P-035: AI-based models for the identification of critical genetic biomarkers to distinguish MM from MGUS using the WES data

2021 ◽  
Vol 21 ◽  
pp. S57
Author(s):  
Vivek Ruhela ◽  
Akanksha Farswan ◽  
Anubha Gupta ◽  
Sriram K ◽  
Gurvinder Kaur ◽  
...  
Keyword(s):  
Genetic Biomarkers

Genetic Biomarkers for Migraine

2006 ◽  
Vol 46 (7) ◽  
pp. 1059-1068 ◽  
Author(s):  
Boukje De Vries ◽  
Joost Haan ◽  
Rune R. Frants ◽  
Arn M.J.M. Van den Maagdenberg ◽  
Michel D. Ferrari
Keyword(s):  
Genetic Biomarkers

scholarly journals Combined Genetic Biomarkers and Betel Quid Chewing for Identifying High-Risk Group for Oral Cancer Occurrence

2017 ◽  
Vol 10 (6) ◽  
pp. 355-362 ◽  
Author(s):  
Chia-Min Chung ◽  
Chien-Hung Lee ◽  
Mu-Kuan Chen ◽  
Ka-Wo Lee ◽  
Cheng-Che E. Lan ◽  
...  
Keyword(s):  
High Risk ◽  
Oral Cancer ◽  
Risk Group ◽  
High Risk Group ◽  
Betel Quid ◽  
Genetic Biomarkers ◽  
Cancer Occurrence ◽  
Betel Quid Chewing

scholarly journals Genetic biomarkers of posttraumatic epilepsy: A systematic review

Seizure ◽  
2017 ◽  
Vol 46 ◽  
pp. 53-58 ◽  
Author(s):  
Devyn Cotter ◽  
Andrew Kelso ◽  
Aidan Neligan
Keyword(s):  
Systematic Review ◽  
Posttraumatic Epilepsy ◽  
Genetic Biomarkers

scholarly journals Genetic determinants of COVID-19 drug efficacy revealed by genome-wide CRISPR screens

2020 ◽  
Author(s):  
Wei Jiang ◽  
Ailing Yang ◽  
Jingchuan Ma ◽  
Dawei Lv ◽  
Mingxian Liu ◽  
...  
Keyword(s):  
Clinical Trial Data ◽  
Drug Efficacy ◽  
Metabolic Activation ◽  
Trial Data ◽  
Genetic Determinants ◽  
Immunomodulatory Agents ◽  
Genetic Biomarkers ◽  
Preliminary Information ◽  
Genome Wide ◽  
Screen Approach

AbstractImmunomodulatory agents dexamethasone and colchicine, antiviral drugs remdesivir, favipiravir and ribavirin, as well as antimalarial drugs chloroquine phosphate and hydroxychloroquine are currently used in the combat against COVID-191–16. However, whether some of these drugs have clinical efficacy for COVID-19 is under debate. Moreover, these drugs are applied in COVID-19 patients with little knowledge of genetic biomarkers, which will hurt patient outcome. To answer these questions, we designed a screen approach that could employ genome-wide sgRNA libraries to systematically uncover genes crucial for these drugs’ action. Here we present our findings, including genes crucial for the import, export, metabolic activation and inactivation of remdesivir, as well as genes that regulate colchicine and dexamethasone’s immunosuppressive effects. Our findings provide preliminary information for developing urgently needed genetic biomarkers for these drugs. Such biomarkers will help better interpret COVID-19 clinical trial data and point to how to stratify COVID-19 patients for proper treatment with these drugs.

scholarly journals Genetic Biomarkers in Epilepsy

2014 ◽  
Vol 11 (2) ◽  
pp. 324-333 ◽  
Author(s):  
Yvonne G. Weber ◽  
Anne T. Nies ◽  
Matthias Schwab ◽  
Holger Lerche
Keyword(s):  
Genetic Biomarkers

Genetic biomarkers in non-contact muscle injuries in elite soccer players

2016 ◽  
Vol 25 (10) ◽  
pp. 3311-3318 ◽  
Author(s):  
Ricard Pruna ◽  
Rosa Artells ◽  
Matilda Lundblad ◽  
Nicola Maffulli
Keyword(s):  
Soccer Players ◽  
Muscle Injuries ◽  
Genetic Biomarkers

Genetic Biomarkers to Identify the Risk of Osteonecrosis in Children with Acute Lymphoblastic Leukemia

2016 ◽  
Vol 20 (6) ◽  
pp. 519-522 ◽  
Author(s):  
Marissa A. H. den Hoed ◽  
Saskia M. F. Pluijm ◽  
André G. Uitterlinden ◽  
Rob Pieters ◽  
Marry M. van den Heuvel-Eibrink
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Genetic Biomarkers
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