scholarly journals Seroprevalence of IgG antibodies to SARS-coronavirus in asymptomatic or subclinical population groups

2005 ◽  
Vol 134 (2) ◽  
pp. 211-221 ◽  
Author(s):  
G. M. LEUNG ◽  
W. W. LIM ◽  
L.-M. HO ◽  
T.-H. LAM ◽  
A. C. GHANI ◽  
...  
Keyword(s):  
Health Care ◽  
Close Contact ◽  
Meta Analysis ◽  
Confirmatory Test ◽  
Igg Antibodies ◽  
Testing Procedures ◽  
Population Immunity ◽  
Care Workers ◽  
General Community ◽  
Animal Handlers

We systematically reviewed the current understanding of human population immunity against SARS-CoV in different groups, settings and geography. Our meta-analysis, which included all identified studies except those on wild animal handlers, yielded an overall seroprevalence of 0·10% [95% confidence interval (CI) 0·02–0·18]. Health-care workers and others who had close contact with SARS patients had a slightly higher degree of seroconversion (0·23%, 95% CI 0·02–0·45) compared to healthy blood donors, others from the general community or non-SARS patients recruited from the health-care setting (0·16%, 95% CI 0–0·37). When analysed by the two broad classes of testing procedures, it is clear that serial confirmatory test protocols resulted in a much lower estimate (0·050%, 95% CI 0–0·15) than single test protocols (0·20%, 95% CI 0·06–0·34). Potential epidemiological and laboratory pitfalls are also discussed as they may give rise to false or inconsistent results in measuring the seroprevalence of IgG antibodies to SARS-CoV.

scholarly journals Hand washing practice among health care workers in Ethiopia: systemic review and meta-analysis, 2020

Heliyon ◽  
2021 ◽  
Vol 7 (5) ◽  
pp. e06972
Author(s):  
Haileyesus Gedamu ◽  
Teshager W/giorgis ◽  
Getasew Tesfa ◽  
Yilkal Tafere ◽  
Minichil Genet
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Meta Analysis ◽  
Hand Washing ◽  
Systemic Review ◽  
Care Workers

scholarly journals Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol

Pathogens ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 911
Author(s):  
Marie Pouquet ◽  
Dorine Decarreaux ◽  
Pol Prévot-Monsacré ◽  
Corentin Hervé ◽  
Andréas Werner ◽  
...  
Keyword(s):  
Health Care ◽  
Primary Health Care ◽  
Health Care Workers ◽  
Phase 1 ◽  
Vaccination Campaign ◽  
Igg Antibodies ◽  
Household Contacts ◽  
Primary Health ◽  
Care Workers ◽  
Natural Protection

Background: The protocol study will focus on the seroprevalence of IgG antibodies to SARS-CoV-2 achieved by vaccination and/or natural protection as well as the history, symptoms, and risk factors for SARS-CoV-2 in four primary health-care workers (PHCWs) and their household contacts in metropolitan France. Methods: Here, we propose a protocol for a nationwide survey to determine the seroprevalence of IgG antibodies to SARS-CoV-2 achieved by vaccination and/or natural protection in four PHCW populations (general practitioners, pediatricians, pharmacists and assistants, and dentists and assistants) and their household contacts. Participants will be included from June to July 2021 (Phase 1) among PHCW populations located throughout metropolitan France. They will be asked to provide a range of demographic and behavioral information since the first SARS-CoV-2 wave and a self-sampled dried blood spot. Phase 1 will involve also a questionnaire and serological study of PHCWs’ household contacts. Seroprevalence will be estimated using two ELISAs designed to detect specific IgG antibodies to SARS-CoV-2 in humoral fluid, and these results will be confirmed using a virus neutralization test. This study will be repeated from November to December 2021 (Phase 2) to evaluate the evolution of immune status achieved by vaccination and/or natural protection of PHCWs and to describe the history of exposure to SARS-CoV-2.

INVESTIGATION OF SEROPREVALENCE OF IgG ANTIBODIES AMONG HEALTH CARE WORKERS IN VIRAL RESEARCH AND DIAGNOSTIC LABORATORY, AMRITSAR

2021 ◽  
pp. 63-65
Author(s):  
Vaibhav Chawla ◽  
Amandeep Kaur ◽  
Arashdeep Kaur ◽  
Kanwardeep Singh ◽  
Shailpreet Kaur Sidhu ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Data Entry ◽  
Risk Exposure ◽  
Government Medical College ◽  
Igg Antibodies ◽  
Serum Samples ◽  
Diagnostic Laboratory ◽  
Medical College ◽  
Care Workers

Health care workers constitute the group of people who take care of COVID-19 patients. Thus, they are highly vulnerable to contract SARS-CoV-2 infection and pose a great threat to co-workers and general public. Seroprevalence studies are an important tool to monitor the prevalence of SARS-CoV-2 infection and assess the level of exposure among HCWs. Thus, the present study aims to investigate the seroprevalence of IgG antibodies against SARS-CoV-2 among Health Care Workers. Materials and Methods: A prospective study was conducted at Viral Research and Diagnostic Laboratory, Government Medical College, st th Amritsar for a period from 1 December 2020 to 15 January 2021. During this period, 90 blood samples were collected from the healthcare workers from Department of Microbiology and Viral Research and Diagnostic Laboratory, Government Medical College, Amritsar. Serum samples were separated and used for detection of Anti-SARS-CoV-2 IgG antibodies by ELISA technique. Results: Out of the 90 samples, 31 (34.44%) were found to be positive. Higher number of males 24 (26.67%) and lesser number of females 7 (7.78%) were observed with seropositivity. Out of the total participants in the study, 45.16% of laboratory supporting personnel, 19.35% of junior residents followed by housekeeping staff (12.90%), data entry operators (9.67%), consultants (6.45%) and Senior Residents/Research Scientists (6.45%) were observed to be IgG positive. It was also seen that in high risk exposure category 27.78% were seropositive and in low risk exposure group only 6.67% were seropositive and the difference between two groups was statistically signicant (p<0.000). Conclusion: High seropositivity was observed among health care workers due to their nature of work as frontline workers

Prevalence and causes of unreported needle stick injuries among health care workers: a systematic review and meta-analysis

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Razieh Behzadmehr ◽  
Abbas Balouchi ◽  
Mehran Hesaraki ◽  
Farshid Alazmani Noodeh ◽  
Hosein Rafiemanesh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Health Care ◽  
Health Care Workers ◽  
Health Workers ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Needle Stick ◽  
Care Workers ◽  
Needle Stick Injuries

Abstract Objectives Health care workers (HCWs) are exposed to needle needles daily. Despite individual studies, there is no statistics on the prevalence of unreported needle stick injuries (NSIs) have been reported. This study was performed to determine the prevalence and causes of unreported NSIs among HCWs. Content In present systematic review and meta-analysis study, three international databases (Web of Science, Scopus, PubMed) were searched from January 1, 2000 to December 31, 2018. The random model was used to determine the prevalence of unreported needle stick among HCWs. Summary and outlook Forty-one studies performed on 19,635 health care workers entered the final stage. Based-on random effect model, pooled prevalence of unreported needle stick injuries was 59.9% (95% CI: 52.0, 67.7; I2=98.9%). The most common cause of unreported NSIs was: They were not worried about NSIs (n=12). The high prevalence of unreported needle sticks injuries indicates the urgency and necessity of paying attention to strategies to improve reporting among health workers.

scholarly journals Infection, screening, and psychological stress of health care workers with COVID-19 in a non-frontline clinical department

2020 ◽  
pp. 1-25
Author(s):  
Ge Wang ◽  
Jia-Lun Guan ◽  
Xiu-Qing Zhu ◽  
Mu-Ru Wang ◽  
Dan Fang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Health Care ◽  
Psychological Stress ◽  
Health Care Workers ◽  
Close Contact ◽  
Endoscopic Examination ◽  
Viral Shedding ◽  
Clinical Department ◽  
Care Workers ◽  
Ward Rounds

ABSTRACT Objective: To investigate risk factors and psychological stress of health care workers (HCWs) with COVID-19 in a non-frontline clinical department. Methods: Data of 2 source patients and all HCWs with infection risk were obtained in a department in Wuhan from January to February 2020. A questionnaire was designed to evaluate psychological stress of COVID-19 on HCWs. Results: The overall infection rate was 4.8% in HCWs. 10 of 25 HCWs who contacted with 2 source patients were diagnosed with confirmed COVID-19 (8/10) and suspected COVID-19 (2/10). Other 2 HCWs were transmitted by other patients or colleagues. Close care behaviours included physical examination (6/12), life nursing (4/12), ward rounds (4/12), endoscopic examination (2/12). Contacts fluctuated from 1 to 24 times and each contact was short (8.1 min ± 5.6 min). HCWs wore surgical masks (11/12), gloves (7/12), and isolation clothing (3/12) when providing medical care. Most HCWs experienced a mild course with 2 asymptomatic infections, taking 9.8 days and 20.9 days to obtain viral shedding and clinical cure, respectively. Psychological stress included worry (58.3%), anxiety (83.3%), depression (58.3%), and insomnia (58.3%). Conclusions: Close contact with COVID-19 patients and insufficient protection were key risk factors. Precaution measures and psychological support on COVID-19 is urgently required for HCWs.

scholarly journals Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study

2020 ◽  
Vol 5 (9) ◽  
pp. e475-e483 ◽  
Author(s):  
Long H Nguyen ◽  
David A Drew ◽  
Mark S Graham ◽  
Amit D Joshi ◽  
Chuan-Guo Guo ◽  
...  
Keyword(s):  
Health Care ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Health Care Workers ◽  
Prospective Cohort ◽  
Front Line ◽  
Care Workers ◽  
General Community

scholarly journals Consideration for the asymptomatic transmission of COVID-19: Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Khaiwal Ravindra ◽  
Vivek Singh Malik ◽  
Bijaya K Padhi ◽  
Sonu Goel ◽  
Madhu Gupta
Keyword(s):  
Systematic Review ◽  
Health Care ◽  
Health Care Workers ◽  
Meta Analysis ◽  
Chest Ct ◽  
Nucleic Acid Testing ◽  
Social Distancing ◽  
Care Workers ◽  
Children Health ◽  
Chest Ct Scan

AbstractObjectiveWorldwide countries are experiencing viral load in their population, leading to potential infectivity of asymptomatic COVID-19. Current systematic review and meta-analysis aimed to investigate the role of asymptomatic infection worldwide reported in family-cluster, adults, children, health care workers, and travelers.DesignOnline literature search (PubMed, Google Scholar, medRixv, and BioRixv) was accomplished using standard Boolean operators, studies published till 07th June 2020.SettingStudies were included from case reports, short communication, and retrospective to cover sufficient asymptomatic COVID-19 transmission reported.ParticipantsFamilial-clusters, adults, children, health care workers, and travelers.ResultsWe observed asymptomatic transmission among familial-cluster, adults, children, health care workers, and travelers with a proportion of 32% 37%, 26%, 6%, and 32%, respectively. This study observed an overall proportion of 31% (95%CI: 0.19-0.44) with heterogeneity of I2 (97.28%, p=<0.001) among all asymptomatic populations mentioned in this study. Among children and healthcare workers, this study showed no heterogeneity; to overcome the interpretation from a fixed model, the random effect model was also applied to estimate the average distribution across studies included in the meta-analysis.ConclusionWe found and suggest the rigorous epidemiological history, early isolation, social distancing, and increased quarantine period (at least 28 days) after screening asymptomatic cases as well as their close contacts for chest CT scan even after their negative nucleic acid testing to minimize the spread among the community. This systematic review and meta-analysis support asymptomatic COVID-19 transmission between person to person depending on the variation of virus incubation period among individuals. Children especially, school-going aged <18 years, need to be monitored and prevention strategy, e.g., chest CT and social distancing required to prevent the community transmission of COVID-19 in asymptomatic mode.Strengths and limitations of this studyExamine the possibility of asymptomatic COVID-19 transmission in the community at different levels.Supports contact tracing, social distancing, early isolation, and increased quarantine period to minimize the risk of virus spread.Supports chest CT scan and viral nucleic acid testing to identify the asymptomatic cases in the community.Supports rigorous epidemiological history with multiple detection methods.A higher proportion of asymptomatic incidence was seen, suggests monitoring, and maintaining social distancing.

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