Antibody responses after repeated influenza A virus immunizations among schoolchildren in Japan

SummaryAntibody responses to influenza virus immunizations were examined among junior high school students. The students received two doses of a commercial split-product vaccine containing influenza A H1N1 during a 2-year period following the first appearance of H1N1 virus in the winter of 1977–78. In haemagglutination-inhibition (HI) tests, the students who had been infected with H1N1 virus in 1977–78 showed a better response and wider cross-reactivity to the drift strain than the students who had not experienced earlier H1N1 influenza infection. Neuraminidase-inhibition (NAI) antibody titres after immunization depended upon a history of natural infection with H1N1 virus, since students not previously infected showed no significant NAI antibody rise after immunization.

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Knowledge and preventive measures practiced by junior high school students from Mexico City regarding influenza A (H1N1)

Health ◽

10.4236/health.2012.430152 ◽

2012 ◽

Vol 04 (10) ◽

pp. 995-999 ◽

Cited By ~ 3

Author(s):

Verónica Cruz-Licea ◽

Fernando González-Domínguez ◽

Laura Vargas-Parada ◽

Mónica Hernández-Riquelme ◽

Ana Flisser

Keyword(s):

High School ◽

High School Students ◽

Mexico City ◽

Junior High School ◽

Influenza A ◽

Preventive Measures ◽

Junior High ◽

Junior High School Students ◽

School Students ◽

Influenza A H1n1

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The importance of antineuraminidase antibodies in resistance to influenza A and immunologic memory for their synthesis

Journal of Hygiene ◽

10.1017/s0022172400060101 ◽

1983 ◽

Vol 91 (1) ◽

pp. 131-138 ◽

Cited By ~ 6

Author(s):

A. N. Naikhin ◽

I. M. Tsaritsina ◽

E. V. Oleinikova ◽

L. G. Syrodoeva ◽

N. L. Korchanova ◽

...

Keyword(s):

Protective Effect ◽

Influenza A ◽

Natural Infection ◽

Haemagglutination Inhibition ◽

Surface Antigens ◽

Antigenic Structure ◽

Immunologic Memory ◽

Antibody Synthesis ◽

Influenza A H1n1 ◽

Simplified Method

SUMMARYEight hundred and seventy-seven sera from 360 adults aged 18–50 who were under permanent observation from October 1980 to March 1981 have been studied by haemagglutination-inhibition (HI) and erythrocyte elution-inhibition (EI) tests – a simplified method of antineuraminidase antibody titration. It was demonstrated in some subjects infected with influenza A H1N1 and H3N2 viruses that the antibody rise was to one of the surface antigens only – haemagglutinin or neuraminidase. These subjects made up 5·2–25·8% of all examinees. The protective effect of antibodies to neuraminidase was similar to that of antihaemagglutinins. Interaction of both types of antibodies was observed in protection against the disease. Data have been obtained on the influence of antineuraminidase antibodies in decreasing the severity of natural infection with influenza A.A study of heterologous immunologic responses to haemagglutinin and neuraminidase among persons immunized with live influenza A H1N1 and H3N2 vaccines and among children naturally infected with influenza A H3N2 demonstrated the presence of immunologic memory for antineuraminidase antibody synthesis. Thus, the suggestion of a common antigenic structure for neuraminidase Nl and N2 is made.

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Serum Antibody Response to Matrix Protein 2 Following Natural Infection With 2009 Pandemic Influenza A(H1N1) Virus in Humans

The Journal of Infectious Diseases ◽

10.1093/infdis/jit811 ◽

2013 ◽

Vol 209 (7) ◽

pp. 986-994 ◽

Cited By ~ 31

Author(s):

Weimin Zhong ◽

Carrie Reed ◽

Patrick J. Blair ◽

Jacqueline M. Katz ◽

Kathy Hancock ◽

...

Keyword(s):

Antibody Response ◽

Pandemic Influenza ◽

Influenza A ◽

Matrix Protein ◽

H1n1 Virus ◽

Natural Infection ◽

Serum Antibody ◽

Serum Antibody Response ◽

Influenza A H1n1

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Immunophenotype Expressions and Cytokine Profiles of Influenza A H1N1 Virus Infection in Pediatric Patients in 2009

Disease Markers ◽

10.1155/2014/195453 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Shih-Min Wang ◽

Yu-Ting Liao ◽

Yu-Shiang Hu ◽

Tzong-Shiann Ho ◽

Ching-Fen Shen ◽

...

Keyword(s):

Influenza A ◽

Pediatric Patients ◽

Mononuclear Cells ◽

H1n1 Virus ◽

Influenza Pandemic ◽

Influenza Infection ◽

Plasma Concentrations ◽

Pulmonary Complications ◽

Cytokine Profiles ◽

Influenza A H1n1

Background. A novel swine-origin influenza A H1N1 virus (S-OIV) caused human infection and acute respiratory illness in 2009, resulting in an influenza pandemic.Objectives. This study characterized the immune responses of S-OIV infection in pediatric patients at risk of pulmonary complications.Methods. All enrolled pediatric patients were confirmed virologically for S-OIV infection in 2009-2010, prospectively. Changes in cellular immunophenotypes were analyzed using flow cytometry. Plasma cytokine levels associated with S-OIV infection by pulmonary and without pulmonary complications were measured using cytokine cytometric bead assay kits.Results. A total of 85 patients with a mean age of 10.3 years were recruited. The level of C-reactive protein (CRP) was high in patients exhibiting pulmonary complications. The percentage of cellular immunophenotypes did not change between patients with and without pulmonary complications. The absolute numbers of peripheral blood mononuclear cells (PBMC), CD3, CD8, and CD16CD56 decreased with acute S-OIV pulmonary complications. Acute influenza infection with pulmonary complications was associated with high plasma concentrations of IL-1β, IL-6, IL-12, and IFN-γ.Conclusion. Immunophenotype studies have reported variability in immune response to the severity of S-OIV infections. Acute phase cytokine profiles of the 2009 S-OIV infection might have contributed to the pathogenesis of the pulmonary complications.

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Infection with influenza A H1N1: 1. Production and persistence of antibody

Journal of Hygiene ◽

10.1017/s0022172400066080 ◽

1986 ◽

Vol 96 (2) ◽

pp. 335-343 ◽

Cited By ~ 12

Author(s):

E. A. Grilli ◽

J. R. Davies ◽

A. J. Smith

Keyword(s):

Primary Infection ◽

Influenza A ◽

H1n1 Virus ◽

Haemagglutination Inhibition ◽

Boarding School ◽

Similar Response ◽

Serological Response ◽

Peak Response ◽

Influenza A H1n1

SUMMARYThree outbreaks of influenza caused by influenza A H1N1 occurred in a boys' boarding school in 1978, 1979 and 1983. The serological response to infection with variants of the H1N1 virus was studied by radial haemolysis and haemagglutination inhibition after primary infection and reinfection. The persistence of this antibody was also studied. Infection in 1978 resulted in the production of persistent antibody to both the haemagglutinin and neuraminidase of the homotypic strain. Antibody which cross-reacted with later variants of the virus was less frequently produced, the peak response was delayed and such antibody persisted less well. Infection in 1979 resulted in a similar response to that observed in 1978 after primary infection. Reinfection resulted in a broad response in all cases. In 1983 all infected boys produced antibody which reacted with the homotypic strain but only approximately one-third of primary infections produced antibody which reacted with the A/USSR/92/77 strain. The neuraminidase of the A/USSR strain failed to detect one third of the primary infections. Reinfection again resulted in a broad response.

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Household Transmission of 2009 Pandemic Influenza A (H1N1) and Nonpharmaceutical Interventions among Households of High School Students in San Antonio, Texas

Clinical Infectious Diseases ◽

10.1093/cid/ciq057 ◽

2011 ◽

Vol 52 (suppl_1) ◽

pp. S146-S153 ◽

Cited By ~ 18

Author(s):

Fleetwood Loustalot ◽

Benjamin J. Silk ◽

Amber Gaither ◽

Trudi Shim ◽

Mark Lamias ◽

...

Keyword(s):

High School ◽

High School Students ◽

Pandemic Influenza ◽

Influenza A ◽

San Antonio ◽

School Students ◽

Household Transmission ◽

Influenza A H1n1 ◽

Nonpharmaceutical Interventions

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Influenza A(H1N1)pdm09 antibodies after pandemic and trivalent seasonal influenza vaccination as well as natural infection in November 2010 in Hamburg, Germany

Eurosurveillance ◽

10.2807/ese.17.02.20052-en ◽

2012 ◽

Vol 17 (2) ◽

Author(s):

J P Cramer ◽

T Mac ◽

B Hogan ◽

S Stauga ◽

S Eberhardt ◽

...

Keyword(s):

Influenza Vaccination ◽

Vaccination Coverage ◽

Influenza A ◽

Seasonal Influenza ◽

Influenza Pandemic ◽

Natural Infection ◽

Haemagglutination Inhibition ◽

Seasonal Influenza Vaccination ◽

Influenza A H1n1 ◽

Antibody Titres

The 2009 influenza pandemic has introduced the new re-assorted influenza A(H1N1)pdm09 virus which recirculated during the 2010/11 influenza season. Before that season, it was possible to acquire protective immunity either by pandemic or seasonal influenza vaccination against influenza A(H1N1)pdm09 or by natural infection. To obtain data on vaccination coverage and antibody levels in a reference population and to calculate whether or not the herd immunity threshold (HIT, calculated as 33% given an R0 of 1.5) was reached at the beginning of the 2010/11 season we performed a seroprevalence study in November 2010 in Hamburg, Germany. Antibody titres were assessed applying a haemagglutination inhibition test. Vaccination coverage was very low: 14% for pandemic and 11% for seasonal 2010/11 vaccinations. Even in those with underlying risk factors, vaccination coverage was not much higher: 17% for both vaccines. Serological analysis revealed antibody titres of ≥1:10 in 135 of 352 (38%) and of ≥1:40 in 61 of 352 study participants (17%). Specific antibodies were measurable in 26% of those without history of vaccination or natural infection, indicating a high proportion of subclinical and mild influenza disease. Nevertheless, the HIT was not reached, leaving the majority of the population susceptible to influenza A(H1N1)pdm09 and its potential complications.

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Faculty Opinions recommendation of Serum antibody response to matrix protein 2 following natural infection with 2009 pandemic influenza A(H1N1) virus in humans.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718204838.793495066 ◽

2014 ◽

Author(s):

Albert Osterhaus

Keyword(s):

Antibody Response ◽

Pandemic Influenza ◽

Influenza A ◽

Matrix Protein ◽

H1n1 Virus ◽

Natural Infection ◽

Serum Antibody ◽

Serum Antibody Response ◽

Influenza A H1n1

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Severe Influenza A(H1N1) Virus Infection Complicated by Myositis, Refractory Rhabdomyolysis, and Compartment Syndrome

Case Reports in Medicine ◽

10.1155/2019/1540761 ◽

2019 ◽

Vol 2019 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Camila D. Odio ◽

Charisse Mandimika ◽

Thiago A. Jabuonski ◽

Maricar Malinis

Keyword(s):

Renal Failure ◽

Virus Infection ◽

Compartment Syndrome ◽

Influenza A ◽

H1n1 Virus ◽

Obese Woman ◽

Influenza Infection ◽

Severe Influenza ◽

Influenza A H1n1 ◽

H1n1 Virus Infection

Myositis is a rare and morbid complication of influenza infection that can rapidly progress to rhabdomyolysis with acute renal failure. Here, we describe a 35-year-old obese woman with severe influenza A(H1N1) virus infection complicated by myositis, refractory rhabdomyolysis, and compartment syndrome.

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