scholarly journals Prevalence Estimate of Cerebral Palsy in Northern Alberta: Births, 2008-2010

2017 ◽  
Vol 44 (4) ◽  
pp. 366-374 ◽  
Author(s):  
Charlene M.T. Robertson ◽  
M. Florencia Ricci ◽  
Kathleen O’Grady ◽  
Maryam Oskoui ◽  
Helly Goez ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Gestational Age ◽  
Developed Countries ◽  
Population Based ◽  
Prevalence Estimate ◽  
Administrative Databases ◽  
Live Births ◽  
Prevalence Estimates ◽  
And Function ◽  
Northern Alberta

AbstractObjectives: The objectives of this study were to determine prevalence estimates of cerebral palsy (CP) among 5-year-old children in northern Alberta; to provide congenital, gestational age– and birth weight–specific, and postneonatal CP rates; and to describe motor subtypes and function. Methods: This population-based prevalence estimate study, part of the Canadian Cerebral Palsy Registry, reports confirmed CP diagnoses at age 5 years made by pediatric rehabilitation and child neurology specialists. Prevalence rates with 95% confidence intervals (CIs) used Alberta government denominators of same-age children and live births. Results: The Northern Alberta CP rate (birth years, 2008-2010) for 173 5-year-old children is 2.22 (95% CI 2.12, 2.32) per 1000 5-year-old children. The congenital CP rate is 1.99 (95% CI, 1.89-2.09) per 1000 live births; unilateral congenital CP, 1.0 (95% CI, 0.64-1.36) per 1000 live births; and postneonatal CP, 0.12 (95% CI, 0.1-0.14) per 1000 live births. Gestational age-specific rates are similar: age <28 weeks, 27.2 (95% CI, 23.05-31.35) and 28 to 31 weeks, 29.5 (95% CI, 25.78-33.22). Motor subtypes for 169 children (data missing, 4; male, 97; postnatal, 9) are: spastic, 148 (87.6%) including 31 (20.9%) with diplegia, 10 (6.8%) triplegia, 33 (22.2%) quadriplegia, 74 (50%) hemiplegia/monoplegia); and dyskinetic, 18 (10.6%) and ataxic, 3 (1.8%). A total of 107 (63.3%) ambulate without assistive devices and 111(65.7%) handle most objects with their hands independently. Conclusions: This is the fourth Canadian CP prevalence study; one from Quebec used a similar case ascertainment approach and two 1980s studies from Alberta and British Columbia used administrative databases. Northern Alberta CP rates are comparable with other developed countries. The hemiplegic subtype is the most common. Rates among preterm children have declined but are similar for the <28 and 28 to 31 gestation-week groups.

scholarly journals A Bayesian approach to estimating the population prevalence of mood and anxiety disorders using multiple measures

2021 ◽  
Vol 30 ◽  
Author(s):  
Jordan Edwards ◽  
A. Demetri Pananos ◽  
Amardeep Thind ◽  
Saverio Stranges ◽  
Maria Chiu ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Anxiety Disorders ◽  
Administrative Data ◽  
Population Based ◽  
Accurate Estimate ◽  
Service Planning ◽  
Prevalence Estimate ◽  
Population Prevalence ◽  
Mood And Anxiety Disorders ◽  
Prevalence Estimates

Abstract Aims There is currently no universally accepted measure for population-based surveillance of mood and anxiety disorders. As such, the use of multiple linked measures could provide a more accurate estimate of population prevalence. Our primary objective was to apply Bayesian methods to two commonly employed population measures of mood and anxiety disorders to make inferences regarding the population prevalence and measurement properties of a combined measure. Methods We used data from the 2012 Canadian Community Health Survey – Mental Health linked to health administrative databases in Ontario, Canada. Structured interview diagnoses were obtained from the survey, and health administrative diagnoses were identified using a standardised algorithm. These two prevalence estimates, in addition to data on the concordance between these measures and prior estimates of their psychometric properties, were used to inform our combined estimate. The marginal posterior densities of all parameters were estimated using Hamiltonian Monte Carlo (HMC), a Markov Chain Monte Carlo technique. Summaries of posterior distributions, including the means and 95% equally tailed posterior credible intervals, were used for interpretation of the results. Results The combined prevalence mean was 8.6%, with a credible interval of 6.8–10.6%. This combined estimate sits between Bayesian-derived prevalence estimates from administrative data-derived diagnoses (mean = 7.4%) and the survey-derived diagnoses (mean = 13.9%). The results of our sensitivity analysis suggest that varying the specificity of the survey-derived measure has an appreciable impact on the combined posterior prevalence estimate. Our combined posterior prevalence estimate remained stable when varying other prior information. We detected no problematic HMC behaviour, and our posterior predictive checks suggest that our model can reliably recreate our data. Conclusions Accurate population-based estimates of disease are the cornerstone of health service planning and resource allocation. As a greater number of linked population data sources become available, so too does the opportunity for researchers to fully capitalise on the data. The true population prevalence of mood and anxiety disorders may reside between estimates obtained from survey data and health administrative data. We have demonstrated how the use of Bayesian approaches may provide a more informed and accurate estimate of mood and anxiety disorders in the population. This work provides a blueprint for future population-based estimates of disease using linked health data.

Neurodevelopmental Disabilities in Canadian Children: Prevalence Data from the National Longitudinal Study of Children and Youth

2019 ◽  
Author(s):  
Asuri Narayan Prasad ◽  
Bradley Corbett
Keyword(s):  
Cerebral Palsy ◽  
Census Data ◽  
Population Based ◽  
Children And Youth ◽  
Prevalence Rates ◽  
Cross Sectional ◽  
Neurodevelopmental Disabilities ◽  
Changing Trends ◽  
Prevalence Estimates ◽  
Statistics Canada

Abstract Aim Using population surveys of chronic health conditions, the present study aims to examine changing trends in the prevalence of neurodevelopmental disabilities (NDD) with age and determine population-based estimates of prevalence and census-based estimates of absolute numbers of affected children. Methods We analyzed data from three cycles (1994–1999) of Canada's National Longitudinal Survey of Children and Youth (NLSCY) (Statistics Canada Survey). Results Cross-sectional prevalence rates for chronic NDD in children from birth to 15 years across cycle 1 to 3 of the NLSCY show an increasing trend over the years from 1994 to 1999. Population-based estimates were also calculated from census data. Weighted prevalence rates for four conditions in children aged birth to 15 years increased across the three cycles, except for cerebral palsy. Prevalence estimates in cycle 3 were: epilepsy 5.26/1,000 (95% confidence interval [CI]: 5.01, 5.52), cerebral palsy 2.81/1,000 (95% CI: 2.62, 2.99), intellectual disability 4.77/1,000 (95% CI: 4.53, 5.02), and learning disability 57.06/1,000 (95% CI, 56.36, 57.76). A male gender preponderance was noted for each NDD using logistic regression. Interpretation Prevalence rates of NDD in Canadian children show an incremental trend across three cycles in four conditions covered in the survey. The changing trends over the three cycles are discussed.

Smallness at Birth and Neonatal Death: Reexamining the Current Indicator Using Sibling Data

2019 ◽  
Vol 38 (01) ◽  
pp. 076-081
Author(s):  
Maya Tabet ◽  
Louise H. Flick ◽  
Hong Xian ◽  
Chang Jen Jen
Keyword(s):  
United States ◽  
Gestational Age ◽  
Neonatal Death ◽  
Retrospective Cohort ◽  
Significant Interaction ◽  
Neonatal Period ◽  
The United States ◽  
Population Based ◽  
Live Births ◽  
Second Births

Abstract Objective The similarity in size among siblings has implications for neonatal death, but research in this area is lacking in the United States. We examined the association between small-for-gestational age (SGA), defined as a birthweight <10th percentile for gestational age, and neonatal death, defined as death within the first 28 days of life, among second births who had an elder sibling with SGA (“repeaters”) versus those whose elder sibling did not have SGA (“nonrepeaters”). Study Design We conducted a population-based retrospective cohort study including 179,436 women who had their first two nonanomalous singleton live births in Missouri (1989–2005). Logistic regression was used to evaluate the association between SGA and neonatal death among second births, stratified by whether the elder sibling was SGA. Results Out of 179,436 second births, 297 died in the neonatal period. There was a significant interaction between birthweight-for-gestational age of first and second births in relation to neonatal death (p = 0.001). Second births with SGA had increased odds of neonatal death by 2.15-fold if they were “repeaters,” and 4.44-fold if they were “nonrepeaters,” as compared with non-SGA second births. Conclusion Our findings suggest that referencing sibling birthweight may be warranted when evaluating infant size in relation to neonatal death.

Systemic Sclerosis and Associated Interstitial Lung Disease in Ontario, Canada: An Examination of Prevalence and Survival Over 10 Years

2021 ◽  
pp. jrheum.201049
Author(s):  
Janet E. Pope ◽  
Kobina Quansah ◽  
Shazia Hassan ◽  
Soo Jin Seung ◽  
Jason Flavin ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Survival Rates ◽  
Population Based ◽  
Pulmonary Complications ◽  
Administrative Databases ◽  
Fiscal Year ◽  
Discharge Abstract Database ◽  
Kaplan Meier ◽  
Prevalence Estimates ◽  
Icd 10

Objective Systemic sclerosis (SSc) is a rare autoimmune disease. Pulmonary complications of SSc are one of the leading causes of morbidity and mortality. The objective of this study was to determine prevalence and survival estimates of SSc and SSc-ILD in a Canadian province (Ontario) using administrative data over 10 years. Methods Using ICD-10-CA codes, adult patients diagnosed with SSc and SSc-ILD between April 1, 2008 and March 31, 2018 were identified from the National Ambulatory Care Reporting System (NACRS) and Discharge Abstract Database (DAD) administrative databases. SSc was identified first and ILD if present occurred after the SSc diagnosis. Prevalence estimates were determined for both SSc and SSc-ILD. For survival, Kaplan Meier survival curves were generated. Results At the start of fiscal year 2017/18 (final year of the cohort), there were 2,114 prevalent SSc cases for a cumulative prevalence of 19.1 per 100,000 persons and 257 prevalent cases of SSc-ILD, generating a prevalence of 2.32 cases per 100,000 persons. Mean age was 57 and 58 years with 84% and 80% females for SSc and SSc- ILD patients, respectively. One, 5 and 10 year survival rates respectively for the SSc group were 85.0%, 64.5% and 44.9%, and 77.1%, 44.4% and 22.0% for the SSc-ILD. Conclusion This study provides the first population-based estimates of SSc and SSc- ILD in Canada for prevalence and survival. Results confirm that the prevalence estimates of SSc-ILD falls within the Canadian threshold of rare disease. It also demonstrates the poor survival in SSc especially when ILD is also present.

The Origin of the Cerebral Palsies: Contribution of Population-Based Neuroimaging Data

2020 ◽  
Vol 51 (02) ◽  
pp. 113-119 ◽  
Author(s):  
Veronka Horber ◽  
Elodie Sellier ◽  
Karen Horridge ◽  
Gija Rackauskaite ◽  
Guro L. Andersen ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
White Matter ◽  
Gestational Age ◽  
Large Population ◽  
Population Based ◽  
White Matter Injury ◽  
Brain Pathology ◽  
Resonance Imaging ◽  
Neuroimaging Data ◽  
Imaging Classification

Abstract Background Surveillance of cerebral palsy in Europe (SCPE) presents the first population-based results on neuroimaging findings in children with cerebral palsy (CP) using a magnetic resonance imaging classification system (MRICS). Method MRIs of children with CP born between 1999 and 2009 from 18 European countries were analyzed. MRICS identifies patterns of brain pathology according to timing during brain development which was analyzed with respect to CP subtypes and gestational age. Results MRIs or written reports from 3,818 children were available. The main clinical characteristics were similar to the 5,415 without such data. Most frequent was predominant white matter injury (49%), followed by predominant gray matter injury (21%). Maldevelopments were found in 11% of cases. Miscellaneous findings were present in 8.5% and normal findings in 10.6%. MRI patterns of children with unilateral spastic, bilateral spastic, and dyskinetic CP were mainly lesional (77, 71, and 59%, respectively), whereas children with ataxic CP had more maldevelopments, miscellaneous, and normal findings (25, 21, and 32%, respectively). In children born preterm, predominant white matter injury was most prevalent (80% in children born <32 weeks of gestation). Conclusion Analysis of MRI in the European CP database identified CP as a mainly lesional condition on a large population basis, maldevelopments were relatively uncommon. An exception was ataxic CP. Children born preterm mostly presented with a lesion typical for their gestational age (GA) at birth. The decreasing prevalence of CP in this group suggests that progress in perinatal and neonatal medicine may lead to a reduction of these lesions.

scholarly journals Trends in Prevalence and Severity of Pre/Perinatal Cerebral Palsy Among Children Born Preterm From 2004 to 2010: A SCPE Collaboration Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Catherine Arnaud ◽  
Virginie Ehlinger ◽  
Malika Delobel-Ayoub ◽  
Dana Klapouszczak ◽  
Oliver Perra ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Incidence Rate ◽  
Gestational Age ◽  
Rate Ratio ◽  
Negative Binomial ◽  
Incidence Rate Ratio ◽  
Age Groups ◽  
Negative Binomial Regression ◽  
Population Based ◽  
Preterm Born

Aim: To report on prevalence of cerebral palsy (CP), severity rates, and types of brain lesions in children born preterm 2004 to 2010 by gestational age groups.Methods: Data from 12 population-based registries of the Surveillance of Cerebral Palsy in Europe network were used. Children with CP were eligible if they were born preterm (&lt;37 weeks of gestational age) between 2004 and 2010, and were at least 4 years at time of registration. Severity was assessed using the impairment index. The findings of postnatal brain imaging were classified according to the predominant pathogenic pattern. Prevalences were estimated per 1,000 live births with exact 95% confidence intervals within each stratum of gestational age: ≤27, 28–31, 32–36 weeks. Time trends of both overall prevalence and prevalence of severe CP were investigated using multilevel negative binomial regression models.Results: The sample comprised 2,273 children. 25.8% were born from multiple pregnancies. About 2-thirds had a bilateral spastic CP. 43.5% of children born ≤27 weeks had a high impairment index compared to 37.0 and 38.5% in the two other groups. Overall prevalence significantly decreased (incidence rate ratio per year: 0.96 [0.92–1.00[) in children born 32–36 weeks. We showed a decrease until 2009 for children born 28–31 weeks but an increase in 2010 again, and a steady prevalence (incidence rate ratio per year = 0.97 [0.92–1.02] for those born ≤27 weeks. The prevalence of the most severely affected children with CP revealed a similar but not significant trend to the overall prevalence in the corresponding GA groups. Predominant white matter injuries were more frequent in children born &lt;32 weeks: 81.5% (≤27 weeks) and 86.4% (28–31 weeks), compared to 63.6% for children born 32–36 weeks.Conclusion: Prevalence of CP in preterm born children continues to decrease in Europe excepting the extremely immature children, with the most severely affected children showing a similar trend.

scholarly journals The Prevalence of Cerebral Palsy in British Columbia, 1991-1995

2008 ◽  
Vol 35 (3) ◽  
pp. 342-347 ◽  
Author(s):  
Les Smith ◽  
Karen D. Kelly ◽  
Glenda Prkachin ◽  
Donald C. Voaklander
Keyword(s):  
British Columbia ◽  
Cerebral Palsy ◽  
Birth Cohort ◽  
International Classification Of Diseases ◽  
Population Based ◽  
Linkage Study ◽  
Diagnostic Code ◽  
Live Births ◽  
Classification Of Diseases

Objective:To quantify the prevalence of cerebral palsy (CP) in British Columbia within a four-year birth cohort.Methods:The study was a population-based record linkage study of a birth cohort of British Columbian children born between April 1, 1991 and March 31, 1995. Cases were identified by the presence of International Classification of Diseases, Version 9 (ICD-9) diagnostic code “343” recorded at three years of age or older or by having the ICD-9 diagnostic code “343” recorded prior to the third birthday with two confirmatory diagnoses within the first three years of life through a record search of the BC Medical Services Plan billing files for the fiscal years 1991 to 1995.Results/Conclusion:This research has provided an estimate of the prevalence of CP in the four-year birth cohort 1991 to 1995 in British Columbia. An aggregate prevalence rate of CP was measured as 2.68 per 1000 live births, and a congenital rate was measured at 2.57 for the same population. Birth weight and gestational age demonstrated a significant relationship with the development of CP. This study should lend credence to the establishment of a CP register in British Columbia.

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