Dietary inflammatory index before diagnosis and survival in an Italian cohort of women with breast cancer

AbstractThe dietary inflammatory indexTM (DII) has been shown to correlate with concentrations of several inflammatory markers and a variety of chronic disease endpoints, including cancers of various anatomic sites. We investigated whether the DII was associated with the risk for death among women with breast cancer (BrCa). This retrospective cohort study included 1453 women with BrCa, diagnosed between 1990 and 1994, and previously enrolled in a case–control study in northern Italy. With a median follow-up of 12·6 years, we observed 503 deaths, among which 398 were due to BrCa. The usual diet was assessed at BrCa diagnosis using a validated FFQ. DII scores were calculated using thirty-one foods/nutrients. Hazard ratios (HR) of death from all causes or from BrCa, with corresponding 95 % CI, were calculated using the Cox models, adjusted for age at diagnosis, tumour stage, oestrogen/progesterone receptor status and other potential confounders. The median DII score of the study women was −1·23, with a relatively narrow range (interquartile range −2·24 to −0·11), indicating a mainly anti-inflammatory diet. There was no difference in survival according to DII tertiles, neither considering all-cause mortality (HRtertile III v. I 1·00; 95 % CI 0·78, 1·28) nor BrCa-specific mortality (HRtertile III v. I 0·97; 95 % CI 0·73, 1·27). Study findings did not suggest an association between the inflammatory potential of diet, measured by the DII, and the survival of BrCa women. However, further studies are needed in populations reporting higher DII scores and a broader range of variability in the scores.

Download Full-text

A higher Dietary Inflammatory Index score is associated with a higher risk of breast cancer among Chinese women: a case–control study

British Journal Of Nutrition ◽

10.1017/s0007114517001192 ◽

2017 ◽

Vol 117 (10) ◽

pp. 1358-1367 ◽

Cited By ~ 19

Author(s):

Wu-Qing Huang ◽

Xiong-Fei Mo ◽

Yan-Bin Ye ◽

Nitin Shivappa ◽

Fang-Yu Lin ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Case Control Study ◽

Chinese Women ◽

Case Control ◽

Dietary Inflammatory Index ◽

Inflammatory Index ◽

Increased Risk ◽

Control Study

AbstractPrevious studies have investigated the association between dietary inflammatory potential and the development of cancer. For breast cancer the results have been equivocal. The present study aimed to investigate whether higher Dietary Inflammatory IndexTM (DII) scores were associated with increased risk of breast cancer among Chinese women. A total of 867 cases and 824 controls were recruited into the present case–control study from September 2011 to February 2016. DII scores were computed based on baseline dietary intake assessed by a validated 81-item FFQ. The OR and 95 % CI were assessed by multivariable logistic regression after adjusting for various potential confounders. DII scores in this study ranged from −5·87 (most anti-inflammatory score) to +5·71 (most proinflammatory score). A higher DII score was associated with a higher breast cancer risk (adjusted ORquartile 4 v. 1 2·28; 95 % CI 1·71, 3·03; adjusted ORcontinuous 1·40; 95 %CI 1·25, 1·39). In stratified analyses, positive associations also were observed except for underweight women or women with either oestrogen receptor+ or progesterone receptor+ status (but not both). Results from this study indicated that higher DII scores, corresponding to more proinflammatory diets, were positively associated with breast cancer risk among Chinese women.

Download Full-text

Association between the dietary inflammatory index and breast cancer in a large Italian case-control study

Molecular Nutrition & Food Research ◽

10.1002/mnfr.201600500 ◽

2016 ◽

Vol 61 (3) ◽

pp. 1600500 ◽

Cited By ~ 15

Author(s):

Nitin Shivappa ◽

James R. Hébert ◽

Valentina Rosato ◽

Maurizio Montella ◽

Diego Serraino ◽

...

Keyword(s):

Breast Cancer ◽

Case Control Study ◽

Case Control ◽

Dietary Inflammatory Index ◽

Inflammatory Index ◽

Italian Case ◽

Control Study

Download Full-text

Dietary inflammatory index and odds of breast cancer: A case–control study

Food Science & Nutrition ◽

10.1002/fsn3.2493 ◽

2021 ◽

Author(s):

Shatha S. Hammad ◽

Reema Mahmoud ◽

Nitin Shivappa ◽

James R. Hebert ◽

Lina Marie ◽

...

Keyword(s):

Breast Cancer ◽

Case Control Study ◽

Case Control ◽

Dietary Inflammatory Index ◽

Inflammatory Index ◽

Control Study

Download Full-text

Dietary Inflammatory Index and Risk of Breast Cancer Based on Hormone Receptor Status: A Case-Control Study in Korea

Nutrients ◽

10.3390/nu11081949 ◽

2019 ◽

Vol 11 (8) ◽

pp. 1949 ◽

Cited By ~ 5

Author(s):

Lee ◽

Quiambao ◽

Lee ◽

Ro ◽

Lee ◽

...

Keyword(s):

Breast Cancer ◽

Hormone Receptor ◽

Case Control Study ◽

Case Control ◽

Hormone Receptor Status ◽

Korean Women ◽

Dietary Inflammatory Index ◽

Receptor Status ◽

Inflammatory Index ◽

Control Study

Breast cancer is the most common cancer in women globally, and the risk of developing breast cancer is associated with inflammation. The present study aimed to examine the association between the Dietary Inflammatory Index (DII®) and breast cancer in Korean women and investigate whether the tumor’s hormone receptor status affects this association. In this case-control study, we enrolled 364 breast cancer patients and 364 age-matched controls. DII scores were calculated from dietary intake evaluated by a 106-item food frequency questionnaire. The DII score was significantly higher in cases than in controls. After adjusting for potential confounders, the odds ratio (OR) of breast cancer was higher in the highest DII tertile (OR = 3.68, 95% confidence interval (CI): 2.34–5.80, p for trend < 0.0001) than in the lowest tertile. We found that higher DII scores were related to an increased risk of breast cancer for estrogen receptor (ER)+/progesterone receptor (PR)+ tumors regardless of menopausal status (OR = 2.59, 95% CI: 1.37–4.88 in the highest DII category, p for trend = 0.01 for premenopausal women; OR = 11.00, 95% CI: 2.93–41.30 in the highest DII category, p for trend = 0.0004 for postmenopausal women), but not for ER−/PR− status. Our results suggested that the DII scores are positively associated with breast cancer risk in Korean women and that this relationship is more robust in ER+/PR+ tumors.

Download Full-text

Dietary Inflammatory Index and Odds of Breast Cancer in a Case-Control Study from Iran

Nutrition and Cancer ◽

10.1080/01635581.2018.1494843 ◽

2018 ◽

Vol 70 (7) ◽

pp. 1034-1042 ◽

Cited By ~ 6

Author(s):

Saba Jalali ◽

Nitin Shivappa ◽

James R. Hébert ◽

Zeinab Heidari ◽

Azita Hekmatdoost ◽

...

Keyword(s):

Breast Cancer ◽

Case Control Study ◽

Case Control ◽

Dietary Inflammatory Index ◽

Inflammatory Index ◽

Control Study

Download Full-text

Dietary Inflammatory Index and Breast Cancer: report from a Large-Scale Case-Control Study

Nutrition and Cancer ◽

10.1080/01635581.2021.1957489 ◽

2021 ◽

pp. 1-9

Author(s):

Bahareh Sasanfar ◽

Fatemeh Toorang ◽

Maedeh Mozafari Nia ◽

Amin Salehi-Abargouei ◽

Kazem Zendehdel

Keyword(s):

Breast Cancer ◽

Large Scale ◽

Case Control Study ◽

Case Control ◽

Dietary Inflammatory Index ◽

Inflammatory Index ◽

Control Study

Download Full-text

Abstract P132: Potato Consumption And Risk Of Diabetes And Cardiovascular Mortality In The Alpha Omega Cohort

Circulation ◽

10.1161/circ.143.suppl_1.p132 ◽

2021 ◽

Vol 143 (Suppl_1) ◽

Author(s):

Esther Cruijsen ◽

Anne W Simon ◽

Indira M Indyk ◽

Maria C Busstra ◽

Johanna M Geleijnse

Keyword(s):

Population Based ◽

French Fries ◽

Cox Models ◽

Preparation Methods ◽

Hazard Ratios ◽

Increased Risk ◽

Alpha Omega ◽

All Cause Mortality ◽

Potato Consumption

Introduction: Higher potatoes intake, especially French fries, was unfavorably associated with cardiometabolic endpoints in population-based studies. Little is known about this in coronary heart disease (CHD) patients. Hypothesis: Boiled potatoes and French fries intake might increase the risk of type 2 diabetes (T2D), cardiovascular disease (CVD) mortality and all-cause mortality after myocardial infarction (MI). Methods: We analyzed 3401 Dutch patients (60-80 y, 78% male) from the Alpha Omega Cohort, free from T2D, with an MI ≤ 10 y before enrolment. Diet was assessed at baseline (2002-2006) using a 203-item validated food frequency questionnaire, including potato preparation methods. T2D incidence (self-reported physician diagnosis and/or prescribed anti-diabetes medication) was monitored during the first 40 months of follow-up and cause-specific mortality through December 2018. Multivariable Cox models were used to obtain Hazard Ratios (HRs) for incident T2D and fatal endpoints in potato categories. Results: Patients had a median potato intake (mainly boiled) of 111 g/d (3.8 weekly servings of 200 g), with 6% consuming <1 serving per week. French fries were consumed by 48% of the patients (median: 6 g/d). Total potato intake was non-linearly associated with T2D risk during early follow-up (186 cases). Compared to 0-2 servings, HRs were 1.52 (0.97, 2.39) for 3-4 servings and 1.78 (1.10, 2.89) for ≥5 servings per week. During >12 y of follow-up (38,987 person-years) 1618 deaths occurred, of which 697 from CVD, 431 from CHD and 128 from stroke. HRs for fatal endpoints were non-significant in categories of total and boiled potatoes (Table). For French fries (consumers vs. non-consumers), HRs were 1.23 (0.89, 1.69) for T2D, 1.03 (0.87, 1.22) for fatal CVD and 0.93 (0.83, 1.04) for all-cause mortality. Conclusion: In Dutch post-MI patients, potatoes (mainly boiled) were neutrally associated with CVD and all-cause mortality. An increased risk of T2D was found for French fries, which warrants further study in CHD patient cohorts.

Download Full-text

Sense of coherence and risk of breast cancer

eLife ◽

10.7554/elife.61469 ◽

2020 ◽

Vol 9 ◽

Author(s):

Kejia Hu ◽

Mikael Eriksson ◽

Yvonne Wengström ◽

Kamila Czene ◽

Per Hall ◽

...

Keyword(s):

Breast Cancer ◽

Cohort Study ◽

Sense Of Coherence ◽

Standard Deviation Increase ◽

Cox Models ◽

Hazard Ratios ◽

Risk Of Cancer ◽

Incident Cases ◽

Incident Breast Cancer

Sense of coherence (SoC) is the origin of health according to Antonovsky. The link between SoC and risk of cancer has however rarely been assessed. We performed a cohort study of 46,436 women from the Karolinska Mammography Project for Risk Prediction of Breast Cancer (Karma). Participants answered a SoC-13 questionnaire at recruitment to Karma and were subsequently followed up for incident breast cancer. Multivariate Cox models were used to assess the hazard ratios (HRs) of breast cancer in relation to SoC. We identified 771 incident cases of breast cancer during follow-up (median time: 5.2 years). No association was found between SoC, either as a categorical (strong vs. weak SoC, HR: 1.08, 95% CI: 0.90–1.29) or continuous (HR: 1.08; 95% CI: 1.00–1.17 per standard deviation increase of SoC) variable, and risk of breast cancer. In summary, we found little evidence to support an association between SoC and risk of breast cancer.

Download Full-text

Energy-adjusted Dietary Inflammatory Index scores predict long-term cardiovascular disease mortality and other causes of death in an ecological analysis of the Seven Countries Study

European Journal of Preventive Cardiology ◽

10.1177/2047487320903866 ◽

2020 ◽

pp. 204748732090386

Author(s):

Paolo E Puddu ◽

Nitin Shivappa ◽

Alessandro Menotti ◽

James R Hébert ◽

Hanna Tolonen ◽

...

Keyword(s):

Cardiovascular Disease ◽

Coronary Heart Disease ◽

Dietary Inflammatory Index ◽

Cardiovascular Disease Mortality ◽

Inflammatory Index ◽

Disease Mortality ◽

Seven Countries Study ◽

All Cause Mortality

Using data from the Seven Countries Study of Cardiovascular Diseases, the first study to conduct international comparisons of men in different European, USA, and Japanese cohorts, we examined the effect of diet-associated inflammation on prediction of coronary heart disease-, other major cardiovascular disease- and all-cause mortality after 50-years of follow-up. The energy-adjusted Dietary Inflammatory Index was used to quantify the effect of diet on systemic inflammation. Positive linear correlations were observed between the cohort-average energy-adjusted Dietary Inflammatory Index score and both overall death rates ( R = 0.61, p = 0.0114) and major cardiovascular disease mortality rates ( R = 0.51, p = 0.0337) but not cancer. Correlations for all-cause mortality were higher when the Belgrade outlier cohort was omitted ( R = 0.72, p = 0.0024) or when analyses were adjusted for socioeconomic status ( R = 0.67, p = 0.0065). There was also a significant reverse correlation between energy-adjusted Dietary Inflammatory Index score and age at death ( R = –0.50 to –0.68, p = 0.0480 to 0.0012). Adjusting for systolic blood pressure, cholesterol, and smoking habits did not modify these correlations that were still significant. With control for these covariates a significant correlation emerged for coronary heart disease. Results obtained using a 25-year follow-up to allow unprojected data from all cohorts were similar. Results from this long-term follow-up study are consistent with a recommendation to increase consuming an anti-inflammatory diet characterized by high concentrations of fruits and vegetables and low consumption of simple carbohydrates and fats.

Download Full-text