1P-0068 Insulin resistance in type 2 diabetes with coronary artery disease: An association with lower antioxidant enzyme activity

Background: Adipose tissue produces pro-inflammatory mediators involved in the atherosclerotic process. We investigated whether 12-month exercise training in patients with type 2 diabetes mellitus and coronary artery disease would reduce circulating levels and genetic expression of mediators in the interleukin-18, Caspase-1 and NLR pyrin domain containing 3 pathways. Correlations to glucometabolic variables; fasting glucose, HbA1c, duration of diabetes, insulin, C-peptide, insulin resistance (measured by homeostatic model assessment indexes – insulin resistance) and body mass index at baseline were further assessed. Methods: 137 patients (aged 41–81 years, 17.2% female participants) were included and randomized to a 12-month exercise programme or to a control group. Fasting blood and adipose tissue samples were taken at inclusion and after 12 months. Results: No statistically significant difference in changes of any variable between the intervention and the control group was found. At baseline, a positive correlation between insulin and homeostatic model assessment indexes – insulin resistance, interleukin-18 expression in adipose tissue and an inverse correlation between some glucometabolic variables and leukocyte expression of NLR pyrin domain containing 3 and Caspase-1 were observed. Conclusion: No significant effects of long-term exercise training were observed on the inflammasome-related mediators in our patients with combined coronary artery disease and type 2 diabetes mellitus. The observed correlations may indicate a pro-inflammatory state in adipose tissue by overweight and a compensatory downregulation of these mediators in circulating leucocytes.

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Potential Biomarkers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease

International Journal of Endocrinology ◽

10.1155/2013/698567 ◽

2013 ◽

Vol 2013 ◽

pp. 1-11 ◽

Cited By ~ 38

Author(s):

Sharifah Intan Qhadijah Syed Ikmal ◽

Hasniza Zaman Huri ◽

Shireene Ratna Vethakkan ◽

Wan Azman Wan Ahmad

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Type 2 Diabetes Mellitus ◽

Coronary Artery ◽

Endothelial Dysfunction ◽

Biological Marker ◽

Artery Disease

Type 2 diabetes mellitus patients with coronary artery disease have become a major public health concern. The occurrence of insulin resistance accompanied with endothelial dysfunction worsens the state of atherosclerosis in type 2 diabetes mellitus patients. The combination of insulin resistance and endothelial dysfunction leads to coronary artery disease and ischemic heart disease complications. A recognized biological marker, high-sensitivity C-reactive protein, has been used widely to assess the progression of atherosclerosis and inflammation. Along with coronary arterial damage and inflammatory processes, high-sensitivity C-reactive protein is considered as an essential atherosclerosis marker in patients with cardiovascular disease, but not as an insulin resistance marker in type 2 diabetes mellitus patients. A new biological marker that can act as a reliable indicator of both the exact state of insulin resistance and atherosclerosis is required to facilitate optimal health management of diabetic patients. Malfunctioning of insulin mechanism and endothelial dysfunction leads to innate immune activation and released several biological markers into circulation. This review examines potential biological markers, YKL-40, alpha-hydroxybutyrate, soluble CD36, leptin, resistin, interleukin-18, retinol binding protein-4, and chemerin, as they may play significant roles in insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease.

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We-P11:26 Coronary artery disease in type 2 diabetes: Relationship between changes in LDL particle size, lipoprotein subfraction levels and insulin resistance

Atherosclerosis Supplements ◽

10.1016/s1567-5688(06)81382-6 ◽

2006 ◽

Vol 7 (3) ◽

pp. 351

Author(s):

K. Lalic ◽

M. Zamaklar ◽

N.M. Lalic ◽

M. Ostojic ◽

V. Kalimanovska ◽

...

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Particle Size ◽

Coronary Artery ◽

Ldl Particle Size ◽

Lipoprotein Subfraction ◽

Artery Disease

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Independent Association of Type 2 Diabetes and Coronary Artery Disease With Myocardial Insulin Resistance

Diabetes ◽

10.2337/diabetes.51.10.3020 ◽

2002 ◽

Vol 51 (10) ◽

pp. 3020-3024 ◽

Cited By ~ 95

Author(s):

P. Iozzo ◽

P. Chareonthaitawee ◽

D. Dutka ◽

D. J. Betteridge ◽

E. Ferrannini ◽

...

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Artery Disease ◽

Independent Association ◽

Myocardial Insulin Resistance

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Single Nucleotide Polymorphism rs17173608 in the Chemerin Encoding Gene: Is It a Predictor of Insulin Resistance and Severity of Coronary Artery Disease in Non-Obese Type 2 Diabetes?

Healthcare ◽

10.3390/healthcare9060623 ◽

2021 ◽

Vol 9 (6) ◽

pp. 623

Author(s):

Sangeetha Perumalsamy ◽

Wan Azman Wan Ahmad ◽

Hasniza Zaman Huri

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Retinoic Acid Receptor ◽

Secondary Analysis ◽

Single Nucleotide ◽

P Values ◽

Artery Disease

(1) Background: Chemerin, or the RARRES2 (Retinoic Acid Receptor Responder 2) gene, is found to be associated with an increased incidence of insulin resistance, endothelial dysfunction, type 2 diabetes (T2D), and coronary artery disease (CAD). This study investigates associations of RARRES2rs17173608 with insulin resistance and the severity of CAD in non-obese T2D patients in relation to the clinical and genetic factors. (2) Methods: A total of 300 patients with T2D and CAD were recruited in this study. The associations of insulin resistance and the severity of CAD with RARRES2rs17173608 and clinical factors were assessed. The genotyping procedures were performed using the TaqMan method. The significant associations (p ≤ 0.05) from preliminary tests were employed to carry out the secondary analysis. (3) Results: RARRES2rs17173608 (TT, TG, and GG polymorphisms in the preliminary analysis; TG and GG polymorphisms in a secondary analysis) was associated with insulin resistance and the severity of CAD in both the preliminary and secondary analysis (all p-values were < 0.05). Additionally, in the secondary analysis, FPG and ACEI were also associated with insulin resistance and the severity of CAD (all p-values were < 0.05). (4) Conclusion: From the preliminary findings, rs17173608 is a significant predictor of insulin resistance and the severity of CAD.

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