn ◽

Ying Lu ◽

Hua Jin ◽

Michael D. Ries ◽

Sharmila Majumdar

Keyword(s):

Relaxation Time ◽

Mr Imaging ◽

Knee Osteoarthritis ◽

T2 Relaxation Time ◽

T2 Relaxation

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Overcoming the Clinical–MR Imaging Paradox of Multiple Sclerosis: MR Imaging Data Assessed with a Random Forest Approach

American Journal of Neuroradiology ◽

10.3174/ajnr.a2864 ◽

2011 ◽

Vol 32 (11) ◽

pp. 2098-2102 ◽

Cited By ~ 8

Author(s):

K. Kac̆ar ◽

M.A. Rocca ◽

M. Copetti ◽

S. Sala ◽

Š. Mesaroš ◽

...

Keyword(s):

Multiple Sclerosis ◽

Random Forest ◽

Mr Imaging ◽

Imaging Data

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Intraoperative computed tomography registration and electromagnetic neuronavigation for transsphenoidal pituitary surgery: accuracy and time effectiveness

Journal of Neurosurgery ◽

10.3171/2010.5.jns091821 ◽

2011 ◽

Vol 114 (2) ◽

pp. 329-335 ◽

Cited By ~ 22

Author(s):

Paula Eboli ◽

Bob Shafa ◽

Marc Mayberg

Keyword(s):

Mr Imaging ◽

Operating Room ◽

Navigation System ◽

Surgical Techniques ◽

Imaging Data ◽

3D Navigation ◽

Closure Time ◽

Bony Landmarks ◽

Room Time ◽

Operating Room Time

Object The authors assessed the feasibility, anatomical accuracy, and cost effectiveness of frameless electromagnetic (EM) neuronavigation in conjunction with portable intraoperative CT (iCT) registration for transsphenoidal adenomectomy (TSA). Methods A prospective database was established for data obtained in 208 consecutive patients who underwent TSA in which the iCT/EM navigation technique was used. Data were compared with those acquired in a retrospective cohort of 65 consecutive patients in whom fluoroscope-assisted TSA had been performed by the same surgeon. All patients in both groups underwent transnasal removal of pituitary adenomas or neuroepithelial cysts, using identical surgical techniques with an operating microscope. In the iCT/EM technique–treated cases, a portable iCT scan was obtained immediately prior to surgery for registration to the EM navigation system, which did not require rigid head fixation. Preexisting (nonnavigation protocol) MR imaging studies were fused with the iCT scans to enable 3D navigation based on MR imaging data. The accuracy of the navigation system was determined in the first 50 iCT/EM cases by visual concordance of the navigation probe location to 5 preselected bony landmarks. For all patients in both cohorts, total operating room time, incision-to-closure time, and relative costs of imaging and surgical procedures were determined from hospital records. Results In every case, iCT registration was successful and preoperative MR images were fused to iCT scans without affecting navigation accuracy. There was 100% concordance between probe tip location and predetermined bony loci in the first 50 cases involving the iCT/EM technique. Total operating room time was significantly less in the iCT/EM cases (mean 108.9 ± 24.3 minutes [208 patients]) compared with the fluoroscopy group (mean 121.1 ± 30.7 minutes [65 patients]; p < 0.001). Similarly, incision-to-closure time was significantly less for the iCT/EM cases (mean 61.3 ± 18.2 minutes) than for the fluoroscopy cases (mean 71.75 ± 19.0 minutes; p < 0.001). Relative overall costs for iCT/EM technique and intraoperative C-arm fluoroscopy were comparable; increased costs for navigation equipment were offset by savings in operating room costs for shorter procedures. Conclusions The use of iCT/MR imaging–guided neuronavigation for transsphenoidal surgery is a time-effective, cost-efficient, safe, and technically beneficial technique.

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