scholarly journals PND35 IMPACT OF NATALIZUMAB ON PATIENT OUTCOMES IN MULTIPLE SCLEROSIS: A CROSS-SECTIONAL SURVEY

2008 ◽  
Vol 11 (3) ◽  
pp. A147
Author(s):  
JJ Stephenson ◽  
K Rajagopalan ◽  
S Kamat
Keyword(s):  
Multiple Sclerosis ◽  
Patient Outcomes ◽  
Cross Sectional Survey ◽  
Cross Sectional

scholarly journals Factors for Lower Walking Speed in Persons with Multiple Sclerosis

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Leandro Alberto Calazans Nogueira ◽  
Luciano Teixeira dos Santos ◽  
Pollyane Galinari Sabino ◽  
Regina Maria Papais Alvarenga ◽  
Luiz Claudio Santos Thuler
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Physical Activity Level ◽  
Walking Speed ◽  
Motor Planning ◽  
Activity Level ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Balance Confidence ◽  
Significant Difference

Objective. The purpose of this study was to analyze factors related to lower walking speed in persons with multiple sclerosis (PwMS).Methods. A cross-sectional survey was conducted. The study participants were 120 consecutive PwMS, who were able to walk, even with device assistance. Demographic and clinical data were collected. Walking speed was measured in 10 m walk test. Possible factors were assessed: disability, fatigue, visual functioning, balance confidence, physical activity level, walking impact, cognitive interference, and motor planning. A forward linear multiple regression analysis examined the correlation with lower speed.Results. Lower walking speed was observed in 85% of the patients. Fatigue (41%), recurrent falls (30%), and balance problems were also present, even with mild disability (averageEDSS=2.68). A good level of physical activity was noted in most of the subjects. Dual-task procedure revealed 11.58% of walking speed reduction. Many participants (69.57%) imagined greater walking speed than motor execution (mean ≥ 28.42%). Physical activity level was the only characteristic that demonstrated no significant difference between the groups (lower versus normal walking speed). Many mobility measures were correlated with walking speed; however, disability, balance confidence, and motor planning were the most significant.Conclusions. Disability, balance confidence, and motor planning were correlated with lower walking speed.

scholarly journals Patient autonomy in dental medical decision making – demonstrating the need for shared decision making

2020 ◽  
Author(s):  
Mareike Benecke ◽  
Jürgen Kasper ◽  
Christoph Heesen ◽  
Nina Schäffler ◽  
Daniel Reissmann
Keyword(s):  
Multiple Sclerosis ◽  
Decision Making ◽  
General Practice ◽  
Shared Decision Making ◽  
Treatment Decisions ◽  
Medical Decision ◽  
Shared Decision ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Study Results

Abstract Background: Evidence-based Dentistry (EBD), decision aids, patient preferences and autonomy preferences (AP) play an important role in shared decision making (SDM) and are useful tools in the process of medical and dental decisions as well as in developing of quality criteria for decision making in many fields of health care. However, there aren’t many studies on SDM and AP in the field of dentistry. This study aimed at exploring patients’ autonomy preferences in dentistry in comparison to other medical domains. Methods: As a first step, a consecutive sample of 100 dental patients and 16 dentists was recruited at a university-based prosthodontic clinic to assess and compare patients’ and dentists’ preferences regarding their roles in dental decision making for commonly performed diagnostic and treatment decisions using the Control Preference Scale (CPS). This was followed by a cross sectional survey to study autonomy preferences in three cohorts of 100 patients each recruited from general practices, a multiple sclerosis clinic, and a university-based prosthodontic clinic . A questionnaire with combined items from the Autonomy Preference Index (API) to assess general and the CPS to assess specific preferences was used in this process. Results: Dentists were slightly less willing to deliver control than patients willing to enact autonomy. Decisions about management of tooth loss were however considered relevant for a shared decision making by both parties. Highest AP was expressed by people with multiple sclerosis, lowest by patients in dentistry (CPS means: dentistry 2.5, multiple sclerosis 2.1, general practice 2.4, p=.035). Patients analysis showed considerable differences in autonomy preferences referring to different decision types (p<.001). More autonomy was needed for treatment decisions in comparison to diagnostic decisions, for trivial compared to severe conditions, and for dental care compared to general practice (all: p<.001). Conclusion: The study results showed substantial relevance of patient participation in decision making in dentistry. Furthermore, a need has been discovered to refer to specific medical decisions instead of assessing autonomy preferences in general.

scholarly journals Stigma in Multiple Sclerosis: The Important Role of Sense of Coherence and Its Relation to Quality of Life

2021 ◽  
Author(s):  
Lydia Grothe ◽  
Matthias Grothe ◽  
Judith Wingert ◽  
Georg Schomerus ◽  
Sven Speerforck
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Sense Of Coherence ◽  
Contributing Factors ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Promising Target ◽  
Enacted Stigma ◽  
Underlying Mechanisms

Abstract Background Anticipated and experienced stigma constitute important issues for patients with multiple sclerosis receiving adequate healthcare. Stigma is likely to be associated with lower quality of life in patients with multiple sclerosis, but the underlying mechanisms and contributing factors are unclear. Methods We conducted a cross-sectional survey among N = 101 patients with a diagnosis of multiple sclerosis in a German outpatient department. Patients completed questionnaires on enacted and self-stigma (SSCI-8), sense of coherence (SOC-L9) and quality of life (MusiQol). Age, sex, disease duration, disability or extent of limitations (EDSS), cognition (SDMT), depression (BDI-II) and fatigue (FSMC) were used as covariates in linear regression and mediation models. Results 57.3% of patients with MS reported having experienced stigmatization due to MS at least once. Fatigue (b = -0.199, p < 0.001), enacted stigmatization experience (b = -0.627, p = 0.010) and sense of coherence (b = 0.654, p < 0.001) were significant predictors for quality of life. The mediation analysis showed a partial mediation of the association between enacted stigma and quality of life by patients’ sense of coherence (direct effect: b = -1.042, t = -4.021, p < 0.001; indirect effect: b = -0.773, CI = -1.351—-0.339. The association of self-stigma with quality of life was fully mediated by sense of coherence (b = -1.579, CI = -2.954—-0.669). Conclusion Patients with multiple sclerosis are affected by stigma, which is associated with lower quality of life. Sense of coherence is a potentially important mediator of stigma and represents a promising target to refine existing stigma interventions and improve the quality of life in these patients.

scholarly journals COVID-19 vaccine hesitancy in multiple sclerosis: A cross-sectional survey

2021 ◽  
pp. 135245852110306
Author(s):  
Lauren Uhr ◽  
Farrah J Mateen
Keyword(s):  
Multiple Sclerosis ◽  
Influenza Vaccine ◽  
Functional Disability ◽  
Vaccine Hesitancy ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Immunosuppressed Patients ◽  
Effective Public Health ◽  
The Relationship

Background: Vaccine willingness among people living with multiple sclerosis (PwMS) requires assessment following the approval of the first COVID-19 vaccines, since there remains uncertainty on multiple aspects of COVID-19 vaccination in immunosuppressed patients. Objective: To understand COVID-19 and influenza vaccine willingness and its associations among PwMS, following the approval of the first two mRNA COVID-19 vaccines. Methods: A survey was distributed to PwMS via an online platform from December 2020 to February 2021. Logistic regression models were constructed to determine the relationship between (1) COVID-19 and (2) influenza vaccination willingness with demographic and clinical characteristics. Results: Of 701 responding PwMS, 76.6% were COVID-19 vaccine willing. COVID-19 vaccine willingness was significantly associated with influenza vaccine willingness ( p < 0.001). In multivariable models, older age increased the odds of COVID-19 and influenza vaccine willingness (odds ratios (ORs) > 1) and other race decreased the odds of COVID-19 and influenza vaccine willingness (ORs < 1); higher functional disability decreased the odds of COVID-19 vaccine willingness (OR = 0.88, 95% confidence interval = 0.80–0.96). Prevalent vaccine-related concerns include safety ( n = 244) and efficacy ( n = 122). Conclusion: Our findings identify demographic and clinical factors as well as concerns influencing vaccine hesitancy in PwMS. These results may inform effective public health interventions to improve vaccine acceptability in this at-risk group.

scholarly journals The Prevalence of Pain in Adults with Multiple Sclerosis: A Multicenter Cross-Sectional Survey

Pain Medicine ◽  
2015 ◽  
Vol 16 (8) ◽  
pp. 1597-1602 ◽  
Author(s):  
Jelena Drulovic ◽  
Vanja Basic-Kes ◽  
Sanja Grgic ◽  
Slobodan Vojinovic ◽  
Evica Dincic ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Prevalence Of Pain
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