scholarly journals Parental brain and socioeconomic epigenetic effects in human development

2012 ◽  
Vol 35 (5) ◽  
pp. 378-379 ◽  
Author(s):  
James E. Swain ◽  
Suzanne C. Perkins ◽  
Carolyn J. Dayton ◽  
Eric D. Finegood ◽  
S. Shaun Ho
Keyword(s):  
Evolutionary Biology ◽  
Social Cognitive ◽  
Behavioral Genetics ◽  
Brain Areas ◽  
Brain Physiology ◽  
Epigenetic Effects ◽  
Maternal Brain ◽  
Brain Structure And Function ◽  
And Function ◽  
Parental Brain

AbstractCritically significant parental effects in behavioral genetics may be partly understood as a consequence of maternal brain structure and function of caregiving systems recently studied in humans as well as rodents. Key parental brain areas regulate emotions, motivation/reward, and decision making, as well as more complex social-cognitive circuits. Additional key environmental factors must include socioeconomic status and paternal brain physiology. These have implications for developmental and evolutionary biology as well as public policy.

scholarly journals Prenatal Origins of Neurological Development

2011 ◽  
Vol 20 (6) ◽  
pp. 384-389 ◽  
Author(s):  
Laura M. Glynn ◽  
Curt A. Sandman
Keyword(s):  
Brain Structure ◽  
Physiological Stress ◽  
Postnatal Period ◽  
Parent Child Relationship ◽  
Child Relationship ◽  
Maternal Brain ◽  
Brain Structure And Function ◽  
The Central Nervous System ◽  
And Function ◽  
Reciprocal Influences

A rapidly accumulating literature indicates that the prenatal period must be taken into account if we are to understand development of the central nervous system (CNS) across the life span. Evidence now suggests that intrauterine signals influence brain structure and affect cognitive function and emotional and physiological stress regulation in the offspring. Furthermore, prenatal hormone exposures are critical for priming the maternal brain for the challenges of motherhood and have implications for the mother’s brain structure and function that may last the rest of her lifetime. Just as the reciprocal nature of the parent–child relationship must be understood during the postnatal period, in order to understand the persisting influences of the intrauterine environment on neurodevelopment, the effects of the prenatal environment on both fetus and mother, as well as their reciprocal influences, must be appreciated. This is critical because the same hormones that program fetal development are those that shape the maternal brain and because prenatal bidirectional signaling may provide an adaptive function for both mother and fetus.

scholarly journals The Application of Connectome-Based Predictive Modeling to the Maternal Brain: Implications for Mother–Infant Bonding

2019 ◽  
Vol 30 (3) ◽  
pp. 1538-1547
Author(s):  
Helena J V Rutherford ◽  
Marc N Potenza ◽  
Linda C Mayes ◽  
Dustin Scheinost
Keyword(s):  
Predictive Modeling ◽  
Network Connectivity ◽  
Maternal Anxiety ◽  
Maternal Bonding ◽  
Early Postpartum ◽  
Pregnancy And Postpartum ◽  
Maternal Brain ◽  
Brain Structure And Function ◽  
And Function ◽  
Brain Functional Connectivity

Abstract Maternal bonding early postpartum lays an important foundation for child development. Changing brain structure and function during pregnancy and postpartum may underscore maternal bonding. We employed connectome-based predictive modeling (CPM) to measure brain functional connectivity and predict self-reported maternal bonding in mothers at 2 and 8 months postpartum. At 2 months, CPM predicted maternal anxiety in the bonding relationship: Greater integration between cerebellar and motor–sensory–auditory networks and between frontoparietal and motor–sensory–auditory networks were associated with more maternal anxiety toward their infant. Furthermore, greater segregation between the cerebellar and frontoparietal, and within the motor-sensory-auditory networks, was associated with more maternal anxiety regarding their infant. We did not observe CPM prediction of maternal bonding impairments or rejection/anger toward the infant. Finally, considering 2 and 8 months of data, changes in network connectivity were associated with changes in maternal anxiety in the bonding relationship. Our results suggest that changing connectivity among maternal brain networks may provide insight into the mother–infant bond, specifically in the context of anxiety and the representation of the infant in the mother’s mind. These findings provide an opportunity to mechanistically investigate approaches to enhance the connectivity of these networks to optimize the representational and behavioral quality of the caregiving relationship.

scholarly journals Mapping brain recovery after concussion

Neurology ◽  
2019 ◽  
Vol 93 (21) ◽  
pp. e1980-e1992 ◽  
Author(s):  
Nathan W. Churchill ◽  
Michael G. Hutchison ◽  
Simon J. Graham ◽  
Tom A. Schweizer
Keyword(s):  
Symptom Severity ◽  
Mean Diffusivity ◽  
Return To Play ◽  
Long Term Effects ◽  
Brain Physiology ◽  
Acute Symptom ◽  
Medical Clearance ◽  
Brain Recovery ◽  
Brain Structure And Function ◽  
And Function

ObjectiveTo test the hypothesis that concussion-related brain alterations seen at symptomatic injury and medical clearance to return to play (RTP) will have dissipated by 1 year after RTP.MethodsFor this observational study, 24 athletes with concussion were scanned longitudinally within 1 week after injury, at RTP, and 1 year after RTP. A large control cohort of 122 athletes were also scanned before the season. Each imaging session assessed global functional connectivity (Gconn) and cerebral blood flow (CBF), along with white matter fractional anisotropy (FA) and mean diffusivity (MD). The main effects of concussion on MRI parameters were evaluated at each postinjury time point. In addition, covariation was assessed between MRI parameters and clinical measures of acute symptom severity and time to RTP.ResultsDifferent aspects of brain physiology showed different patterns of recovery over time. Both Gconn and FA displayed no significant effects at 1 year after RTP, whereas CBF and MD exhibited persistent long-term effects. The effects of concussion on MRI parameters were also dependent on acute symptom severity and time to RTP for all postinjury time points.ConclusionThis study provides the first longitudinal evaluation of concussion focused on time of RTP and 1 year after medical clearance, using multiple different MRI measures to assess brain structure and function. These findings significantly enhance our understanding of the natural course of brain recovery after a concussion.

The ENIGMA Brain Injury Working Group: Approach, Challenges, and Potential Benefits

2019 ◽  
Author(s):  
Elisabeth A. Wilde ◽  
Emily L. Dennis ◽  
David F Tate
Keyword(s):  
Brain Injury ◽  
Working Group ◽  
Meta Analysis ◽  
Special Issue ◽  
Group Approach ◽  
Challenges And Opportunities ◽  
Brain Structure And Function ◽  
Potential Benefits ◽  
And Function ◽  
Neuroimaging Genetics

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium brings together researchers from around the world to try to identify the genetic underpinnings of brain structure and function, along with robust, generalizable effects of neurological and psychiatric disorders. The recently-formed ENIGMA Brain Injury working group includes 8 subgroups, based largely on injury mechanism and patient population. This introduction to the special issue summarizes the history, organization, and objectives of ENIGMA Brain Injury, and includes a discussion of strategies, challenges, opportunities and goals common across 6 of the subgroups under the umbrella of ENIGMA Brain Injury. The following articles in this special issue, including 6 articles from different subgroups, will detail the challenges and opportunities specific to each subgroup.

Effects Of Exercise-induced Hypohydration On Brain Structure And Function, A MRI Study

2017 ◽  
Vol 49 (5S) ◽  
pp. 824 ◽  
Author(s):  
X. r. Tan ◽  
Ivan C. C. Low ◽  
Mary C. Stephenson ◽  
T. Kok ◽  
Heinrich W. Nolte ◽  
...  
Keyword(s):  
Brain Structure ◽  
Structure And Function ◽  
Brain Structure And Function ◽  
Exercise Induced ◽  
Mri Study ◽  
And Function

Effects of low-level sarin and cyclosarin exposure and Gulf War Illness on Brain Structure and Function: A study at 4T

2011 ◽  
Vol 32 (6) ◽  
pp. 814-822 ◽  
Author(s):  
Linda L. Chao ◽  
Linda Abadjian ◽  
Jennifer Hlavin ◽  
Deiter J. Meyerhoff ◽  
Michael W. Weiner
Keyword(s):  
Brain Structure ◽  
Gulf War ◽  
Structure And Function ◽  
Gulf War Illness ◽  
Low Level ◽  
Brain Structure And Function ◽  
And Function

Sex Steroids and Human Behavior: Implications for Developmental Psychopathology

CNS Spectrums ◽  
2001 ◽  
Vol 6 (1) ◽  
pp. 75-88 ◽  
Author(s):  
Gerianne M. Alexander ◽  
Bradley S. Peterson
Keyword(s):  
Sex Differences ◽  
Human Behavior ◽  
Sex Steroids ◽  
Developmental Psychopathology ◽  
Mammalian Species ◽  
Brain Structures ◽  
Postnatal Life ◽  
Brain Structure And Function ◽  
Atypical Development ◽  
And Function

AbstractIn a variety of mammalian species, prenatal androgens organize brain structures and functions that are later activated by steroid hormones in postnatal life. In humans, studies of individuals with typical and atypical development suggest that sex differences in reproductive and nonreproductive behavior derive in part from similar prenatal and postnatal steroid effects on brain development. This paper provides a summary of research investigating hormonal influences on human behavior and describes how sex differences in the prevalences and natural histories of developmental psychopathologies may be consistent with these steroid effects. An association between patterns of sexual differentiation and specific forms of psychopathology suggests novel avenues for assessing the effects of sex steroids on brain structure and function, which may in turn improve our understanding of typical and atypical development in women and men.

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