Interleukin 6 and C-reactive protein levels in patients with acute allergic reactions: an emergency department-based study

Objective: In this study, we aimed to explore the role of the plasma presepsin level in patients with community-acquired pneumonia during admission to the emergency department in assessing the diagnosis, severity, and prognosis of the disease. In addition, we wanted to investigate the relationship of presepsinin with procalcitonin, C-reactive protein and pneumonia severity scores. Methods: One hundred twenty-three patients over the age of 18 who presented with a diagnosis of pneumonia to the emergency department were included in the study. The vital signs, symptoms, examination findings, background information, laboratory results, and radiological imaging results of the patients were recorded. The 30-day mortality rates of the patients were determined. Results: A statistically significant difference was found between the presepsin levels of the patients diagnosed with pneumonia and those of healthy subjects (p < 0.05). The plasma presepsin levels of the patients who died (8.63 ± 6.46) were significantly higher than those of the patients who lived (5.82 ± 5.97) (p < 0.05). The plasma procalcitonin and C-reactive protein levels of the dead patients were significantly higher than those living (p < 0.05). A presepsin cut-off value of 3.3 ng/mL for 30-day mortality was established (AUROC, 0.65; specificity, 45%; sensitivity, 82%). Procalcitonin is the most successful biomarker in the determination of mortality (AUROC, 0.70). A significant correlation was available between presepsin and lactate, C-reactive protein and procalcitonin (p < 0.05). There was a significant correlation between the Pneumonia Severity Index values and presepsin levels (p < 0.001, r = 0.311). Conclusion: The plasma presepsin level can be utilized for diagnosing community-acquired pneumonia. Plasma presepsin, procalcitonin and C-reactive protein levels can be used to predict the severity and mortality of community-acquired pneumonia.

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THE DYNAMICS OF INTERLEUKIN-6 AND C-REACTIVE PROTEIN LEVELS IN HYPERTENSIVE PATIENTS TREATED BY BISOPROLOL

Journal of Hypertension ◽

10.1097/00004872-200406002-00560 ◽

2004 ◽

Vol 22 (Suppl. 2) ◽

pp. S164

Author(s):

O. V. Gerasimenko ◽

O. N. Kovalova

Keyword(s):

Interleukin 6 ◽

C Reactive Protein ◽

Hypertensive Patients ◽

Protein Levels ◽

Reactive Protein

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Assessment of Stages of Fetal Inflammatory Response Syndrome by Early Postnatal Interleukin-6 and C-Reactive Protein Levels in Preterm Infants

Pediatric Research ◽

10.1038/pr.2011.679 ◽

2011 ◽

Vol 70 ◽

pp. 454-454

Author(s):

K Inomata ◽

S Iwatani ◽

Y Kishida ◽

H Sakai ◽

M Mizobuchi ◽

...

Keyword(s):

Inflammatory Response ◽

Preterm Infants ◽

Interleukin 6 ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Fetal Inflammatory Response

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Six-month results of stenting of the femoropopliteal artery and predictive value of interleukin-6: Comparison with high-sensitivity C-reactive protein

Vascular ◽

10.1177/1708538120921005 ◽

2020 ◽

Vol 28 (6) ◽

pp. 715-721

Author(s):

Songlin Guo ◽

Zhang Zhang ◽

Lei Wang ◽

Liangxi Yuan ◽

Junmin Bao ◽

...

Keyword(s):

Confidence Interval ◽

Interleukin 6 ◽

Odds Ratio ◽

High Sensitivity ◽

C Reactive Protein ◽

Femoropopliteal Artery ◽

Protein Levels ◽

Reactive Protein ◽

Stent Restenosis ◽

In Stent Restenosis

Objectives To determine the association of pre- and postinterventional serum levels of interleukin-6 and high-sensitivity C-reactive protein at the six-month evaluation of restenosis after stenting of the femoropopliteal artery. Methods Sixty-eight consecutive patients with steno-occlusive femoropopliteal artery disease of Rutherford category III or IV who underwent stent implantation were included. Six-month patency was evaluated with color-coded duplex ultrasound. The association of in-stent restenosis with interleukin-6 and high-sensitivity C-reactive protein levels at baseline, and 24-h postintervention was assessed with a multivariate logistic regression analysis. Results In-stent restenosis was found in 15 patients (22.1%) within six months. Interleukin-6 and high-sensitivity C-reactive protein levels were significantly increased at 24-h postintervention compared to their preintervention values ( p < 0.001 and p = 0.002, respectively). Interleukin-6 values at baseline (odds ratio, 1.11; 95% confidence interval: 1.00, 1.23; p = 0.044) and 24-h postintervention (odds ratio, 1.04; 95% confidence interval: 1.02, 1.06; p < 0.001) were independently associated with six-month in-stent restenosis. Twenty-four-hour postinterventional high-sensitivity C-reactive protein levels were also found to be related to restenosis (odds ratio, 1.15; 95% confidence interval: 1.04, 1.26; p = 0.006), but high-sensitivity C-reactive protein levels at baseline did not show an independent association with in-stent restenosis (odds ratio, 0.57; 95% confidence interval: 0.35, 1.80; p = 0.667). Smoking, diabetes mellitus, and cumulative stent length were other parameters associated with an increased risk for in-stent restenosis. Conclusions Femoropopliteal artery angioplasty with stent placement induces an inflammatory response. Interleukin-6 is a powerful independent predictor of intermediate-term outcomes for stenting of the femoropopliteal artery, suggesting that its predictive value may be superior to that of high-sensitivity C-reactive protein.

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