Extrapulmonary small cell carcinoma in head and neck

2015 ◽  
Vol 129 (S2) ◽  
pp. S83-S85 ◽  
Author(s):  
R Yasumatsu ◽  
T Nakashima ◽  
M Yamauchi ◽  
S Toh ◽  
S Komune
Keyword(s):  
Cell Carcinoma ◽  
Head And Neck ◽  
Small Cell Carcinoma ◽  
Neck Region ◽  
Small Cell ◽  
Response To Treatment ◽  
Treatment Modalities ◽  
Head And Neck Region ◽  
Disease Entities ◽  
Extrapulmonary Small Cell Carcinoma

AbstractPurpose:The management of extrapulmonary small cell carcinoma has not been standardised to date. This study reviewed the clinical course, management and survival outcomes of patients with extrapulmonary small cell carcinoma in the head and neck region.Methods:Nine patients with extrapulmonary small cell carcinoma in the head and neck were included in this study.Results:Five patients received radical surgery followed by adjuvant chemotherapy or radiotherapy or both. Two other patients were treated with chemotherapy consisting of CPT11 plus cisplatin or CPT11 plus cisplatin plus VP-16 three times. Two other patients received chemoradiotherapy consisting of S-1 or CPT11 plus cisplatin. The median overall survival was 14.5 months, with a three-year survival rate of 23.7 per cent.Conclusions:The prognosis of extrapulmonary small cell carcinoma is generally poor. Further prospective multicentre studies are required for better understanding of disease entities and response to treatment modalities.

Neuroendocrine Carcinomas of the Upper Airways: A Small Case Series with Histopathological Considerations

2007 ◽  
Vol 93 (5) ◽  
pp. 499-503 ◽  
Author(s):  
Marco Capelli ◽  
Giulia Bertino ◽  
Patrizia Morbini ◽  
Chiara Villa ◽  
Stefano Zorzi ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Head And Neck ◽  
Small Cell Carcinoma ◽  
Radical Surgery ◽  
Neck Region ◽  
Small Cell ◽  
Upper Airways ◽  
Head And Neck Region ◽  
Poorly Differentiated ◽  
Neuroendocrine Carcinomas

Neuroendocrine carcinomas are rare tumors. In the head and neck region they are most common in the larynx, where they represent 0.5-1% of epithelial cancers. Diagnosis requires the recognition of the typical neuroendocrine architecture and morphology and the immunohistochemical confirmation of neuroendocrine differentiation. In the 1991 WHO classification laryngeal neuroendocrine carcinomas have been divided into carcinoids, atypical carcinoids, small cell carcinomas and paragangliomas. Atypical carcinoids in the head and neck region usually show an aggressive behavior analogous to poorly differentiated carcinomas, and are resistant to chemo- and radiotherapy. For this reason, it was recently proposed to change their designation to “moderately differentiated neuroendocrine carcinomas”. We present the clinical and histopathological features of 2 moderately differentiated neuroendocrine carcinomas of the larynx, one large cell poorly differentiated neuroendocrine carcinoma of the oropharynx, and one small cell carcinoma of the minor salivary glands of the tongue. The patient with small cell carcinoma was free from disease 26 months after radical surgery, while the other patients showed liver, lung and bone metastases 18, 26 and 24 months after the diagnosis despite radical surgery or concomitant intra-arterial chemotherapy and radiotherapy.

Hypopharyngeal Squamous Cell Carcinoma and Laryngeal Neuroendocrine Carcinoma Colliding in the Aryepiglottic Fold: A Case Report

2017 ◽  
Vol 103 (1_suppl) ◽  
pp. S1-S4 ◽  
Author(s):  
Roberta Marangoni ◽  
Simone Mauramati ◽  
Giulia Bertino ◽  
Antonio Occhini ◽  
Marco Benazzo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Neuroendocrine Carcinoma ◽  
Squamous Cell ◽  
Neck Region ◽  
Collision Tumor ◽  
Small Cell ◽  
Head And Neck Region

Purpose A collision tumor consists of 2 different histologically distinct and topographically independent tumors merging in the same mass. In the head and neck region they are rare, with only 4 cases reported in the larynx. Case report A 60-year-old heavy smoker complained of a left submandibular lesion in October 2014. The lesion was excised and showed a poorly differentiated carcinoma, suggestive for adenocarcinoma. After a positron emission tomography-computed tomography scan showed increased metabolic activity in the left laterocervical region and right vocal cord, the patient underwent endoscopic biopsy of the lesion of the left piriform sinus, which was positive for moderately differentiated squamous cell carcinoma (SCC). He was then submitted to circular pharyngolaryngectomy, reconstruction with a radial forearm free flap, and bilateral neck dissection. The histopathologic examination showed an in situ and microinvasive SCC of the left pyriform sinus colliding with a high-grade, non-small-cell neuroendocrine carcinoma of the larynx. Conclusions To our knowledge, this is the first case described of laryngeal collision tumor comprising a neuroendocrine component. The choice of treatment of this kind of lesion is difficult because of the presence of 2 different histologies and of the controversial prognostic correlation of non-small-cell neuroendocrine neoplasms of the head and neck region.

Small Cell Carcinoma in the Head and Neck

2019 ◽  
Vol 128 (11) ◽  
pp. 1006-1012 ◽  
Author(s):  
Takahiro Wakasaki ◽  
Ryuji Yasumatsu ◽  
Muneyuki Masuda ◽  
Mioko Matsuo ◽  
Akihiro Tamae ◽  
...  
Keyword(s):  
Head And Neck ◽  
Distant Metastasis ◽  
Radical Surgery ◽  
Survival Rates ◽  
Observation Time ◽  
Small Cell ◽  
Response To Treatment ◽  
Treatment Modalities ◽  
Disease Entities ◽  
Stage Ivb

Objectives: Small cell carcinomas in extrapulmonary sites (ESmCCs) are very rare. ESmCCs originating in the head and neck account for approximately 10% of all ESmCCs, and there are few reports about this disease. ESmCCs have an aggressive natural history characterized by widespread metastasis. The aim of this study was to investigate the characteristics and outcomes of patients with ESmCCs of the head and neck. Methods: The outcomes of 21 patients with ESmCCs of the head and neck treated between January 2001 and December 2015 at the authors’ hospital and associated facilities were reviewed. Results: There were 18 men and 3 women, and the median age was 74 years (range, 53-91 years). The tumor site was the larynx in 6 patients; the paranasal sinus in 5; the hypopharynx in 3; the oropharynx in 2; the nasopharynx in 2; and the oral cavity, salivary gland, and primary unknown in 1 patient each. The extent of the disease was staged as follows: stage I or II, 3 cases; stage III, 4 cases; stage IVA, 9 cases; stage IVB, 1 case; and stage IVC, 4 cases. The median observation time was 17 months (range, 1-103 months). Four patients (19%) had distant metastasis at initial treatment, and 13 patients (62%) developed distant metastasis within 3 years. Treatments were administered, including radical surgery (9 patients), radiation therapy (5 patients), chemoradiotherapy (7 patients), and chemotherapy (6 patients). The 1- and 3-year overall survival rates of patients were 56% and 37%, respectively. More than half of the patients died of distant metastasis. Conclusions: ESmCCs of the head and neck have a poor prognosis, similar to those of carcinomas in many other sites. Control of distant metastasis would contribute to improving the prognosis of ESmCCs of the head and neck. Further studies are required for better understanding these disease entities and their response to treatment modalities.

scholarly journals Optimal Postoperative Treatment for Composite Laryngeal Small Cell Carcinoma

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Koji Ebisumoto ◽  
Akihiro Sakai ◽  
Kenji Okami ◽  
Ryousuke Sugimoto ◽  
Kosuke Saito ◽  
...  
Keyword(s):  
Adjuvant Chemotherapy ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Treatment Strategies ◽  
Neck Region ◽  
Small Cell ◽  
Postoperative Treatment ◽  
Pathological Examination ◽  
Tumor Biopsy ◽  
Head And Neck Region

Small cell carcinoma (SmCC) most commonly occurs in the lung and rarely arises from the head and neck region. Further, composite SmCC is extremely rare. Therefore, no postoperative treatment strategy has been established. We report a 59-year-old male patient referred to our outpatient clinic for further examination and treatment of a laryngeal tumor. Biopsy from the tumor revealed squamous cell carcinoma (SCC). The preoperative diagnosis was supraglottic SCC (T3N2bM0), and total laryngectomy and bilateral neck dissection were performed. Pathological examination revealed 2 individual cancer components: SmCC and SCC. Postoperative chemoradiotherapy (2 courses of cisplatin (CDDP) and etoposide (VP-16)) was indicated. Following the postoperative chemoradiotherapy, 2 courses of adjuvant chemotherapy were administered. The patient is currently alive with no evidence of disease at 36 months following the completion of therapy. Postoperative chemoradiotherapy and adjuvant chemotherapy are optimal treatment strategies for laryngeal composite SmCC.

scholarly journals Vulvar Merkel Cell Carcinoma: A Rare Entity

2011 ◽  
Vol 3 (3) ◽  
pp. 145-146
Author(s):  
Monica Soni ◽  
Sudesh Aggarwal ◽  
Prasoon Soni ◽  
Puja Gupta ◽  
Shaifali Dadhich ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Neck Region ◽  
Small Cell ◽  
Rare Entity ◽  
Merkel Cell ◽  
Head And Neck Region ◽  
Vulvar Tumor ◽  
Trabecular Carcinoma

ABSTRACT Merkel cell carcinoma is a primary small cell carcinoma of the skin that resembles oat cell carcinomas of the lung. This tumor has a predilection for head and neck region but may rarely occur as isolated vulvar tumor. It has aggressive malignant behavior and should not be missed while evaluating vulvar masses. We report a case of 45-year-old Mrs I, who presented with recurrent vulvar swelling and was diagnosed as stage III Merkel cell carcinoma of the vulva. Synonyms Primary neuroendocrine carcinoma, Trabecular carcinoma, Primary small cell carcinoma, Cutaneous apudoma.

scholarly journals Case of metastatic small cell carcinoma of the oropharynx successfully treated with image-guided volumetric modulated arc therapy (IG-VMAT): pushing the limits of technology to match treatment intent

2018 ◽  
Vol 11 (1) ◽  
pp. bcr-2018-226522
Author(s):  
Irfan Ahmad ◽  
Pavel Singh ◽  
Chandi Prasad Bhatt ◽  
Irfan Bashir
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Volumetric Modulated Arc Therapy ◽  
Neck Region ◽  
Complete Response ◽  
Final Diagnosis ◽  
Small Cell ◽  
Response To Treatment ◽  
Curative Intent ◽  
Aggressive Approach

Extrapulmonary small cell carcinomas (EPSCC) are a rare subtype of neuroendocrine tumours which have been documented to arise from a multitude of sites and treatment outcomes are disappointing. The most common site involved in the head and neck region is the larynx and the oropharynx as a primary site has been infrequently reported. The patient presented with bilateral neck swelling and an ulcerated lesion was noted in the base of tongue (BOT). A biopsy revealed small cell carcinoma (SCC) and was confirmed with immunohistochemistry. The final diagnosis after workup was SCC of BOT stage IVc. He received induction chemotherapy to which the tumour responded partially, followed by curative intent chemoradiotherapy and adjuvant chemotherapy. The patient achieved a radiological complete response to treatment and almost all treatment-induced toxicities resolved. An aggressive approach to managing EPSCC is possible with modern radiotherapy techniques, with tolerable treatment-induced toxicities.

scholarly journals Melioidosis of the Head and Neck: A Case Series from Eastern India

2020 ◽  
Vol 12 (3) ◽  
pp. 36-45
Author(s):  
Srujana Mohanty ◽  
Saurav Sarkar ◽  
Baijayantimala Mishra
Keyword(s):  
Head And Neck ◽  
Burkholderia Pseudomallei ◽  
Case Series ◽  
Neck Region ◽  
Treatment Modalities ◽  
Eastern India ◽  
Fatal Disease ◽  
Head And Neck Region ◽  
Disease Prognosis ◽  
Disease Entities

Melioidosis is an emerging entity in India. Though it is a potentially fatal disease, prognosis is excellent with early detection and appropriate management, especially of localized infections like abscesses of the head and neck area. We report nine cases of focal abscesses in the head and neck region due to Burkholderia pseudomallei, the causative agent of melioidosis, presenting to our hospital within a span of two-and-half years. Since melioidotic abscesses in the cervicofacial and head and neck region are likely to be confused with cold abscesses caused by Mycobacterium tuberculosis in a tuberculosis-endemic country like India, increased vigilance is necessary because of the widely divergent treatment modalities of the two disease entities.

scholarly journals Extrapulmonary small cell carcinoma: Current status and strategy

2017 ◽  
Vol 5 (4) ◽  
pp. 1-5
Author(s):  
B P Rouniyar ◽  
K R Devkota
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Treatment Modality ◽  
Standard Treatment ◽  
Small Cell ◽  
Current Status ◽  
Treatment Modalities ◽  
Current Management Strategy ◽  
Extrapulmonary Small Cell Carcinoma ◽  
Almost All

Extrapulmonary small cell carcinoma is very rare. Its prognosis is poor and there is no established treatment modality. It has been considered as a distinct clinicopathological entity. It is distinct from small cell carcinoma of the lung, though it shares similar clinicopathologic features to the latter. It has a similar staging and treatment modality. The aim is to review existing studies and provide new results on diagnosis and current management strategy for patients with extrapulmonary small cell carcinoma. The study involves the review of the literature using the electronic database MEDLINE and hand searching of journals. The outcome measures are addressed and analyzed. Studies have shown wide variations of treatment modalities adopted and the outcome observed. Almost all studies are of inadequate power to establish standard treatment modality. Multi-centre studies are required to institutionalize standard treatment modality.

Mucosal Adenoid Squamous Cell Carcinoma of the Head and Neck

1996 ◽  
Vol 105 (5) ◽  
pp. 409-413 ◽  
Author(s):  
Alfio Ferlito ◽  
Kenneth O. Devaney ◽  
Christopher M. Milroy ◽  
Alessandra Rinaldo ◽  
Antonino Carbone
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Adenosquamous Carcinoma ◽  
Neck Region ◽  
Metastatic Adenocarcinoma ◽  
Head And Neck Region ◽  
Adenoid Cystic ◽  
Basaloid Squamous

Adenoid squamous cell carcinoma is an uncommon variant of squamous cell carcinoma. The lesion is histologically distinctive and it is usually localized on the skin of the head and neck region; it only rarely involves the mucosal sites. The differential diagnoses include adenosquamous carcinoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, basaloid squamous cell carcinoma, and metastatic adenocarcinoma. Surgery is the treatment of choice. The biologic behavior of this neoplasm is more aggressive when it involves mucosal areas, and the prognosis seems worse than that of conventional squamous cell carcinoma.

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