scholarly journals Stressful life events moderate the effect of neural reward responsiveness in childhood on depressive symptoms in adolescence

2019 ◽  
Vol 50 (9) ◽  
pp. 1548-1555 ◽  
Author(s):  
Brandon L. Goldstein ◽  
Ellen M. Kessel ◽  
Autumn Kujawa ◽  
Megan C. Finsaas ◽  
Joanne Davila ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Life Events ◽  
Stressful Life Events ◽  
Community Sample ◽  
Reward Processing ◽  
Event Related Potential ◽  
Self Report ◽  
Stressful Life ◽  
Depression Symptoms

AbstractBackgroundReward processing deficits have been implicated in the etiology of depression. A blunted reward positivity (RewP), an event-related potential elicited by feedback to monetary gain relative to loss, predicts new onsets and increases in depression symptoms. Etiological models of depression also highlight stressful life events. However, no studies have examined whether stressful life events moderate the effect of the RewP on subsequent depression symptoms. We examined this question during the key developmental transition from childhood to adolescence.MethodsA community sample of 369 children (mean age of 9) completed a self-report measure of depression symptoms. The RewP to winning v. losing was elicited using a monetary reward task. Three years later, we assessed stressful life events occurring in the year prior to the follow-up. Youth depressive symptoms were rated by the children and their parents at baseline and follow-up.ResultsStressful life events moderated the effect of the RewP on depression symptoms at follow-up such that a blunted RewP predicted higher depression symptoms in individuals with higher levels of stressful life events. This effect was also evident when events that were independent of the youth's behavior were examined separately.ConclusionsThese results suggest that the RewP reflects a vulnerability for depression that is activated by stress.

Comparability of Self-Report Checklist and Interview Data in the Assessment of Stressful Life Events in Young Adults

2003 ◽  
Vol 93 (2) ◽  
pp. 459-471 ◽  
Author(s):  
Peter M. Lewinsohn ◽  
Paul Rohde ◽  
Jeffrey M. Gau
Keyword(s):  
Young Adults ◽  
Life Events ◽  
Adolescent Depression ◽  
Stressful Life Events ◽  
Self Report ◽  
Stressful Life ◽  
Depression Symptoms ◽  
Inclusion Criteria ◽  
Incremental Value ◽  
Stress Interview

The purpose of this study was to evaluate the incremental value of conducting an interview to assess stressful life events over the self-report questionnaire approach, first by examining the degree to which life events reported on a questionnaire met inclusion criteria in a detailed stress interview, and second, by comparing the magnitude of prospective associations with depression symptoms for the two different assessment procedures. Data from the Oregon Adolescent Depression Project were examined, in which 191 community-residing young adults (55% female; M age = 23.6, SD = 0.6) completed a mailed questionnaire assessing the frequency with which 33 life events had occurred to them or to other important people in their lives prior to the diagnostic and stress interviews. An average of 67.5% of events occurring to self met criteria for classification as a life event on the stress interview, as did 19.7% of the events occurring to others. Events having a large effect on the participant had a greater likelihood of meeting inclusion criteria on the stress interview. Contrary to expectation, stress scores from the interview assessment did not result in stronger associations with depression. Recommendations for assessment of stressful life events are offered.

Neuroticism, social network, stressful life events: Association with mood disorders, depressive symptoms and suicidal ideation in a community sample of women

2015 ◽  
Vol 226 (1) ◽  
pp. 38-44 ◽  
Author(s):  
Laura Mandelli ◽  
Finiki A. Nearchou ◽  
Chrysostomos Vaiopoulos ◽  
Costas N. Stefanis ◽  
Silia Vitoratou ◽  
...  
Keyword(s):  
Social Network ◽  
Depressive Symptoms ◽  
Suicidal Ideation ◽  
Mood Disorders ◽  
Life Events ◽  
Stressful Life Events ◽  
Community Sample ◽  
Stressful Life

Aggression, depression, and stressful life events predicting peer rejection in children

1995 ◽  
Vol 7 (4) ◽  
pp. 845-856 ◽  
Author(s):  
Stephanie A. Little ◽  
Judy Garber
Keyword(s):  
Depressive Symptoms ◽  
Life Events ◽  
Life Stress ◽  
Stressful Life Events ◽  
Peer Rejection ◽  
Sixth Grade ◽  
Self Report ◽  
Stressful Life ◽  
Future Research ◽  
Peer Nominations

AbstractThis short-term prospective study examined the contribution of aggression and depression, stressful life events, and their interactions to the prediction of peer rejection. Subjects were 497 fifth- and sixth-grade children who completed questionnaires at two time points separated by approximately 3 months. Levels of peer rejection and aggression were assessed by peer nominations; level of depressive symptoms and number of stressful life events were measured by self-report questionnaires. Controlling for sex and baseline level of peer rejection, aggression directly predicted peer rejection. In contrast, depressive symptoms interacted with life stress to predict peer rejection. Examination of the Depression × Stress interaction revealed that depressive symptoms in children who had experienced high levels of life stress were not associated with increased levels of peer rejection, whereas depressive symptoms in children with low levels of stress were predictive of subsequent peer rejection. Several interpretations of these findings and directions for future research are suggested.

Stressful life events and depressive symptoms among adolescents in Malaysia: the mediating role of maladaptive cognitive schema

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Yi Shan Wong ◽  
Nor Sheereen Zulkefly ◽  
Kit-Aun Tan
Keyword(s):  
Depressive Symptoms ◽  
Life Events ◽  
Stressful Life Events ◽  
Negative Life Events ◽  
Daily Hassles ◽  
Self Report ◽  
Mediation Effect ◽  
Stressful Life ◽  
Cognitive Schema

AbstractObjectivesThe present study aimed to examine the mediational role of maladaptive cognitive schema in the association between stressful life events, which are operationalised as major (i. e. negative life events) and minor (i. e. daily hassles) life stressors, and depressive symptoms among adolescents.MethodsA cross-sectional correlational study was conducted to recruit participants across four selected states of Kedah, Kelantan, Melaka and Selangor in Peninsular Malaysia. This study involved a total of 1,032 adolescents from 25 government secondary schools, identified using probability proportional to size cluster sampling technique. Data were collected through a self-report questionnaire.ResultsUsing structural equation modelling analyses, findings revealed a full mediation effect of maladaptive cognitive schema between negative life events and depressive symptoms, and a partial mediation effect between daily hassles and depressive symptoms.ConclusionsThis study provided valuable insights about the significance of maladaptive cognitive schema as a mediator in the stress-depression association and advanced the understanding of mechanism underlying development of depressive symptoms among adolescents in Malaysia. Findings also benefit the clinical practice in the development of targeted depression prevention and intervention programs.

Neuroticism and reward-related ventral striatum activity: Probing vulnerability to stress-related depression

2020 ◽  
Author(s):  
Erin Bondy ◽  
David A Baranger ◽  
Jared V. Balbona ◽  
Kendall Sputo ◽  
Sarah Emily Paul ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Life Events ◽  
Ventral Striatum ◽  
Stressful Life Events ◽  
Neural Mechanism ◽  
Reward Processing ◽  
Stressful Life ◽  
Significant Depression ◽  
Vulnerability To Stress ◽  
Reported Data

Background: Elevated neuroticism may confer vulnerability to the depressogenic effects of stressful life events (SLEs). Vulnerability to stress-related disruption of neural reward processing is a promising neural mechanism undergirding links between stress and depression. Methods: Data came from 2 studies: the St. Louis Personality and Aging Network (SPAN) study and the Duke Neurogenetics Study (DNS). In SPAN, we used longitudinal self-reported data from older adults (n=971) to examine whether neuroticism moderates the association between recent stressful life events and subsequent depressive symptoms. In the DNS, we tested whether this interaction is present among young adult college students (n=1,343), and further whether neuroticism moderates the association between SLEs and reward-related ventral striatum activation as measured using functional magnetic resonance imaging (n=1,195).Results: In SPAN, SLEs prospectively predicted future depressive symptoms, especially among those reporting elevated N, even after accounting for prior depressive symptoms and previous SLE exposure (NxSLE interaction: p=0.016, ΔR2=0.003). In Study 2, we replicated this effect (NxSLE interaction: p=0.019, ΔR2=0.003). Further, neuroticism moderated the association between SLEs and reward-related left VS activity such that individuals with high neuroticism who were also exposed to more SLEs had blunted reward-related left VS activation (NxSLE: p=0.017, ΔR2=0.0048) which was associated with a lifetime depression diagnosis (r=-0.07, p=0.02), but not current depressive symptoms (r=-0.003, p=0.93).Conclusions: These data suggest that neuroticism may promote vulnerability to stress-related depression, and that sensitivity to stress-related VS dysfunction may be a potential neural mechanism underlying vulnerability to stress-related clinically significant depression.

Self-Criticism, Maladaptive Perfectionism, and Depression Symptoms in a Community Sample: A Longitudinal Test of the Mediating Effects of Person-Dependent Stressful Life Events

2009 ◽  
Vol 23 (4) ◽  
pp. 336-349 ◽  
Author(s):  
Brian J. Cox ◽  
Ian P. Clara ◽  
Murray W. Enns
Keyword(s):  
Life Events ◽  
Stressful Life Events ◽  
Longitudinal Research ◽  
Community Sample ◽  
Stressful Life ◽  
Depression Symptoms ◽  
Mediation Model ◽  
Socially Prescribed Perfectionism ◽  
Maladaptive Perfectionism ◽  
The Relationship

Both self-criticism and maladaptive dimensions of perfectionism have been associated with depression symptoms, based on cross-sectional and some longitudinal research with selective clinical and student samples. The present study evaluated a mediation model involving self-criticism, maladaptive dimensions of perfectionism, and depression-related symptoms at baseline (Time 1), and person-dependent stressful life events and depression-related symptoms 12 months later (Time 2), in a more representative noninstitutionalized sample. Participants included 723 community-based adults in an urban area. A proposed mediation model based on recent theoretical writings was evaluated, whereby the effects of self-criticism and maladaptive perfectionism on subsequent depression symptoms were hypothesized to be mediated by person-dependent stressful life events. In female respondents, the relationship between self-criticism and Time 2 depression was not mediated by person-dependent stressful life events and the relationship between socially prescribed perfectionism and Time 2 depression was fully mediated by person-dependent life events. In male respondents, self-criticism showed evidence of partial mediation while doubts about actions and socially prescribed perfectionism did not have significant main effects on Time 2 depression. Clinical and research implications of this important cognitive diathesis domain in association with person-dependent stressful life events and subsequent depression are discussed.

Suicidal ideation in elderly Korean population: a two-year longitudinal study

2013 ◽  
Vol 26 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Hee-Ju Kang ◽  
Robert Stewart ◽  
Bo-Ok Jeong ◽  
Seon-Young Kim ◽  
Kyung-Yeol Bae ◽  
...  
Keyword(s):  
Social Support ◽  
Depressive Symptoms ◽  
Suicidal Ideation ◽  
Life Events ◽  
Severe Pain ◽  
Stressful Life Events ◽  
Stressful Life ◽  
Elderly Subjects ◽  
Monthly Income

ABSTRACTBackground:This study aimed to assess the prevalence, incidence, and persistence of suicidal ideation (SI), and to investigate the psychosocial factors associated with these.Methods:A total of 1,204 community dwelling elderly adults aged 65 years or older were evaluated at baseline, 909 (75%) of whom were followed two years later. The presence of SI was identified using the questions from the community version of the Geriatric Mental State (GMS) diagnostic schedule (GMS B3) at both baseline and follow-up interviews. Baseline measures included demographic status, years of education, rural/urban residence, accommodation, past and current occupation, monthly income, marital status, stressful life events, social support deficits, number of physical illnesses, severity of pain, physical activity, disability, depressive symptoms, anxiety, insomnia, cognitive function, alcohol consumption, and smoking.Results:Baseline SI prevalence, follow-up incidence (SI rate at follow-up of 805 elderly subjects who did not have SI at baseline), and persistence (SI rate at follow-up of 104 elderly subjects who had SI at baseline) were 11.5%, 9.6%, and 36.5%, respectively. Baseline SI was independently associated with no current employment, lower monthly income, stressful life events, more severe pain, presence of disability, depressive symptoms, and smoking. Incident SI was independently predicted by baseline unmarried status, social support deficit, severe pain, presence of depressive symptoms, and smoking. Persistent SI was independently predicted by baseline stressful life events and depressive symptoms.Conclusions:Depressive symptoms were independently associated with prevalent, incident, and persistent SI, but other predictors varied according to incidence and persistence outcomes.

scholarly journals Factors associated with the onset of major depressive disorder in adults with type 2 diabetes living in 12 different countries: results from the INTERPRET-DD prospective study

2020 ◽  
Vol 29 ◽  
Author(s):  
C. E. Lloyd ◽  
N. Sartorius ◽  
H. U. Ahmed ◽  
A. Alvarez ◽  
S. Bahendeka ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Major Depressive Disorder ◽  
Depressive Symptoms ◽  
Depressive Disorder ◽  
Life Events ◽  
Stressful Life Events ◽  
Regression Analyses ◽  
Major Depressive

Abstract Aims To examine the factors that are associated with changes in depression in people with type 2 diabetes living in 12 different countries. Methods People with type 2 diabetes treated in out-patient settings aged 18–65 years underwent a psychiatric assessment to diagnose major depressive disorder (MDD) at baseline and follow-up. At both time points, participants completed the Patient Health Questionnaire (PHQ-9), the WHO five-item Well-being scale (WHO-5) and the Problem Areas in Diabetes (PAID) scale which measures diabetes-related distress. A composite stress score (CSS) (the occurrence of stressful life events and their reported degree of ‘upset’) between baseline and follow-up was calculated. Demographic data and medical record information were collected. Separate regression analyses were conducted with MDD and PHQ-9 scores as the dependent variables. Results In total, there were 7.4% (120) incident cases of MDD with 81.5% (1317) continuing to remain free of a diagnosis of MDD. Univariate analyses demonstrated that those with MDD were more likely to be female, less likely to be physically active, more likely to have diabetes complications at baseline and have higher CSS. Mean scores for the WHO-5, PAID and PHQ-9 were poorer in those with incident MDD compared with those who had never had a diagnosis of MDD. Regression analyses demonstrated that higher PHQ-9, lower WHO-5 scores and greater CSS were significant predictors of incident MDD. Significant predictors of PHQ-9 were baseline PHQ-9 score, WHO-5, PAID and CSS. Conclusion This study demonstrates the importance of psychosocial factors in addition to physiological variables in the development of depressive symptoms and incident MDD in people with type 2 diabetes. Stressful life events, depressive symptoms and diabetes-related distress all play a significant role which has implications for practice. A more holistic approach to care, which recognises the interplay of these psychosocial factors, may help to mitigate their impact on diabetes self-management as well as MDD, thus early screening and treatment for symptoms is recommended.

scholarly journals Stressful life events are not associated with the development of dementia

2013 ◽  
Vol 26 (1) ◽  
pp. 147-154 ◽  
Author(s):  
Anna Sundström ◽  
Michael Rönnlund ◽  
Rolf Adolfsson ◽  
Lars-Göran Nilsson
Keyword(s):  
Life Events ◽  
Stressful Life Events ◽  
Negative Life Events ◽  
Emotional Adjustment ◽  
Population Based ◽  
Stressful Life ◽  
Emotional Impact ◽  
Population Based Study ◽  
Positive Life Events

ABSTRACTBackground:The impact of stressful life events as a risk factor of dementia diseases is inconclusive. We sought to determine whether stressful negative life events are associated with incidental dementia in a population-based study with long-term follow-up. We also tested the hypothesis that the occurrence of positive life events could mitigate or overcome the possible adverse effects of negative life events on dementia conversion.Methods:The study involved 2,462 dementia-free participants aged 55 years and older. Information on life events was ascertained at baseline from a comprehensive Life Event Inventory, which included 56 questions about specific life events. For each life event, the emotional impact (both positive and negative) and emotional adjustment were asked for.Results:During follow-up, 423 participants developed dementia; of these, 240 developed Alzheimer's disease (AD). Cox regression analysis showed no association between the total number of negative life events and the incidence of dementia when adjusted solely for age and gender (hazard ratio = 0.97, 95% CI = 0.92–1.02), or with multiple adjustments for a range of covariates (hazard ratio = 0.96, 95% CI = 0.91–1.01). Similarly, neither emotional impact nor emotional adjustment to these life events was associated with incident dementia. A separate analysis of AD did not alter the results.Conclusions:The result of this population-based study finds no association between negative or positive life events and dementia. Accordingly, our results reject the hypothesis that stressful life events trigger the onset of dementia diseases.

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