scholarly journals The Sri Lankan twin registry biobank: South Asia's first twin biobank

2020 ◽  
Vol 5 ◽  
Author(s):  
Kaushalya Jayaweera ◽  
Lakshan Warnakula ◽  
Lasith Dissanayake ◽  
Anushka Adikari ◽  
Sisira Siribaddana ◽  
...  
Keyword(s):  
Linked Data ◽  
Venous Blood ◽  
Future Research ◽  
Sri Lankan ◽  
Serum Samples ◽  
Follow Up Study ◽  
Genetics Research ◽  
Twin Registry ◽  
Clinical Investigations

Abstract Introduction Biobanks are a valuable resource for creating advancements in science through cutting-edge omics research. Twin research methods allow us to understand the degree to which genetics and environmental factors contribute to health outcomes. Methods The Sri Lankan Twin Registry biobank (SLTR-b) was established in 2015 as part of Colombo Twin and Singleton Follow-up Study. Venous blood and urine were collected from twins and comparative sample of singletons for clinical investigations and biobanking. Results The SLTR-b currently houses 3369 DNA and serum samples. Biobank specimens are linked to longitudinal questionnaire data, clinical investigations, anthropometric measurements, and other data. Discussion The SLTR-b aims to address gaps in health and genetics research. It will provide opportunities for academic collaborations, local and international, and capacity building of future research leaders in twin and omics research. This paper provides a cohort profile of the SLTR-b and its linked data, and an overview of the strategies used for biobanking.

scholarly journals A novel protein biochip screening serum anti-sperm antibody expression and natural pregnancy rate in a follow-up study in Chinese infertility

2020 ◽  
Vol 40 (2) ◽  
Author(s):  
Feihong Xu ◽  
Lei Ye ◽  
Yuan Hu ◽  
Chengyun Cai ◽  
Zhen Wang ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Serum Samples ◽  
Self Assembled Monolayer ◽  
Autoimmune Reaction ◽  
Protein Assay ◽  
Follow Up Study ◽  
Healthy Donors ◽  
Positive Rate ◽  
Reproductive Processes

Abstract Production of anti-sperm antibody (ASA) often suffers from autoimmune reaction against sperms in human infertility. The antibodies are measured in both blood and seminal plasma of males. Here, we reported a simple protein biochip methodology that takes advantage of a functionalized self-assembled monolayer modified by N-hydroxysuccinimide (NHS) and enables identification of anti-sperm antibody in Chinese male infertility. To validate this biochip platform, we immobilized purified sperm protein on the biochip surface and tested a variety of parameters in quality controls for the protein assay, respectively. Then, we analyzed serum samples from 368 patients with infertility and 116 healthy donors by means of this biochip simultaneously. We found that positive rate of serum ASA was 20.92% (77/368) in the cases and 1.72% (2/116) in the controls, respectively. Furthermore, we further corroborated the biochip assay in comparison with ELISA method. We found that both methods were compatible for the detection of serum ASA in the patients. In addition, a follow-up study for natural conception in ASA-positive and ASA-negative patients was conducted. The result showed a significant correlation between serum ASA expression and natural pregnancy rate 6.5% in ASA-positive patients while 18.9% in ASA-negative patients, indicating the potential roles of ASA in naturally reproductive processes.

scholarly journals Twins with implanted pacemakers: Is there an increased mortality risk for the co-twin? A follow-up study based on the Danish Twin Registry and the Danish Pacemaker Register

EP Europace ◽  
2005 ◽  
Vol 7 (6) ◽  
pp. 598-603 ◽  
Author(s):  
C TVESKOV ◽  
A SKYTTHE ◽  
P ARNSBO ◽  
J VAUPEL ◽  
M MOLLER ◽  
...  
Keyword(s):  
Mortality Risk ◽  
Follow Up Study ◽  
Twin Registry ◽  
Danish Twin

scholarly journals P2-151: THE ALZHEIMER'S DISEASE SEQUENCING PROJECT - FOLLOW UP STUDY (ADSP-FUS): INCREASING ETHNIC DIVERSITY IN ALZHEIMER'S GENETICS RESEARCH

2019 ◽  
Vol 15 ◽  
pp. P634-P634
Author(s):  
Pedro Ramon Mena ◽  
Brian W. Kunkle ◽  
Kelley Faber ◽  
Katrina Celis ◽  
Larry D. Adams ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Ethnic Diversity ◽  
Sequencing Project ◽  
Follow Up Study ◽  
Genetics Research

scholarly journals Evaluation of biochemical and haematological changes in dengue fever and dengue hemorrhagic fever in Sri Lankan children: a prospective follow up study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Grace Angeline Malarnangai Kularatnam ◽  
Eresha Jasinge ◽  
Sunethra Gunasena ◽  
Dulani Samaranayake ◽  
Manouri Prasanta Senanayake ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Hemorrhagic Fever ◽  
Sri Lankan ◽  
Sri Lankan Children ◽  
Follow Up Study ◽  
Haematological Changes

scholarly journals EP29.06: Metabolic syndrome and risk of endometrial carcinoma among asymptomatic, postmenopausal, urban Sri Lankan females: a community cohort follow-up study

2017 ◽  
Vol 50 ◽  
pp. 393-393
Author(s):  
T. Dias ◽  
M. Niriella ◽  
S. de Silva ◽  
C. Motha ◽  
T.S. Palihawadana ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Endometrial Carcinoma ◽  
Sri Lankan ◽  
Follow Up Study

scholarly journals Detectability of cannabinoids in the serum samples of cannabis users: Indicators of recent cannabis use? A follow‐up study

2021 ◽  
Author(s):  
Michael Kraemer ◽  
Martin Schaeper ◽  
Kristina Duecker ◽  
Alexandra Philipsen ◽  
Moritz Losacker ◽  
...  
Keyword(s):  
Cannabis Use ◽  
Serum Samples ◽  
Follow Up Study

scholarly journals The Second Wave of SARS-CoV-2 Circulation—Antibody Detection in the Domestic Cat Population in Germany

Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1009
Author(s):  
Anna Michelitsch ◽  
Jacob Schön ◽  
Donata Hoffmann ◽  
Martin Beer ◽  
Kerstin Wernike
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Human Population ◽  
Domestic Cat ◽  
Antibody Detection ◽  
Domestic Cats ◽  
Serum Samples ◽  
Follow Up Study ◽  
Second Wave

Registered cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in the German human population increased rapidly during the second wave of the SARS-CoV-2 pandemic in winter 2020/21. Since domestic cats are susceptible to SARS-CoV-2, the occurrence of trans-species transmission needs to be monitored. A previous serosurvey during the first wave of the pandemic detected antibodies against SARS-CoV-2 in 0.65% of feline serum samples that were randomly sampled across Germany. In the here-presented follow-up study that was conducted from September 2020 to February 2021, the seroprevalence rose to 1.36% (16/1173). This doubling of the seroprevalence in cats is in line with the rise of reported cases in the human population and indicates a continuous occurrence of trans-species transmission from infected owners to their cats.

scholarly journals Is Regular Physical Activity Practice During a Submarine Patrol an Efficient Coping Strategy?

2021 ◽  
Vol 12 ◽  
Author(s):  
Charles Martin-Krumm ◽  
Barbara Lefranc ◽  
Alan Moelo ◽  
Charlotte Poupon ◽  
Julien Pontis ◽  
...  
Keyword(s):  
Physical Activity ◽  
Total Duration ◽  
Sensory Stimulation ◽  
Future Research ◽  
Follow Up Study ◽  
Visual Accommodation ◽  
Mood And Cognition ◽  
The Impact ◽  
Sophisticated Technology

Introduction: A nuclear-powered ballistic missile submarine (SSBN) is a singular professional environment, exposing personnel to isolation and confinement amidst sophisticated technology for the duration of a mission. Submariners see their mood and cognition deteriorate as their mission progresses. With regard to the benefits of physical activity (PA) on mental health, this study evaluates the impact of regular PA on the maintenance of thymia and sensory functioning during patrols.Method: This pragmatic exploratory cohort follow-up study included 29 volunteer submariners before, during and 1 month after return from patrol. PA practice was evaluated by a daily self-questionnaire. This allowed submariners to be classified into two groups according to the median of the total duration in minutes of a sport practiced during the patrol (PA practicing submariners and non-practicing). Changes in mood and psychological activation, health (including sleep), unipodal stability, and accommodation distances were compared between the two groups over the period of the patrol.Results: Overall thymic functioning deteriorated during the patrol. Submariners who practice PA maintain a stable level of activation unlike non-practicing PA submariners, but they exhibited both worse general health and sleep at recovery. For these personnel, postural control is better at the end of the patrol and far visual accommodation tends to be preserved.Conclusion: PA during patrol alone is not sufficient to compensate for the thymic dysregulation induced by the SSBN environment. Nevertheless, it seems to help in maintaining an exteroceptive functioning. This exploratory study suggests directions for possible future research on physical activity associated with sensory stimulation amongst submariners, and more generally amongst people working in isolated and confined environments.

scholarly journals The Washington State Twin Registry: 2019 Update

2019 ◽  
Vol 22 (6) ◽  
pp. 788-793 ◽  
Author(s):  
Glen E. Duncan ◽  
Ally R. Avery ◽  
Eric Strachan ◽  
Eric Turkheimer ◽  
Siny Tsang
Keyword(s):  
Human Genetics ◽  
Washington State ◽  
Future Research ◽  
Special Issue ◽  
Twin Research ◽  
Construction Methods ◽  
Twin Registry ◽  
Future Research Directions ◽  
Current Special Issue

AbstractIt has been over 5 years since the last special issue of Twin Research and Human Genetics on ‘Twin Registries Worldwide: An Important Resource for Scientific Research’ was published. Much progress has been made in the broad field of twin research since that time, and the current special issue is a follow-up to update the scientific community about twin registries around the globe. The present article builds upon our 2013 Registry description by summarizing current information on the Washington State Twin Registry (WSTR), including history and construction methods, member characteristics, available data, and major research goals. We also provide a section with brief summaries of recently completed studies and discuss the future research directions of the WSTR. The Registry has grown in terms of size and scope since 2013; highlights include recruitment of youth pairs under 18 years of age, extensive geocoding work to develop environmental exposures that can be linked to survey and administrative health data such as death records, and expansion of a biobank with specimens collected for genotyping, DNA methylation, and microbiome based-studies.

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