scholarly journals Effect of vitamin D supplementation, directly or via breast milk for term infants, on serum 25 hydroxyvitamin D and related biochemistry, and propensity to infection: a randomised placebo-controlled trial

2016 ◽  
Vol 116 (1) ◽  
pp. 52-58 ◽  
Author(s):  
David D. Chandy ◽  
Jahnavi Kare ◽  
Shakal N. Singh ◽  
Anjoo Agarwal ◽  
Vinita Das ◽  
...  
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Controlled Trial ◽  
Sun Exposure ◽  
Vitamin D Supplementation ◽  
Elevated Alkaline Phosphatase ◽  
Hydroxyvitamin D ◽  
Group A ◽  
25 Hydroxyvitamin D ◽  
Group B

AbstractWe assessed the effect of vitamin D supplementation on related biochemistry, infection and dentition of the infant. In a double-blind, placebo-controlled trial conducted in Lucknow, India (latitude 26°N), 230 mother –newborn pairs were randomised to receive, for 9 months, 3000µg/month oral vitamin D3 by the mother (group A) or 10µg/d by the infant (group B) or double placebo (group C). All babies received 15 min of sun exposure (unclothed) during massage. Infants’ median 25-hydroxyvitamin D (25(OH)D) was lower in group C (median 45·3; interquartile range (IQR) 22–59·5 nmol/l) than in groups A (median 60·8; IQR 41·3–80·5 nmol/l (P<0·01)) and B (median 61·3; IQR 41·3–75·3 nmol/l (P<0·05)) at 3·5 months. Infant 25(OH)D correlated negatively with infant parathyroid hormone (r −0·46, P<0·01). Elevated alkaline phosphatase (>7.5µkat/l) was significantly more frequent in group C babies (16 %) than in group A (4 %) or group B (0 %) babies. The number of days with respiratory or diarrhoeal infection by 9 months of age was higher in group C (median 46·5; IQR 14·8–73·3 d) than in group A (median 18·5; IQR 8·8–31·0 d (P<0·01)) or group B (median 13·0; IQR 7·0–28·5 (P<0·05)). We conclude that monthly maternal or daily infant supplementation with vitamin D along with sun exposure is superior to sun exposure alone in maintaining normal infant 25(OH)D at 3·5 months, and provide protection from elevated alkaline phosphatase and infectious morbidity.

scholarly journals Is preoperative calcium and vitamin D supplementation effective in prevention of postoperative hypocalcaemia in thyroidectomised patients?

2021 ◽  
Author(s):  
Anna Grzegory ◽  
Lech Pomorski ◽  
Konrad Pagacz ◽  
Karol Sieniawski ◽  
Krzysztof Kaczka
Keyword(s):  
Vitamin D ◽  
Calcium Carbonate ◽  
Total Thyroidectomy ◽  
Vitamin D Supplementation ◽  
Oral Supplementation ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
Group A ◽  
25 Hydroxyvitamin D ◽  
Group B

IntroductionHypocalcaemia remains the most common postoperative complication after total thyroidectomy. The purpose of the study was to evaluate the clinical usefulness of routine preoperative oral calcium and vitamin D supplementation in the prevention of hypocalcaemia after total thyroidectomy.Material and methodsOne hundred fifty-three consecutive patients with nontoxic multinodular goitre were randomly assigned to routinely receive (group B) or not to receive (group A) calcium carbonate (3 g/d) and alfacalcidol (1 µg/d) on the day before surgery and calcium carbonate (1 g/d) and alfacalcidol (1 µg/d) taken once in the morning on the day of operation. Their preoperative 25-hydroxyvitamin D (25-OHD) levels, hypocalcemic symptoms, serum calcium and parathyroid hormone (iPTH) levels were determined 6 and 24 hour postoperatively and 6 weeks after surgery.ResultsSymptomatic hypocalcaemia was observed in 41/153(26.79%) patients. The incidence of symptomatic hypocalcaemia was significantly lower in the supplemented group than in the group not receiving supplementation: 10 of 77 participants (12.99%) versus 31 of 76 patients (40.79%) (p<0.05). The rates of laboratory and severe hypocalcaemia (corrected calcium <2.0 mmol/l) were 67.11% and 28.95% in group A and 50.65% and 9.09% in group B, respectively (p=0.04, p<0.05). There were no significant differences between groups A and B in corrected calcium levels after surgery and postoperative decreases in corrected calcium levels (p=0.06). 112(73.20%) participants had 25-OHD<20 ng/ml. Vitamin D levels did not influence corrected calcium level changes (p=0.98).ConclusionsOral supplementation of calcium and alfacalcidol may help in the prevention of postthyroidectomy hypocalcaemia. Vitamin D deficiency was widespread among operated patients.

25-Hydroxyvitamin D levels in serum at the onset of multiple sclerosis

2005 ◽  
Vol 11 (3) ◽  
pp. 266-271 ◽  
Author(s):  
M Soilu-Hänninen ◽  
L Airas ◽  
I Mononen ◽  
A Heikkilä ◽  
M Viljanen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Metabolism ◽  
Sun Exposure ◽  
Serum Levels ◽  
Vitamin D Supplementation ◽  
Hydroxyvitamin D ◽  
Normal Bone ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D ◽  
Lower Vitamin

Past sun exposure and vitamin D supplementation have been associated with a reduction in the risk of MS. We measured the serum concentration of 25-hydroxyvitamin D (25[OH]D) at the time of MS diagnosis in 40 MS patients and 40 controls. We found no difference in the serum levels of 25(OH)D between MS patients and controls when all samples or samples obtained during winter months were compared, but MS patients had significantly lower serum 25(OH)D concentrations in June to September than the controls. The vitamin D stores were adequate for bone metabolism (> 37 nmol/L) in 70% of MS patients throughout the year and within the hypovitaminosis level (< 37 nmol/L) in 30% of MS patients at some time of the year. During MS-relapses, 25(OH)D levels were lower than in remission, but mostly within the reference range observed in relation with normal bone metabolism. We conclude that the vitamin D stores in most MS patients are adequate for their normal bone metabolism. However, lower vitamin D levels during MS relapses than in remission suggest that vitamin D could be involved in the regulation of the clinical disease activity of MS. The optimal serum levels of vitamin D for the regulation of immune responses remain to be determined.

scholarly journals Effects of vitamin D binding protein phenotypes and vitamin D supplementation on serum total 25(OH)D and directly measured free 25(OH)D

2016 ◽  
Vol 174 (4) ◽  
pp. 445-452 ◽  
Author(s):  
Stina T Sollid ◽  
Moira Y S Hutchinson ◽  
Vivian Berg ◽  
Ole M Fuskevåg ◽  
Yngve Figenschau ◽  
...  
Keyword(s):  
Vitamin D ◽  
Binding Protein ◽  
Controlled Trial ◽  
Inverse Correlation ◽  
Vitamin D Supplementation ◽  
Vitamin D Binding Protein ◽  
Baseline Serum ◽  
Hydroxyvitamin D ◽  
Direct Measurements ◽  
25 Hydroxyvitamin D

ObjectiveTo determine the relationship between serum total 25-hydroxyvitamin D (25(OH)D), directly measured free 25(OH)D and calculated free 25(OH)D with regard to vitamin D-binding protein (DBP) phenotypes, sex, BMI, age and season, and their interrelationship to vitamin D supplementation.Design, patients and interventionsA randomized controlled trial with 20 000 IU of vitamin D3per week or placebo for 12 months was designed. A total of 472 subjects, 236 in each of the intervention groups, were included in the analyses.Main outcome measuresBaseline serum concentrations and increases in serum total 25(OH)D, directly measured free 25(OH)D, calculated free 25(OH)D and DBP.ResultsSerum total 25(OH)D and DBP concentrations were significantly lower in subjects with the phenotype Gc2/Gc2 compared to phenotypes with the Gc1S allele, and lower in males compared to females. When using directly measured free 25(OH)D, the differences related to DBP phenotypes and sexes were clearly diminished. All calculated free 25(OH)D concentrations were overestimated compared to the directly measured free 25(OH)D. Serum parathyroid hormone showed an inverse correlation with all vitamin D parameters analyzed. The increases after 12 months of vitamin D supplementation were not significantly different for any of the vitamin D parameters regardless of DBP phenotype, sex or age. Supplementation with vitamin D did not affect serum DBP.ConclusionDirect measurements of free 25(OH)D reduce the differences seen in total 25(OH)D between DBP phenotype groups and sexes, probably caused by differences in DBP concentrations. With conditions affecting serum DBP concentrations, direct measurements of free 25(OH)D should be considered.

Vitamin D Dosing Strategies Among Jordanians With Hypovitaminosis D

2016 ◽  
Vol 30 (2) ◽  
pp. 172-179 ◽  
Author(s):  
Nahla Khawaja ◽  
Mohammed Liswi ◽  
Mohammed El-Khateeb ◽  
Dana Hyassat ◽  
Dalila Bajawi ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Hypovitaminosis D ◽  
Hydroxyvitamin D ◽  
Dosing Strategies ◽  
Optimal Maintenance ◽  
Group A ◽  
25 Hydroxyvitamin D ◽  
The Mean ◽  
Group B

Objective: To compare between weekly and daily cholecalciferol in patients with hypovitaminosis D and to determine the optimal maintenance dose. Methods: Seventy-one volunteers with hypovitaminosis D were randomly assigned to 2 dose regimens: cholecalciferol 50 000 IU weekly for 8 weeks, then 50 000 IU monthly for 2 months (group A) and 7000 IU daily for 8 weeks, then 12 500 IU weekly for 2 months (group B). Cholecalciferol was stopped for 2 months and reintroduced as 50 000 IU bimonthly for group A and 50 000 IU monthly for group B. Results: Two months after therapy, the mean serum 25-hydroxyvitamin D (25(OH)D) level increased from 11.4 to 51.2 ng/mL and from 11.7 to 44.9 ng/mL in groups A and B, respectively ( P = .065). The levels of 25(OH)D declined similarly in both groups during maintenance and after holding therapy. After resuming cholecalciferol, 25(OH)D levels increased to 33.8 and 28.8 ng/mL in groups A and B, respectively ( P = .027). There was a negative correlation between serum 25(OH)D levels and body mass index (BMI; P = .040). Conclusion: Timing and frequency of the dosing (daily vs weekly) have no effect on the rise in serum 25(OH)D levels as long as the accumulative dose of cholecalciferol is similar. Cholecalciferol 50 000 IU bimonthly is required to maintain sufficient 25(OH)D levels.

scholarly journals Effects of Vitamin D Supplementation on Serum 25-Hydroxyvitamin D Concentrations in Cirrhotic Patients: A Randomized Controlled Trial

Nutrients ◽  
2016 ◽  
Vol 8 (5) ◽  
pp. 278 ◽  
Author(s):  
Stefan Pilz ◽  
Csilla Putz-Bankuti ◽  
Martin Gaksch ◽  
Walter Spindelboeck ◽  
Marius Haselberger ◽  
...  
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Hydroxyvitamin D ◽  
Randomized Controlled ◽  
25 Hydroxyvitamin D ◽  
Cirrhotic Patients

scholarly journals VITAMIN D AND PNEUMONIA

2018 ◽  
Vol 25 (04) ◽  
pp. 532-537
Author(s):  
Muhammad Shamaoon ◽  
Dr Maryam ◽  
Muhammad Ahsan ◽  
Rahman Ahmad
Keyword(s):  
Vitamin D ◽  
Controlled Trial ◽  
Intervention Group ◽  
Vitamin D Supplementation ◽  
Hospital Treatment ◽  
Randomized Controlled ◽  
Inflammatory Conditions ◽  
Group A ◽  
Group B

Background: Pneumonia is lower respiratory tract infection (LRTI) andrepresents inflammatory conditions of the lungs i.e of the lower respiratory tracts, air sacs andlung parenchyma.1 Objectives: To determine the role of vitamin D supplementation in reducingmorbidity in children with pneumonia. Study Design: Randomized Controlled trial. Place andDuration of Study: Pediatric Department, Mayo Hospital Lahore from December 2014 to May2015. Patient & Methods: Two hundred children of age 2 – 59 months with pneumonia (fever,cough, tachypnea, and subcostal recessions) and low vitamin D level (< 20 ng/ml) were includedin the study. One Hundred pneumonia patients received antibiotics (group A) and vitamins D(100,000 IU) while another group of hundred patients received only antibiotics without vitaminsupplementation (group B). When respiratory distress settled, length of stay in hospital wascalculated at the time of discharged. All patients were followed in pediatric OPDs for 3 monthsafter in-hospital treatment to pick recurrence of pneumonia symptoms (if any). Results: Themean recovery time for vitamin D group (5.7 +2.8 days) and non-vitamin D (6.1+2.8 days)was almost same with P=0.29. But the frequency of repeated episodes of pneumonia within30 days of treatment was lower in intervention group n=4 (2%) than the non-intervention groupn=18 (9%) (P = 0.002). Conclusion: 100,000 IU of vitamin D given once during treatment ofpneumonia decreases the chances of recurrence in the next 30 days.

scholarly journals Effects of Moderate Sun Exposure and Vitamin D Supplementation on Serum 25-Hydroxyvitamin D Concentration Among Malay Women

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1304-1304
Author(s):  
Norliyana Aris ◽  
Hamid Jan Bin Jan Mohamed ◽  
Wan Mohd Izani Bin Wan Mohamed
Keyword(s):  
Vitamin D ◽  
Placebo Group ◽  
Vitamin D Deficiency ◽  
Sun Exposure ◽  
Vitamin D Supplementation ◽  
Dietary Vitamin ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Hands And Feet ◽  
Vitamin D Supplement

Abstract Objectives Known as ‘sunshine vitamin’, sun exposure is a major and natural source of vitamin D. This study aimed to investigate the effects of moderate sun exposure and vitamin D supplementation on vitamin D concentration among Malay women in Kelantan, Malaysia. Methods A quasi-experimental study design was carried out among female indoor workers with vitamin D deficiency (serum 25-hydroxyvitamin D &lt; 50 nmol/l) for 12 weeks to evaluate the effects of moderate sun exposure (n = 19; 15 minutes sun exposure biweekly on face, lower arms, hands and feet), vitamin D supplementation (n = 15; 50 000 IU cholecalciferol weekly) and placebo (n = 15) on serum 25-hydroxyvitamin D (25(OH)D) levels. Data was collected twice from each respondent, firstly during baseline and secondly during endpoint. Body composition measurements (body fat percentage and body mass index), fasting blood test (serum 25(OH)D level) and questionnaire (socio-demographic, physical activity and dietary vitamin D intake) were conducted. The vitamin D classification was based on the 2011 Endocrine Society Clinical Practice Guidelines. Repeated measure ANOVA within group analysis was applied. Results The baseline characteristics did not differ significantly among study groups except for age (F = 6.15, p = 0.004). After 12 weeks, serum 25(OH)D levels increased significantly in sun exposure (mean difference (MD) = 14.27 nmol/l, p &lt; 0.001) and vitamin D supplement group (MD = 14.30 nmol/l, p &lt; 0.001) but not in the placebo group (MD = 1.63 nmol/l, p = 0.067). Conclusions The 12-weeks intervention with moderate sun exposure and vitamin D supplementation showed a similar significant increment in serum 25(OH)D levels. However, no changes in serum 25(OH)D was observed in the placebo group. These results showed that sunlight exposure and vitamin D supplement were equally helpful in improving serum 25(OH)D levels in participants with vitamin D deficiency. Funding Sources Short Term Research Grant, Universiti Sains Malaysia.

scholarly journals Sun behaviour and physical activity associated with autumn vitamin D status in 4–8-year-old Danish children

2018 ◽  
Vol 21 (17) ◽  
pp. 3158-3167 ◽  
Author(s):  
Charlotte Mortensen ◽  
Christian Mølgaard ◽  
Hanne Hauger ◽  
Michael Kristensen ◽  
Camilla T Damsgaard
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
School Children ◽  
Sun Exposure ◽  
Vitamin D Supplementation ◽  
Fat Free Mass ◽  
Protection Factor ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
25 Hydroxyvitamin D

AbstractObjectiveTo explore determinants of serum 25-hydroxyvitamin D (s-25(OH)D) during autumn in young, Caucasian children not consuming vitamin D-fortified foods or supplements, and explore differences in sun behaviours between pre-school and school children.DesignIn September–October, s-25(OH)D was measured by LC–MS/MS; physical activity, sun behaviours and vitamin D intake were assessed with questionnaires.SettingBaseline data from the ODIN Junior trial at 55°N.SubjectsChildren aged 4–8 years (n130), of whom 96% gave blood samples.ResultsMean s-25(OH)D was 56·8 (sd12·5) nmol/l and positively associated with fat-free mass index (P=0·014). Children being active 6–7 h/week had 5·6 (95% CI 1·1, 10·0) nmol/l higher s-25(OH)D than less active children (P=0·014). Children seeking shade sometimes or rarely/never had 7·0 (95% CI 1·2, 12·9;P=0·018) and 7·2 (95% CI 0·8, 13·6;P=0·028) nmol/l higher s-25(OH)D, respectively, than children always/often seeking shade. Pre-school children had more sun-safe behaviour than school children in terms of use of a hat, sunscreen and sunscreen sun protection factor (P<0·05). In school but not pre-school children, using a hat rarely/never was associated with 12·1 (95% CI 2·5, 21·7;P=0·014) nmol/l higher s-25(OH)Dv. always/often (Pinteraction=0·019). Vitamin D intake was not associated with s-25(OH)D (P=0·241).ConclusionsPhysical activity and sun behaviours are associated with s-25(OH)D in young children. Identifying factors influencing autumn s-25(OH)D is relevant to optimize levels before sun exposure diminishes. Strategies to reduce risk of inadequacy should consider risk of skin cancer and sunburn, and could include fortification and/or vitamin D supplementation.

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