scholarly journals Key Recommendations from the 2021 “Inclusion of Older Adults in Clinical Research” Workshop

2022 ◽  
pp. 1-14
Author(s):  
Darina V. Petrovsky ◽  
Lan N. Ðoàn ◽  
Maria Loizos ◽  
Rachel O’Conor ◽  
Micah Prochaska ◽  
...  
Keyword(s):  
Older Adults ◽  
Clinical Research ◽  
Research Workshop

Inclusion of older adults in emergency department clinical research: Strategies to achieve a critical goal

2021 ◽  
Author(s):  
Katherine M. Hunold ◽  
Elizabeth M. Goldberg ◽  
Jeffrey M. Caterino ◽  
Ula Hwang ◽  
Timothy F. Platts‐Mills ◽  
...  
Keyword(s):  
Older Adults ◽  
Emergency Department ◽  
Clinical Research ◽  
Research Strategies

scholarly journals Willingness to Participate in Vaccine-Related Clinical Trials among Older Adults

2018 ◽  
Vol 15 (8) ◽  
pp. 1743 ◽  
Author(s):  
Divyanshu Raheja ◽  
Evelyn Davila ◽  
Eric Johnson ◽  
Rijalda Deović ◽  
Michele Paine ◽  
...  
Keyword(s):  
Older Adults ◽  
Clinical Trials ◽  
Clinical Research ◽  
Elderly Person ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Willingness To Participate ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Research Findings

The purpose of this study is to understand among a convenience sample of 400 adults aged 60 years of age or older (1) reasons for being willing or unwilling to participate in a vaccine clinical research study and (2) overall perceptions about vaccine clinical research. A cross-sectional study using a sample of older adults residing in the metro-Atlanta area and surrounding neighborhoods was conducted. The study questionnaire contained 37 questions, including questions about socio-demographics and perceptions about clinical trial processes. Statistical analysis was conducted using logistic regression. The adjusted modeling results indicated that sex, distance to research clinic, and being informed about the research findings played a role in the likelihood of an elderly person participating in a vaccine study. Males were more likely to participate in clinical trials as compared to females (OR: 2.486; CI: 1.042–5.934). Most participants were willing to travel up to 25 miles from the research clinic. Of the respondents, 45% were unlikely to participate if the results of the current trial are not shared. Improving access to clinical trials in terms of distance traveled and ensuring streamlined processes to inform participants about the results of the trial in the future would increase willingness to participate in vaccine clinical trials. The survey could serve as a useful tool for conducting vaccine studies and other clinical trials by understanding the barriers specific to the elderly.

scholarly journals Leucine Supplementation Partially Protects Leg Lean Mass in Older Adults During Seven Days of Bed Rest (OR18-02-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Emily Arentson-Lantz ◽  
Fego Galvan ◽  
Rachel Deer ◽  
Adam Wacher ◽  
Doug Paddon-Jones
Keyword(s):  
Older Adults ◽  
Clinical Research ◽  
Muscle Fiber ◽  
Lean Mass ◽  
Fiber Type ◽  
Bed Rest ◽  
Research Center ◽  
Leucine Supplementation ◽  
Clinical Research Center ◽  
Increased Risk

Abstract Objectives Older adults are at increased risk of being hospitalized or bedridden and experiencing a host of negative health outcomes including loss of lean body mass. We hypothesized that supplementing daily meals with a small quantity (3–4 g/meal) of leucine will partially preserve lean leg mass and function during bed rest. Methods Men and women (67.8 ± 1.1 y) were randomized to receive isoenergentic meals supplemented with leucine (LEU, 0.06 g/kg/meal; n = 10) or an alanine control, (CON, 0.06 g/kg/meal; n = 10). Subjects were admitted to the Clinical Research Center for 7 days of bed rest followed by 7 days of rehabilitation. Muscle fiber type and cross-sectional area (CSA) as well as single fiber characteristics were assessed from biopsies of the vastus lateralis obtained prior to (Pre-BR) and after bed rest (Post-BR) and after rehabilitation (Post-RE). Body composition measured using iDEXA was also determined at the same time points. Results Leucine-supplementation partially protected leg lean mass during bed rest (−1035 vs. −423 ± 143 g; P = 0.008). Leg lean mass did not differ between the groups Post-RE (P = 0.16). There was no significant effect of time (P = 0.16) or treatment (P = 0.92) on muscle fiber CSA; however, CON subjects, but not LEU subjects, exhibited an increased number of smaller fibers (<2000 um) and fewer larger fibers (>6000 um) Post-BR. Additionally, CON subjects tended to have a greater decrement in fiber width (P = 0.085) that did not return to baseline following rehabilitation. Conclusions Supplementing older adults with moderate amounts of leucine has the potential to partially negate some of the deleterious effects on muscle health during short bouts of inactivity. Funding Sources National Institutes of Health, The Claude D. Pepper Older Americans Independence Center, Sealy Center on Aging and Institute for Translational Sciences-Clinical Research Center.

Vivre sans ma voiture : une intervention pour soutenir les Canadiens-francophones âgés

2020 ◽  
Vol 39 (4) ◽  
pp. 614-625
Author(s):  
Caroline Pigeon ◽  
Evelyne Blais ◽  
Roxanne Grondin ◽  
Esther Bolduc-Rouleau ◽  
Laura Fontaine-Pagé ◽  
...  
Keyword(s):  
Older Adults ◽  
Clinical Research ◽  
Cognitive Impairments ◽  
The Elderly ◽  
Social Involvement ◽  
French Canadian ◽  
Canadian Context ◽  
Near Future ◽  
Difficult Transition ◽  
Positive Impacts

AbstractThe cessation of driving is a difficult transition for the elderly, but it can be facilitated through interventions. The purpose of this study was to explore the satisfaction, usefulness and applicability of the CarFreeMe intervention in the French-Canadian context. A qualitative clinical research device was used on ten older adults aged between 61 and 90 years. The participants had stopped driving within the last twelve months or were planning to stop driving in the near future and did not have cognitive impairments. After the intervention, the participants were generally satisfied and reported on its usefulness and applicability in a French-Canadian context. In addition, they identified the positive impacts related to their social involvement as they re-engaged in or pursued their significant activities. Further research is required to assess the intervention’s effects and the practicability of implementing it in Canada.

Pancreatic Adenocarcinoma in the Older Adult

2010 ◽  
Vol 06 ◽  
pp. 53
Author(s):  
Arlene A Gayle ◽  
Noelle K LoConte ◽  
◽  
Keyword(s):  
Older Adults ◽  
Clinical Research ◽  
Effective Treatment ◽  
Pancreatic Adenocarcinoma ◽  
Older Adult ◽  
Treatment Options ◽  
Medical Conditions ◽  
Future Directions ◽  
Large Numbers

Pancreatic adenocarcinoma is common among older adults, who may be more frail or have comorbid medical conditions that make treatment more challenging. Pancreatic adenocarcinoma is a lethal malignancy with relatively few effective treatment options. To date, most clinical research has not enrolled large numbers of older adults, despite this being the demographic predominantly affected by this illness. In this article, etiology and treatments for pancreatic adenocarcinoma are reviewed with a particular emphasis on studies that have examined matters relating to treating older adults; future directions for research are also explored.

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