scholarly journals Effects of Subtypes of Child Maltreatment on CRP in Adulthood

2021 ◽  
Vol 12 ◽  
Author(s):  
Vicki Bitsika ◽  
Christopher F. Sharpley ◽  
Mary E. McMillan ◽  
Emmanuel Jesulola ◽  
Linda L. Agnew
Keyword(s):  
Mental Health ◽  
Childhood Maltreatment ◽  
Life Stress ◽  
Specific Aspect ◽  
Self Report ◽  
Physical And Mental Health ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Depression Status ◽  
Rural Australia

In order to evaluate the effects of specific forms of childhood maltreatment (CM) upon adult C-reactive protein (CRP) concentrations, and to further describe the potentially confounding role that recent life stress and depression hold in that relationship, 221 participants from rural Australia (M age = 44yr, SD = 17.8yr) completed self-report questionnaires and provided a blood sample. There were no sex differences in any variables across the 91 males and 130 females, but depression status did confound the association between global CM and CRP. The specific aspect of CM was identified as physical and mental health abuse, and this was significantly associated with CRP level in participants with depressive symptoms and those without. There was no significant confound from recent life stressors. Results hold implications for the diagnosis of CM-related CRP elevation and (potentially) depression.

scholarly journals Genetic contributions to self-reported tiredness

2017 ◽  
Vol 23 (3) ◽  
pp. 609-620 ◽  
Author(s):  
V Deary ◽  
◽  
S P Hagenaars ◽  
S E Harris ◽  
W D Hill ◽  
...  
Keyword(s):  
Mental Health ◽  
Smoking Status ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Physical And Mental Health ◽  
C Reactive Protein ◽  
Major Depressive ◽  
Reactive Protein ◽  
Genome Wide

Abstract Self-reported tiredness and low energy, often called fatigue, are associated with poorer physical and mental health. Twin studies have indicated that this has a heritability between 6 and 50%. In the UK Biobank sample (N=108 976), we carried out a genome-wide association study (GWAS) of responses to the question, ‘Over the last two weeks, how often have you felt tired or had little energy?’ Univariate GCTA-GREML found that the proportion of variance explained by all common single-nucleotide polymorphisms for this tiredness question was 8.4% (s.e.=0.6%). GWAS identified one genome-wide significant hit (Affymetrix id 1:64178756_C_T; P=1.36 × 10−11). Linkage disequilibrium score regression and polygenic profile score analyses were used to test for shared genetic aetiology between tiredness and up to 29 physical and mental health traits from GWAS consortia. Significant genetic correlations were identified between tiredness and body mass index (BMI), C-reactive protein, high-density lipoprotein (HDL) cholesterol, forced expiratory volume, grip strength, HbA1c, longevity, obesity, self-rated health, smoking status, triglycerides, type 2 diabetes, waist–hip ratio, attention deficit hyperactivity disorder, bipolar disorder, major depressive disorder, neuroticism, schizophrenia and verbal-numerical reasoning (absolute r g effect sizes between 0.02 and 0.78). Significant associations were identified between tiredness phenotypic scores and polygenic profile scores for BMI, HDL cholesterol, low-density lipoprotein cholesterol, coronary artery disease, C-reactive protein, HbA1c, height, obesity, smoking status, triglycerides, type 2 diabetes, waist–hip ratio, childhood cognitive ability, neuroticism, bipolar disorder, major depressive disorder and schizophrenia (standardised β’s had absolute values<0.03). These results suggest that tiredness is a partly heritable, heterogeneous and complex phenomenon that is phenotypically and genetically associated with affective, cognitive, personality and physiological processes.

scholarly journals Prevalence and Risk Factors of COVID-19 Symptoms among U.S. Adults with Allergies

2021 ◽  
Vol 18 (5) ◽  
pp. 2231
Author(s):  
Marlene Camacho-Rivera ◽  
Jessica Yasmine Islam ◽  
Denise Christina Vidot ◽  
Sunit Jariwala
Keyword(s):  
Mental Health ◽  
Social Dynamics ◽  
Adult Population ◽  
Physical Symptoms ◽  
Economic Security ◽  
Self Report ◽  
Physical And Mental Health ◽  
Mental Health Symptoms ◽  
Health Symptoms ◽  
Physician Diagnosis

Background: This study sought to evaluate COVID-19 associated physical and mental health symptoms among adults with allergies compared to the general U.S. adult population. Methods: Data for these analyses were obtained from the publicly available COVID-19 Household Impact Survey, which provides national and regional statistics about physical health, mental health, economic security, and social dynamics among U.S. adults (ages 18 and older). Data from 20–26 April 2020; 4–10 May 2020; and 30 May–8 June 2020 were included. Our primary outcomes for this analysis were physical and mental health symptoms experienced in the last seven days. The primary predictor was participants’ self-report of a physician diagnosis of an allergy. Results/Discussion: This study included 10,760 participants, of whom 44% self-reported having allergies. Adults with allergies were more likely to report physical symptoms compared to adults without allergies including fever (aOR 1.7, 95% CI 1.44–1.99), cough (aOR 1.9, 95% CI 1.60–2.26), shortness of breath (aOR 2.04, 95% CI 1.71–2.43), and loss of taste or sense of smell (aOR 1.9, 95% CI 1.58–2.28). Adults with allergies were more likely to report feeling nervous (cOR 1.34, 95% CI 1.13, 1.60), depressed (cOR 1.32, 95% CI 1.11–1.57), lonely (cOR 1.23, 95% CI 1.04–1.47), hopeless (cOR 1.44, 95% CI 1.21–1.72), or having physical reactions when thinking about COVID-19 pandemic (cOR 2.01, 95% CI 1.44–2.82), compared to those without allergies. During the COVID-19 pandemic, adults with allergies are more likely to report physical and mental health symptoms compared to individuals without allergies. These findings have important implications for diagnostic and treatment challenges for allergy physicians.

scholarly journals Physical Health Profile and Associated Behavior During the COVID-19 Pandemic in Patients With Bipolar Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Jon Dyg Sperling ◽  
Nina Dalkner ◽  
Christina Berndt ◽  
Eva Fleischmann ◽  
Michaela Ratzenhofer ◽  
...  
Keyword(s):  
Mental Health ◽  
Physical Health ◽  
Public Mental Health ◽  
Brief Symptom Inventory ◽  
Self Report ◽  
Control Group ◽  
Healthy Controls ◽  
Physical And Mental Health ◽  
Healthy Control ◽  
Mental And Physical Health

Background: The COVID-19 pandemic has led to an increased psychological strain on public mental health and may impact behavioral, mental, and physical health, presumably with effects on patients with severe mental disorders. This study examines pandemic-related physical and mental health and (compensatory) behavioral changes, in patients with BD as compared to healthy control individuals.Method: Physical and mental health and self-reported changes in daily structure and behavior due to the pandemic were assessed using a self-constructed questionnaire and the brief symptom inventory (BSI) in Germany, Austria, and Denmark in individuals with BD and a healthy control group.Results: The present study included 118 individuals with BD and 215 healthy controls. Individuals with BD reported statistically significant higher physical risk burden, increased weight gain, more physical comorbidities, and a decrease in physical activity and they further reported higher rates of COVID-19 testing, had more worries concerning health, and experienced more anxiety but less social distancing.Conclusion: The COVID-19 pandemic seems to have a greater impact on physical health in individuals with BD than in healthy controls. Individuals with BD appear to be having more difficulties compensating their behavior due to the pandemic which could amplify the effect of risk factors associated with poorer physical health. This highlights the necessity for optimizing and targeting the overall treatment of both mental and physical health in patients with BD during periods with far-reaching changes such as the COVID-19 pandemic.Limitations: Sampling issues and self-report forms, selectivity (missing elderly, and those lacking access or knowledge of technology).

scholarly journals Physical, cognitive and mental health impacts of COVID-19 following hospitalisation: a multi-centre prospective cohort study

2021 ◽  
Author(s):  
Rachael Andrea Evans ◽  
Hamish McAuley ◽  
Ewen M Harrison ◽  
Aarti Shikotra ◽  
Amisha Singapuri ◽  
...  
Keyword(s):  
Mental Health ◽  
Clinical Care ◽  
Acute Illness ◽  
Physical And Mental Health ◽  
White Ethnicity ◽  
Reactive Protein ◽  
Active Approach ◽  
Health Related ◽  
Biochemical Testing ◽  
The Impact

Background The impact of COVID-19 on physical and mental health, and employment following hospitalisation is poorly understood. Methods PHOSP-COVID is a multi-centre, UK, observational study of adults discharged from hospital with a clinical diagnosis of COVID-19 involving an assessment between two- and seven-months later including detailed symptom, physiological and biochemical testing. Multivariable logistic regression was performed for patient-perceived recovery with age, sex, ethnicity, body mass index (BMI), co-morbidities, and severity of acute illness as co-variates. Cluster analysis was performed using outcomes for breathlessness, fatigue, mental health, cognition and physical function. Findings We report findings of 1077 patients discharged in 2020, from the assessment undertaken a median 5 [IQR4 to 6] months later: 36% female, mean age 58 [SD 13] years, 69% white ethnicity, 27% mechanical ventilation, and 50% had at least two co-morbidities. At follow-up only 29% felt fully recovered, 20% had a new disability, and 19% experienced a health-related change in occupation. Factors associated with failure to recover were female, middle-age, white ethnicity, two or more co-morbidities, and more severe acute illness. The magnitude of the persistent health burden was substantial and weakly related to acute severity. Four clusters were identified with different severities of mental and physical health impairment: 1) Very severe (17%), 2) Severe (21%), 3) Moderate with cognitive impairment (17%), 4) Mild (46%), with 3%, 7%, 36% and 43% feeling fully recovered, respectively. Persistent systemic inflammation determined by C-reactive protein was related to cluster severity, but not acute illness severity. Interpretation We identified factors related to recovery from a hospital admission with COVID-19 and four different phenotypes relating to the severity of physical, mental, and cognitive health five months later. The implications for clinical care include the potential to stratify care and the need for a pro-active approach with wide-access to COVID-19 holistic clinical services. Funding: UKRI and NIHR

The characteristics associated with alcohol co-ingestion in patients visited to the emergency department with deliberate self-poisoning: retrospective study

2021 ◽  
Keyword(s):  
Emergency Department ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Blood Alcohol Concentration ◽  
Alcohol Concentration ◽  
Self Report ◽  
C Reactive Protein ◽  
Alcohol Group ◽  
Reactive Protein ◽  
History Of

Objective: The aim of this study was to investigate the characteristics associated with alcohol co-ingestion by measuring blood alcohol concentration in patients visited to the emergency department with deliberate self-poisoning. Also, it was to evaluate the accuracy of self-reported alcohol ingestion. Methods: The initial assessment forms, medical records and laboratory tests of patients visited to the ED after DSP between March 2017 and June 2020 were retrospectively reviewed. Based on the patients’ BAC, two groups were formed: the non-alcohol group and the alcohol group. Results: This study included 286 patients (56.6%, n = 162) in the non-alcohol group and 43.4% (n = 124) in the alcohol group. In multivariate logistic analysis, alcohol co-ingestion was independently associated with no history of psychiatric admission (Odds Ratio = 6.222, 95% Confidence Interval = 1.148-33.716, P = 0.034), lactate (mg/dL)(Odds Ratio = 1.961, 95% Confidence Interval = 1.274-3.019, P = 0.002), and C-reactive protein level (mg/dL) (Odds Ratio = 0.003, 95% Confidence Interval = 0.000-0.897, P = 0.046). The receiver operating characteristics analysis of lactate value for the association with alcohol co-ingestion showed a cutoff value of 1.45, with 88.1% sensitivity, 71.6%specificity, and an area under the curve of 0.845. There was no statistically significant difference in emergency department disposition between the two groups. Using the 261 subjects who completed the self-report of alcohol co-ingestion, self-report resulted in 77.6% sensitivity and 76.6% specificity for the assessment of alcohol co-ingestion. The positive and negative predictive values for self-reporting were 72.6% and 81.0%, respectively. Conclusions: Alcohol co-ingestion was associated with no history of psychiatric ward admission, high lactate levels, and low C-reactive protein values in patients who visited the emergency department with deliberate self-poisoning. This study showed that self-reported alcohol co-ingestion was not a substitute for the blood alcohol concentration test.

scholarly journals The Utility of the Timed Up-and-Go Test in Predicting Cognitive Performance: A Cross-Sectional Study of Independent Living Adults in a Retirement Community

2019 ◽  
Vol 39 (10) ◽  
pp. 1163-1168 ◽  
Author(s):  
Ryan Van Patten ◽  
Ellen E. Lee ◽  
Sarah A. Graham ◽  
Colin A. Depp ◽  
Ho-Cheol Kim ◽  
...  
Keyword(s):  
Mental Health ◽  
Physical Health ◽  
Cognitive Performance ◽  
Psychiatric Symptoms ◽  
Functional Mobility ◽  
Self Report ◽  
Physical And Mental Health ◽  
Cognitive Changes ◽  
Timed Up And Go ◽  
Health Measures

Physical, emotional, and cognitive changes are well documented in aging populations. We administered a comprehensive battery of mental and physical health measures and the Montreal Cognitive Assessment (MoCA; a cognitive screening tool) to 93 independently living older adults (OAs) residing in a Continuing Care Senior Housing Community. Performance on the Timed Up-and-Go (TUG) test (a measure of functional mobility) correlated more strongly with the MoCA total score than did measures of aging, psychiatric symptoms, sleep, and both self-report and objective physical health. Furthermore, it was associated with MoCA Attention, Language, Memory, and Visuospatial/Executive subscales. The MoCA-TUG relationship remained significant after controlling for demographic and physical/mental health measures. Given that the TUG explained significantly more variance in broad cognitive performance than a comprehensive battery of additional physical and mental health tests, it may function as a multimodal measure of health in OAs, capturing physical changes and correlating with cognitive measures.

Move your mind: embedding accredited exercise physiology services within a hospital-based mental health service

2020 ◽  
pp. 103985622094303 ◽  
Author(s):  
Bonnie J Furzer ◽  
Kemi E Wright ◽  
Azam Edoo ◽  
Andrew Maiorana
Keyword(s):  
Mental Health ◽  
Mental Health Service ◽  
Health Service ◽  
Psychotic Disorders ◽  
Exercise Physiology ◽  
Self Report ◽  
Physical And Mental Health ◽  
Hospital Environments ◽  
Audit Period ◽  
Service Data

Objective: Despite support for the role of exercise in improving physical and mental health for various psychiatric disorders, few service implementation evaluations within diverse hospital environments exist. This study presents the feasibility and implementation of a clinical exercise physiology service within a hospital mental health service. Method: Feasibility and service data were collected from databases and self-report (consumer and staff) for 6 months from the commencement of new exercise services (gym and group sessions) for community and inpatients (one secure and three open wards). Results: One hundred and twenty consumers engaged with exercise services with 70 direct referrals over the 6-month audit period (mean age 40 ± 13 years (19–69); 41% male). The overwhelming reason for referral was related to weight loss/management (65.7%), with the majority of patients (51%) presenting with schizophrenia spectrum and other psychotic disorders. Further, 549 exercise service interactions were delivered and 78% gym attendees and 69% group session attendees rated the exercise sessions as ‘Good’ or ‘Great’, and intention to return ranged from 78% for inpatient gym sessions to 91% for community gym sessions. Conclusions: Embedding exercise physiology into a mental health service is feasible and well accepted and the evaluation of long-term consumer outcomes in ‘real-world’ will serve as a crucial step.

A review and preview of developments in the measurement of sociability

2020 ◽  
Vol 84 (1) ◽  
pp. 79-101
Author(s):  
Nicholas Boswell ◽  
Jian Cao ◽  
W. Jackeline Torres ◽  
Margaret Beier ◽  
Ashutosh Sabharwal ◽  
...  
Keyword(s):  
Mental Health ◽  
Social Interactions ◽  
Quantitative Measurement ◽  
Measurement Methods ◽  
Self Report ◽  
Physical And Mental Health ◽  
Qualitative And Quantitative ◽  
Social Patterns ◽  
Advantages And Disadvantages ◽  
Mental Health Effects

Sociability is a complex, multifactorial trait. Its importance is underscored by a multitude of negative physical and mental health effects related to loneliness and social isolation. However, current measures of sociability primarily rely on subjective recall and self- report, which have inherent weaknesses and limitations. Although objective and automatic measurements could help to avoid some of these issues, they are still in early stages of development. In this article, the authors review past and present methods of measuring sociability and social interactions. This encompasses both subjective and objective subsets of qualitative and quantitative measurement modalities to gain a broader, more accurate perspective on sociability. Through an analysis of advantages and disadvantages of measurement methods within these categories, a foundational knowledge of sociability measurement can be understood. Utilizing current technology and research methods holds promise to more accurately represent individuals' social networks and social patterns.

scholarly journals The psychological burden experienced by Chinese citizens during the COVID-19 outbreak: prevalence and determinants

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Zhengjia Ren ◽  
Yuchu Zhou ◽  
Yanhong Liu
Keyword(s):  
Mental Health ◽  
Social Media ◽  
Survey Methodology ◽  
Multiple Logistic Regression Analysis ◽  
Media Exposure ◽  
Self Report ◽  
Anxiety And Depression ◽  
Physical And Mental Health ◽  
Psychological Burden ◽  
Item Scale

Abstract Background The present study is aims to investigate the prevalence and determinants of depression and anxiety among the general population in the context of coronavirus disease 2019 (COVID-19) outbreak in China. Methods A cross-sectional self-report survey methodology was used to gather the following data from Chinese citizens: sociodemographic information, physical and mental health disorder history, daily online time, social media exposure, feeling toward social media exposure, perception of the disease, infection cases in the local area, and previous experiences with stressful life incidents. Levels of anxiety and depression were self-reported employing the Generalized Anxiety Disorder 7-item scale and the Patient Health Questionnaire 9-item scale, respectively. Results Among the 6130 participants, the prevalence of anxiety and depression was 7.1 and 12%, respectively. Multiple logistic regression analysis revealed that psychological disturbances were associated with gender, people with religious background, being a medical professional, having physical or mental health disease, difficulty accessing medical aids, experience with traumatic incidents, the perceived possibility of sequelae after being cured of COVID-19, daily online time, the source of the information relevant to COVID-19, frequency of receiving information regarding COVID-19, and negative feelings triggered by social media. Conclusions There needs to be a consistent message from authorities to reduce the panic and confusion of the public, and to decrease public exposure to persistently negative information. It is necessary to help people transform their negative experiences into positive changes especially for individuals with physical illness, individuals with mental health disorders, and medical professionals.

Relationship between biological and self-reported measures of stress among informal caregivers of patients with prostate cancer

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 18506-18506
Author(s):  
W. P. Witt ◽  
S. Pickard ◽  
T. Kuzel ◽  
T. McDade ◽  
S. Perry ◽  
...  
Keyword(s):  
Mental Health ◽  
Prostate Cancer ◽  
Cancer Patients ◽  
Epstein Barr Virus ◽  
Informal Caregivers ◽  
C Reactive Protein ◽  
Barr Virus ◽  
Reactive Protein ◽  
Biological Stress ◽  
Epstein Barr

18506 Background: Informal caregivers of prostate cancer patients often experience chronic psychological stress that may adversely impact their physical and mental health, and their ability to care for their families and the patient. This study aims to determine the association between perceived and biological stress among informal caregivers of prostate cancer patients. Methods: A total of 24 informal caregivers of prostate cancer patients were recruited from both the Jesse Brown VA Center (Lakeside and Westside, Chicago) and the Robert H. Lurie Comprehensive Cancer Center at Northwestern University. Caregivers completed self-reported measures of stress, somatization, life events, burden, health status (SF-36) and mental health. Capillary blood spot samples from caregivers were used to examine two measures of biological stress, Epstein-Barr virus antibody titer and C-reactive protein. Results: Informal caregivers had a mean age of 63 years and were mostly female and spouses of patients with prostate cancer. Many had preexisting co-morbidities, including 45.8% with hypertension, 45.8% with arthritis, and 33.3% with diabetes. Nearly 30% had been hospitalized in the last 12 months. 33.3% of caregivers experienced at least one major life event in the last year and 62.5% had symptoms of somatization illness. Caregivers with symptoms of somatization illness had higher mean Epstein-Barr antibody titers as compared with those without symptoms (Mean EBV antibody titer: 198.3 versus 141.8, respectively (p < 0.05)). Caregiver-reported measures were not correlated with C-reactive protein levels. Caregivers with higher levels of strain perceived more stress in their lives (p < 0.05), but showed relatively high self-esteem (mean = 30.6, SD = 2.8, on a 7–35 scale). Conclusions: These preliminary findings suggest that informal caregivers who report symptoms of somatization illness exhibit signs of relative suppression of the cell-mediated immune processes as a result of the reactivation of the Epstein-Barr virus. Final analyses will be conducted that control for potential confounders and will further elucidate if caregiver stress is associated with suppression of the immune system. No significant financial relationships to disclose.

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