The effect of melatonin implants on breeding activity and litter size in commercial sheep flocks in the UK

1990 ◽  
Vol 50 (1) ◽  
pp. 111-121 ◽  
Author(s):  
W. Haresign ◽  
A. R. Peters ◽  
L. D. Staples

ABSTRACTTwo trials were undertaken to investigate the effects of treating seasonally anoestrous ewes with melatonin implants on date of first oestrus and other aspects of reproductive performance.Trial 1 involved a total of 368 Mule ewes and 79 Scottish Blackface ewes on five farms, approximately half of which were treated with a single subcutaneous implant of melatonin (Regulin®), containing 18 mg melatonin, between 23 July and 6 August 1986 and the remainder acted as untreated controls. Treatment had no significant effect on the date of first oestrus or conception rate in Mule ewes, although it increased the number of Scottish Blackface ewes mating (92% v. 73%) and the number of mated ewes conceiving (69% v. 54%) in a 5-week mating period, resulting in significantly more treated ewes lambing (63% v. 37%; P < 0·01). Litter size was higher in 4/5 flocks, although this only reached statistical significance in one Mule flock and the Scottish Blackface flock.A total of 2116 ewes from 17 commercial flocks were used in trial 2, approximately half of which were Suffolk/Suffolk-cross ewes and the remainder Mule/Mule-cross ewes. Implantation with melatonin occurred between 22 June and 24 July 1987. Flocks with over 100 ewes were divided into three equal-sized groups and treated with either 18 mg melatonin (one implant of Regulin, 36 mg melatonin (two implants of Regulin given at the same time) or acted as untreated controls. Flocks with less than 100 ewes contained only the 18 mg melatonin and untreated control groups. Treatment with melatonin significantly advanced the date of first oestrus in most flocks of both breeds (P < 0·05) but the magnitude of this effect was variable. Significant (P < 0·05 at least) increases in ‘potential’ (from scanning) mean litter size (+0·13 to +0·18) and actual mean litter size (+0·11 to +0·14) resulting from treatment with melatonin were apparent in ewes of both breeds when the data were pooled across all flocks, but only in 4/17 of the individual flocks.These results indicate that treatment with melatonin implants may be a simple and effective way of advancing the breeding season and enhancing litter size of early lambing flocks under commercial farming conditions in the United Kingdom, but treatment must be given >60 days before the start of the natural breeding season for benefits in date of first oestrus to be manifest.

2019 ◽  
Vol 19 (5) ◽  
pp. 3043-3063 ◽  
Author(s):  
Carole Helfter ◽  
Neil Mullinger ◽  
Massimo Vieno ◽  
Simon O'Doherty ◽  
Michel Ramonet ◽  
...  

Abstract. We present a mass balance approach to estimate the seasonal and annual budgets of carbon dioxide (CO2) and methane (CH4) of the United Kingdom (excluding Scotland) and the Republic of Ireland from concentration measurements taken on a ferry along the east coast of the United Kingdom over a 3-year period (2015–2017). We estimate the annual emissions of CH4 to be 2.55±0.48 Tg, which is consistent with the combined 2.29 Tg reported to the United Nations Framework Convention on Climate Change by the individual countries. The net CO2 budget (i.e. including all anthropogenic and biogenic sources and sinks of CO2) is estimated at 881.0±125.8 Tg, with a net biogenic contribution of 458.7 Tg (taken as the difference between the estimated net emissions and the inventory value, which accounts for anthropogenic emissions only). The largest emissions for both gases were observed in a broad latitudinal band (52.5–54∘ N), which coincides with densely populated areas. The emissions of both gases were seasonal (maxima in winter and minima in summer), strongly correlated with natural gas usage and, to a lesser extent, also anti-correlated with mean air temperature. Methane emissions exhibited a statistically significant anti-correlation with air temperature at the seasonal timescale in the central region spanning 52.8–54.2∘ N, which hosts a relatively high density of waste treatment facilities. Methane emissions from landfills have been shown to sometimes increase with decreasing air temperature due to changes in the CH4-oxidising potential of the topsoil, and we speculate that the waste sector contributes significantly to the CH4 budget of this central region. This study brings independent verification of the emission budgets estimated using alternative products (e.g. mass balance budgets by aircraft measurements, inverse modelling, inventorying) and offers an opportunity to investigate the seasonality of these emissions, which is usually not possible.


2011 ◽  
Vol 15 (05) ◽  
pp. 1069-1092 ◽  
Author(s):  
PETER LINDELÖF

This paper identifies differences in institutional contexts (legislation) between Sweden and the UK and their effects on technology transfer policies. It then proceeds to examine how such activities are organized by universities. Empirical evidence from surveys conducted with technology transfer managers at eight Swedish universities and eleven UK universities gathered in Sweden and the UK during 2004 is analyzed. It is argued that the historical developments of these systems depend on different institutional contexts, which influence the modes of organization. The UK technology transfer system is based on similar legislation to that of the US, with IPRs being granted to the universities. The Swedish system, however, grants IPRs to the individual researchers, though with some new features — such as science parks and incubators — suggesting a change towards greater agent (university) involvement in encouraging technology transfer. This change indicates a breakthrough for the "entrepreneurial university" in Sweden.


2016 ◽  
Vol 46 (2) ◽  
pp. 313-330 ◽  
Author(s):  
AVISHAI BENISH ◽  
HANAN HABER ◽  
ROTEM ELIAHOU

AbstractHow does the rising ‘regulatory welfare state’ address social policy concerns in pension markets? This study examines this question by comparing the regulatory responses to high charges paid by low-income workers in pension markets in the UK and Israel. In the UK, with the recognition that the market would not cater to low-income workers, the regulatory response was the creation of a publicly operated low-cost pension fund (NEST), a ‘public option’ within the market. This allowed low-income workers access to a low level of charges, previously reserved for high-income and organised workers. In Israel, regulation sought to empower consumers, while providing minimal social protection by capping pension charges at a relatively high level, thereby leaving most of the responsibility for reducing the charges with the individual saver. By comparing these two cases, the article develops an analytical framework for the study of the regulatory welfare state, making two contributions. First, it highlights different types of regulatory citizenship: minimal regulatory social protection as opposed to a more egalitarian approach. Second, it identifies an overlooked regulatory welfare state strategy: creating ‘public option’ arrangements, whereby a state-run (but not funded) service operates within the market.


1997 ◽  
Vol 21 (2) ◽  
pp. 124-128 ◽  
Author(s):  
I. McCurdie ◽  
R. Hanspal ◽  
R. Nieveen

The management of the individual with a trans-tibial amputation has been strongly influenced by the increasing use of the ICEROSS socket system over recent years. Despite this growth in clinical experience, there has been very little research into its place in current prosthetic practice, and prescribing activity is largely determined by personal experience. In order to formulate the current consensus view on the use of ICEROSS, questionnaires were sent to 42 doctors and 43 senior prosthetists around the UK. The influence of 38 different factors on prescribing activity was assessed using a grading system (ranging from “primary indication” to “absolute contraindication”). An 85% response rate was achieved and no significant differences in response between the two professional groups were identified. Those factors considered by most to be positive indications for using ICEROSS were “pistoning”, “shear-sensitive skin / split-skin grafts”, “patient unsuccessful with supracondylar (s/c) or cuff suspension” and “insufficient suspension due to change in type or level of activity”. Those considered by most to be absolute contra-indications were “ulceration / unhealed scars”, “poor patient hygiene” and “poor patient commitment to prosthetic rehabilitation”. This consensus of opinion is in keeping with the results of the few published audits of ICEROSS usage. There was a lack of consensus, however, about the use of ICEROSS in some situations, including skin complications. Whilst some consensus does exist about the use of ICEROSS, the results of this survey indicate significant variations in clinical practice which serve to illustrate the urgent need for data from prospective clinical trials.


1983 ◽  
Vol 7 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Anne Crook

The United Kingdom Government is about to enact legisla tion for data protection. It is intended that this will safeguard the pnvacy of the individual which is seen to be threatened by the increasing use and capabilities of computerised personal information systems. There are also fears that the British computer and data processing industries will be at a disad vantage when competing in the international market without legislation equivalent to that already operating in other coun tries. The legislation will enable the UK to ratify the Council of Europe Data Protection Convention and to comply with the OECD Guidelines on Transborder Data Flow. Data protection is a valuable example of the interaction of information technology and society. This paper presents an overview of the issues involved. It examines what is meant by data privacy and how that privacy may be infringed by the use of both computerised and manual record systems. The impact of technology on the privacy problem is descnbed, including linkage of computer systems and the contribution of computer security. The need for legislation is discussed, both within the context of the international situation and of the early attempts at domestic legislation.


Author(s):  
Stephen Clark ◽  
Michelle Morris ◽  
Nik Lomax ◽  
Mark Birkin

AbstractCOVID-19 is a disease that has been shown to have outcomes that vary by certain socio-demographic and socio-economic groups. It is increasingly important that an understanding of these outcomes should be derived not from the consideration of one aspect, but by a more multi-faceted understanding of the individual. In this study use is made of a recent obesity driven classification of participants in the United Kingdom Biobank (UKB) to identify trends in COVID-19 outcomes. This classification is informed by a recently created obesity systems map, and the COVID-19 outcomes are: undertaking a test, a positive test, hospitalisation and mortality. It is demonstrated that the classification is able to identify meaningful differentials in these outcomes. This more holistic approach is recommended for identification and prioritisation of COVID-19 risk and possible long-COVID determination.


Author(s):  
Gordon Lynch

AbstractThe Introduction sets this book in the wider context of recent studies and public interest in historic child abuse. Noting other international cases of child abuse in the context of public programmes and other institutional contexts, it is argued that children’s suffering usually arose not from an absence of policy and legal protections but a failure to implement these effectively. The assisted migration of unaccompanied children from the United Kingdom to Australia is presented, particularly in the post-war period, as another such example of systemic failures to maintain known standards of child welfare. The focus of the book on policy decisions and administrative systems within the UK Government is explained and the relevance of this study to the historiography of child migration and post-war child welfare is also set out.


Author(s):  
Sarah Vickerstaff ◽  
Wendy Loretto

The drift of government policy affecting older workers in the UK has been focused on encouraging individual responsibility for working longer and saving more, often with an idealised 'adult worker' in mind; an individual devoid of family context and family demands and accumulated advantages or disadvantages. As a result the policies have a differential impact on women and men and diverse incomes groups and are likely to lead to greater inequality between older workers. The focus on the individual (the supply side in the labour market) also takes emphasis away from the problem of demand: whether employers want to retain or recruit older workers. There is an increasingly strong moral assertion that to live longer should mean to work longer, but research demonstrates that those most likely to be unemployed before state pension age are out of work because of lack of job opportunities, poor health or caring responsibilities.


Author(s):  
Andrew McDonald

This chapter assesses freedom of information (FOI) in the United Kingdom. It discusses the terminology associated with FOI, namely, transparency and openness. FOI refers to access to non-personal information; the regulation of personal information is typically governed by privacy or data-protection laws. Some jurisdictions take an integrated approach to both categories of information, but this chapter focuses on information that does not relate primarily to the individual. The family of information statutes – encompassing FOI, privacy, official secrecy and the like – are known collectively as Access to Information laws. Finally, open government is a term close to openness, since both are concerned with systems and delivery.


1999 ◽  
Vol 69 (1) ◽  
pp. 217-222 ◽  
Author(s):  
L. M. Mitchell ◽  
M. E. King ◽  
R. P. Aitken ◽  
J. M. Wallace

AbstractThe objective was to determine the effect of previous lambing date and subsequent month of mating on reproductive performance in Mule (Bluefaced Leicester × Scottish Blackface) ewes. Sixty-four ewes which had previously lambed in January (13 January (s.e. = 1 day)) and 80 ewes which had previously lambed in May (15 May (s.e. = 1 day)) were allocated equally to four mating periods (30 August to 17 September, 1 November to 19 November, 3 January to 21 January and 14 February to 4 March) in a 2 × 4 factorial design. From 20 days before and during their designated mating period, January- and May-lambing ewes were separately housed in straw-bedded pens under natural photoperiod and were given 1 kg per head per day dried grass pellets. A vasectomized ram was continuously present with each group for 17 days and was replaced by a raddled, fertility tested entire Suffolk ram at the start of the mating period. Ewes were mated at a single natural oestrus and those marked by the ram were recorded daily. Ovulation rate was measured by laparoscopy on day 6 after mating. For ewes which had previously lambed in January (16 per group), numbers by month of mating that showed oestrous behaviour, ovulated and were pregnant, respectively, were: September, 16, 15 and 12; November, 16, 15 and 14; January, 15, 15 and 10 and February, 15, 16 and 7. Mean (s.e.) ovulation rates by month of mating were 2·1 (0.16), 2·5 (0.19), 2·1 (0.09) and 2·2 (0.19) corpora lutea per ewe ovulating, and lambing rates by month of mating were 1·3 (0.25), 1·9 (0.25), 1·2 (0.24) and 0·8 (0.23) lambs per ewe to the ram. For ewes which had previously lambed in May (20 per group), numbers by month of mating that showed oestrous behaviour, ovulated and were pregnant, respectively, were: September, 13, 20 and 12; November, 20, 20 and 19; January, 20, 20 and 17 and February, 20, 20 and 13. Mean (s.e.) ovulation rates by month of mating were 2·0 (0.13), 2·3 (0.11), 2·1 (0.05) and 2·2 (0.11) corpora lutea per ewe ovulating, and lambing rates by month of mating were 1·0 (0.21), 2·1 (0.15), 1·5 (0.17) and 1·2 (0.21) lambs per ewe to the ram. Ovulation, pregnancy and lambing rates were not influenced by previous lambing date, but lambing rates were significantly (P < 0·01) reduced for ewes mated in September and February compared with November. Results demonstrate that in Mule ewes acceptable ovulation rates can be achieved throughout the period September to February but lambing rates are reduced when ewes are mated at the extremes of their natural breeding season. The main factor contributing to the reduction in lambing rates was an increase in the number of ewes failing to establish pregnancy as a consequence of ovulation without oestrous behaviour, fertilization failure and (or) total embryo loss.


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