Diet adherence dynamics and physiological responses to a tomato product whole-food intervention in African–American men

Tomatoes may have beneficial effects on prostate health. Efficacy trials would require long-term adherence to high levels of tomato product (TP) consumption. Therefore, factors that affect adherence in men most at risk and whether increased consumption of TP negatively affects diet and health are important concerns. Cancer-free African–American (AA) men (n 36) with mean serum prostate-specific antigen of 7·4 sd 5·6) ng/ml were randomised to consume one serving of TP/d or a control diet for 3 months. Mean intervention group lycopene intake rose to 464 %, with negligible control group increase. Plasma lycopene levels rose by 53 and 40 % in the intervention group in months 1 and 3, respectively (P< 0·0001), with no control group change. The intervention group's barriers to adherence score was inversely associated with both dietary (r − 0·49, P= 0·02) and plasma lycopene concentration (r − 0·37, P= 0·02). Their TP disadvantage score negatively correlated with the 3-month plasma lycopene concentrations (r − 0·37, P= 0·008) and their weekly incentives and impediments were remarkably stable, ‘concern for prostate health’ being the most consistent over time. ‘Liking tomatoes’ and ‘study participation’ decreased in citation frequency at weeks 6 and 9, respectively. No major shifts occurred in dietary cholesterol or saturated fat, with no adverse effects on gastrointestinal complaints, serum total cholesterol, body weight or blood pressure. Lower socio-economic status AA men at higher prostate cancer risk can successfully achieve a whole food intervention goal with a corresponding rise in plasma lycopene concentrations, with no adverse effects on self-selected diet quality or health parameters.

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Impact of a Pharmacist-Led Intervention on 30-Day Readmission and Assessment of Factors Predictive of Readmission in African American Men With Heart Failure

American Journal of Men s Health ◽

10.1177/1557988318814295 ◽

2018 ◽

Vol 13 (1) ◽

pp. 155798831881429 ◽

Cited By ~ 3

Author(s):

DeAngelo McKinley ◽

Pamela Moye-Dickerson ◽

Shondria Davis ◽

Ayman Akil

Keyword(s):

Heart Failure ◽

African American ◽

Predictive Model ◽

Nearest Neighbor ◽

African American Men ◽

Intervention Group ◽

Admission Diagnosis ◽

Control Group ◽

K Nearest Neighbor ◽

The Impact

Heart failure (HF) is responsible for more 30-day readmissions than any other condition. Minorities, particularly African American males (AAM), are at much higher risk for readmission than the general population. In this study, demographic, social, and clinical data were collected from the electronic medical records of 132 AAM patients (control and intervention) admitted with a primary or secondary admission diagnosis of HF. Both groups received guideline-directed therapy for HF. Additionally the intervention group received a pharmacist-led intervention. Data collected from these patients were used to develop and validate a predictive model to evaluate the impact of the pharmacist-led intervention, and identify predictors of readmission in this population. After propensity score matching, the intervention was determined to have a significant impact on readmission, as a significantly smaller proportion of patients in the intervention group were readmitted as compared to the control group (11.5% vs. 42.9%; p = .03). A predictive model for 30-day readmission was developed using K-nearest neighbor (KNN) classification algorithm. The model was able to correctly classify about 71% patients with an AUROC of 0.70. Additionally, the model provided a set of key patient attributes predictive of readmission status. Among these predictive attributes was whether or not a patient received the intervention. A relative risk analysis identified that patients who received the intervention are less likely to be readmitted within 30 days. This study demonstrated the benefit of a pharmacist-led intervention for AAM with HF. Such interventions have the potential to improve quality of life for this patient population.

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Serum carotenoid and retinol levels in African-Caribbean Tobagonian men with high prostate cancer risk in comparison with African-American men

British Journal Of Nutrition ◽

10.1017/s0007114517000873 ◽

2017 ◽

Vol 117 (8) ◽

pp. 1128-1136 ◽

Cited By ~ 2

Author(s):

Alicia C. McDonald ◽

Clareann H. Bunker ◽

Jay Raman ◽

John Richie ◽

Alan L. Patrick

Keyword(s):

Prostate Cancer ◽

African American ◽

African American Men ◽

Specific Antigen ◽

Elevated Serum ◽

Prostate Cancer Risk ◽

Serum Retinol ◽

Populations At Risk ◽

African Caribbean ◽

Black Populations

AbstractBlack men are known to have a higher risk for prostate cancer (PC). Carotenoids and retinol, linked to PC, have not been compared in different black populations at risk. We examined serum carotenoid and retinol levels between PC-free African-Caribbean (AC) Tobagonian men with a high PC risk (high-grade prostatic intraepithelial neoplasia, atypical foci or repeated abnormal PC screenings) and African-American (AA) men with elevated serum prostate-specific antigen (PSA) levels (≥4 ng/ml). AC men who participated in the 2003 lycopene clinical trial and AA men who participated in the 2001–2006 National Health and Nutrition Examination Survey were compared. Serum specimens were analysed for carotenoid (β-carotene, α-carotene, β-cryptoxanthin, lutein/zeaxanthin and lycopene) and retinol levels by isocratic HPLC. Quantile regression was used to examine the association between serum carotenoid and retinol levels and black ethnicity, overall and among men with elevated serum PSA. There were sixty-nine AC men and sixty-five AA men, aged 41–79 years, included. AC men were associated with lower serum lycopene and retinol levels, and higher serum α- and β-carotenes and lutein/zeaxanthin levels compared with AA men, after adjusting for age, BMI, ever smoked cigarettes, education and hypertension (P≤0·03). Among men with elevated PSA, serum retinol was no longer statistically significant with ethnicity (P=0·06). Possible differences may be attributed to dietary intake, genetics and/or factors that influence bioavailability of these micronutrients. Prospective studies are warranted that investigate whether these differences in micronutrients between AC Tobagonian and AA men influence PC risk.

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Prostate Cancer Ambassadors

American Journal of Men s Health ◽

10.1177/1557988316644979 ◽

2016 ◽

Vol 11 (1) ◽

pp. 54-62 ◽

Cited By ~ 2

Author(s):

Anissa I. Vines ◽

Jaimie C. Hunter ◽

Veronica A. Carlisle ◽

Alan N. Richmond

Keyword(s):

Prostate Cancer ◽

African American ◽

Collective Efficacy ◽

African American Men ◽

Prostate Cancer Screening ◽

Specific Antigen ◽

Prostate Cancer Risk ◽

Informed Decision ◽

Cancer Information ◽

Cancer Knowledge

African American men bear a higher burden of prostate cancer than Caucasian men, but knowledge about how to make an informed decision about prostate cancer screening is limited. A lay health advisor model was used to train “Prostate Cancer Ambassadors” on prostate cancer risk and symptoms, how to make an informed decision for prostate-specific antigen screening, and how to deliver the information to members of their community. Training consisted of two, 6-hour interactive sessions and was implemented in three predominantly African American communities over an 8-month period between 2013 and 2014. Following training, Ambassadors committed to contacting at least 10 people within 3 months using a toolkit composed of wallet-sized informational cards for distribution, a slide presentation, and a flip chart. Thirty-two Ambassadors were trained, with more than half being females (59%) and half reporting a family history of prostate cancer. Prostate cancer knowledge improved significantly among Ambassadors ( p ≤ .0001). Self-efficacy improved significantly for performing outreach tasks ( p < .0001), and among women in helping a loved one with making an informed decision ( p = .005). There was also an improvement in collective efficacy in team members ( p = .0003). Twenty-nine of the Ambassadors fulfilled their commitment to reach at least 10 people (average number of contacts per Ambassador was 11). In total, 355 individuals were reached with the prostate cancer information. The Ambassador training program proved successful in training Ambassadors to reach communities about prostate cancer and how to make an informed decision about screening.

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456: Genetic Polymorphisms in CYP17, CYPJA4, CYP19 and SRD5A2 and Prostate Cancer Risk in African American Men: the Flint Men's Health Study

The Journal of Urology ◽

10.1016/s0022-5347(18)30709-2 ◽

2007 ◽

Vol 177 (4S) ◽

pp. 153-153

Author(s):

Aruna V. Sarma ◽

Leslie Lange ◽

Anna Ray ◽

Ethan Lange ◽

Rodney L. Dunn ◽

...

Keyword(s):

Prostate Cancer ◽

African American ◽

Cancer Risk ◽

Genetic Polymorphisms ◽

African American Men ◽

Prostate Cancer Risk ◽

Men’S Health ◽

Health Study ◽

Men's Health

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PD10-05 UNDERESTIMATION OF PROSTATE CANCER RISK AT DIAGNOSIS AMONG AFRICAN AMERICAN MEN

The Journal of Urology ◽

10.1016/j.juro.2017.02.568 ◽

2017 ◽

Vol 197 (4S) ◽

Author(s):

Nathan Peffer ◽

Daniel Parker ◽

Laura Giusto ◽

Joshua Jones ◽

Anastasia Kamenko ◽

...

Keyword(s):

Prostate Cancer ◽

African American ◽

Cancer Risk ◽

African American Men ◽

Prostate Cancer Risk

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Religious Involvement and Prostate Cancer Screening Behaviors Among Southeastern African American Men

American Journal of Men s Health ◽

10.1177/1557988308318686 ◽

2008 ◽

Vol 3 (3) ◽

pp. 214-223 ◽

Cited By ~ 15

Author(s):

Cheryl L. Holt ◽

Theresa A. Wynn ◽

Jasmine Darrington

Keyword(s):

Prostate Cancer ◽

African American ◽

Cancer Screening ◽

African American Men ◽

Prostate Cancer Screening ◽

Specific Antigen ◽

Digital Rectal Examination ◽

Religious Involvement ◽

Educational Interventions ◽

Religious Behaviors

This study examined the relationship between religious involvement and prostate cancer screening behavior among a probability sample of 199 African American men. Religious involvement was assessed by telephone via a multidimensional instrument. Engaging in religious behaviors was predictive of reporting a digital rectal examination (DRE) within the past year. Religious beliefs and behaviors were predictive of behavioral intention for DRE in the next 6 months. Religious behaviors were predictive of reporting an appointment for a DRE in the next 6 months. All analyses were controlled for age, education, and marital status. None of the predictions were significant for prostate-specific antigen testing. Understanding the role of religious involvement in cancer beliefs and screening is important. Such knowledge can inform educational interventions for this group, which is disproportionately affected by prostate cancer.

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