The incidence of complement-fixing antibody to varicella-zoster virus in hospital patients and blood donors

SUMMARYThe sera of 308 patients, not suffering from varicella or zoster infections, and the sera of 183 blood donors were examined for complement-fixing antibody to varicella-zoster virus. In both groups about 70% of sera from persons aged 11–40 years had antibody titres ≥ 1/4; the incidence was less in the age range 41–60 years and increased in later decades. Antibody titres of 1/16 or 1/32 were noticeably less frequent in those aged 41–60 years than in younger or older groups.It was concluded that an unchanging titre of 1/16 or 1/32 was of no diagnostic significance. The age distribution of antibody was consistent with the theory that zoster only occurs when antibody has declined.

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Facial herpes zoster complicated by varicella zoster virus (VZV) encephalitis: The diagnostic significance of atypical lymphocytes in cerebrospinal fluid (CSF)

Heart & Lung ◽

10.1016/j.hrtlng.2010.05.059 ◽

2011 ◽

Vol 40 (2) ◽

pp. 164-167 ◽

Cited By ~ 9

Author(s):

Burke A. Cunha ◽

Stephanie Strollo ◽

Nicole Durie ◽

Mohammad S. Ibrahim

Keyword(s):

Cerebrospinal Fluid ◽

Herpes Zoster ◽

Varicella Zoster Virus ◽

Diagnostic Significance ◽

Varicella Zoster

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Detection of Anti-Varicella-Zoster Virus Antibodies in Blood Donors by Automated Passive Haemagglutination

Vox Sanguinis ◽

10.1159/000460653 ◽

1981 ◽

Vol 41 (4) ◽

pp. 245-248

Author(s):

A. Chung ◽

D.H. Naylor

Keyword(s):

Varicella Zoster Virus ◽

Blood Donors ◽

Passive Haemagglutination ◽

Varicella Zoster

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Serological evidence of increased susceptibility to varicella-zoster virus reactivation or reinfection in natalizumab-treated patients with multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458515576984 ◽

2015 ◽

Vol 21 (14) ◽

pp. 1823-1832 ◽

Cited By ~ 11

Author(s):

Rebekka Kohlmann ◽

Anke Salmen ◽

Andrew Chan ◽

Cornelius Knabbe ◽

Jürgen Diekmann ◽

...

Keyword(s):

Multiple Sclerosis ◽

Herpes Zoster ◽

Varicella Zoster Virus ◽

Blood Donors ◽

Virus Reactivation ◽

Igg Antibody ◽

Varicella Zoster ◽

Neurotropic Viruses ◽

Potential Marker ◽

Increased Risk

Background: Serious adverse drug reactions of disease-modifying drugs in multiple sclerosis (MS) therapy may include enhanced susceptibility to reactivation of neurotropic herpes viruses like varicella-zoster virus (VZV) and the John Cunningham (JC) polyomavirus. Objective: Because symptomatic reactivation of these viruses are rare events, we determined the incidence of rises in anti-VZV IgG antibody levels as a potential marker for enhanced susceptibility to subclinical and symptomatic reactivation of neurotropic viruses. Methods: Anti-VZV IgG levels were measured in paired serum samples taken 6–8 months apart from natalizumab-treated MS patients, healthy blood donors and human immunodeficiency virus (HIV) infected patients. Results: The incidence of significant rises in anti-VZV IgG levels in natalizumab-treated MS patients was 4.26 per 100 person-years, which was significantly higher than in healthy blood donors. Retrospective evaluation of the available medical records of patients with rises of anti-VZV IgG levels did not reveal herpes zoster (i.e. shingles) manifestations. Conclusions: The increased incidence of significant rises of anti-VZV IgG levels in natalizumab-treated MS patients might indicate an association of natalizumab treatment of MS with an elevated risk of a subclinical VZV reactivation and/or reinfection events. Whether this is predictive of an increased risk of herpes zoster or even symptomatic reactivation of other neurotropic viruses remains to be determined in larger prospective studies.

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Prevalence of chickenpox in primary school children in Baquba city

Diyala Journal of Medicine ◽

10.26505/djm.21026000425 ◽

2021 ◽

Vol 21 (2) ◽

pp. 70-75

Author(s):

Sarmad Yahya Abbood ◽

◽

Saad D Hameed ◽

Wathik M Hussein

Keyword(s):

Varicella Zoster Virus ◽

Teaching Hospital ◽

Statistical Data ◽

Age Groups ◽

Viral Disease ◽

Primary School Children ◽

Age Group ◽

Varicella Zoster ◽

Hospital Patients ◽

Monthly Distribution

Background: Chickenpox is a viral disease caused by a virus called Varicella Zoster Virus (VZV). It is more prevalent among children less than 10 years. Objective: To estimate the prevalence of chickenpox among the different age groups and monthly distribution per year in Baquba city sectors recorded in Baquba teaching hospital. Patients and Methods: Data was collected of 82 patients from 1st January –31 th July 2019, and the statistical data was recorded as name, age, sectored where patients' lives. Results: Eighty-two patients with chickenpox data were collected in Baquba teaching hospital, male 52(63.4%) , and female 30(36.5%) of cases in different age groups, were highest prevalence in(9-12) years age group (30) cases, and lowest in cases older than 12 years old were (6) cases reported, t-test (2.671). Conclusion: Chickenpox more common in male, highest infections were reported in winter months. Keywords: Chickenpox, Varicella-Zoster Virus, children

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Antibodies to varicella-zoster virus in blood donors with genetic variance in CC chemokine receptor 5

The Lancet ◽

10.1016/s0140-6736(02)08066-2 ◽

2002 ◽

Vol 359 (9311) ◽

pp. 1034-1036 ◽

Cited By ~ 3

Author(s):

Mingdong Zhang ◽

Scott Schmid ◽

Mary Carrington ◽

Thomas R O'Brien

Keyword(s):

Varicella Zoster Virus ◽

Chemokine Receptor ◽

Blood Donors ◽

Genetic Variance ◽

Varicella Zoster ◽

Cc Chemokine ◽

Cc Chemokine Receptor 5 ◽

Chemokine Receptor 5

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1654. Chickenpox Outbreak in a Tribal District Rayagada, Odisha, India: Warrants Need for Vaccination

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.1518 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S605-S605

Author(s):

Anna Salomi. Kerketta ◽

Nilam Somalkar ◽

Bhagirathi Dwibedi ◽

Jyotsnamayee Sabat ◽

Pradeepta Subudhi

Keyword(s):

Qualitative Research ◽

Varicella Zoster Virus ◽

Health Workers ◽

Serological Test ◽

Group Discussion ◽

Age Distribution ◽

Asian Country ◽

Primary Case ◽

Traditional Practice ◽

Varicella Zoster

Abstract Background Chickenpox or varicella is caused by Varicella zoster virus. In India chickenpox outbreak is not uncommon as the vaccination against varicella is not included in the program. We report, chickenpox outbreak in a tribal district Rayagada, Odisha state of India a South Asian country. The outbreak investigation was undertaken to assess the characteristics and determinants of the outbreak and make appropriate recommendations for control and prevention of further transmission. Methods A door to door survey was made for case finding and line listing with detailed travel, exposure and vaccination history. Qualitative research tools including key informant’s interview and focus group discussion were undertaken to understand community behavior and practice. Intravenous blood samples were collected for serological test to detect antibody to varicella-zoster virus. Results A total of 59 individuals out of 767 residents were affected with chickenpox in this outbreak with an attack rate of 8.73 per 100 populations. Age distribution indicated 69.5% belonged to the age group less than 14 years. No severe complication was reported. Blood sample of 33 case-patients was tested for Varicella zoster virus IgM antibodies and 24 (72.7%) found seropositive. The primary case was an 11-year-old girl who contracted infection in her residential school. None of the community members had received vaccination against chickenpox. Qualitative research indicated traditional beliefs and remedies prevailing in the communities that prevented case isolation and the modern treatment. Conclusion The study highlights the need for regular training of peripheral health workers for an effective awareness campaign to change beliefs and traditional practice and vaccination against Varicella zoster virus for prevention of such outbreaks. Disclosures All authors: No reported disclosures.

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