Tu-P7:2 Altered gene expression in abdominal adipose tissue of a novel animal model for the metabolic syndrome

2006 ◽  
Vol 7 (3) ◽  
pp. 185
Author(s):  
K. Tahira ◽  
T. Ueno ◽  
N. Fukuda ◽  
H. Takagi ◽  
M. Mitsumata ◽  
...  
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Animal Model ◽  
Adipose Tissue ◽  
Abdominal Adipose Tissue ◽  
Altered Gene Expression ◽  
The Metabolic Syndrome ◽  
Altered Gene

Abstract 040: Comparison of Effects of Reux en Y Gastric Bypass and Intra-abdominal Lipectomy on Cardiovascular Function in the Metabolic Syndrome

Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Amanda Soler ◽  
Brenda Hutcheson ◽  
Jenny Yang ◽  
Chastity Bradford ◽  
Frank Zhang ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Gastric Bypass ◽  
Adipose Tissue ◽  
Coronary Artery ◽  
Carotid Artery ◽  
Abdominal Adipose Tissue ◽  
The Metabolic Syndrome ◽  
Artery Stiffness ◽  
Abdominal Lipectomy

Central (visceral) obesity is a key feature of the metabolic syndrome and an independent predictor of cardiovascular disease. Reux en Y gastric bypass (RnY) has been shown to offer protection against cardiovascular disease, but residual risk remains. It is also unknown whether the cardiovascular benefit is a consequence of a decrease in visceral (intra-abdominal) adipose tissue or of other factors. In this study, we compared the effects of RnY vs. removal of 90% of visceral adipose tissue (=5% body weight) by intra-abdominal lipectomy on cardiac function (echocardiography), macrovascular function (carotid artery stiffness) and microvascular function (coronary artery endothelium-dependent vasorelaxation) in a metabolic syndrome rat model (JCR:LA-cp, JCR). Cardiac output (CO) and ejection fraction (EF) were significantly decreased in JCR vs. normal (Sprague-Dawley, SD) rats (CO=50±5%, EF=45±2% of normal), and were significantly improved by both RnY and intra-abdominal lipectomy (CO=75±6%, EF=82±2% and CO=80±3%, EF=90±2% of normal, respectively). Likewise, acetylcholine-dependent coronary artery vasorelaxation was impaired in JCR rats (50±1% of normal), and was significantly improved by both RnY and intra-abdominal lipectomy (98±2% and 98±3% of normal, respectively). Carotid artery stiffness was significantly increased in JCR rats (~2 fold vs. SD), and was normalized by intra-abdominal lipectomy (to equal SD), but not by RnY (~2 fold vs. SD). Intra-abdominal lipectomy but not RnY also decreased cardiac and vascular elastin degradation in JCR rats (Lipectomy: ~50% (heart), ~75% (carotid); RnY: ~15% (heart), ~5% (carotid) vs. untreated JCR, respectively), concomitant with a decrease in matrix metalloproteinase 12 (MMP12), a major elastase, activation (~50% (heart), ~75% (carotid), ~87% (visceral fat), ~75% (circulating) vs. untreated JCR) and in 20-hydroxyeicosatetraeonic acid (20-HETE) levels (~4 (heart), ~7 (carotid), ~4 (visceral fat), ~4 (circulating) fold vs. untreated JCR). Thus, our data indicate that intra-abdominal adipose tissue itself is a source of factors that may be important negative regulators of micro- and macrovascular and cardiac function, but are not eliminated by RnY.

CD36 Gene Expression Induced by Fish Oil in Abdominal Adipose Tissue of Rats with Metabolic Syndrome

2017 ◽  
Vol 06 (02) ◽  
Author(s):  
Ofelia Angulo Guerrero ◽  
Alfonso Alexander Aguilera ◽  
Rodolfo Quintana Castro ◽  
Ida Soto Rodriguez ◽  
Guadalupe Sanchez Otero ◽  
...  
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Fish Oil ◽  
Abdominal Adipose Tissue ◽  
Cd36 Gene

Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long‐term caloric restriction

2003 ◽  
Vol 18 (2) ◽  
pp. 1-26 ◽  
Author(s):  
Yoshikazu Higami ◽  
Thomas D. Pugh ◽  
Grier P. Page ◽  
David B. Allison ◽  
Tomas A. Prolla ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Energy Metabolism ◽  
Caloric Restriction ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Altered Gene Expression ◽  
Altered Gene
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