2174 Building the next generation of translational researchers in health disparities

OBJECTIVES/SPECIFIC AIMS: Translational research involves researchers’ teams working together to address health issues. However, successful translational researchers in health disparities require a set of competencies and skills. In order to increase the number of new minority investigators in translational research focused on health disparities, the Hispanics-in-Research Capability: SoHP & SoM Partnership and the Puerto Rico Clinical and Translational Research Consortium designed and implemented a webinar series “Fostering the Next Generation of Researchers in Health Disparities.” METHODS/STUDY POPULATION: From March 31 to July 14, 2017, this webinar series offered the theoretical perspectives of health disparities, research methodology specific to its study, and intervention strategies to address health disparities in communities through minority investigators. National and local interdisciplinary experts were the presenters. Participants’ experience and impact were assessed through a self-administrated questionnaire. RESULTS/ANTICIPATED RESULTS: A total of 78 minority investigators participated in this webinar. Overall, participants indicated that the webinar improved their knowledge and skills about health disparities research. DISCUSSION/SIGNIFICANCE OF IMPACT: Results guide the programs actions plans to enhance and support the translational researchers’ capacity. Diverse capacity building initiatives including peer-to-peer education, online course, tailored coaching, and other interventions have been designed to address researchers’ needs. This webinar was a pathway to build the next generation of translational researchers in health disparities.

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2292 Evaluating the impact of a K-award on clinical and translational research

Journal of Clinical and Translational Science ◽

10.1017/cts.2018.207 ◽

2018 ◽

Vol 2 (S1) ◽

pp. 55-55

Author(s):

Elias M. Samuels ◽

Thomas E. Perorazio ◽

Ellen Champagne ◽

Brenda Eakin

Keyword(s):

Translational Research ◽

Research Training ◽

Research Support ◽

Research Experiences ◽

Research Careers ◽

Study Population ◽

The Impact ◽

Over Time ◽

Clinical And Translational Research ◽

Research Service

OBJECTIVES/SPECIFIC AIMS: Identify the impact of the provision of clinical and translational research training awards on investigators’ pursuit of clinical and translational research careers. METHODS/STUDY POPULATION: Propensity score matching and qualitative analysis/investigators receiving MICHR’s KL2 research training awards. RESULTS/ANTICIPATED RESULTS: While the evaluations of the impact of this service have shown participants find them to be valuable it is expected that participation in the workshop may be more beneficial to investigators with certain types of prior research experiences and who utilize more CTSA research support. DISCUSSION/SIGNIFICANCE OF IMPACT: Because this evaluation of a research service incorporate data representing investigator’s receipt of different CTSA resources, the findings can be used to inform the ongoing coordination of these services in ways that optimize their impact on the production of clinical and translational research. There is an enduring need for evaluations of CTSA programs to account for investigators’ use of different constellations of research services in order to identify what combinations of services over time are most effective at fostering successful clinical and translational research careers.

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Next-generation RNA sequencing versus RNA microarray gene expression profiling for personalized medicine approaches in oncology: Lessons from relapsed and refractory neuroblastoma patients from the Neuroblastoma Medulloblastoma Translational Research Consortium (NMTRC).

Journal of Clinical Oncology ◽

10.1200/jco.2014.32.15_suppl.e22083 ◽

2014 ◽

Vol 32 (15_suppl) ◽

pp. e22083-e22083

Author(s):

Christina Kay Lettieri

Keyword(s):

Gene Expression ◽

Personalized Medicine ◽

Translational Research ◽

Gene Expression Profiling ◽

Rna Sequencing ◽

Expression Profiling ◽

Next Generation ◽

Microarray Gene Expression ◽

Microarray Gene ◽

Research Consortium

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3406 Understanding the Barriers, Challenges, and Facilitators to Community-Engaged Research: A Review of a CTSA Community Engagement Pilot Program

Journal of Clinical and Translational Science ◽

10.1017/cts.2019.226 ◽

2019 ◽

Vol 3 (s1) ◽

pp. 99-100

Author(s):

Ashley Dunn ◽

Kendra L. Smith ◽

Rhonda McClinton-Brown ◽

Jill W. Evans ◽

Lisa Goldman-Rosas ◽

...

Keyword(s):

Health Disparities ◽

Focus Group ◽

Community Engagement ◽

Translational Research ◽

Pilot Project ◽

Pilot Program ◽

Stanford University ◽

Community Engaged Research ◽

Academic Partnerships ◽

Clinical And Translational Research

OBJECTIVES/SPECIFIC AIMS: Engaging patients and consumers in research is a complex process where innovative strategies are needed to effectively translate scientific discoveries into improvements in the public’s health (Wilkins et. al., 2013; Terry et. al., 2013). The Clinical Translational Science Awards (CTSA)—supported by the National Institute of Health (NIH) under the auspices of the National Center for Advancing Translational Sciences (NCATS)—aim to provide resources and support needed to strengthen our nation’s clinical and translational research (CTR) enterprise. In 2008, Stanford University was awarded a CTSA from the NIH, establishing Spectrum (Stanford Center for Clinical and Translational Research and Education) and its Community Engagement (CE) Program aimed at building long-standing community-academic research partnerships for translational research in the local area surrounding Stanford University. To date, the CE Pilot Program has funded 38 pilot projects from the 2009-2017 calendar year. The purpose of this study was to understand, through a unique pilot program, the barriers, challenges, and facilitators to community-engaged research targeting health disparities as well as community-academic partnerships. METHODS/STUDY POPULATION: Investigators conducted a qualitative study of the community engagement pilot program. Previous pilot awardees were recruited via email and phone to participate in a one-hour focus group to discuss their pilot project experience—describing any barriers, challenges, and facilitators to implementing their pilot project. RESULTS/ANTICIPATED RESULTS: The focus group revealed that community engage research through the pilot program was not only appreciated by faculty, but projects were successful, and partnerships developed were sustained after funding. Specifically, the pilot program has seen success in both traditional and capacity building metrics: the initial investment of $652,250.00 to fund 38 projects has led to over $11 million dollars in additional grant funding. In addition, pilot funding has led to peer-reviewed publications, data resources for theses and dissertations, local and national presentations/news articles, programmatic innovation, and community-level impact. Challenges and barriers were mainly related to timing, grant constraints, and university administrative processes. DISCUSSION/SIGNIFICANCE OF IMPACT: The Community Engagement Pilot Program demonstrates an innovative collaborative approach to support community-academic partnerships. This assessment highlights the value and importance of pilot program to increase community engaged research targeting health disparities. Challenges are mainly administrative in nature: pilot awardees mentioned difficulties working on university quarterly timelines, challenges of subcontracting or sharing money with community partners, onerous NIH prior approval process, and limitations to carryover funding. However, pilot grants administered through the program strengthen the capacity to develop larger scale community-based research initiatives.

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2332

Journal of Clinical and Translational Science ◽

10.1017/cts.2017.261 ◽

2017 ◽

Vol 1 (S1) ◽

pp. 74-74 ◽

Cited By ~ 1

Author(s):

Dennis P. Scanlon ◽

Laura J. Wolf ◽

Cynthia Chuang ◽

Jen Kraschnewski ◽

Eugene Lengerich ◽

...

Keyword(s):

Conceptual Framework ◽

Community Engagement ◽

Translational Research ◽

Research Committee ◽

Literature Synthesis ◽

Individual Project ◽

Study Population ◽

Effective Community ◽

Major Factors ◽

Clinical And Translational Research

OBJECTIVES/SPECIFIC AIMS: Community engagement is a commonly used term, but is complex in both meaning and application. In order to help academic institutions and administrators develop infrastructure to promote and support community engagement and to help investigators work productively with communities, this analysis discusses the major components of community engagement in research on both the institutional and individual project levels as well as the interplay between them. METHODS/STUDY POPULATION: A literature synthesis conducted by a community engagement in research committee at 1 CTSA institution that examined the myriad factors related to effective community engagement in research identified across multiple disciplines was used to distill the major factors identified, assesses the interplay of the identified factors, and produce a conceptual model to help administrators and investigators apply best practices in engaging communities in clinical and translational research. RESULTS/ANTICIPATED RESULTS: This work takes a concept—community engagement in research—that is often stated and discussed, but is highly complex and challenging to implement—and identifies and discusses the multiple, interrelated factors germane to it. The model illustrates that while community engagement in research is implemented in the context of individual projects, a deep and continual interplay between individual projects and the goals, capacity, and policies of research institutions is needed for rigorous, ethical, and effective community engagement. DISCUSSION/SIGNIFICANCE OF IMPACT: Results are presented through a conceptual framework which displays the major components needed for rigorous, ethical, and effective community engagement in clinical and translational research. In addition, the conceptual framework presented will provide assistance to those developing approaches to measure and evaluate institutional readiness for community engagement in research as well as the effectiveness of individual community engagement efforts.

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2496

Journal of Clinical and Translational Science ◽

10.1017/cts.2017.285 ◽

2017 ◽

Vol 1 (S1) ◽

pp. 81-81 ◽

Cited By ~ 1

Author(s):

Meryl Sufian ◽

Derrick Tabor ◽

Phuong-Tu Le

Keyword(s):

Health Care ◽

Health Disparities ◽

Translational Research ◽

Health Disparity ◽

Minority Health ◽

Underserved Populations ◽

Burden Of Illness ◽

Adherence To Medication ◽

Wide Range ◽

Clinical And Translational Research

OBJECTIVES/SPECIFIC AIMS: (1) To explain and discuss minority health and health disparities and the mechanisms, for example, individual behaviors and lifestyle, genetics and epigenetics, physical and cultural environment, and clinical events and health care, that lead to health disparities. (2) To explore the intersection between health disparity science and clinical and translational science. (3) To present and discuss the NIMHD Framework and how it can be used to guide multilevel research to address minority health and health disparities. (4) To highlight examples of NIMHD-funded novel and innovative research relevant to clinical and translational research from a health disparities perspective. METHODS/STUDY POPULATION: The NIMHD Research Framework will be introduced that is currently being used by NIMHD to address minority health and health disparity research. The Framework looks at targeted populations in relation to biological, behavioral, physical, and sociocultural environmental domains of influence as well as the health care system. These domains have different levels of influence: individual, family/interpersonal, community, and population. Targeted populations include NIH-designated health disparity populations, that include racial/ethnic minorities, socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minorities. The following research opportunities are among the many opportunities offered by NIMHD: Disparities in Surgical Care and Outcomes Social Epigenomics for Minority Health and Health Disparities Addressing Health Disparities Among Immigrant Populations. RESULTS/ANTICIPATED RESULTS: Select examples of NIMHD supported minority health and health disparities research that intersects with clinical and translational research will be presented. Candidate examples include: Genetic Architecture of Lupus (SLE) in individuals with Asian ancestry; A Novel Racial Disparity Marker for Risk Prediction in Triple Negative Breast Cancer Patients; Self-Applied Wearable Ultrasound Therapy for Osteoarthritis Management in Rural Central NY; Design and Development of a Multifunctional Self-service Health Screening Kiosk. DISCUSSION/SIGNIFICANCE OF IMPACT: Despite notable improvements gained as a result of medical and scientific advances, there continues to be an alarming disproportionate burden of illness and lack of representation in research among minority and other socially disadvantaged and underserved populations. To meet this challenge, NIMHD is committed to supporting a wide range of clinical and translational research aimed at the development of innovative strategies and approaches to reduce and, eventually, eliminate health disparities. NIMHD’s mission, research priorities, and funding opportunities are relevant to the efforts and interests of clinical and translational scientists, especially those interested in the translation of research findings into interventions, products, and tools that may improve minority health and quality of life, increase adherence to medication and treatment regimens, increase access, and improve the delivery of health services.

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Scientometric analysis of the Puerto Rico Clinical and Translational Research Consortium (PRCTRC) research publications, 2010–2018

Journal of Clinical and Translational Science ◽

10.1017/cts.2020.43 ◽

2020 ◽

pp. 1-7

Author(s):

Mariela Torres-Cintrón ◽

Carlamarie Noboa-Ramos ◽

Zulmarie De Pedro-Serbia ◽

Mariela Lugo-Picó ◽

Lorena González-Sepúlveda ◽

...

Keyword(s):

Puerto Rico ◽

Translational Research ◽

Scientific Production ◽

Scientometric Analysis ◽

Annual Percent Change ◽

H Index ◽

Average Citation ◽

Research Consortium ◽

The Impact ◽

Clinical And Translational Research

Abstract We analyzed the publication productivity supported by the Puerto Rico Consortium for Clinical and Translational Research (PRCTRC) using the structured process of scientometrics. The objective of this study was to evaluate the impact of the research and collaborations as presented in publications. Manuscripts published from 2010 to 2018 and that had the PRCTRC award number and a PMCID number were retrieved from the Science Citation Index database. Scientometric indicators included h-index (HI), average citation (AC), collaboration coefficient (CC), collaboration index (CI), and degree of collaboration (DC) analysis, and relative citation ratio (RCR) was done with Web of Science Platform, iCite, and Stata software. Joinpoint Trend Analysis Software was used to calculate the annual percent change (APC). From 2010 to 2018, 341 publications were identified with an average of 38 publications per year and a total of 3569 citations excluding self-citations. A significant growth (APC: 17.76%, P < 0.05) of scientific production was observed. The overall HI was 31, and the AC per item was 11.04. The overall CC was 0.82, the CI was 8.59, and the DC was 99.1%. This study demonstrates a statistically significant increase in the PRCTRC scientific production. Results allow for the assessment of the progress resulting from the provided support and to plan further strategies accordingly.

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3072 Scientometric Analysis of the Puerto Rico Clinical and Translational Research Consortium (PRCTRC) Research Publications, 2010-2017

Journal of Clinical and Translational Science ◽

10.1017/cts.2019.303 ◽

2019 ◽

Vol 3 (s1) ◽

pp. 133-133

Author(s):

Mariela Torres- Cintrón ◽

Carlamarie Noboa ◽

Mariela Lugo-Pico ◽

Lorena Gonzalez-Sepulveda ◽

Naydi Perez ◽

...

Keyword(s):

Scientific Production ◽

Scientometric Analysis ◽

Annual Percent Change ◽

H Index ◽

Scientometric Indicators ◽

Study Population ◽

Research Consortium ◽

The Impact ◽

Clinical And Translational Research ◽

Scientific Collaborations

OBJECTIVES/SPECIFIC AIMS: The objective of this study was to evaluate the impact of the research and the scientific collaborations as shown in research publication supported by the PRCTRC. METHODS/STUDY POPULATION: Manuscripts published from 2010 to 2017 were retrieved from the Science Citation Index database. Our search criteria included manuscripts: 1) with the PRCTRC grant number and 2) with a PMCID number. Scientometric indicators including h-index (HI), average citation (AC), collaboration coefficient (CC), collaboration index (CI) and degree of collaboration (DC) were calculated using the Web of Science Platform and Stata software for statistical inquiry. Joinpoint was used to calculate the annual percent change (APC). RESULTS/ANTICIPATED RESULTS: A total of 316 publications were identified from 2010-2017, with an average of 39.5 publications per year, and a total of 2,383 citing articles without self-citations. During this period a significant growth (APC = ¬15.3%, p < 0.05) of scientific production was observed. The overall HI was 28, and the AC per item was 9.31. Regarding collaboration, the overall CC was 0.82, the CI was 6.93, and the DC was 99.3. DISCUSSION/SIGNIFICANCE OF IMPACT: This study demonstrated that the PRCTRC scientific production increased statistically significantly. Application of the scientometric indicators allows the PRCTRC assess the research productivity and collaboration to design and implement interventions according to program experience and needs.

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