Morphogenesis of a New Human Herpes-Type Virus Isolate (Sasha Virus)

1973 ◽  
Vol 31 ◽  
pp. 592-593
Author(s):  
R. F. Zeigel ◽  
W. Munyon
Keyword(s):  
Virus Isolate ◽  
Calf Serum ◽  
Uranyl Acetate ◽  
Human Herpes ◽  
Human Embryonic Lung ◽  
Human Herpes Virus ◽  
Intracytoplasmic Inclusions ◽  
Hel Cells ◽  
And Control

In continuing studies on the role of viruses in biochemical transformation, Dr. Munyon has succeeded in isolating a highly infectious human herpes virus. Fluids of buccal pustular lesions from Sasha Munyon (10 mo. old) uiere introduced into monolayer sheets of human embryonic lung (HEL) cell cultures propagated in Eagles’ medium containing 5% calf serum. After 18 hours the cells exhibited a dramatic C.P.E. (intranuclear vacuoles, peripheral patching of chromatin, intracytoplasmic inclusions). Control HEL cells failed to reflect similar changes. Infected and control HEL cells were scraped from plastic flasks at 18 hrs. of incubation and centrifuged at 1200 × g for 15 min. Resultant cell packs uiere fixed in Dalton's chrome osmium, and post-fixed in aqueous uranyl acetate. Figure 1 illustrates typical hexagonal herpes-type nucleocapsids within the intranuclear virogenic regions. The nucleocapsids are approximately 100 nm in diameter. Nuclear membrane “translocation” (budding) uias observed.

Role of human herpes virus 6 in multiple sclerosis, neuro-AIDS, brain lymphoma and control brain

1994 ◽  
Vol 54 (1-2) ◽  
pp. 176
Author(s):  
W. Liedtke ◽  
R. Malessa ◽  
P.M. Faustmann ◽  
K. Schwechheimer ◽  
K. Truebner ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Herpes Virus ◽  
Human Herpes ◽  
Brain Lymphoma ◽  
Control Brain ◽  
Human Herpes Virus ◽  
Human Herpes Virus 6 ◽  
Herpès Virus ◽  
And Control

Role of Cytomegalovirus, Epstein-Barr Virus, and Human Herpes Virus-8 in Benign Lymphoepithelial Cysts of the Parotid Gland

2004 ◽  
Vol 114 (8) ◽  
pp. 1500-1505 ◽  
Author(s):  
Thomas L. Yen ◽  
Andrew H. Murr ◽  
Joseph Rabin ◽  
Anand N. Mhatre ◽  
Anil K. Lalwani
Keyword(s):  
Parotid Gland ◽  
Epstein Barr Virus ◽  
Human Herpes ◽  
Human Herpes Virus 8 ◽  
Barr Virus ◽  
Human Herpes Virus ◽  
Lymphoepithelial Cysts ◽  
Epstein Barr ◽  
Herpès Virus

Malignancies in HIV

2019 ◽  
pp. 337-378
Author(s):  
Eva Clark ◽  
Elizabeth Chiao
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Human Herpes ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
Herpès Virus ◽  
The Impact

• Review the epidemiology and role of antiretroviral therapy (ART) on the impact of AIDS-defining malignancies, which remain common among individuals with HIV. • Discuss the role of human herpes virus-8 (HHV-8) in the development of Kaposi’s sarcoma (KS), which remains the most common tumor associated with HIV infection....

scholarly journals Male infertility and viral infection: Interference role of the human herpesvirus types (3 – 6) with disturbances effects of some cytokines hypersecretion and seminal oxidative defense system in the infertility etiopathogenesis of some idiopathic infertile Iraqi patients

2019 ◽  
Vol 12 (3) ◽  
pp. 1181-1192
Author(s):  
Jasim Mohammed Muhsin ◽  
Sura O. Yousif ◽  
Ameer M. Hadi ◽  
Mohammed Haider Hamad
Keyword(s):  
Male Infertility ◽  
Viral Infection ◽  
Herpes Virus ◽  
Semen Quality ◽  
Human Herpes ◽  
Human Herpes Virus ◽  
Antioxidant Defense Systems ◽  
Ifn Γ ◽  
Herpès Virus

To study the role of potential relationship of chronic human herpes virus types (3 – 6) infection and their correlation with the up-regulation of some cytokines (IL-2, IL-10 and IFN gamma) and effect of (8-OHdG) and (TAOC) levels onto male infertility. A Case – control study with semen samples which were collected by masturbation during the routine semen analysis of a total ninety age-matched participants as; fertile males 35 (38.9%) with proven fertility as a normal semen quality and infertile males 55 (61.1%) with at least one year of infertility and poor semen quality. All semen biomarkers of Human herpes viruses (HHVs): Varicella zoster virus (VZV-IgG), Epstein-Barr virus (EBV-IgG), Cytomegalovirus (CMV-IgG), Human herpes virus type 6 (HHV6-IgG), Interlukin-2 (IL-2), Interlukin-10 (IL-10), Interferon-gamma (IFN-γ), 8-hydroxy-2'-deoxy guanosine (8-OHdG) and Total Antioxidant Capacity (TAOC) which were included in the study had been estimated by quantitative ELISA based method and the correlations with sperms parameters were evaluated. The main significant outcomes in this study of the infertile males group 55 (61.1%) were: high percentages of seminal IgG; N (%; Mean±SD) were detected of HHV6, 48 (53.3%;1.26± 0.51) then CMV, 39 (43.3%;1.51± 0.95) followed by EBV, 34 (37.8%; 2.20±1.47), and the highest abnormal cytokines levels were estimated in; 44 (48.9%; 112.62±38.64) and 40 (44.4%; 22.75±10.65) for IFN-γ and IL-10 respectively. Furthermore, High 8-OHdG level was detected in 47 (52.2%;7.29±2.15) and very low level of TAOC was detected in 16 (17.8%;19.34±12.17). Significant negative correlation between semen biomarkers and standard sperms parameters was found which were represented by: 45 (50.0%) of total sperms count less than (33 million ml), 52 (57.8%) of progressive motile sperms less than (31%). Finally, about 33 (24.4%) of abnormal sperm morphology was detected. Our results hypothesized that chronic asymptomatic viral infection with increasing of cytokines concentrations consequently disturbance the semen oxidative status, antioxidant defense systems that induce sperms DNA damage then might be collectively act as a co-factors on the etiology of the male infertility.

Role of Human Herpes Virus 6 in Corneal Inflammation Alone or With Human Herpesviruses

Cornea ◽  
2011 ◽  
Vol 30 (2) ◽  
pp. 204-207 ◽  
Author(s):  
Toshiomi Okuno ◽  
Laura C Hooper ◽  
Roxana Ursea ◽  
Janine Smith ◽  
Robert Nussenblatt ◽  
...  
Keyword(s):  
Herpes Virus ◽  
Human Herpes ◽  
Corneal Inflammation ◽  
Human Herpes Virus ◽  
Human Herpes Virus 6 ◽  
Herpès Virus ◽  
Human Herpesviruses

Syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL): A case report with serial electroencephalography (EEG) recordings.. Is there an association with human herpes virus type 7 (HHV-7) infection?

Cephalalgia ◽  
2016 ◽  
Vol 36 (13) ◽  
pp. 1296-1301 ◽  
Author(s):  
Bianca ML Stelten ◽  
Jeroen Venhovens ◽  
Lieven BJ van der Velden ◽  
Jan Meulstee ◽  
Wim IM Verhagen
Keyword(s):  
Cerebrospinal Fluid ◽  
Viral Infection ◽  
Virus Type ◽  
Neurological Deficits ◽  
Human Herpes ◽  
Human Herpes Virus ◽  
Eeg Recordings ◽  
Herpès Virus ◽  
Human Herpes Virus Type

Introduction The syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL) is a diagnosis made by exclusion. In the literature, different etiological explanations are proposed for HaNDL, including an immune-mediated reaction after a viral infection. Case description We present a case of a 23-year-old woman with several episodes of transient headache, neurological deficits and cerebrospinal fluid lymphocytosis. All diagnostic criteria for the HaNDL syndrome were fulfilled; however, additional cerebrospinal fluid analysis showed a positive polymerase chain reaction (PCR) for human herpes virus type 7 (HHV-7). Discussion The possible role of a (prodromal) viral infection in the etiology of HaNDL is discussed. Also the role of electroencephalography (EEG) recordings is discussed. Serial EEG recordings showed generalized slowing, frontal intermittent rhythmic delta activity (FIRDA) and symmetric triphasic frontal waves with a dilation lag.

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