scholarly journals Alcohol consumption as a risk factor for oesophageal squamous cell carcinoma risk in sub-Saharan Africa

2021 ◽  
Author(s):  
Violet Kayamba
Keyword(s):  
Squamous Cell Carcinoma ◽  
Risk Factor ◽  
Alcohol Consumption ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Sub Saharan Africa ◽  
Oesophageal Squamous Cell Carcinoma ◽  
Sub Saharan ◽  
Carcinoma Risk

scholarly journals Gender Differences in Oesophageal Squamous Cell Carcinoma in a South African Tertiary Hospital

2020 ◽  
Vol 17 (19) ◽  
pp. 7086
Author(s):  
Lucien Ferndale ◽  
Colleen Aldous ◽  
Richard Hift ◽  
Sandie Thomson
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Risk Factor ◽  
Alcohol Consumption ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Presentation ◽  
Tertiary Hospital ◽  
Oesophageal Squamous Cell Carcinoma ◽  
Males And Females

(1) Oesophageal squamous cell carcinoma is common in Africa and has a male preponderance. The gender-based differences in clinical presentation and risk factor exposure are poorly studied in the African context. Our aim was to compare males and females with this disease. We analyzed the differences in clinical features and risk factor exposure between males and females with oesophageal cancer. (2) Data from patients presenting to a tertiary hospital in South Africa with oesophageal squamous cell carcinoma were analyzed. Data collected included patient demographics, clinical presentation, pathology and risk factor exposure. (3) Three hundred and sixty three patients were included in the study. The male to female ratio was 1.4:1. The mean age was 66 years for females and 61 years for males (p < 0.0001). A significantly larger percentage of males were underweight compared to females (60% vs. 32%, p < 0.001). There were no differences between the genders with regards to performance status, dysphagia grade and duration and tumor length, location and degree of differentiation. There were significant differences between risk factor exposure between the two genders. Smoking and alcohol consumption was an association in more than 70% of males but in less than 10% of females There was no difference survival. (4) Female patients with oesophageal squamous cell carcinoma (OSCC) are older and have a higher body mass index (BMI) than their male counterparts. Traditionally purported risk factors of smoking and alcohol consumption are infrequent associations with OSCC in female patients and other environmental risk factors may be more relevant in this gender.

scholarly journals Squamous Cell Carcinoma in African Children with Xeroderma Pigmentosum: Three Case Reports

2016 ◽  
Vol 8 (3) ◽  
pp. 311-318 ◽  
Author(s):  
Mamadou Kaloga ◽  
Pauline Dioussé ◽  
Boubacar Ahy Diatta ◽  
Mariama Bammo ◽  
Sarah Kourouma ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Xeroderma Pigmentosum ◽  
Case Reports ◽  
Sub Saharan Africa ◽  
Skin Cancers ◽  
Black Skin ◽  
The Mean ◽  
Sub Saharan

Introduction: Xeroderma pigmentosum is a rare autosomal recessive genetic disease. This disease predisposes patients to early-onset skin cancers, particularly squamous cell carcinoma. Here, we report 3 pediatric cases, including 2 deaths. Observation: The subjects included 2 boys and 1 girl with skin type VI. All subjects were from consanguineous marriages, and the average age was 7.6 years. The patients all had ulcerative budding tumor lesions in the cephalic region, and the mean disease duration was 18 months. In all 3 cases, the diagnosis of xeroderma pigmentosum was made before the poikilodermal appearance of sun-exposed areas and photophobia. Neurological-type mental retardation was noted in 1 case. Histology confirmed squamous cell carcinoma in all 3 cases. The evolutions were marked by the death of 2 children (cases 1 and 3). In one case, the outcome was favorable following cancer excision and subsequent chemotherapy with adjuvant radiotherapy. Conclusion: Squamous cell carcinoma is a serious complication related to xeroderma pigmentosum in Sub-Saharan Africa. Prevention is based on the early diagnosis of xeroderma pigmentosum, black skin photoprotection, screening and early treatment of lesions, and genetic counseling.

scholarly journals Association between alcohol consumption and oesophageal microbiota in oesophageal squamous cell carcinoma

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wenqing Rao ◽  
Zheng Lin ◽  
Shuang Liu ◽  
Zhihui Zhang ◽  
Qianwen Xie ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Alcohol Consumption ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Diversity Index ◽  
16S Rrna Gene Sequencing ◽  
Rrna Gene ◽  
Oesophageal Squamous Cell Carcinoma ◽  
Sequencing Data ◽  
Linear Discriminant

Abstract Background Microbiota has been reported to play a role in cancer patients. Nevertheless, little is known about the association between alcohol consumption and resultant changes in the diversity and composition of oesophageal microbiota in oesophageal squamous cell carcinoma (ESCC). Methods We performed a hospital-based retrospective study of 120 patients with pathologically diagnosed primary ESCC. The relevant information for all study participants were collected through a detailed questionnaire. The differences in adjacent tissues between non-drinkers and drinkers were explored using 16S rRNA gene sequencing. Raw sequencing data were imported into QIIME 2 to analyse the diversity and abundance of microbiota. Linear discriminant analysis effect size (LEfSe) and unconditional logistic regression were performed to determine the bacterial taxa that were associated with drinking. Results The Shannon diversity index and Bray-Curtis distance of oesophageal microbiota were significantly different among drinkers(P < 0.05). The alcohol-related bacteria were primarily from the orders Clostridiales, Gemellales and Pasteurellales, family Clostridiaceae, Lanchnospiraceae, Helicobacteraceae, Alcaligenaceae, Bacteroidaceae, Pasteurellaceae and Gemellaceae; genus Clostridium, Helicobacter, Catonella, Bacteroides, Bacillus, Moraxella, and Bulleidia; and species B. moorei and longum (genus Bifidobacterium). In addition, the diversity and abundance of these microbiota were observed to be affected by the age, residential districts of the patients, and sampling seasons. Moreover, the higher the frequency and years of alcohol consumption, the lower was the relative abundance of genus Catonella that was observed. Conclusion Alcohol consumption is associated with alterations in both the diversity and composition the of the oesophageal microbiota in ESCC patients.

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