scholarly journals Association of high-sensitivity C-reactive protein with cardiometabolic risk factors and micronutrient deficiencies in adults of Ouagadougou, Burkina Faso

2012 ◽  
Vol 109 (7) ◽  
pp. 1266-1275 ◽  
Author(s):  
Augustin N. Zeba ◽  
Hélène F. Delisle ◽  
Clémentine Rossier ◽  
Genevieve Renier
Keyword(s):  
Risk Factors ◽  
Burkina Faso ◽  
Cardiometabolic Risk ◽  
High Sensitivity ◽  
Sub Saharan Africa ◽  
Micronutrient Deficiencies ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Sub Saharan ◽  
Hs Crp

Increasing evidence suggests that high-sensitivity C-reactive protein (hs-CRP) is associated with cardiometabolic risk factors (CMRF) while being also related to micronutrient deficiencies. As part of a project on the double burden of under- and overnutrition in sub-Saharan Africa, we assessed the relationship between hs-CRP and both CMRF and micronutrient deficiencies in a population-based cross-sectional study carried out in the Northern district of Ouagadougou, the capital city of Burkina Faso. We randomly selected 330 households stratified by income tertile. In each income stratum, 110 individuals aged 25–60 years and having lived in Ouagadougou for at least 6 months were randomly selected, and underwent anthropometric measurements and blood sample collection. The prevalence of high hs-CRP was 39·4 %, with no sex difference. Vitamin A-deficient subjects (12·7 %) exhibited significant risk of elevated hs-CRP (OR 2·5;P= 0·015). Serum ferritin was positively correlated with log hs-CRP (r0·194;P= 0·002). The risk of elevated hs-CRP was significant in subjects with BMI ≥ 25 kg/m2(OR 6·9; 95 % CI 3·6, 13·3), abdominal obesity (OR 4·6; 95 % CI 2·2, 7·3) and high body fat (OR 10·2; 95 % CI 5·1, 20·3) (P< 0·001, respectively). Independent predictors of hs-CRP in linear regression models were waist circumference (β = 0·306;P= 0·018) and serum TAG (β = 0·158;P= 0·027). In this sub-Saharan population, hs-CRP was consistently associated with adiposity. Assuming that plasma hs-CRP reflects future risk of cardiovascular events, intervention which reduces CRP, or chronic and acute nutrition conditions associated with it, could be effective in preventing their occurrence particularly in sub-Saharan Africa.

scholarly journals Increased C-Reactive Protein in Brazilian Children: Association with Cardiometabolic Risk and Metabolic Syndrome Components (PASE Study)

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Lara Gomes Suhett ◽  
Helen Hermana Miranda Hermsdorff ◽  
Naruna Pereira Rocha ◽  
Mariane Alves Silva ◽  
Mariana De Santis Filgueiras ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cardiometabolic Risk ◽  
Disease Risk ◽  
Elevated Serum ◽  
Cardiometabolic Risk Factors ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Brazilian Children

C-reactive protein (CRP) is a marker of subclinical inflammation that has been found to be associated with cardiovascular disease risk. However, few studies have investigated the relationship between CRP and cardiometabolic markers in a representative sample of prepubescent children. The objective was to evaluate the high-sensitive CRP (hs-CRP) and its association with traditional and nontraditional cardiometabolic risk factors, as well as metabolic syndrome (MetS) components in Brazilian children. This is a cross-sectional representative study, with participants of the Schoolchildren Health Assessment Survey (PASE). Children from 8 to 9 years old (n=350) enrolled in public and private schools in the municipality of Viçosa, Minas Gerais, Brazil, were evaluated. Sociodemographic evaluation was performed through a semistructured questionnaire. Anthropometric, body composition, clinical, and biochemical measures were analyzed for cardiometabolic risk assessment. The total mean of serum hs-CRP concentration was 0.62 (±1.44) mg/L. hs-CRP was significantly correlated with several anthropometric, biochemical, and clinical parameters in this population (P<0.05). hs-CRP was positively associated with the accumulation of cardiometabolic risk factors and MetS components (P<0.05). Children with excessive weight; abdominal obesity; increased gynoid and android body fat; low HDL-c; hyperglycemia; and elevated uric acid, homocysteine, and apoB had higher chances of presenting increased hs-CRP (P<0.05). In this study, Brazilian children with cardiometabolic risk already presented elevated serum hs-CRP concentration. hs-CRP was associated with the increase of traditional and nontraditional cardiometabolic risk factors, as well as the accumulation of MetS components.

scholarly journals Prevalence of cardiometabolic risk factors among Malaysian obese adults

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Siti Zuhaidah Shahadan ◽  
Azlina Daud ◽  
Muhammad Lokman Md Isa ◽  
Samsul Deraman ◽  
Muhammad Ibrahim
Keyword(s):  
Risk Factors ◽  
Cardiometabolic Risk ◽  
Fasting Blood Glucose ◽  
High Sensitivity ◽  
Obese Adults ◽  
Mean Values ◽  
Reactive Protein ◽  
High Prevalence ◽  
The Mean ◽  
Hs Crp

Introduction: Obese adults are associated with increased cardiometabolic risk (CMR). The study aims to investigate the prevalence of CMR factor abnormalities in obese adults in Kuantan. Methods: Seventy-six obese adults with a mean (standard deviation) age of 33.7 years (9.8 years) participated in this study. All participants had a waist circumference (WC) measured, blood pressure (BP) taken, and assessment of fasting blood glucose (FBG), lipid profile (LP) and high-sensitivity C-reactive protein (hs-CRP) level. Results: For CMR factors, the mean values for WC was 97.2 ± 9.6 cm, mean overall BP was 119 ± 15/76 ± 11 mmHg, mean FBG level was 4.8 ± 0.5 mmol/L and the mean of total cholesterol (TC) and triglyceride (TG) was 5.4 ± 1.0 mmol/L and 1.4 ± 0.7 mmol/L, respectively. Lastly, the mean of hs-CRP was 6.0 ± 6.1 mg/L. The CMR factors with the highest prevalence of abnormal values included WC (male 100%; female 98%) and TC (male 73.1%; female 52%) for both genders, systolic BP (50%) and TG level (61.5%) for male, and hs-CRP level (68%) for female. Out of the nine CMR factors measured, five CMR risk factors were shown to have a high prevalence of abnormalities. Conclusions: The present study suggests that obese adults in Kuantan have multiple CMR factor abnormalities. A larger trial, sensibly informed of this trial, can now build upon and confirm these results.

scholarly journals Influence of Diet and Levels of Zonulin, Lipopolysaccharide and C-Reactive Protein on Cardiometabolic Risk Factors in Young Subjects

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4472
Author(s):  
Constanza C. Astudillo-López ◽  
Natividad Castro-Alarcón ◽  
Ana C. Ariza ◽  
José F. Muñoz-Valle ◽  
Ulises de la Cruz-Mosso ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intestinal Permeability ◽  
Systemic Inflammation ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Low Grade ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Young Subjects ◽  
Hs Crp

A western diet and increased intestinal permeability may contribute to systemic inflammation and the development of cardio-metabolic alterations. The aim of this study was to assess the relationship between diet, biomarkers of intestinal permeability, and chronic low-grade inflammation on the cardiometabolic profile. A cross-sectional study was carried out in 238 young subjects aged 18–29 years, divided into two groups: with <3 cardiometabolic risk factors (CRF) and ≥3 risk factors. Anthropometric parameters, biochemical profile, and serum levels of zonulin, lipopolysaccharide (LPS), and high-sensitivity C-reactive protein (hs-CRP) were measured, and the macronutrient intake was evaluated. Interaction models showed elevated glucose levels in the presence of high biomarker levels: zonulin ≥51.6 ng/mL plus LPS ≥ 1.35 EU/mL (β = 1.1, p = 0.006), and LPS ≥1.35 EU/mL plus hs-CRP ≥ 4.3 mg/L (β = 1.2, p = 0.007). In addition, triglyceride levels increased in the presence of LPS ≥ 1.35 EU/mL and hs-CRP ≥ 4.3 mg/L (β = 3.9, p = 0.01). Despite having increased biomarker levels, a higher consumption of water (≥2100 mL), polyunsaturated fatty acids (≥60 g), or fiber (≥30 g) decreased triglyceride (β = −9.6, p = 0.03), total cholesterol (β = −5.1, p = 0.01), and LDL-C levels (β = −7.7, p = 0.01). These findings suggest that the increased consumption of water, PUFA and fiber may improve lipid profile in subjects with intestinal permeability dysfunction or low-grade systemic inflammation.

scholarly journals C-Reactive Protein and Reactive Oxygen Metabolites in Subjects with Metabolic Syndrome

2012 ◽  
Vol 40 (3) ◽  
pp. 1074-1081 ◽  
Author(s):  
K Kotani ◽  
N Sakane
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cardiometabolic Risk ◽  
Reactive Oxygen ◽  
Cardiometabolic Risk Factors ◽  
Reactive Oxygen Metabolites ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Oxygen Metabolites

OBJECTIVE: This cross-sectional study investigated the correlation between diacron reactive oxygen metabolites (d-ROMs) and high-sensitivity C-reactive protein (hs-CRP) in subjects with or without metabolic syndrome. METHODS: Cardiometabolic risk factors, d-ROMs and hs-CRP were determined in 457 women: 123 with metabolic syndrome and 334 without metabolic syndrome. The correlation between d-ROMs and hs-CRP levels was compared between the two groups. RESULTS: The group with metabolic syndrome had significantly higher d-ROMs and hs-CRP levels than the group without metabolic syndrome. While the d-ROMs level was significantly and positively correlated with the hs-CRP level in both groups, the correlation level between the two groups was significantly different. Multiple linear regression analysis adjusted for other cardiometabolic risk factors also showed significant positive correlation between d-ROMs and hs-CRP levels in both groups. CONCLUSION: Subjects with metabolic syndrome may have a closer relationship between inflammation and oxidative stress than subjects without metabolic syndrome, possibly reflecting their increased predisposition to atherosclerosis. Further studies are necessary to confirm the observed relationship.

High-Sensitivity C-Reactive Protein is Not Independently Associated with Peripheral Subclinical Atherosclerosis

Angiology ◽  
2008 ◽  
Vol 60 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Mario Bo ◽  
Laura Corsinovi ◽  
Alessia Brescianini ◽  
Alessandro Sona ◽  
Marco Astengo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Subclinical Atherosclerosis ◽  
High Sensitivity ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Lipid Clinic ◽  
Hs Crp ◽  
Cv Disease

Objective This study investigated whether high-sensitivity C-reactive protein (hs-CRP) levels are independently associated with subclinical peripheral atherosclerosis. Methods. Clinical variables, cardiovascular (CV) risk factors, 10-year CV risk, the antebrachial Index (ABI), and the carotid intima—media thickness (cIMT) were determined in a sample of consecutive subjects free from previous CV disease, admitted for a first visit at a lipid clinic. Results. In the overall sample (320 subjects, mean age 63 years, 35.8% men), hs-CRP levels were associated with major CV risk factors, 10-year CV risk, lower ABI, and higher cIMT values. In a logistic model, after adjustment for significant covariates, the associations of hs-CRP levels with ABI and cIMT were no longer statistically significant. Conclusions. Among asymptomatic, moderate- to-high CV risk subjects, hs-CRP levels were associated with severity of peripheral atherosclerosis, but these associations were not independent of traditional CV risk factors, suggesting a limited predictive role of hs-CRP for subclinical atherosclerosis.

scholarly journals EVALUATION OF SERUM γ-GLUTAMYL TRANSFERASE AND ITS ASSOCIATION WITH HIGH SENSITIVITY C-REACTIVE PROTEIN AND INSULIN LEVELS IN THE PATIENTS WITH METABOLIC SYNDROME

2019 ◽  
Vol 5 (1) ◽  
pp. 10-16
Author(s):  
R. Dharuni ◽  
B. V. Maruthi Prasad ◽  
H. L. Vishwanth
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
High Sensitivity ◽  
Atherosclerotic Cardiovascular Disease ◽  
Gamma Glutamyl Transferase ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Glutamyl Transferase

Background. Metabolic syndrome (MS), a collection of cardiovascular risk factors, is a major worldwide public health problem. The gathered data prove that serum gamma-glutamyl transferase (γGT) activity is a true marker of atherosclerotic cardiovascular disease (CVD) and is of a prognostic importance as well as the high-sensitivity C-reactive protein (hs-CRP). Objectives. In the study, we sought to evaluate serum γGT activity, hs-CRP and insulin resistance in patients with MS. Methods. The study involved 50 persons with metabolic syndrome and 50 healthy age and sex matched controls. Fasting serum samples of all participants were investigated for γGT, hs-CRP, insulin, blood glucose, lipid profile and liver function tests. Anthropometric measurements and BMI were also calculated Results. In that case 50% showed significantly high γGT compared to the controls, 30% proved increased hs-CRP levels above >0.5 mmol/L, whereas 94% of the controls were within the reference range. 74% of cases revealed the presence of insulin resistance while 32% of the controls showed insulin resistance. High γGT levels were also observed in that case with deranged lipids levels and high BMI. Conclusions. The study suggests that the patients with MS have a higher serum γGT activity. This study also proves that hs-CRP and HOMA-IR, which are independent risk factors of CVD, are also associated with MS. The correlation between γGT and the components of MS are also found significant compared to hs-CRP. Thus, γGT can be considered as an inexpensive and authentic predictor of MS, which can be a manifestation of CVD in near future.

scholarly journals Relationship between plasma high-sensitivity c-reactive protein and traditional cardiovascular risk factors among active-duty military personnel in Republic of Serbia

2021 ◽  
pp. 30-30
Author(s):  
Nenad Ratkovic ◽  
Milena Pandrc ◽  
Vitomir Peric ◽  
Maja Stojanovic ◽  
Nemanja Rancic
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Military Personnel ◽  
High Sensitivity ◽  
Active Duty ◽  
C Reactive Protein ◽  
Score System ◽  
Reactive Protein ◽  
Active Duty Military ◽  
Hs Crp

Background/Aim. Approximately one third of individuals with no or one risk factor, as well as 40% individuals with concentraction of cholesterol less than average die from cardiovascular disease (CVD). Recent study underlined significant role of inflammation in atherosclerosis and its complications. Our study is the first one in Serbia which have for the aim that analyses the association of high-sensitivity C-reactive protein (hs-CRP) with traditional risk factors for coronary heart disease. Metods: This study is observational cross-sectional study which included 205 active-duty military personnel similar socioepidemiological and economic characteristics. Plasma high-sensitivity C-reactive protein (hs-CRP) and traditional cardiovascular risk factors were evaluated. The relative cardiovascular risk was staged as low (hs-CRP <1mg/L), intermediate (hs-CRP between 1 and 3mg/L) and high (hs-CRP >3mg/L). The Systematic COronary Risk Evaluation (SCORE) system was used for absolute cardiovascular risk assessment, and total risk (fatal and non-fatal events). Results: Our study included 205 participants, average age of 39 (35-43) years, with median and interquartile range values of hs-CRP 0.80 mg/L (0.43-1.75), with average hs-CRP values 0.71mg/L in the youngers than 40 years and 1.2 mg/L in the olders. Between the study groups the significant diferrence in hsCRP-a values was registrated; hs-CRP was significantly higher in the group older than 40 years ( p=0.006). There was a significant positive correlation between hsCRP and age (r=0.266, p<0.001); weight (r=0.223 p=0.001), body mass index (BMI) (r=0.344, p<0.001), diastolic hypertension (r=0.190, p=0.007), LDL cholesterol (r=0.152, p=0.032), triglycerides (r=0.144, p=0.039), number of risk factors (r=0.210, p<0.003), as well as negative correlation with HDL cholesterol concentration (r=-0.159, p<0.023). There was no significant correlation between hsCRP concentration and total cholesterol (r=0.131, p=0.062). According to hs-CRP values, high CV risk was found in 17.7% participants older than 40 years, and based on SCORE system staging, 90% participants have intermmediate CV risk. The results of stepwise multiple regression analyses showed that BMI was independently associated with hsCRP concentration in the group younger than 40 years. Among the olders, age was found to be associated with fibrinogen values. Conclusions. In the population of active military personnel in the Republic of Serbia, hs-CRP is correlated with some of the risk factors for CVD, and only BMI is independently 4 correlated with hs-CRP in those under 40 years of age. Levels of serum hs-CRP are increased with aging, imply that hs-CRP measurement may provide a more accurate assessment of the individual overall risk profile for CVD in the Serbian military personnel population.

Abstract P041: Relations of Three Types of Low Carbohydrate Diet to Cardiometabolic Risk Factors and C-Reactive Protein: The INTERLIPID Study

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Yasuyuki Nakamura ◽  
Hirotsugu Ueshima ◽  
Nagako Okuda ◽  
Katsuyuki Miura ◽  
Yoshikuni Kita ◽  
...  
Keyword(s):  
Risk Factors ◽  
Fatty Acids ◽  
Cardiometabolic Risk ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Cardiometabolic Risk Factors ◽  
Regression Analyses ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Low Carbohydrate

Introduction: Sizable numbers of people have tried low carbohydrate diets (LCD) of varied types; data are sparse on effects on cardiometabolic risk factors with different types of LCD. Hypothesis: We assessed the hypothesis that relationships of LCD score to cardiometabolic risk factors and an inflammatory marker, high-sensitivity C-reactive protein (CRP), are different among usual, animal-based, and plant-based LCD. Methods: We assessed serum concentrations of high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc), high sensitivity C-reactive protein (CRP), and nutrient intakes by standardized methods in men and women ages 40 to 59 years from four population samples of Japanese in Japan (553 men and 544 women, combined). For people consuming usual, animal-based, and plant-based LCDs, we calculated LCD scores, based on relative level of fat, protein, and carbohydrate, by modifying the methods of Halton, et al. Instead of calculating scores based on animal or vegetable fat, we used saturated fatty acids (SFA) or monounsaturated fatty acids (MUFA) +polyunsaturated fatty acids (PUFA). Multiple linear regression analyses were used to examine relations of LCD scores to log-CRP and cardiometabolic risk factors. Results: In multivariate regression analyses with adjustment for site, age, sex, BMI, smoking, alcohol intake, physical activity, years of education, and Keys dietary lipid score, all three LCD scores were significantly directly related to HDLc (all Ps<0.001), but not to LDLc. The plant-based LCD score was significantly inversely related to log-CRP (coefficient=-0.011, P=0.017). Conclusions: All three LCD scores were significantly directly related to HDLc, but not to LDLc. The plant-based LCD score, associated with higher PUFA and lower SFA and dietary cholesterol in comparison with the other two LCD scores, was significantly inversely related to log-CRP.

Sign in / Sign up

Export Citation Format

Share Document