Relationship between bacteriology of the adenoid core and middle meatus in children with sinusitis

2010 ◽  
Vol 125 (3) ◽  
pp. 279-281 ◽  
Author(s):  
S Elwany ◽  
A N El-Dine ◽  
A El-Medany ◽  
A Omran ◽  
Z Mandour ◽  
...  
Keyword(s):  
Predictive Value ◽  
Bacterial Species ◽  
Group A Streptococci ◽  
Middle Meatus ◽  
University Hospitals ◽  
Coagulase Negative Staphylococci ◽  
Airway Patency ◽  
Group A ◽  
Adenoidal Tissue ◽  
Core Culture

AbstractObjective:To assess the correlation between bacterial pathogens in the adenoid core and the middle meatus, in children with hypertrophied adenoids and chronic or recurrent sinusitis.Design:The study was conducted at Alexandria University Hospitals. We included 103 children aged four to 12 years who were scheduled for adenoidectomy and who had clinical and/or radiological evidence of chronic or recurrent sinusitis. Adenoid core specimens and middle meatal swabs were obtained from every patient and were sent for bacteriological evaluation using standard qualitative and quantitative microbiological techniques. The results were statistically analysed.Results:The bacterial species isolated most frequently from the adenoid core were coagulase-negative staphylococci (40.8 per cent),Staphylococcus aureus(22.3 per cent),Streptococcus pneumoniae(18.4 per cent),Haemophilus influenzae(16.5 per cent) and group A streptococci (15.5 per cent). The bacterial species isolated most frequently from the middle meatus were coagulase-negative staphylococci (41.7 per cent),S aureus(32 per cent),S pneumoniae(28.1 per cent),H influenzae(21.6 per cent) and group A streptococci (19.4 per cent). The adenoid core and middle meatal cultures were both positive for at least one bacterial species in 63 cases, and were both negative in 25 cases. In six cases, a positive adenoid core culture was associated with a negative middle meatal culture. In five cases, a negative adenoid core culture was associated with a positive middle meatal culture (for one or more pathogenic species). Thus, adenoid core culture had a positive predictive value of 91.5 in forecasting the middle meatal culture result, and a negative predictive value of 84.3.Conclusion:Apart from its effect on nasal airway patency, adenoidal tissue may function as a bacterial reservoir initiating and maintaining sinus infection in children. These study findings support a potential role for adenoidectomy in the treatment of chronic or recurrent paediatric sinusitis.

scholarly journals THE ENDOTOXIC PROPERTIES OF LYSATES OF GROUP A HEMOLYTIC STREPTOCOCCI

1956 ◽  
Vol 104 (6) ◽  
pp. 921-934 ◽  
Author(s):  
Chandler A. Stetson
Keyword(s):  
Bacterial Species ◽  
Intradermal Injection ◽  
Glass Beads ◽  
Group A Streptococci ◽  
Gram Negative ◽  
Inflammatory Reactions ◽  
Intravenous Injections ◽  
Mechanical Disruption ◽  
Systemic Reactions ◽  
Group A

Suspensions of group A streptococci were subjected to mechanical disruption by shaking with glass beads. The supernatant solutions produced severe delayed inflammatory reactions on intradermal injection into normal rabbits. Intravenous injections caused systemic reactions characterized by fever, leucopenia, and peripheral vasomotor phenomena. These effects were more pronounced in rabbits which had previously been infected with group A streptococci. The local and generalized Shwartzman phenomena were reproduced with these crude streptococcal lysates, and the data suggest that streptococci possess an endotoxin similar to those of Gram-negative bacterial species.

scholarly journals THE OCCURRENCE OF POLYGLYCEROPHOSPHATE AS AN ANTIGENIC COMPONENT OF VARIOUS GRAM-POSITIVE BACTERIAL SPECIES

1959 ◽  
Vol 109 (4) ◽  
pp. 361-378 ◽  
Author(s):  
Maclyn McCarty
Keyword(s):  
Cellular Localization ◽  
Bacterial Species ◽  
Dry Weight ◽  
Group A Streptococci ◽  
Immunochemical Analysis ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Precipitin Reaction ◽  
Group A ◽  
And Function

A bacterial substance has been described which gives a precipitin reaction with certain antisera to Group A streptococci. The precipitating antigen is present in various Gram-positive bacteria, including most hemolytic streptococci, staphylococci, and aerobic sporulating bacilli. It is not present in any of the Gram-negative species examined or in pneumococci, clostridia, or corynebacteria. Analysis of purified preparations obtained from Group A streptococci indicates that the antigen is a simple polymer of glycerophosphate. The identification has been confirmed by immunochemical studies, including precipitin tests and specific inhibition with synthetic polyglycerophosphates. In addition, the infrared spectra of bacterial and synthetic polyglycerophosphate are shown to be closely similar. Immunochemical analysis suggests that the amount of polyglycerophosphate present in Group A streptococci and staphylococci is approximately 1 per cent of the dry weight of the cells. The cellular localization and function of the polyglycerophosphate have not been established.

Antibiotic Susceptibility Evaluation of Bacterial Agents Causing Infection in Children with Acute Tonsillopharyngitis

2020 ◽  
Vol 20 ◽  
Author(s):  
Hamidreza Sherkatolabbasieh ◽  
Majid Firouzi ◽  
Shiva Shafizadeh ◽  
Iman Amiri
Keyword(s):  
Sore Throat ◽  
Predictive Value ◽  
Positive Culture ◽  
Clinical Score ◽  
Streptococcal Pharyngitis ◽  
Diffusion Method ◽  
Disk Diffusion Method ◽  
Cross Sectional ◽  
Clinical Sensitivity ◽  
Group A

Background: The aim of this study is to evaluate the prevalence of group A beta-hemolytic pharyngitis by assessing the outcome of the culture and the resistance and sensitivity of group A beta hemolytic streptococcus to antibiotics. Methods: This cross-sectional study was conducted on 170 patients, aged 3-15 years, referred to the clinic with complaints of sore throat. Patients’ history was collected and physical examination was performed and were score based on clinical findings. Patients with other underlying pathologies and those taking antibiotics prior to the study were excluded from our study. Antimicrobial susceptibility test was performed by disk diffusion method against cephalexin, cefazolin, erythromycin and amoxicillin. Results: A total of 170 patients were reported with sore throat. Patients with positive culture results were 60% male and 40% female. Amoxicillin resistance was the greatest (5%) in the culture. All isolated bacteria were sensitive to amoxicillin, cephalexin, cefazolin and erythromycin. Patients with McIssac score ≥ 6 showed clinical sensitivity 75% specificity 61% negative predictive value 94.8% and positive predictive value 20.3% for Group A beta-hemolytic streptococcal pharyngitis. Conclusion: The results showed the higher the clinical score, the greater the chance of positive throat culture.

Adherence and fibronectin binding are environmentally regulated in the group A streptococci

1993 ◽  
Vol 9 (6) ◽  
pp. 1213-1222 ◽  
Author(s):  
Tambryn VanHeyningen ◽  
George Fogg ◽  
Debra Yates ◽  
Emanuel Hanski ◽  
Michael Caparon
Keyword(s):  
Group A Streptococci ◽  
Group A ◽  
Fibronectin Binding

Kinetics of Serum Cytokine Profile in Mice after Injection of Supernatants of Group A Streptococci Culture

2019 ◽  
Vol 167 (3) ◽  
pp. 367-370 ◽  
Author(s):  
Т. А. Danilova ◽  
G. А. Danilina ◽  
А. А Аdzhieva ◽  
A. G. Minko
Keyword(s):  
Cytokine Profile ◽  
Group A Streptococci ◽  
Serum Cytokine ◽  
Group A ◽  
Kinetics Of

scholarly journals Clinical and Microbiological Evaluation of Local Doxycycline and Antimicrobial Photodynamic Therapy during Supportive Periodontal Therapy: A Randomized Clinical Trial

Antibiotics ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 277
Author(s):  
Raluca Cosgarea ◽  
Sigrun Eick ◽  
Ionela Batori-Andronescu ◽  
Søren Jepsen ◽  
Nicole B. Arweiler ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Bacterial Species ◽  
Periodontal Therapy ◽  
Local Drug Delivery ◽  
Control Group ◽  
Periodontal Pathogens ◽  
Supportive Periodontal Therapy ◽  
Group A ◽  
Group B ◽  
Attachment Level

The aim of this study was to evaluate the clinical and microbiological effects of subgingival instrumentation (SI) alone or combined with either local drug delivery (LDD) or photodynamic therapy (PDT) in persistent/recurrent pockets in patients enrolled in supportive periodontal therapy (SPT). A total of 105 patients enrolled in SPT were randomly treated as follows: group A (n = 35): SI +PDT and 7 days later 2nd PDT; group B (n = 35): SI+LDD; group C (n = 35): SI (control). Prior intervention, at 3 and 6 months after therapy, probing pocket depths, clinical attachment level, number of treated sites with bleeding on probing (n BOP), full mouth plaque and bleeding scores (gingival bleeding index, %BOP) were recorded. At the same time points, 8 periodontopathogens were quantitatively determined. All three treatments resulted in statistically significant improvements (p < 0.05) of all clinical parameters without statistically significant intergroup differences (p > 0.05). Several bacterial species were reduced in both test groups, with statistically significantly higher reductions for LDD compared to PDT and the control group. In conclusion, the present data indicate that: (a) In periodontal patients enrolled in SPT, treatment of persistent/recurrent pockets with SI alone or combined with either PDT or LDD may lead to comparable clinical improvements and (b) the adjunctive use of LDD appears to provide better microbiological improvements for some periodontal pathogens than SI alone or combined with PDT.

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