Cisplatin in children: hearing loss correlates with iris and skin pigmentation

1995 ◽  
Vol 109 (10) ◽  
pp. 926-929 ◽  
Author(s):  
N. Wendell Todd ◽  
Carlos S. Alvarado ◽  
Debra B. Brewer
Keyword(s):  
Hearing Loss ◽  
Retrospective Study ◽  
High Frequency ◽  
Skin Pigmentation ◽  
Weak Correlation ◽  
High Frequency Hearing Loss ◽  
Auditory Thresholds ◽  
Individual Susceptibility ◽  
Adult Humans ◽  
The Individual

AbstractPigmentation is reported to affect cisplatin-induced ototoxicity in adult humans. The hearing loss is worse in people with brown irises, than in those with blue irises. We assessed the hypothesis that cisplatintreated children with dark irises suffer more deterioration in auditory thresholds than do those with less pigmentation. For the 19 children whose data met the requirements of this observational retrospective study, we found a weak correlation (Spearman's r = 0.50; p>0.05) of high frequency hearing loss (at 4000 Hz) and pigmentation. Blue or hazel-eyed children averaged 2.9 dB worsening at 4000 Hz, in contrast to 14.2 dB worsening for brown or black-eyed children.Pigmentation may account for some of the individual susceptibility to cisplatin ototoxicity. We suggest that iris colour be included in future reports of cisplatin-related hearing loss

Modified Earpieces and CROS for High Frequency Hearing Losses

1968 ◽  
Vol 11 (1) ◽  
pp. 204-218 ◽  
Author(s):  
Elizabeth Dodds ◽  
Earl Harford
Keyword(s):  
Hearing Loss ◽  
Hearing Aids ◽  
High Frequency ◽  
Hearing Aid ◽  
Sound Field ◽  
Intensity Level ◽  
Test Results ◽  
High Frequency Hearing Loss ◽  
Increased Sensitivity ◽  
Difficult Cases

Persons with a high frequency hearing loss are difficult cases for whom to find suitable amplification. We have experienced some success with this problem in our Hearing Clinics using a specially designed earmold with a hearing aid. Thirty-five cases with high frequency hearing losses were selected from our clinical files for analysis of test results using standard, vented, and open earpieces. A statistical analysis of test results revealed that PB scores in sound field, using an average conversational intensity level (70 dB SPL), were enhanced when utilizing any one of the three earmolds. This result was due undoubtedly to increased sensitivity provided by the hearing aid. Only the open earmold used with a CROS hearing aid resulted in a significant improvement in discrimination when compared with the group’s unaided PB score under earphones or when comparing inter-earmold scores. These findings suggest that the inclusion of the open earmold with a CROS aid in the audiologist’s armamentarium should increase his flexibility in selecting hearing aids for persons with a high frequency hearing loss.

scholarly journals Evaluating the Effectiveness of Earplugs in Preventing Noise-Induced Hearing Loss in an Auto Parts Factory in China

2021 ◽  
Vol 18 (13) ◽  
pp. 7190
Author(s):  
Wei Gong ◽  
Liangliang Zhao ◽  
Ling Li ◽  
Thais C. Morata ◽  
Wei Qiu ◽  
...  
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Health And Safety ◽  
Health Department ◽  
Detectable Effect ◽  
High Frequency Hearing Loss ◽  
Mandatory Requirement ◽  
Exposed Workers ◽  
Fit Testing ◽  
Auto Parts

A survey was administered to 385 noise-exposed workers from an auto parts factory and 1268 non-noise-exposed health department employees in China. Individual 8 h A-weighted equivalent sound levels (LAeq,8h), earplug personal attenuation ratings (PARs), and pure-tone audiometric tests were performed. The average LAeq,8h of noise-exposed workers was 87 dB (A) with a mean PAR of 7 dB. The prevalence of high-frequency hearing loss was 65% for noise-exposed workers and 33% for the non-noise-exposed employees. The use of earplugs had no observable effect on the prevalence of high-frequency hearing loss of the study participants (OR 0.964, 95% CI 0.925–1.005, p = 0.085). No significant relationship between the effectiveness offered by earplug use and high-frequency hearing thresholds at 3, 4, and 6 kHz was found (t = −1.54, p = 0.125). The mandatory requirement of earplug use without individualized training on how to wear HPDs correctly had no detectable effect on the prevention of hearing loss at the auto parts factory. The hearing conservation program at the surveyed factory was not effective. Periodic hearing tests, earplug fit testing, expanding the offer of different types of hearing protection, and employee education about the importance of protecting their hearing were recommended to the occupational health and safety program.

Caudal Pontine Reticular Formation of C57BL/6J Mice: Responses to Startle Stimuli, Inhibition by Tones, and Plasticity

1998 ◽  
Vol 79 (5) ◽  
pp. 2603-2614 ◽  
Author(s):  
Stephanie Carlson ◽  
James F. Willott
Keyword(s):  
Hearing Loss ◽  
Reticular Formation ◽  
Auditory System ◽  
Neural Plasticity ◽  
High Frequency ◽  
Acoustic Startle ◽  
Acoustic Startle Response ◽  
Pontine Reticular Formation ◽  
High Frequency Hearing Loss ◽  
Old Mice

Carlson, Stephanie and James F. Willott. Caudal pontine reticular formation of C57BL/6J mice: responses to startle stimuli, inhibition by tones, and plasticity. J. Neurophysiol. 79: 2603–2614, 1998. C57BL/6J (C57) mice were used to examine relationships between the behavioral acoustic startle response (ASR) and the responses of neurons in the caudal pontine reticular formation (PnC) in three contexts: 1) responses evoked by basic startle stimuli; 2) the prepulse inhibition (PPI) paradigm; and 3) the effects of high-frequency hearing loss and concomitant neural plasticity that occurs in middle-aged C57 mice. 1) Responses (evoked action potentials) of PnC neurons closely paralleled the ASR with respect to latency, threshold, and responses to rapidly presented stimuli. 2) “Neural PPI” (inhibition of responses evoked by a startle stimulus when preceded by a tone prepulse) was observed in all PnC neurons studied. 3) In PnC neurons of 6-mo-old mice with high-frequency (>20 kHz) hearing loss, neural PPI was enhanced with 12- and 4-kHz prepulses, as it is behaviorally. These are frequencies that have become “overrepresented” in the central auditory system of 6-mo-old C57 mice. Thus neural plasticity in the auditory system, induced by high-frequency hearing loss, is correlated with increased salience of the inhibiting tones in both behavioral and neural PPI paradigms.

scholarly journals High Frequency Hearing Loss and Hyperactivity in DUX4 Transgenic Mice

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0151467 ◽  
Author(s):  
Abhijit Dandapat ◽  
Benjamin J. Perrin ◽  
Christine Cabelka ◽  
Maria Razzoli ◽  
James M. Ervasti ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Transgenic Mice ◽  
High Frequency ◽  
High Frequency Hearing Loss

scholarly journals Real-World Performance of a Reverse-Horn Vent

2005 ◽  
Vol 16 (09) ◽  
pp. 653-661
Author(s):  
Francis Kuk ◽  
Denise Keenan ◽  
Chi-Chuen Lau ◽  
Nick Dinulescu ◽  
Richard Cortez ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hearing Aids ◽  
High Frequency ◽  
Objective Measures ◽  
Subjective Ratings ◽  
High Frequency Hearing Loss ◽  
Speech In Noise ◽  
Objective Performance ◽  
Occlusion Effect

The present study compared differences in subjective and objective performance in completely-in-the-canal (CIC) hearing aids with conventional uniform 1.5 mm parallel vents and another with a reverse horn vent where the diameter increased from 1.5 mm on the lateral faceplate to 3 mm on the medial opening of the hearing aid. Nine hearing-impaired persons with a high-frequency hearing loss participated. The test battery included unaided in situ thresholds, amount of available gain before feedback, speech in quiet, speech in noise (HINT), subjective ratings of hollowness and tolerance, objective measures of the occlusion effect, and real-ear aided response. Results showed less available gain before feedback but less occlusion effect for subjective ratings and objective measures with the reverse horn vent. This type of vent design may be useful to increase the effective vent diameter of custom (including CIC) hearing aids.

Tinnitus Suppression Effect of Hearing Aids in Patients With High-frequency Hearing Loss

2019 ◽  
Vol 40 (7) ◽  
pp. 865-871 ◽  
Author(s):  
Natalia Yakunina ◽  
Woo Hyun Lee ◽  
Yoon-Jong Ryu ◽  
Eui-Cheol Nam
Keyword(s):  
Hearing Loss ◽  
Hearing Aids ◽  
High Frequency ◽  
High Frequency Hearing Loss ◽  
Suppression Effect

scholarly journals Hearing threshold levels and hearing loss among people in Zhejiang, China: a population-based cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. e027152 ◽  
Author(s):  
Dahui Wang ◽  
Huai Zhang ◽  
Haiyan Ma ◽  
Long Zhang ◽  
Lei Yang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Age Groups ◽  
Hearing Threshold ◽  
Population Based ◽  
Cross Sectional Study ◽  
Zhejiang Province ◽  
Sectional Study ◽  
Cross Sectional ◽  
High Frequency Hearing Loss

Hearing loss (≥26 dB threshold in the better ear), as a common chronic condition in humans, is increasingly gaining attention. Relevant research in China is relatively scarce, so we conduct a population-based study to investigate the prevalence of hearing loss among age groups, genders and ears in Zhejiang province, China, from September 2016 to June 2018.Study designPopulation-based cross-sectional studyParticipantsA total of 3754 participants aged 18–98 years and living in Zhejiang province, China.Outcome measuresPure-tone audiometric thresholds were measured at frequencies of 0.125–8 kHz for each subject. All participants were asked to complete a structured questionnaire, in the presence of a healthcare official.ResultsThe prevalence of speech-frequency and high-frequency hearing loss was 27.9% and 42.9%, respectively, in Zhejiang. There were significant differences in auditory thresholds at most frequencies among the age groups, genders (male vs female: 31.6%vs24.1% at speech frequency; 48.9% vs 36.8% at high frequency) and ears. In addition to the common factors affecting both types of hearing loss, a significant correlation was found between personal income and speech-frequency hearing loss (OR=0.69, 95% CI 0.52 to 0.92), and between hyperlipidaemia and high-frequency hearing loss (OR=1.45, 95% CI 1.02 to 2.07).ConclusionThe prevalence of hearing loss was high among people living in Zhejiang, particularly males, and in the left ear. Moreover, hearing thresholds increased with age. Several lifestyle and environment factors, which can be influenced by awareness and education, were significantly associated with hearing loss.

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