scholarly journals Association ofn-3 andn-6 long-chain polyunsaturated fatty acids in plasma lipid classes with inflammatory bowel diseases

2007 ◽  
Vol 97 (6) ◽  
pp. 1154-1161 ◽  
Author(s):  
Mária Figler ◽  
Beata Gasztonyi ◽  
Judit Cseh ◽  
Gábor Horváth ◽  
Andrea G. Kisbenedek ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Plasma Lipids ◽  
Plasma Lipid ◽  
Lipid Classes ◽  
Biochemical Basis ◽  
Chain Pufa ◽  
Inflammatory Bowel ◽  
Long Chain

In order to establish the biochemical basis for dietary interventions, we investigated the fatty acid composition of plasma lipid classes in patients with inactive inflammatory bowel disease. In this cross-sectional study thirty patients with ulcerative colitis (UC), twenty-one with Crohn disease (CD) and twenty-four controls were investigated (mean age: UC, 40·8 (sd12·1); CD, 37·6 (sd11·0); control, 31·5 (sd8·4) years). Fatty acid composition of plasma lipids was determined by high-resolution capillary GLC. In plasma phospholipids, significantly higher values of eicosapentaenoic (20 : 5n-3), docosapentaenoic (22 : 5n-3) and γ-linolenic (18 : 3n-6) acids were found in control patients and patients with UC as compared to patients with CD [median % (weight by weight), controlv.UCv.CD : 20 : 5n-3, 0·09 (interquartile range (IQR) 0·05)v.0·14 (IQR 0·10)v.0·16 (IQR 0·10),P < 0·05; 22 : 5n-3, 0·14 (IQR 0·10)v.0·27 (IQR 0·16)v.0·31 (IQR 0·10),P < 0·001; 18 : 3n-6, 0·02 (IQR 0·02)v.0·03 (IQR 0·02)v.0·05 (IQR 0·03),P < 0·05]. When compared to the control, values of the principaln-3 andn-6 long-chain PUFA, arachidonic acid (20 : 4n-6) and DHA (22 : 6n-3) were significantly higher in patients with UC but not in patients with CD [median % (w/w), UCv.control: 20 : 4n-6, 8·43 (IQR 3·23)v.6·92 (IQR 2·96),P < 0·05; 22 : 6n-3, 1·22 (IQR 0·56)v.0·73 (IQR 0·39),P < 0·05]. As seen there are considerable differences between the long-chain PUFA status of patients suffering from UC or CD. The data obtained in the present study do not support the concept of eicosapentaenoic acid or DHA deficiency in patients with either UC or CD.

scholarly journals The Source of Long-Chain PUFA in Formula Supplements Does Not Affect the Fatty Acid Composition of Plasma Lipids in Full-Term Infants

2004 ◽  
Vol 134 (4) ◽  
pp. 868-873 ◽  
Author(s):  
Aleix Sala-Vila ◽  
Ana I. Castellote ◽  
Cristina Campoy ◽  
Montserrat Rivero ◽  
María Rodriguez-Palmero ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Plasma Lipids ◽  
Full Term ◽  
Term Infants ◽  
Chain Pufa ◽  
Long Chain

Fatty Acid Profile of Plasma Lipid Classes in Coronary Heart Disease, in Primary Hyperlipoproteinemias, and in Healthy Subjects

1973 ◽  
Vol 51 (11) ◽  
pp. 1509-1514 ◽  
Author(s):  
Claude Allard ◽  
Jean Davignon ◽  
Yves L. Marcel ◽  
Claude Goulet ◽  
Kanta Kuba ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Healthy Subjects ◽  
Total Phospholipid ◽  
Plasma Lipid ◽  
Coronary Arteriography ◽  
Lipid Classes ◽  
Gas Liquid Chromatography ◽  
Coronary Patients

The plasma fatty acid composition of the cholesteryl esters triglycerides, and total phospholipid was studied by gas–liquid chromatography in clinically healthy subjects and coronary patients; all of whom had had a recent selective coronary arteriography. The fatty acid composition of the same lipid classes mentioned above was investigated in the different types of hyperlipoproteinemia. All the subjects or patients investigated were on a regular diet. The fatty acid patterns in the various lipid classes were found the same in coronary patients and in healthy subjects. However, great differences were noted in the fatty acid profiles in the various types of hyperlipoproteinemia. Noteworthy was the fact that type II (especially type IIa) contained the greatest proportion of linoleic acid in all lipid classes. This study indicated again biochemical heterogeneity within types of primary hyperlipoproteinemias and also between types IIa and IIb.

scholarly journals Influence of feeding graded levels of canned sardines on the inflammatory markers and tissue fatty acid composition of Wistar rats

2014 ◽  
Vol 112 (3) ◽  
pp. 309-319 ◽  
Author(s):  
Pedro O. Rodrigues ◽  
Susana V. Martins ◽  
Paula A. Lopes ◽  
Cristina Ramos ◽  
Samuel Miguéis ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Wistar Rats ◽  
Inflammatory Marker ◽  
Plasma Lipid ◽  
Hdl Cholesterol ◽  
Chain Pufa ◽  
Retroperitoneal Adipose Tissue

Canned sardines are a ready-to-use fish product with excellent nutritional properties owing to its highn-3 long-chain PUFA content, mainly EPA (20 : 5n-3) and DHA (22 : 6n-3). The present study aimed to assess the effect of two dosages of canned sardines, recommended for the primary and secondary prevention of human CVD, on the inflammatory marker concentrations and fatty acid composition of erythrocytes and key metabolic tissues (liver, muscle, adipose tissue and brain) in the rat model. Wistar rats were fed a diet containing 11 % (w/w) of canned sardines (low-sardine (LS) diet) and a diet containing 22 % (w/w) of canned sardines (high-sardine (HS) diet) for 10 weeks. Daily food intake, weight gain, and organ and final body weights were not affected by the dietary treatments. The concentrations of total cholesterol, HDL-cholesterol and LDL-cholesterol decreased in both the LS and HS groups, while those of alanine aminotransferase and adiponectin increased. The concentrations of IL-1β increased only with the highest dosage of sardine. The dose-dependent influence of the graded levels of EPA+DHA was tissue specific. Compared with that of other tissues and erythrocytes, the fatty acid composition of the brain was less affected by the canned sardine-supplemented diets. In contrast, the retroperitoneal adipose tissue was highly responsive. The deposition ratios of EPA and DHA indicated that the LS diet was optimal for DHA deposition across the tissues, except in the retroperitoneal adipose tissue. Taken together, our findings indicate that a LS diet positively affects plasma lipid profiles and inflammatory mediators, whereas a HS diet has contradictory effects on IL-1β, which, in turn, is not associated with variations in the concentrations of other pro-inflammatory cytokines. This finding requires further investigation and pathophysiological understanding.

Sign in / Sign up

Export Citation Format

Share Document