Effects of dairy products, calcium and vitamin D on ovarian cancer risk: a meta-analysis of twenty-nine epidemiological studies

2020 ◽  
Vol 124 (10) ◽  
pp. 1001-1012 ◽  
Author(s):  
Min-Qi Liao ◽  
Xu-Ping Gao ◽  
Xiao-Xuan Yu ◽  
Yu-Fei Zeng ◽  
Shu-Na Li ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Dairy Products ◽  
Meta Analysis ◽  
Dietary Vitamin ◽  
Ovarian Cancer Risk ◽  
Low Fat ◽  
Whole Milk ◽  
Dietary Vitamin D

AbstractFindings for the roles of dairy products, Ca and vitamin D on ovarian cancer risk remain controversial. We aimed to assess these associations by using an updated meta-analysis. Five electronic databases (e.g. PubMed and Embase) were searched from inception to 24 December 2019. Pooled relative risks (RR) with 95 % CI were calculated. A total of twenty-nine case–control or cohort studies were included. For comparisons of the highest v. lowest intakes, higher whole milk intake was associated with increased ovarian cancer risk (RR 1·35; 95 % CI 1·15, 1·59), whereas decreased risks were observed for higher intakes of low-fat milk (RR 0·84; 95 % CI 0·73, 0·96), dietary Ca (RR 0·71; 95 % CI 0·60, 0·84) and dietary vitamin D (RR 0·80; 95 % CI 0·67, 0·95). Additionally, for every 100 g/d increment, increased ovarian cancer risks were found for total dairy products (RR 1·03; 95 % CI 1·01, 1·04) and for whole milk (RR 1·07; 95 % CI 1·03, 1·11); however, decreased risks were found for 100 g/d increased intakes of low-fat milk (RR 0·95; 95 % CI 0·91, 0·99), cheese (RR 0·87; 95 % CI 0·76, 0·98), dietary Ca (RR 0·96; 95 % CI 0·95, 0·98), total Ca (RR 0·98; 95 % CI 0·97, 0·99), dietary vitamin D (RR 0·92; 95 % CI 0·87, 0·97) and increased levels of circulating vitamin D (RR 0·84; 95 % CI 0·72, 0·97). These results show that whole milk intake might contribute to a higher ovarian cancer risk, whereas low-fat milk, dietary Ca and dietary vitamin D might reduce the risk.

scholarly journals Associations between dietary vitamin D, calcium and dairy products intakes and colorectal cancer risk: a case-control study in China

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Cai-Xia Zhang ◽  
Xin Zhang ◽  
Hong Luo ◽  
Xiao-Li Feng ◽  
Nai-Qi Zhang
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Dairy Products ◽  
Dietary Calcium ◽  
Food Composition ◽  
Colorectal Cancer Risk ◽  
Dietary Vitamin ◽  
Nutrient Intakes ◽  
Dietary Vitamin D

AbstractIntroductionThe effect of dietary vitamin D, calcium and dairy products intake on colorectal cancer risk is controversial. This study aims to investigate the associations between dietary vitamin D, calcium, dairy products intake and colorectal cancer risk among Chinese population.Materials and MethodsDuring July 2010 to December 2018, 2380 incident, first primary, histologically confirmed colorectal cancer cases and 2389 sex and age-matched (5-year interval) controls were recruited. Dietary intake information was collected by face-to-face interviews using a validated food frequency questionnaire. Energy and other nutrient intakes such as dietary calcium were computed on the basis of the 2002 Chinese Food Composition Table, and the dietary vitamin D intake was calculated according to the United States Department of Agriculture Food Composition Database. Unconditional multivariable logistic regression models were used to calculate the odds ratios (ORs) and 95% confidence interval (CI) after adjusting for various confounders, including socio-demographic characteristics, lifestyle factors, BMI, family history of cancer, energy intake and several nutrient intakes.ResultsThe energy-adjusted mean dietary vitamin D, calcium and total dairy products intakes were 5.69μg/d, 406.94mg/d, 4.02g/d for cases and 6.81μg/d, 468.21mg/d, 9.50g/d for controls. Compared with the controls, cases had a lower intake of dietary vitamin D, calcium and total dairy (P < 0.001). A higher intake of dietary vitamin D and calcium was found to be associated with 43% and 51% reduction in colorectal cancer. The ORs of the highest quartile compared with the lowest quartile intake were 0.57 (95% CI: 0.46, 0.70, Ptrend < 0.001) for dietary vitamin D and 0.49 (95% CI: 0.39, 0.61, Ptrend < 0.001) for dietary calcium. We observed a statistically significant inverse association of dairy products intake with colorectal cancer risk. Compared with the lowest tertile, the adjusted ORs for the highest tertile were 0.31 (95% CI: 0.26, 0.38, Ptrend < 0.001) for total dairy. The inverse associations of dietary vitamin D, calcium and dairy products intakes with colorectal cancer risk were observed in both men and women, colon and rectal cancer.ConclusionOur study indicated that higher dietary vitamin D, calcium and dairy products intakes were associated with a lower colorectal cancer risk.

Associations of circulating and dietary vitamin D with prostate cancer risk: a systematic review and dose–response meta-analysis

2011 ◽  
Vol 22 (3) ◽  
pp. 319-340 ◽  
Author(s):  
Rebecca Gilbert ◽  
Richard M. Martin ◽  
Rebecca Beynon ◽  
Ross Harris ◽  
Jelena Savovic ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
Vitamin D ◽  
Cancer Risk ◽  
Dose Response ◽  
Meta Analysis ◽  
Prostate Cancer Risk ◽  
Dietary Vitamin ◽  
Dietary Vitamin D

Higher intakes of dietary vitamin D, calcium and dairy products are inversely associated with the risk of colorectal cancer: a case–control study in China

2019 ◽  
Vol 123 (6) ◽  
pp. 699-711 ◽  
Author(s):  
Xin Zhang ◽  
Yu-Jing Fang ◽  
Xiao-Li Feng ◽  
Alinuer Abulimiti ◽  
Chu-Yi Huang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Dairy Products ◽  
Dairy Product ◽  
Colorectal Cancer Risk ◽  
Dietary Vitamin ◽  
Cancer Site ◽  
Inverse Association ◽  
Dietary Vitamin D

AbstractThe effects of dietary vitamin D, Ca and dairy products intakes on colorectal cancer risk remain controversial. The present study investigated the association between these dietary intakes and the risk of colorectal cancer in Guangdong, China. From July 2010 to December 2018, 2380 patients with colorectal cancer and 2389 sex- and age-matched controls were recruited. Dietary intake data were collected through face-to-face interviews using a validated FFQ. Unconditional multivariable logistic regression models were used to calculate the OR and 95 % CI after adjusting for various confounders. Higher dietary vitamin D and Ca intakes were associated with 43 and 52 % reductions in colorectal cancer risk, with OR of 0·57 (95 % CI 0·46, 0·70) and 0·48 (95 % CI 0·39, 0·61), respectively, for the highest quartile (v. the lowest quartile) intakes. A statistically significant inverse association was observed between total dairy product intake and colorectal cancer risk, with an adjusted OR of 0·32 (95 % CI 0·27, 0·39) for the highest v. the lowest tertile. Subjects who drank milk had a 48 % lower risk of colorectal cancer than those who did not (OR 0·52, 95 % CI 0·45, 0·59). The inverse associations of dietary vitamin D, Ca, total dairy products and milk intakes with the risk of colorectal cancer were independent of sex and cancer site. Our study supports the protective effects of high dietary vitamin D, Ca and dairy products intakes against colorectal cancer in a Chinese population.

scholarly journals Association about dietary vitamin C intake on the risk of ovarian cancer: A meta-analysis

2019 ◽  
Author(s):  
Yuhang Long ◽  
Hui Fei ◽  
Sumei Xu ◽  
Jianzhen Wen ◽  
Lihua Ye ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Risk ◽  
Vitamin C ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Geographic Location ◽  
Dietary Vitamin ◽  
Ovarian Cancer Risk ◽  
Case Control Studies

Abstract Background: Changes in dietary vitamin C intake have been related to the risks of various cancers. However, the association between dietary vitamin C intake and the risk of ovarian cancer has not been fully determined. A meta-analysis was performed to evaluate the relationship between vitamin C intake and ovarian cancer risk. Methods: Observational studies that evaluated the association between vitamin C intake and ovarian cancer risk were identified via systematic search of PubMed and Embase databases. A random effect model was used to combine relative risk (RR) with corresponding 95% confidence intervals (CI). Results: Sixteen studies (5 cohort studies and 11 case-control studies) with 4,553 cases and 439,741 participants were included. Pooled results showed that dietary vitamin C intake had non-significant association on the risk of ovarian cancer (RR=0.95, 95%CI= 0.81-1.11, I2= 52.1%, P for heterogeneity= 0.008). Subgroup analyses according to characteristics including geographic location and study design showed consistent results with the overall result. Conclusions: In summary, findings from this study indicated that dietary vitamin C intake is not associated with the risk of ovarian cancer.

scholarly journals Association about dietary vitamin C intake on the risk of ovarian cancer: a meta-analysis

2020 ◽  
Vol 40 (8) ◽  
Author(s):  
Yuhang Long ◽  
Hui Fei ◽  
Sumei Xu ◽  
Jianzhen Wen ◽  
Lihua Ye ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Risk ◽  
Vitamin C ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Geographic Location ◽  
Dietary Vitamin ◽  
Ovarian Cancer Risk ◽  
Case Control Studies

Abstract Changes in dietary vitamin C intake have been related to the risks of various cancers. However, the association between dietary vitamin C intake and the risk of ovarian cancer has not been fully determined. A meta-analysis was performed to evaluate the relationship between vitamin C intake and ovarian cancer risk. Observational studies that evaluated the association between vitamin C intake and ovarian cancer risk were identified via systematic search of PubMed and Embase databases. A random-effect model was used to combine relative risk (RR) with corresponding 95% confidence intervals (CIs). As a result, 16 studies (5 cohort studies and 11 case–control studies) with 4553 cases and 439,741 participants were included. Pooled results showed that dietary vitamin C intake had non-significant association on the risk of ovarian cancer (RR = 0.95, 95%CI = 0.81–1.11, I2 = 52.1%, Pfor heterogeneity = 0.008). Subgroup analyses according to characteristics including geographic location and study design showed consistent results with the overall result. In summary, findings from the present study indicated that dietary vitamin C intake is not associated with the risk of ovarian cancer.

Meta-analysis: Circulating vitamin D and ovarian cancer risk

2011 ◽  
Vol 121 (2) ◽  
pp. 369-375 ◽  
Author(s):  
Lu Yin ◽  
Norma Grandi ◽  
Elke Raum ◽  
Ulrike Haug ◽  
Volker Arndt ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Ovarian Cancer Risk

scholarly journals Vitamin D Exposure and Ovarian Cancer Risk and Prognosis

2020 ◽  
Vol 17 (4) ◽  
pp. 1168
Author(s):  
Kevin L’Espérance ◽  
Geetanjali D. Datta ◽  
Samia Qureshi ◽  
Anita Koushik
Keyword(s):  
Ovarian Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Treatment Success ◽  
Sun Exposure ◽  
Dietary Vitamin ◽  
Future Research ◽  
Ovarian Cancer Risk ◽  
Inverse Association ◽  
Long Term Treatment

Given the poor prognosis of ovarian cancer and limited population-level strategies for early detection and long-term treatment success, knowledge of modifiable risk factors for prevention and improved prognosis is important. Vitamin D has received wide scientific interest in cancer research as having the potential to be one such factor. We carried out a systematic narrative review of the literature on vitamin D and ovarian cancer risk and survival. We included 17 case-control and cohort studies on ovarian cancer incidence. Five analyses were of sun exposure, among which three reported an inverse association. Of 11 analyses of dietary vitamin D, two reported an inverse association. Among five studies of 25(OH)D levels, an inverse association was reported in two. Across all studies the findings were inconsistent, but some recent studies have suggested that vitamin D exposure at earlier ages may be important. Only three studies examining vitamin D exposure in relation to survival among ovarian cancer survivors were identified and the findings were inconsistent. The evidence to date supports a null influence of vitamin D on both ovarian cancer risk and survival. Future research should ensure that exposure assessment captures vitamin D exposure from all sources and for the etiologically or prognostically pertinent period.

scholarly journals Dietary vitamin A intake and the risk of ovarian cancer: a meta-analysis

2020 ◽  
Vol 40 (4) ◽  
Author(s):  
Qiaoqiao Wang ◽  
Chaying He
Keyword(s):  
Ovarian Cancer ◽  
Cancer Risk ◽  
Vitamin A ◽  
Meta Analysis ◽  
Positive Association ◽  
Dietary Vitamin ◽  
Ovarian Cancer Risk ◽  
Inverse Association ◽  
Case Control Studies ◽  
North Americans

Abstract BACKGROUND: Previous studies have demonstrated some associations between dietary vitamin A intake and ovarian cancer risk with an inconsistent relationship. We therefore performed the present study to further explore the association between them. METHODS: Databases of PubMed, Embase, and Web of Science were retrieved up to September 1, 2019. Summarized relative risk (RR) with corresponding 95% confidence intervals (CI) were calculated. Stata 14.0 software was used for data analysis. RESULTS: Fifteen articles involving 4882 cases and 443,179 participants were included in this meta-analysis. A positive association between dietary vitamin A intake and ovarian cancer risk was found (RR = 0.816, 95%CI = 0.723–0.920, I2 = 48.4%, Pfor heterogeneity = 0.019). Significant association was also found in case–control studies (RR = 0.769, 95%CI = 0.655–0.902), but not in cohort studies. When we performed the analysis between ovarian cancer risk and geographic locations, we found an inverse association in North American populations (RR = 0.825, 95%CI = 0.720–0.946), instead of other populations. CONCLUSIONS: In summary, findings from the present study suggested that higher dietary intake of vitamin A may contribute to the lower development of ovarian cancer, especially among North Americans.

Dietary Inflammatory Index and Ovarian Cancer Risk: A Meta-Analysis

2021 ◽  
pp. 1-10
Author(s):  
Jiani Yang ◽  
Jun Ma ◽  
Yue Jin ◽  
Shanshan Cheng ◽  
Shan Huang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Ovarian Cancer Risk ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index

scholarly journals Circulating Insulin-Like Growth Factor-1 Level and Ovarian Cancer Risk

2016 ◽  
Vol 38 (2) ◽  
pp. 589-597 ◽  
Author(s):  
Yiyang Li ◽  
Yang Li ◽  
Jialing Zhang ◽  
Changjun Zheng ◽  
He Zhu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Growth Factor ◽  
Cancer Risk ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Ovarian Cancer Risk ◽  
Insulin Like Growth Factor ◽  
Summary Odds Ratio

Background/Aims: Insulin-like growth factor-1 (IGF-1) has an important role in cells' proliferation, differentiation and apoptosis, and it may be involved in carcinogenesis. Several epidemiological studies assessed the association between circulating IGF-1 level and ovarian cancer risk, but there was still no conclusive finding. Methods: A meta-analysis of published studies was performed to assess the association between circulating IGF-1 level and ovarian cancer risk. The summary odds ratio (OR) with 95% confidence interval (95%CI) was calculated through meta-analysis to evaluate the strength of the association. Results: Five eligible studies were included into the meta-analysis, which involved a total of 2,028 cases of ovarian cancer and 4,625 controls. Meta-analysis of total 5 studies showed that high circulating IGF-1 level was correlated with decreased risk of ovarian cancer (OR = 0.84, 95%CI 0.74-0.97, P = 0.013). After adjusting for heterogeneity, high circulating IGF-1 level was still correlated with decreased risk of ovarian cancer (OR = 0.83, 95%CI 0.72-0.95, P = 0.007). Subgroup analysis by age showed that circulating IGF-1 level was not correlated with ovarian cancer risk in women both less than 55 years and more than 55 years. However, after adjusting for heterogeneity, high circulating IGF-1 level was correlated with decreased ovarian cancer risk in women less than 55 years (OR = 0.82, 95%CI 0.72-0.94, P = 0.004). Conclusion: Our meta-analysis suggests that high circulating IGF-1 level may be correlated with decreased ovarian cancer risk, especially in women less than 55 years. More studies are needed to further assess the association between circulating IGF-1 level and ovarian cancer risk in the future.

Sign in / Sign up

Export Citation Format

Share Document