scholarly journals Relationship between plasma high-sensitivity c-reactive protein and traditional cardiovascular risk factors among active-duty military personnel in Republic of Serbia

2021 ◽  
pp. 30-30
Author(s):  
Nenad Ratkovic ◽  
Milena Pandrc ◽  
Vitomir Peric ◽  
Maja Stojanovic ◽  
Nemanja Rancic
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Military Personnel ◽  
High Sensitivity ◽  
Active Duty ◽  
C Reactive Protein ◽  
Score System ◽  
Reactive Protein ◽  
Active Duty Military ◽  
Hs Crp

Background/Aim. Approximately one third of individuals with no or one risk factor, as well as 40% individuals with concentraction of cholesterol less than average die from cardiovascular disease (CVD). Recent study underlined significant role of inflammation in atherosclerosis and its complications. Our study is the first one in Serbia which have for the aim that analyses the association of high-sensitivity C-reactive protein (hs-CRP) with traditional risk factors for coronary heart disease. Metods: This study is observational cross-sectional study which included 205 active-duty military personnel similar socioepidemiological and economic characteristics. Plasma high-sensitivity C-reactive protein (hs-CRP) and traditional cardiovascular risk factors were evaluated. The relative cardiovascular risk was staged as low (hs-CRP <1mg/L), intermediate (hs-CRP between 1 and 3mg/L) and high (hs-CRP >3mg/L). The Systematic COronary Risk Evaluation (SCORE) system was used for absolute cardiovascular risk assessment, and total risk (fatal and non-fatal events). Results: Our study included 205 participants, average age of 39 (35-43) years, with median and interquartile range values of hs-CRP 0.80 mg/L (0.43-1.75), with average hs-CRP values 0.71mg/L in the youngers than 40 years and 1.2 mg/L in the olders. Between the study groups the significant diferrence in hsCRP-a values was registrated; hs-CRP was significantly higher in the group older than 40 years ( p=0.006). There was a significant positive correlation between hsCRP and age (r=0.266, p<0.001); weight (r=0.223 p=0.001), body mass index (BMI) (r=0.344, p<0.001), diastolic hypertension (r=0.190, p=0.007), LDL cholesterol (r=0.152, p=0.032), triglycerides (r=0.144, p=0.039), number of risk factors (r=0.210, p<0.003), as well as negative correlation with HDL cholesterol concentration (r=-0.159, p<0.023). There was no significant correlation between hsCRP concentration and total cholesterol (r=0.131, p=0.062). According to hs-CRP values, high CV risk was found in 17.7% participants older than 40 years, and based on SCORE system staging, 90% participants have intermmediate CV risk. The results of stepwise multiple regression analyses showed that BMI was independently associated with hsCRP concentration in the group younger than 40 years. Among the olders, age was found to be associated with fibrinogen values. Conclusions. In the population of active military personnel in the Republic of Serbia, hs-CRP is correlated with some of the risk factors for CVD, and only BMI is independently 4 correlated with hs-CRP in those under 40 years of age. Levels of serum hs-CRP are increased with aging, imply that hs-CRP measurement may provide a more accurate assessment of the individual overall risk profile for CVD in the Serbian military personnel population.

scholarly journals Association of high-sensitivity C-reactive protein with cardiometabolic risk factors and micronutrient deficiencies in adults of Ouagadougou, Burkina Faso

2012 ◽  
Vol 109 (7) ◽  
pp. 1266-1275 ◽  
Author(s):  
Augustin N. Zeba ◽  
Hélène F. Delisle ◽  
Clémentine Rossier ◽  
Genevieve Renier
Keyword(s):  
Risk Factors ◽  
Burkina Faso ◽  
Cardiometabolic Risk ◽  
High Sensitivity ◽  
Sub Saharan Africa ◽  
Micronutrient Deficiencies ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Sub Saharan ◽  
Hs Crp

Increasing evidence suggests that high-sensitivity C-reactive protein (hs-CRP) is associated with cardiometabolic risk factors (CMRF) while being also related to micronutrient deficiencies. As part of a project on the double burden of under- and overnutrition in sub-Saharan Africa, we assessed the relationship between hs-CRP and both CMRF and micronutrient deficiencies in a population-based cross-sectional study carried out in the Northern district of Ouagadougou, the capital city of Burkina Faso. We randomly selected 330 households stratified by income tertile. In each income stratum, 110 individuals aged 25–60 years and having lived in Ouagadougou for at least 6 months were randomly selected, and underwent anthropometric measurements and blood sample collection. The prevalence of high hs-CRP was 39·4 %, with no sex difference. Vitamin A-deficient subjects (12·7 %) exhibited significant risk of elevated hs-CRP (OR 2·5;P= 0·015). Serum ferritin was positively correlated with log hs-CRP (r0·194;P= 0·002). The risk of elevated hs-CRP was significant in subjects with BMI ≥ 25 kg/m2(OR 6·9; 95 % CI 3·6, 13·3), abdominal obesity (OR 4·6; 95 % CI 2·2, 7·3) and high body fat (OR 10·2; 95 % CI 5·1, 20·3) (P< 0·001, respectively). Independent predictors of hs-CRP in linear regression models were waist circumference (β = 0·306;P= 0·018) and serum TAG (β = 0·158;P= 0·027). In this sub-Saharan population, hs-CRP was consistently associated with adiposity. Assuming that plasma hs-CRP reflects future risk of cardiovascular events, intervention which reduces CRP, or chronic and acute nutrition conditions associated with it, could be effective in preventing their occurrence particularly in sub-Saharan Africa.

High Sensitivity C-reactive Protein And Cardiovascular Risk Factors In Professional Soccer Players

2014 ◽  
Vol 46 ◽  
pp. 745-746
Author(s):  
Francisco J. Diaz ◽  
Magdalena Najera ◽  
Antonio Tovar ◽  
Flora Moreno ◽  
Agustin Moreno ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
High Sensitivity ◽  
Soccer Players ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Professional Soccer

Changes in High-sensitivity C-reactive Protein Levels after Laparoscopic Gastric Stapling Procedures versus Laparoscopic Gastric Banding

2014 ◽  
Vol 80 (10) ◽  
pp. 1044-1048
Author(s):  
Alana Gebhart ◽  
Monica Young ◽  
James Villamere ◽  
Anderson Shih ◽  
Ninh T. Nguyen
Keyword(s):  
Cardiovascular Risk ◽  
Gastric Banding ◽  
Laparoscopic Gastric Banding ◽  
High Sensitivity ◽  
Risk Category ◽  
Morbidly Obese ◽  
C Reactive Protein ◽  
Preoperative Body Mass Index ◽  
Reactive Protein ◽  
Hs Crp

Obesity, hypertension, diabetes, and hyperlipidemia are risk factors for the development of coronary artery disease. High-sensitivity C-reactive protein (hs-CRP) is an inflammatory biomarker that has been shown to be an independent predictor for cardiovascular risk. The aim of the current study was to examine the changes in cardiovascular risk profile in morbidly obese patients who underwent laparoscopic gastric stapling procedures (bypass and sleeve) compared with laparoscopic gastric banding. Levels of hs-CRP were measured preoperatively and at 12 to 24 months post-operatively. Based on hs-CRP levels, cardiovascular risk was categorized as low (less than 1 mg/L), moderate (1 to 3 mg/L), or high (greater than 3 mg/L). A total of 52 patients underwent gastric stapling procedures and 49 underwent gastric banding and both had preoperative and postoperative hs-CRP levels measured. There were no significant differences in age, gender, or preoperative body mass index (BMI) between groups. At baseline, 48.0 per cent of patients undergoing gastric stapling and 38.8 per cent of patients undergoing gastric banding had moderate or high cardiovascular risk. BMI at 24 months was significantly lower in the gastric stapling compared with the gastric banding group (30.4 ± 5.4 vs 36.1 ± 5.5 kg/m2, respectively, P < 0.01). Of the patients with elevated cardiovascular risk, 64.0 per cent of gastric stapling versus 57.8 per cent of gastric banding patients had a reduction in risk category at 12 to 24 months follow-up, whereas 1.9 per cent of patients undergoing gastric stapling versus 4.1 per cent of patients undergoing gastric banding had an increase in risk category. The mean reduction in hs-CRP level for patients with elevated cardiovascular risk was greater for gastric stapling compared with gastric banding procedures (-1.10 ± 0.94 mg/L vs -0.67 ± 0.82 mg/L, respectively, P < 0.05). Cardiovascular risk improved in the majority of patients after bariatric surgery, but a more pronounced improvement occurred in patients who underwent gastric stapling procedures.

scholarly journals High-sensitivity C-reactive protein is a good marker of cardiovascular risk in obese children and adolescents.

2008 ◽  
Vol 159 (1) ◽  
pp. R1-R4 ◽  
Author(s):  
Leandro Soriano-Guillén ◽  
Bárbara Hernández-García ◽  
Jimena Pita ◽  
Nieves Domínguez-Garrido ◽  
Genoveva Del Río-Camacho ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Children And Adolescents ◽  
Hdl Cholesterol ◽  
High Sensitivity ◽  
Oral Glucose ◽  
Obese Children ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

ObjectiveWe intend to assess the utility of the high-sensitivity C-reactive protein (hs-CRP) as a marker of cardiovascular risk in obese children and adolescents.MethodsThe study included children and adolescents between 6 and 18 years of age with a body mass index (BMI) higher than 2 SDS. All the patients had their blood pressure taken and hs-CRP, hepatic function, lipid profile and uric acid were determined after 12 h of fasting. Likewise, an oral glucose tolerance test was performed, determining basal glucose and insulin levels, and after stimulus. We considered the presence of metabolic syndrome when the obese children and teenagers showed at least two of the following conditions: decreased high density lipoprotein (HDL)-cholesterol, hypertriglyceridemia, hypertension or alteration in glucose metabolism.ResultsOut of the 115 obese children studied, 24% showed signs of metabolic syndrome. Those with metabolic syndrome presented higher levels of hs-CRP (mean: 3.8 mg/l; 95% CI: 2.8–4.8) in comparison with the obese patients who did not show signs of metabolic syndrome (mean: 2 mg/l; 95% CI: 1.5–2.5). After a multivariate analysis, the variables that appear to influence the changes in hs-CRP were BMI, triglycerides and HDL-cholesterol levels.ConclusionThe hs-CRP is a useful tool for early diagnosis of cardiovascular risk in obese children and teenagers.

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