Background:
Kidney cancer is one of the most common cancers
worldwide. Recent studies have suggested that single nucleotide polymorphisms
(SNPs) in autophagy-related gene are associated with the risk of kidney cancer.
Objective:
This study was undertaken to investigate the association of autophagyrelated
gene 7 (ATG7) polymorphisms with the risk of clear cell renal cell carcinoma
(ccRCC) in the Chinese Han population.
Methods:
A significant association was observed between allele A of rs6442260 and
ccRCC risk (OR = 0.76, 95% CI: 0.58-0.99, p = 0.039). Genetic model analysis
revealed that rs2606736 (OR = 0.57, 95% CI: 0.34-0.95, p = 0.031) and rs6442260
(OR = 0.44, 95% CI: 0.22-0.90, p = 0.021) were associated with decreased risk of
ccRCC under recessive model. Age stratification analysis showed that rs2606736 (OR =
0.67, 95% CI: 0.46-0.98, p = 0.036) and rs6442260 (OR = 0.26, 95% CI: 0.07-0.89, p =
0.014) were significantly decreased risk of ccRCC under the log-additive model in age > 55 years
old and ≤ 55 years old, respectively.
Results:
A significant association was observed between allele A of rs6442260 and
ccRCC risk (OR = 0.76, 95% CI: 0.58-0.99, p = 0.039). Genetic model analysis
revealed that rs2606736 (OR = 0.57, 95% CI: 0.34-0.95, p = 0.031) and rs6442260
(OR = 0.44, 95% CI: 0.22-0.90, p = 0.021) were associated with decreased risk of
ccRCC under recessive model. Age stratification analysis showed that rs2606736 (OR =
0.67, 95% CI: 0.46-0.98, p = 0.036) and rs6442260 (OR = 0.26, 95% CI: 0.07-0.89, p =
0.014) were significantly decreased risk of ccRCC under the log-additive model in age > 55 years
old and ≤ 55 years old, respectively.
Conclusions:
This study indicated that ATG7 polymorphisms (rs2606736 and
rs6442260) have a protective role for ccRCC risk. Further large sample size and
functional assays are needed to confirm our findings and reveal the role of ATG7
polymorphisms in ccRCC carcinogenesis.