70 THE INCIDENCE OF DE NOVO CANCER AND THE POTENTIAL ROLE OF SIROLIMUS IMMUNOSUPPRESSION CONVERSION IN MORTALITY IN A SINGLE-CENTRE RENAL TRANSPLANTATION COHORT OF 1816 PATIENTS

2011 ◽  
Vol 10 (2) ◽  
pp. 49
Author(s):  
F. Branco ◽  
V. Cavadas ◽  
L. Osório ◽  
F. Carvalho ◽  
E. Lima ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Potential Role ◽  
De Novo ◽  
Single Centre ◽  
De Novo Cancer

Role of Cytomegalovirus and Epstein-Barr virus in Patients with de Novo Colon Cancer after Renal Transplantation

2006 ◽  
Vol 92 (3) ◽  
pp. 219-221 ◽  
Author(s):  
Gian Luigi Adani ◽  
Umberto Baccarani ◽  
Dario Lorenzin ◽  
Vittorio Bresadola ◽  
Giuseppe Currò ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Renal Transplantation ◽  
Epstein Barr Virus ◽  
De Novo ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Cell-autonomous role of TGFβ and IL-2 receptors in CD4+ and CD8+ inducible regulatory T-cell generation during GVHD

Blood ◽  
2012 ◽  
Vol 119 (23) ◽  
pp. 5575-5583 ◽  
Author(s):  
Norifumi Sawamukai ◽  
Atsushi Satake ◽  
Amanda M. Schmidt ◽  
Ian T. Lamborn ◽  
Priti Ojha ◽  
...  
Keyword(s):  
T Cells ◽  
Potential Role ◽  
Acute Gvhd ◽  
De Novo ◽  
Receptor Expression ◽  
Tgfβ Receptor ◽  
Bona Fide ◽  
Deficient Mice ◽  
Transplantation Recipient

Abstract FoxP3+ regulatory T cells (Tregs) suppress GVHD while preserving graft-versus-tumor effects, making them an attractive target for GVHD therapy. The donor-derived Treg pool can potentially be derived from the expansion of preexisting natural Tregs (nTregs) or from de novo generation of inducible Tregs (iTregs) from donor Tconvs in the transplantation recipient. Using an MHC-mismatched model of acute GVHD, in the present study we found that the Treg pool was comprised equally of donor-derived nTregs and iTregs. Experiments using various combinations of T cells from wild-type and FoxP3-deficient mice suggested that both preexisting donor nTregs and the generation of iTregs in the recipient mice contribute to protection against GVHD. Surprisingly, CD8+FoxP3+ T cells represented approximately 70% of the iTreg pool. These CD8+FoxP3+ T cells shared phenotypic markers with their CD4+ counterparts and displayed suppressive activity, suggesting that they were bona fide iTregs. Both CD4+ and CD8+ Tregs appeared to be protective against GVHD-induced lethality and required IL-2 and TGFβ receptor expression for their generation. These data illustrate the complex makeup of the donor-derived FoxP3+ Treg pool in allogeneic recipients and their potential role in protection against GVHD.

scholarly journals Potential role of T2Candida in the management of empirical antifungal treatment in patients at high risk of candidaemia: a pilot single-centre study

2018 ◽  
Vol 73 (10) ◽  
pp. 2856-2859 ◽  
Author(s):  
Maddalena Giannella ◽  
Michela Paolucci ◽  
Greta Roncarati ◽  
Giacomo Vandi ◽  
Renato Pascale ◽  
...  
Keyword(s):  
High Risk ◽  
Potential Role ◽  
Antifungal Treatment ◽  
Single Centre ◽  
Centre Study ◽  
Single Centre Study

Potential role of tacrolimus in erythrocytes’ antioxidative capacity in long-term period after renal transplantation

2015 ◽  
Vol 70 ◽  
pp. 132-139
Author(s):  
Nikola Z. Stefanović ◽  
Tatjana P. Cvetković ◽  
Tatjana M. Jevtović-Stoimenov ◽  
Lilika V. Zvezdanović-Čelebić ◽  
Dijana R. Stojanović ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Potential Role ◽  
Antioxidative Capacity

scholarly journals Serine and one-carbon metabolisms bring new therapeutic venues in prostate cancer

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Carlo Ganini ◽  
Ivano Amelio ◽  
Riccardo Bertolo ◽  
Eleonora Candi ◽  
Angela Cappello ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Carbon Metabolism ◽  
Potential Role ◽  
De Novo ◽  
Cancer Pathogenesis ◽  
Gene And Protein Expression ◽  
Serine Pathway ◽  
One Carbon Metabolism ◽  
Serine Metabolism

AbstractSerine and one-carbon unit metabolisms are essential biochemical pathways implicated in fundamental cellular functions such as proliferation, biosynthesis of important anabolic precursors and in general for the availability of methyl groups. These two distinct but interacting pathways are now becoming crucial in cancer, the de novo cytosolic serine pathway and the mitochondrial one-carbon metabolism. Apart from their role in physiological conditions, such as epithelial proliferation, the serine metabolism alterations are associated to several highly neoplastic proliferative pathologies. Accordingly, prostate cancer shows a deep rearrangement of its metabolism, driven by the dependency from the androgenic stimulus. Several new experimental evidence describes the role of a few of the enzymes involved in the serine metabolism in prostate cancer pathogenesis. The aim of this study is to analyze gene and protein expression data publicly available from large cancer specimens dataset, in order to further dissect the potential role of the abovementioned metabolism in the complex reshaping of the anabolic environment in this kind of neoplasm. The data suggest a potential role as biomarkers as well as in cancer therapy for the genes (and enzymes) belonging to the one-carbon metabolism in the context of prostatic cancer.

Evidence for cAMP as a mediator of gonadotropin secretion from male pituitaries

1987 ◽  
Vol 253 (3) ◽  
pp. E296-E299
Author(s):  
G. A. Bourne ◽  
D. M. Baldwin
Keyword(s):  
Protein Synthesis ◽  
Potential Role ◽  
De Novo ◽  
Follicle Stimulating Hormone ◽  
Gonadotropin Releasing Hormone ◽  
Dibutyryl Camp ◽  
Camp Production ◽  
Gonadotropin Secretion ◽  
De Novo Protein Synthesis

The purpose of this study was to use sodium flufenamate, a compound that inhibits gonadotropin-releasing hormone (GnRH)-stimulated adenosine 3',5'-cyclic monophosphate (cAMP) production in the pituitary, to evaluate the potential role of cAMP as a mediator of GnRH-stimulated gonadotropin secretion from male pituitaries. Quartered male pituitaries were perifused at 37 degrees C and sequential effluent fractions collected every 10 min. Infusions of GnRH resulted in a twofold increase in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion. Cycloheximide, 5 microM, completely inhibited the GnRH-stimulated LH and FSH secretion. Infusions of 0.1 mM flufenamate had similar effects on gonadotropin secretion as cycloheximide, whereas the administration of 5 mM dibutyryl cAMP in combination with GnRH and flufenamate restored the secretory responses of both hormones. The flufenamate-inhibited GnRH stimulated LH and FSH release, which was restored by DBcAMP and appeared to be protein synthesis dependent and specific for cAMP. These results suggest an indirect role for cAMP as a mediator of gonadotropin secretion from male pituitaries. However, in contrast to female pituitaries, the secretion of these hormones from male pituitaries is completely dependent on cAMP and de novo protein synthesis.

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