A Program to Drive Innovation and Entrepreneurship in Academic Cardiovascular Center Incorporating Clinical Team and Patient Co-Design

What explains the rapid and sustained economic rise of Asian countries in high-technology industries, including biomedicals? The biomedical industry, comprised mainly of biopharmaceuticals and medical devices, is among the fastest growing globally and has been an economic-development target of national governments around the world. The book presents a conceptual framework to assess national government management of innovation and entrepreneurship in the fast-growing biomedical industry in Asia, which at current growth rates is on track to become the center of the world economy. Four Asian countries—China, India, Japan, and Singapore—are compared in terms of innovation capacities, government policy, and firm-level strategies underlying competitive advantages in high technology. The book argues that countries that pursue networked technonationalism have been effective in upgrading innovation capacity and also encouraging entrepreneurial activity in targeted industries. The study begins with a global-level analysis of biomedical innovation and entrepreneurship, identifying emerging concentrations of scientific citation, patenting, and firm creation—paying close attention to trends in Asian economies and future prospects. Findings indicate a gradual shift to Asian economies of many biomedical-innovation and new-business-creation activities. The book concludes with implications for innovation policy and entrepreneurship strategy in Asia and elsewhere.

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Conclusions

10.1093/oso/9780198827948.003.0013 ◽

2018 ◽

Author(s):

Stephany Griffith-Jones ◽

José Antonio Ocampo ◽

Paola Arias

Keyword(s):

Developing Countries ◽

Renewable Energy ◽

Exchange Rates ◽

Interest Rates ◽

Development Strategy ◽

National Development ◽

Financial Inclusion ◽

Production Sector ◽

New Instruments ◽

Innovation And Entrepreneurship

Based on the seven case studies analysed in this volume, this chapter concludes that national development banks (NDBs) have been successful in many cases in supporting innovation and entrepreneurship, key new sectors like renewable energy, and financial inclusion. They have developed new instruments, such as far greater use of guarantees, equity (including venture capital) and debt funds, and new instruments for financial inclusion. The context in which they operate is key to their success. Active countercyclical policies, low inflation, fairly low real interest rates, a well-functioning financial sector, and competitive exchange rates are crucial. They are also more effective if the country has a clear development strategy, linked to production sector strategies that foster innovative sectors. Under these conditions, the chapter argues that there is great need for a larger scale of NDB activity in Latin America and in developing countries in general.

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Research on the Cultivation Strategy of College Students’ Innovation and Entrepreneurship Based on Big Data Analysis from the Perspective of Economic Transformation

Journal of Physics Conference Series ◽

10.1088/1742-6596/1915/3/032083 ◽

2021 ◽

Vol 1915 (3) ◽

pp. 032083

Author(s):

Qiong Hu

Keyword(s):

College Students ◽

Big Data ◽

Data Analysis ◽

Big Data Analysis ◽

Economic Transformation ◽

Cultivation Strategy ◽

Innovation And Entrepreneurship

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Critical limb ischemia patients clinically improving with medical treatment have lower neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios

Vascular ◽

10.1177/1708538120986294 ◽

2021 ◽

pp. 170853812098629

Author(s):

Sevinç B Erdoğan ◽

Ümmühan N Selçuk ◽

Murat Baştopçu ◽

Gökhan Arslanhan ◽

Arif Y Çakmak ◽

...

Keyword(s):

Risk Factors ◽

Medical Treatment ◽

Critical Limb Ischemia ◽

Limb Ischemia ◽

Response To Treatment ◽

Standard Regimen ◽

Markers Of Inflammation ◽

Endovascular Revascularization ◽

Cardiovascular Center ◽

Associated Risk Factors

Objectives Inflammation is a component in the pathogenesis of critical limb ischemia. We aimed to assess how inflammation affects response to treatment in patients treated for critical limb ischemia using neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocytes ratios (PLR) as markers of inflammation. Methods Patients in a single tertiary cardiovascular center with critical limb ischemia unsuitable for surgical or interventional revascularization were retrospectively identified. Data were collected on medical history for risk factors, previous surgical or endovascular revascularization, and outcome. A standard regimen of low molecular weight heparin, aspirin, statins, iloprost infusions, and a standard pain medication protocol were applied to each patient per hospital protocol. Patients with improvement in ischemic pain and healed ulcers made up the responders group and cases with no worsening pain or ulcer size or progression to minor or major amputations made up the non-responders group. Responders and Non-responders were compared for risk factors including pretreatment NLR and PLR. Results 268 included patients who were not candidates for surgical or endovascular revascularization were identified. Responders had significantly lower pretreatment NLR (4.48 vs 8.47, p < 0.001) and PLR (162.19 vs 225.43, p = 0.001) values. After controlling for associated risk factors NLR ≥ 4.63 (p < 0.001) and PLR ≥ 151.24 (p = 0.016) were independently associated with no response to treatment. Conclusions Neutrophil-to-lymphocyte ratio and platelet-to-lymphocytes ratio are markers of inflammation that are reduced in patients improving with medical treatment suggesting a decreased state of inflammation before treatment in responding patients.

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