scholarly journals Neurologic Complications of Metronidazole

2013 ◽  
Vol 40 (6) ◽  
pp. 768-776 ◽  
Author(s):  
Justyna R. Sarna ◽  
Sarah Furtado ◽  
A. Keith W. Brownell
Keyword(s):  
Clinical Practice ◽  
Side Effects ◽  
Antimicrobial Agent ◽  
Current Literature ◽  
Neurologic Complications ◽  
Clinical Recovery ◽  
Clinical Syndromes ◽  
Neurotoxic Effects

Metronidazole (Flagyl®) is an antimicrobial agent commonly used in clinical practice. Although it is generally well tolerated with minimal side effects, there are a host of still under-recognized neurologic complications of metronidazole treatment. The following review is aimed at summarizing current literature pertaining to metronidazole-induced neurotoxicity including clinical syndromes, neuroradiological findings, prognosis and proposed pathophysiology. Recognition of the neurotoxic effects of metronidazole is critical as prompt discontinuation is generally associated with full clinical recovery and radiological resolution.

scholarly journals Lithium, an old friend and a forgotten enemy

2020 ◽  
Vol 66 (12) ◽  
pp. 1625-1627
Author(s):  
Cátia Figueiredo ◽  
Joana Lemos
Keyword(s):  
Bipolar Disorder ◽  
Clinical Practice ◽  
Side Effects ◽  
Nephrogenic Diabetes Insipidus ◽  
Urine Osmolality ◽  
Organ Damage ◽  
Daily Basis ◽  
Case Description ◽  
Clinical Recovery ◽  
The Past

SUMMARY INTRODUCTION: Nephrogenic diabetes insipidus (DI) is a polyuric and polydipsic syndrome and can have multiple causing factors. CASE DESCRIPTION: A 69-year-old woman with bipolar disorder medicated with lithium 400mg for 12 years on a daily basis. The patient was admitted, after psychiatric decompensation, with hypernatremia unresponsive to hypotonic iv fluids. The diagnosis of DI was made with high plasmatic osmolality measurement, low urine osmolality, and high levels of antidiuretic hormone. Full clinical recovery was possible with lithium suspension, hydration, and chlorthalidone. DISCUSSION: Although frequently used in the past, Lithium (Li) is nowadays rarely used in clinical practice for prolonged treatments because of its potentially devastating side effects. Clinicians must be aware of those side effects in order to prevent organ damage, mainly in patients with severe bipolar disease and precarious response to alternative treatments.

Recent Advances in the Rational Drug Design Based on Multi-target Ligands

2020 ◽  
Vol 27 (28) ◽  
pp. 4720-4740 ◽  
Author(s):  
Ting Yang ◽  
Xin Sui ◽  
Bing Yu ◽  
Youqing Shen ◽  
Hailin Cong
Keyword(s):  
Drug Resistance ◽  
Clinical Practice ◽  
Side Effects ◽  
Drug Design ◽  
Rational Drug Design ◽  
Health Conditions ◽  
Pharmacokinetic Parameters ◽  
Single Target ◽  
Rational Drug ◽  
Huge Challenge

Multi-target drugs have gained considerable attention in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance. Single-target drugs, although highly selective, may not necessarily have better efficacy or fewer side effects. Therefore, more attention is being paid to developing drugs that work on multiple targets at the same time, but developing such drugs is a huge challenge for medicinal chemists. Each target must have sufficient activity and have sufficiently characterized pharmacokinetic parameters. Multi-target drugs, which have long been known and effectively used in clinical practice, are briefly discussed in the present article. In addition, in this review, we will discuss the possible applications of multi-target ligands to guide the repositioning of prospective drugs.

Development of a brief questionnaire (ICQ-S) to monitor inhaled corticosteroid side-effects in clinical practice

Allergy ◽  
2014 ◽  
Vol 69 (3) ◽  
pp. 372-379 ◽  
Author(s):  
J. M. Foster ◽  
S. Schokker ◽  
R. Sanderman ◽  
D. S. Postma ◽  
T. van der Molen
Keyword(s):  
Clinical Practice ◽  
Side Effects ◽  
Inhaled Corticosteroid

Dermal Discoloration Secondary to Triamcinolone Acetonide Injection Observed in Patients with Autoimmune Disorders

2021 ◽  
Vol 111 (4) ◽  
Author(s):  
James A. Wright ◽  
Jessica A. Wenz ◽  
Gabrielle Jackson Madrigal
Keyword(s):  
Psoriatic Arthritis ◽  
Side Effects ◽  
Autoimmune Disease ◽  
Triamcinolone Acetonide ◽  
Current Literature ◽  
Side Effect ◽  
Inflammatory Conditions ◽  
Rare Side Effect ◽  
History Of ◽  
Synthetic Glucocorticoid

Triamcinolone acetonide is a synthetic glucocorticoid used to treat numerous acute and chronic inflammatory conditions. The various side effects of this drug from parenteral administration are well documented in the literature. In this study, three patients present with a rare side effect of violaceous dermal pigmentation. To the best of the authors' knowledge, this finding is rarely presented in the current literature. The purpose of this study is to provide awareness of a less-documented, delayed side effect from triamcinolone acetonide administration. Although all patients presenting in this study had a known history of autoimmune disease (eg, lupus, psoriatic arthritis) further research is needed to suggest a possible association between dermal violaceous change and the use of triamcinolone.

scholarly journals Comparison of Traditional Versus Evidence-Based Journal Club Formats

2011 ◽  
Vol 2 (1) ◽  
Author(s):  
Kathleen Packard ◽  
Megan Herink ◽  
Thomas L. Lenz
Keyword(s):  
Clinical Practice ◽  
Current Literature ◽  
Clinical Pharmacy ◽  
Journal Club ◽  
Critical Evaluation ◽  
Primary Objective ◽  
Effective Alternative ◽  
Evidence Based ◽  
Study Analysis ◽  
Background Characteristics

Purpose: The objective of the study was to compare a traditionally structured journal club with an evidence based structured journal club during an advanced clinical pharmacy rotation and to determine the best utilization that aligns with recent changes to the pharmacy school accreditation standards. Methods: The study included 21 students who completed journal club utilizing the traditional journal club format and 24 students who utilized an evidence based journal club format. Background characteristics, student reported beliefs, and mean critical evaluation skills scores were evaluated and compared in each group. Results: There were no statistically significant differences between the two cohorts in mean overall percentage grade for the activity. Students in the traditional cohort received significantly higher grades for the Study Analysis and Critique section (90.97 + 12.18 versus 81.25 + 11.18, P=0.01) as well as for the Preparedness section (96.11 + 8.03 versus 85.0 + 17.13, P=0.002). Students in the evidence based cohort received statistically superior grades for the Presentation Skills section (96.43 + 6.39 versus 82.47 + 14.12, P=0.0004). Conclusion: An evidence based journal club is a reasonable and effective alternative to the traditionally structured journal club when the primary objective is to assist students in understanding evidence based concepts and to apply current literature to clinical practice.

scholarly journals Clinical challenges in the management of endocrine side effects of immuno-oncological therapies

2021 ◽  
Author(s):  
Peter Wolf ◽  
Thomas Scherer
Keyword(s):  
Clinical Practice ◽  
Side Effects ◽  
Immune Checkpoint Inhibitor ◽  
Clinical Presentation ◽  
Checkpoint Inhibitor ◽  
Clinical Care ◽  
Short Review ◽  
Current Clinical Practice ◽  
Routine Clinical Care ◽  
Adequate Management

SummaryGiven the growing use of immune checkpoint inhibitor (ICI) therapy in oncology, the prevalence of endocrine side effects is rapidly increasing. As clinicians are nowadays frequently confronted with these side effects in routine clinical care, awareness, better knowledge of endocrine irAEs and their clinical presentation and diagnosis is crucial for an adequate management. In this short-review we give a compact overview of the recent recommendations for the management of endocrine irAE related to ICIs and highlight difficulties and uncertainties in current clinical practice.

scholarly journals Individual Expectation: An Overlooked, but Pertinent, Factor in the Treatment of Individuals Experiencing Musculoskeletal Pain

2010 ◽  
Vol 90 (9) ◽  
pp. 1345-1355 ◽  
Author(s):  
Joel E. Bialosky ◽  
Mark D. Bishop ◽  
Joshua A. Cleland
Keyword(s):  
Clinical Practice ◽  
Clinical Outcomes ◽  
Musculoskeletal Pain ◽  
Current Literature ◽  
Potential Role ◽  
Physical Therapists ◽  
Clinical Perspective ◽  
The Relationship

Physical therapists consider many factors in the treatment of patients with musculoskeletal pain. The current literature suggests expectation is an influential component of clinical outcomes related to musculoskeletal pain for which physical therapists frequently do not account. The purpose of this clinical perspective is to highlight the potential role of expectation in the clinical outcomes associated with the rehabilitation of individuals experiencing musculoskeletal pain. The discussion focuses on the definition and measurement of expectation, the relationship between expectation and outcomes related to musculoskeletal pain conditions, the mechanisms through which expectation may alter musculoskeletal pain conditions, and suggested ways in which clinicians may integrate the current literature regarding expectation into clinical practice.

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