Nuclear microtubular invaginations in acute lymphoblastic leukemia cells

1983 ◽  
Vol 41 ◽  
pp. 688-689
Author(s):  
M.J. Ahearn ◽  
G.S. Yee ◽  
J.M. Trujillo
Keyword(s):  
Acute Lymphocytic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Mitotic Division ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Nuclear Inclusions ◽  
Malignant Cells ◽  
Cross Sectional ◽  
Outer Membranes ◽  
Cytoplasmic Structures

Intranuclear "mitochondrion-like" bodies have been described in the neoplastic cells of both the Sezary syndrome and mycosis fungoides. (2) These cytoplasmic structures are hypothesized to be trapped in the nucleus during mitotic division and to represent another example of the abnormalities of the Sezary cell.We have recently observed identical nuclear inclusions in lymphoblasts from pediatric acute lymphocytic leukemia (ALL) patients, Figs. 1 and 2. In each instance, the malignant cells represent an abnormal variant of thymus-derived lymphocytes. They display a common feature in the pronounced maturation asynchrony between the nucleus and the cytoplasm. Our continuing studies of ALL blasts have revealed the presence of an apparent longitudinal and cross-sectional presentation of the "mitochondrionlike" body, Fig. 3. In this conformation, the similarity between the structure's outer membranes and the double-walled nuclear membrane becomes apparent.

scholarly journals Influence of cytotoxicity enhancers in combination with human serum on the activity of CD22-recombinant ricin A against B cell lines, chronic and acute lymphocytic leukemia cells

Leukemia ◽  
1999 ◽  
Vol 13 (2) ◽  
pp. 241-249 ◽  
Author(s):  
PJ van Horssen ◽  
YVJM van Oosterhout ◽  
S Evers ◽  
HHJ Backus ◽  
MGCT van Oijen ◽  
...  
Keyword(s):  
B Cell ◽  
Human Serum ◽  
Cell Lines ◽  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Ricin A

scholarly journals Interferon system in primary acute lymphocytic leukemia cells with or without deletions of the alpha-/beta-interferon genes

Blood ◽  
1992 ◽  
Vol 79 (8) ◽  
pp. 2076-2083 ◽  
Author(s):  
D Grander ◽  
M Heyman ◽  
K Brondum-Nielsen ◽  
Y Liu ◽  
E Lundgren ◽  
...  
Keyword(s):  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Leukemic Cells ◽  
Malignant Cells ◽  
Oligoadenylate Synthetase ◽  
Gene Deletions ◽  
Functional Studies ◽  
Cell Clones ◽  
Alpha Beta

Abstract Various aspects of the interferon (IFN) system were studied in malignant cells from 37 unselected patients with acute lymphocytic leukemia (ALL). It was found that leukemic cells from two of 37 patients had a complete loss of alpha- and beta-IFN genes, whereas cells from four of 37 had lost one of the alpha-/beta-IFN alleles. In 25 cases, viable cells were also available for functional studies. Cell clones with loss of one of the alpha-/beta-IFN alleles produced low amounts of IFN after virus induction in vitro. Some clones with an apparently normal set of IFN genes were unable to produce detectable amounts of IFN. All clones studied were found to carry high-affinity alpha-IFN receptors. In clones carrying deletions of IFN genes, the cells were sensitive to IFN in vitro as measured by alpha-IFN-induced enhancement of 2′,5′-oligoadenylate synthetase (2′,5′-A synthetase). Cells from four patients with an apparently normal set of IFN genes were insensitive to this effect of IFN. We conclude that of the 17 patients in which IFN genes, IFN production, alpha-IFN receptors, and IFN-induced enhancement of 2′,5′-A synthetase were studied, nine (53%) showed some abnormality in their IFN system. This finding may add some support to the hypothesis that defects in the IFN system could be a step on the path to malignant transformation in ALL. Moreover, patients whose malignant cells carry IFN gene deletions or other defects in their IFN-producing capacity, but are still sensitive to exogenous IFN, could represent a subgroup of ALL with a greater likelihood of responding to IFN therapy.

scholarly journals Lymphoblast purine pathway enzymes in B-cell acute lymphoblastic leukemia

Blood ◽  
1981 ◽  
Vol 58 (2) ◽  
pp. 330-332 ◽  
Author(s):  
GH Reaman ◽  
J Blatt ◽  
DG Poplack
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Metabolic Pathway ◽  
Purine Nucleoside Phosphorylase ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Malignant Cells ◽  
B Cell Malignancies ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Purine Pathway

Abstract Activities of enzymes of the purine metabolic pathway, adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP), and 5′- nucleotidase (5′-N), were investigated in the lymphoblasts of a patient with B-cell acute lymphoblastic leukemia. These lymphoblasts exhibited increased ADA activity and diminished activities of both PNP and 5′N' as compared to normal lymphocytes as well as non-T, non-B leukemia cells. This enzymatic pattern is identical to that which has been described in T-cell leukemic lymphoblasts and differs from that which has been observed in the malignant cells of undifferentiated B-cell lymphomas. These data suggest that there is biochemical heterogeneity within the spectrum of B-cell malignancies. Furthermore, inhibitors of ADA may be of use in those B-cell lymphoid neoplasms that exhibit increased ADA activity.

Cancer Cell Procoagulant Activity

1979 ◽  
Author(s):  
H.R. Gralnick
Keyword(s):  
Overall Survival ◽  
Acute Leukemia ◽  
Acute Lymphocytic Leukemia ◽  
Kinetic Studies ◽  
Lymphocytic Leukemia ◽  
Procoagulant Activity ◽  
Leukemia Cells ◽  
Catabolic Rate ◽  
Human Granulocytes ◽  
Normal Human

Studies of the procoagulant activity (PA) of human acute leukemia cells (ALC) has demonstrated that acute lymphocytic leukemia (ALL) had approximately 25-50% of the PA of normal human granulocytes, while lymphoid leukemias had increased PA. Acute promyelocyte leukemia (APL) had approximately 4-8 times the activity of normal granulocytes while acute myeloblastic leukemia (AML) cells had the same activity as normal. The PA was characterized as tissue factor (TF). Two correlations of the TF activity in ALC is the incidence of the fibrinogen kinetics and intravascular coagulation. He have done fibrinogen survivals on 15 patients with AL. The results of these kinetic studies have revealed that in 5 patients with ALL the T/2 is 2.94 ± .31 days; fraction catabolic rate (FCR) 29.8 ± 4.3%/day were slightly different from the control of T/2 3.69 ± 0.45 days; FCR 22.1 ± 2.5K/day. In 3 patients with AHL, the T/2 was 1.92 ± 0.79 days; FCR 44.2 ± 20.6%/day. In patients with APL, the fibrinogen survival revealed a T/2 of 0.069 ± 0.25 days; FCR 160.9 ± 62.7%/day. The use of anticoagulants in APL markedly decreases death from hemorrhage. In other investigations we have studied the effect of anticoagulation on the spread of peripheral sarcomas in man. Warfarin anticoagulation was used as an adjunct t o amputation of sarcomas. The results of these studies are quite encouraging in that the patients appear to have a longer remission and to have better overall survival.

Factors associated with caregiver burden for mothers of children undergoing Acute Lymphocytic Leukemia (ALL) treatment

2019 ◽  
Vol 18 (4) ◽  
pp. 405-412
Author(s):  
Mansour Arab ◽  
Colleen Bernstein ◽  
Aboutaleb Haghshenas ◽  
Hadi Ranjbar
Keyword(s):  
Social Support ◽  
Single Mothers ◽  
Caregiver Burden ◽  
Acute Lymphocytic Leukemia ◽  
Psychosocial Support ◽  
Lymphocytic Leukemia ◽  
Duration Of Treatment ◽  
Cross Sectional ◽  
Care Experience ◽  
Cultural Variations

AbstractObjectiveThe present study examined the extent to which social support (SS) availability and satisfaction could predict the extent of caregiver burden (CB) among mothers of children with Acute Lymphocytic Leukemia (ALL).MethodThe study was a cross-sectional, descriptive-correlative study. It was conducted on a sample of 117 mothers whose children were undergoing treatment in a public hospital in Bam, Iran. The Norbeck Social Support Scale and the Caregiver Burden Scale were used to measuring study variables. The data were analyzed using Pearson's correlations, t-tests, ANOVAs, and linear regressions.ResultsSignificant correlations were observed between CB and SS availability (r = −0.499, p < 0.001), SS satisfaction (r = −0.543, p < 0.001), the age of the child with cancer (r = −0.22, p = 0.01), and duration of treatment (r = 0.336, p < 0.001). Married mothers experienced less CB than those that were widowed or divorced. Within the regression equation, SS satisfaction, SS availability, marital status, and duration of treatment were the predictors of CB.Significance of resultsBased on the results of the current study, mothers who have less SS, especially those who are single mothers, with younger children, and who have taken care of their child for an extended duration should be given special attention. Furthermore, it appears that there are distinct cultural variations amongst Iranian mothers which suggest that culture may impact upon SS availability. Results also suggest a need for interventions that enhance nurses' ability to provide support to caregivers and the broader family unit as a whole. Nurses in cancer care need to have psychological competencies to help family members of cancer patients especially mothers and more so those that are single mothers. As integral members of the patient care experience, nurses may be uniquely positioned to provide this needed psychosocial support.

Proptosis as Initial Presentation of Acute Lymphoblastic Leukemia in a Child with no associated symptoms: A Case Report

2020 ◽  
Author(s):  
Kourosh Goudarzipour ◽  
Ahmad Mohammadi ◽  
Reza Taherian ◽  
Mehran Arab Ahmadi ◽  
Behdad Behnam ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Myeloid Leukemia ◽  
Acute Lymphocytic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Rapid Diagnosis ◽  
Lymphocytic Leukemia ◽  
Initial Presentation ◽  
Associated Symptoms ◽  
Blast Cells

Acute lymphocytic leukemia (ALL) is one of the frequent malignancies in pediatrics and involves bone marrow and extramedullary sites. Proptosis as extramedullary involvement of leukemia usually present in acute and chronic myeloid leukemia. It is extremely rare for ALL to present initially as proptosis.Here, a-21-month-old boy was presented with proptosis without any associated symptoms except lymphadenopathy. He was referred with the impression of malignancy from an ophthalmologist. After bone marrow biopsy which showed 33% blast cells, all positive for CD10, CD19, and CD79, the diagnosis of pre-B cell ALL was finally made. His symptoms were improved completely 16 days after starting standard protocol for ALL.Afterone-year follow-up, he was free of any symptoms.According to this initial presentation of ALL and no typical associated symptoms, it is important to make rapid diagnosis and start the treatment in the childhood.

scholarly journals Association between thrombocyte and neutrophyl count with cutaneous manifestations in children with acute lymphocytic leukemia and acute myelocytic leukemia

2019 ◽  
Vol 7 (2) ◽  
pp. 551
Author(s):  
Eva Hariani ◽  
Sri Wahyuni Purnama ◽  
Remenda Siregar
Keyword(s):  
Acute Leukemia ◽  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
P Value ◽  
Acute Myelocytic Leukemia ◽  
Cross Sectional ◽  
Hematopoietic Stem ◽  
Cutaneous Manifestations ◽  
Peripheral Tissues ◽  
Myelocytic Leukemia

Background: Acute leukemia is a hematopoietic stem cell malignant disease, with abnormal proliferation of leukemic and immature cells that suppress the production of normal blood cell and extensively invade peripheral tissues organs including skin. Homeostatic abnormalities that occur in leukemia e.g. thrombocytopenia and neutropenia. Various cutaneous manifestations can be observed in leukemia but the etiology is usually unknown, because many factors are responsible for this cutaneous manifestation. The aim of the present study was to determine association between thrombocyte and neutrophyl count with cutaneous manifestations in children with Acute Lymphocytic Leukemia (ALL) and Acute Myelocytic Leukemia (AML).Methods: This is an observational analytical cross-sectional study involving 51 children with acute leukemia (ALL and AML) were hospitalized in H. Adam Malik General Hospital Medan during April – September 2018. Interview, dermatology examination and recording thrombocyte and neutrophil count were performed to the subjects. Differences between thrombocyte and neutrophyl count with cutaneous manifestations were analyzed using Mann Whitney test. Association between thrombocyte and neutrophyl count with cutaneous manifestations were analyzed using Kolmogorov Smirnov test.Results: Children with Acute Leukemia in this study most of them were girls (51.0%), age between 0 - 5years old (39.2%). There were no significant differences between thrombocyte and neutrophyl count with cutaneous manifestations in children with acute leukemia (p value 0.692 and 0.814). There was no significant association between thrombocyte and neutrophyl count with cutaneous manifestations in children with acute leukemia (p value 0.490 and 0.803).Conclusions: There is no significant association between thrombocyte and neutrophyl count with cutaneous manifestations in children with acute leukemia.

scholarly journals Expression of normal myeloid-associated antigens by acute leukemia cells

Blood ◽  
1986 ◽  
Vol 67 (4) ◽  
pp. 1048-1053 ◽  
Author(s):  
PA Dinndorf ◽  
RG Andrews ◽  
D Benjamin ◽  
D Ridgway ◽  
L Wolff ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Acute Lymphocytic Leukemia ◽  
Direct Relationship ◽  
Lymphocytic Leukemia ◽  
Leukemic Cells ◽  
Leukemia Cells ◽  
Acute Nonlymphocytic Leukemia ◽  
Pediatric Age ◽  
Fab Classification ◽  
French American British

Monoclonal antibodies that react with hematopoietic cells and their precursors in a stage and lineage restricted fashion were used in indirect immunofluorescence assays to examine leukemic cells from 105 pediatric age patients. The differentiative states of blasts from 42 patients with acute nonlymphocytic leukemia (ANLL) were defined by these antibodies. When these were compared to their morphologic and histochemical levels of differentiation as defined by the French- American-British (FAB) classification, no direct relationship was found. The reactivity of these antibodies with leukemic cells from 63 patients with acute lymphocytic leukemiA (ALL) was also investigated, and the usefulness of these antibodies in distinguishing leukemias of myeloid from those of lymphoid origin was demonstrated.

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