scholarly journals Gene–environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach

Author(s):  
Varun Warrier ◽  
Alex S F Kwong ◽  
Mannan Luo ◽  
Shareefa Dalvie ◽  
Jazz Croft ◽  
...  
2014 ◽  
Vol 204 (1) ◽  
pp. 3-5 ◽  
Author(s):  
Rudolf Uher ◽  
Ian C. G. Weaver

SummaryMaltreatment in childhood affects mental health over the life course. New research shows that early life experiences alter the genome in a way that can be measured in peripheral blood samples decades later. These findings suggest a new strategy for exploring gene–environment interactions and open opportunities for translational epigenomic research.


2020 ◽  
Vol 7 (1) ◽  
pp. 108-122
Author(s):  
Shannon L. Stewart ◽  
Ashley Toohey ◽  
Natalia Lapshina

Objectives: Research has shown that children who experience abuse and neglect are at much higher risk of experiencing negative outcomes such as physical and mental health problems, social skill deficits, and poor quality of life. The goal of this paper was to examine the relationship between polyvictimization and risk of harm to self and others, taking into account both age and sex differences. Methods: A total of 8980 participants (4156 with maltreatment history) were recruited from over 50 mental health facilities in Ontario, Canada. Group comparisons were completed to examine types of trauma experienced, and risk of harm to self and others. Results: Among our sample, we found that 29% of children and youth had experienced multiple types of interpersonal trauma. We also found that while female children and youth who had experienced trauma were at greater risk of harm to themselves, males were at greater risk of harming others. Further, our results highlight that children and youth who had experienced multiple types of maltreatment, regardless of age or sex, were at the greatest risk of harm to self and others. Implications: Findings from this research highlight that interpersonal trauma is multifaceted and add to existing evidence that there is a cumulative relationship between experiencing multiple types of maltreatment and risk in relation to harming oneself or others. Our findings underscore the importance of a background assessment that takes into account all forms of maltreatment in order to properly understand risk of harm and inform intervention.


2021 ◽  
Vol 12 ◽  
Author(s):  
Vicki Bitsika ◽  
Christopher F. Sharpley ◽  
Mary E. McMillan ◽  
Emmanuel Jesulola ◽  
Linda L. Agnew

In order to evaluate the effects of specific forms of childhood maltreatment (CM) upon adult C-reactive protein (CRP) concentrations, and to further describe the potentially confounding role that recent life stress and depression hold in that relationship, 221 participants from rural Australia (M age = 44yr, SD = 17.8yr) completed self-report questionnaires and provided a blood sample. There were no sex differences in any variables across the 91 males and 130 females, but depression status did confound the association between global CM and CRP. The specific aspect of CM was identified as physical and mental health abuse, and this was significantly associated with CRP level in participants with depressive symptoms and those without. There was no significant confound from recent life stressors. Results hold implications for the diagnosis of CM-related CRP elevation and (potentially) depression.


2019 ◽  
Vol 4 (7) ◽  
pp. 105-110
Author(s):  
Amanda Plácido da Silva Macêdo ◽  
Monnic Maria Lóssio Rocha Maia ◽  
Izadora De Sousa Pereira ◽  
Thânia Maria Rodrigues Figueiredo ◽  
Modesto Leite Rolim Neto

Child maltreatment has serious consequences, including increasing an individual's risk of physical and mental health problems across their life course. Objective: Here we show that there  is an important public health message to focus, not only on approaches that prevent or detect childhood maltreatment, but also to explore methods of prevention and detection of mental ill health. Results: The study Childhood maltreatment and adult suicidality: a comprehensive systematic review with meta-analysis (2019) showed that all different types of childhood maltreatment including sexual abuse [odds ratio (OR) 3.17, 95% confidence interval (CI) 2.76–3.64], physical abuse (OR 2.52, 95% CI 2.09–3.04) and emotional abuse (OR 2.49, 95% CI 1.64–3.77) were associated with two- to three-fold increased risk for suicide attempts. Conclusion: It is important to highlight emotional violence may actually be more powerful than physical and sexual abuse in its impact on adolescent suicide behaviors in low- and middle-income countries. Keywords: Child Maltreatment; Mental Health; Prevention.


2021 ◽  
pp. 1-10
Author(s):  
Sophie Foss ◽  
Hanna C. Gustafsson ◽  
Obianuju O. Berry ◽  
Alison E. Hipwell ◽  
Elizabeth A. Werner ◽  
...  

Abstract Childhood maltreatment (CM) is a known risk factor for adolescent pregnancy. Sleep disturbances and psychological distress, both common negative sequelae of CM, often co-occur during pregnancy, although directionality remains unclear. Furthermore, little is known about how CM affects sleep–distress associations during pregnancy. In pregnant adolescents, we examined: (a) whether there are significant predictive associations from CM to sleep quality and distress and (b) bidirectional influences of distress and sleep quality. Healthy pregnant adolescents (n = 204) were recruited before or during the 2nd trimester. CM was assessed at enrollment; sleep quality and distress were assessed in the 2nd and 3rd trimesters. Hypotheses were tested using path analysis. Findings revealed that CM was associated with worse 2nd trimester sleep quality and distress (β = .19, p < .05 for sleep; β = .30, p < .001 for distress). Higher levels of 2nd trimester distress were associated with lower 3rd trimester sleep quality (β = .19, p < .05). Findings provide novel information about (a) associations from CM to prenatal mood and sleep in pregnant adolescents, and (b) sleep–distress directionality over the course of pregnancy. These results have implications for better understanding the ways in which CM potentially exerts influences later in life, and for targeting interventions to address physical and mental health during pregnancy.


2007 ◽  
Author(s):  
Catherine R. Montgomery ◽  
Lee R. Perry ◽  
Bikat S. Tilahun ◽  
Graham Fawcett ◽  
Cynthia B. Eriksson

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