Estimating time to onset of swine influenza symptoms after initial novel A(H1N1v) viral infection

2010 ◽  
Vol 139 (9) ◽  
pp. 1418-1424 ◽  
Author(s):  
B. D. M. TOM ◽  
A. J. VAN HOEK ◽  
R. PEBODY ◽  
J. McMENAMIN ◽  
C. ROBERTSON ◽  
...  
Keyword(s):  
Incubation Time ◽  
Time Distribution ◽  
Age Groups ◽  
Swine Influenza ◽  
Interval Censoring ◽  
Limited Data ◽  
History Of ◽  
Influenza Case ◽  
Time To Onset

SUMMARYCharacterization of the incubation time from infection to onset is important for understanding the natural history of infectious diseases. Attempts to estimate the incubation time distribution for novel A(H1N1v) have been, up to now, based on limited data or peculiar samples. We characterized this distribution for a generic group of symptomatic cases using laboratory-confirmed swine influenza case-information. Estimates of the incubation distribution for the pandemic influenza were derived through parametric time-to-event analyses of data on onset of symptoms and exposure dates, accounting for interval censoring. We estimated a mean of about 1·6–1·7 days with a standard deviation of 2 days for the incubation time distribution in those who became symptomatic after infection with the A(H1N1v) virus strain. Separate analyses for the <15 years and ⩾15 years age groups showed a significant (P<0·02) difference with a longer mean incubation time in the older age group.

scholarly journals Characterization of Benomyl Resistance in Mycosphaerella fijiensis, Cause of Black Sigatoka of Banana, in Costa Rica

Plant Disease ◽  
1998 ◽  
Vol 82 (8) ◽  
pp. 931-934 ◽  
Author(s):  
Ronald A. Romero ◽  
Turner B. Sutton
Keyword(s):  
Costa Rica ◽  
Disease Severity ◽  
Incubation Time ◽  
High Frequency ◽  
Lower Sensitivity ◽  
Mycosphaerella Fijiensis ◽  
Black Sigatoka ◽  
History Of ◽  
Banana Plantations

Sixty-eight and eighty-six percent of monoascosporic isolates of Mycosphaerella fijiensis from two banana plantations in Costa Rica, in which benomyl was used for ≈10 years to control black Sigatoka, were resistant to benomyl in February and November 1994, respectively. No resistance to benomyl was detected in isolates collected during February 1994 from farms with no history of benomyl use that were located ≈50 km from the nearest banana plantations. Only 1% of isolates was resistant to benomyl in a sample taken during November 1994. In three additional banana farms where benomyl had not been used for 3 to 5 years before sampling, ben-omyl resistance persisted at a high frequency. Benomyl-resistant and -sensitive isolates were distributed equally throughout the range of isolate sensitivity to propiconazole, indicating no relationship between resistance to benomyl and lower sensitivity to propiconazole but double resistance to these two compounds. Five benomyl-resistant and five benomyl-sensitive isolates of M. fijiensis were inoculated to banana plants under greenhouse conditions. Benomyl-resistant isolates were more aggressive than benomyl-sensitive isolates, as determined by measures of disease severity, incubation time, and number of lesions at 40 days after inoculation.

scholarly journals Sheep as a Potential Source of Zoonotic Cryptosporidiosis in China

2018 ◽  
Vol 84 (18) ◽  
Author(s):  
Rongsheng Mi ◽  
Xiaojuan Wang ◽  
Yan Huang ◽  
Guodong Mu ◽  
Yehua Zhang ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Age Groups ◽  
Limited Data ◽  
Genetic Characteristics ◽  
Content Type ◽  
Potential Source ◽  
Four Seasons ◽  
Zoonotic Parasite ◽  
Geographic Differences

ABSTRACTIn this study, we assessed the prevalence and genetic characteristics ofCryptosporidiumin sheep from 10 provinces in China. Fecal samples from 1,035 sheep originating from 16 farms were collected, and 295 (28.5%) were found to beCryptosporidiumpositive by nested PCR.Cryptosporidiumwas detected at all farms, with infection rates between 5.7% and 50.0%. ThreeCryptosporidiumspecies were identified, includingCryptosporidium xiaoi(73.2%, 216/295),Cryptosporidium ubiquitum(21.7%, 64/295), andCryptosporidium parvum(5.1%, 15/295). The distribution ofCryptosporidiumspecies differed by province and by farm. All three species were detected in lambs and adult sheep but the highest infection rate was found in postweaned lambs. All three species were detected in all four seasons, with the highest prevalence found in autumn. FourC. parvumsubtypes (IIaA15G2R1, IIaA17G2R1, IIdA18G1, and IIdA19G1) and oneC. ubiquitumsubtype (XIIa) were identified. For most provinces in this study, we are not aware of a previously published description or molecular characterization ofCryptosporidiuminfections in sheep. This information will improve our knowledge and understanding of the epidemiology of cryptosporidiosis in China.IMPORTANCECryptosporidiumis an important zoonotic parasite that causes diarrhea in humans and animals worldwide. Previous studies suggested geographic differences in the distribution ofCryptosporidiumspecies in sheep. However, molecular characterization studies ofCryptosporidiumspecies in sheep have been carried out in only a few provinces in China, and the limited data available do not reflect the real situation. In this study, five districts, covering most areas where sheep are bred in China, were selected for examination ofCryptosporidiumspecies, andCryptosporidiuminfections were detected at all farms assessed, suggesting thatCryptosporidiumis widespread in sheep in China. We also found geographic differences in the distribution ofCryptosporidiumspecies but did not detect any differences between sheep age groups or seasons. Subtyping analyses showed that all of the subtypes identified in this study have been reported in humans, suggesting that sheep may be a potential source of zoonotic cryptosporidiosis.

Subversive Mobilities

Transfers ◽  
2013 ◽  
Vol 3 (1) ◽  
pp. 7-25 ◽  
Author(s):  
Mikkel Thelle
Keyword(s):  
Public Space ◽  
Cultural History ◽  
Turn Of The Century ◽  
Public Action ◽  
History Of ◽  
Urban Conflict

The article approaches mobility through a cultural history of urban conflict. Using a case of “The Copenhagen Trouble,“ a series of riots in the Danish capital around 1900, a space of subversive mobilities is delineated. These turn-of-the-century riots points to a new pattern of mobile gathering, the swarm; to a new aspect of public action, the staging; and to new ways of configuring public space. These different components indicate an urban assemblage of subversion, and a new characterization of the “throwntogetherness“ of the modern public.

Shakespeare Afoot

2018 ◽  
Author(s):  
John Kerrigan
Keyword(s):  
Early Modern ◽  
Richard Iii ◽  
Midsummer Night's Dream ◽  
As You Like It ◽  
A Midsummer Night's Dream ◽  
History Of ◽  
The Way

That Shakespeare adds a limp to the received characterization of Richard III is only the most conspicuous instance of his interest in how actors walked, ran, danced, and wandered. His attention to actors’ footwork, as an originating condition of performance, can be traced from Richard III through A Midsummer Night’s Dream and As You Like It into Macbeth, which is preoccupied with the topic and activity all the way to the protagonist’s melancholy conclusion that ‘Life’s but a walking shadow, a poor player | That struts and frets his hour upon the stage’. Drawing on classical and early modern accounts of how people walk and should walk, on ideas about time and prosody, and the experience of disability, this chapter cites episodes in the history of performance to show how actors, including Alleyn, Garrick, and Olivier, have worked with the opportunities to dramatize footwork that are provided by Shakespeare’s plays.

Theology in the Church of England

2017 ◽  
Author(s):  
B. W. Young
Keyword(s):  
Eighteenth Century ◽  
Church Of England ◽  
Ecclesiastical History ◽  
International Reputation ◽  
History Of ◽  
Joseph Butler ◽  
Anglican Theology ◽  
The Many ◽  
The Church

The dismissive characterization of Anglican divinity between 1688 and 1800 as defensive and rationalistic, made by Mark Pattison and Leslie Stephen, has proved more enduring than most other aspects of a Victorian critique of the eighteenth-century Church of England. By directly addressing the analytical narratives offered by Pattison and Stephen, this chapter offers a comprehensive re-evaluation of this neglected period in the history of English theology. The chapter explores the many contributions to patristic study, ecclesiastical history, and doctrinal controversy made by theologians with a once deservedly international reputation: William Cave, Richard Bentley, William Law, William Warburton, Joseph Butler, George Berkeley, and William Paley were vitalizing influences on Anglican theology, all of whom were systematically depreciated by their agnostic Victorian successors. This chapter offers a revisionist account of the many achievements in eighteenth-century Anglican divinity.

scholarly journals Predicting COVID-19 mortality with electronic medical records

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Hossein Estiri ◽  
Zachary H. Strasser ◽  
Jeffy G. Klann ◽  
Pourandokht Naseri ◽  
Kavishwar B. Wagholikar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Medical Information ◽  
Age Groups ◽  
Prognostic Models ◽  
Smoking History ◽  
Risk Scores ◽  
Gradient Boosting ◽  
Chronic Obstructive ◽  
Clinical Expertise ◽  
History Of

AbstractThis study aims to predict death after COVID-19 using only the past medical information routinely collected in electronic health records (EHRs) and to understand the differences in risk factors across age groups. Combining computational methods and clinical expertise, we curated clusters that represent 46 clinical conditions as potential risk factors for death after a COVID-19 infection. We trained age-stratified generalized linear models (GLMs) with component-wise gradient boosting to predict the probability of death based on what we know from the patients before they contracted the virus. Despite only relying on previously documented demographics and comorbidities, our models demonstrated similar performance to other prognostic models that require an assortment of symptoms, laboratory values, and images at the time of diagnosis or during the course of the illness. In general, we found age as the most important predictor of mortality in COVID-19 patients. A history of pneumonia, which is rarely asked in typical epidemiology studies, was one of the most important risk factors for predicting COVID-19 mortality. A history of diabetes with complications and cancer (breast and prostate) were notable risk factors for patients between the ages of 45 and 65 years. In patients aged 65–85 years, diseases that affect the pulmonary system, including interstitial lung disease, chronic obstructive pulmonary disease, lung cancer, and a smoking history, were important for predicting mortality. The ability to compute precise individual-level risk scores exclusively based on the EHR is crucial for effectively allocating and distributing resources, such as prioritizing vaccination among the general population.

scholarly journals Low Nucleotide Diversity in Chimpanzees and Bonobos

Genetics ◽  
2003 ◽  
Vol 164 (4) ◽  
pp. 1511-1518 ◽  
Author(s):  
Ning Yu ◽  
Michael I Jensen-Seaman ◽  
Leona Chemnick ◽  
Judith R Kidd ◽  
Amos S Deinard ◽  
...  
Keyword(s):  
Nucleotide Diversity ◽  
Nuclear Dna ◽  
Demographic History ◽  
Nuclear Genome ◽  
Limited Data ◽  
Effective Population ◽  
East Central ◽  
Dna Diversity ◽  
History Of ◽  
Mtdna Diversity

Abstract Comparison of the levels of nucleotide diversity in humans and apes may provide much insight into the mechanisms of maintenance of DNA polymorphism and the demographic history of these organisms. In the past, abundant mitochondrial DNA (mtDNA) polymorphism data indicated that nucleotide diversity (π) is more than threefold higher in chimpanzees than in humans. Furthermore, it has recently been claimed, on the basis of limited data, that this is also true for nuclear DNA. In this study we sequenced 50 noncoding, nonrepetitive DNA segments randomly chosen from the nuclear genome in 9 bonobos and 17 chimpanzees. Surprisingly, the π value for bonobos is only 0.078%, even somewhat lower than that (0.088%) for humans for the same 50 segments. The π values are 0.092, 0.130, and 0.082% for East, Central, and West African chimpanzees, respectively, and 0.132% for all chimpanzees. These values are similar to or at most only 1.5 times higher than that for humans. The much larger difference in mtDNA diversity than in nuclear DNA diversity between humans and chimpanzees is puzzling. We speculate that it is due mainly to a reduction in effective population size (Ne) in the human lineage after the human-chimpanzee divergence, because a reduction in Ne has a stronger effect on mtDNA diversity than on nuclear DNA diversity.

scholarly journals Peasants, Colonialism, and Sovereignty: The Garo rebellions in eastern India

2021 ◽  
pp. 1-37
Author(s):  
SANGHAMITRA MISRA
Keyword(s):  
Historical Narrative ◽  
Colonial State ◽  
Colonial India ◽  
Colonial Modernity ◽  
Northeastern India ◽  
British Rule ◽  
Core Elements ◽  
Colonial Archive ◽  
History Of

Abstract This article studies two seismic decades in the history of the Garo community, marked out in colonial records as among the most violent and isolated people that British rule encountered in eastern and northeastern India. Through a densely knit historical narrative that hinges on an enquiry into the colonial reordering of the core elements of the regional political economy of eastern and northeastern India, it will train its focus on the figure of the rebellious Garo peasant and on the arresting display of Garo recalcitrance between 1807 and 1820. Reading a rich colonial archive closely and against the grain, the article will depart from extant historiography in its characterization of the colonial state in the early nineteenth century as well as of its relationship with ‘tribes’/‘peasants’ in eastern and northeastern India. A critique of the idea of primitive violence and the production of the ‘tribe’ under conditions of colonial modernity will occupy the latter half of the article. Here it will argue that the numerous and apparently disparate acts of headhunting, raids, plunder, and burning by the Garos on the lowlands of Bengal and Assam were in fact an assembling of the first of a series of sustained peasant rebellions in this part of colonial India—a powerful manifestation of a community's historical consciousness of the loss of its sovereign self under British rule.

scholarly journals Critical Review of EMC Standards for the Measurement of Radiated Electromagnetic Emissions from Transit Line and Rolling Stock

Energies ◽  
2021 ◽  
Vol 14 (3) ◽  
pp. 759
Author(s):  
Andrea Mariscotti
Keyword(s):  
Time Distribution ◽  
Communication Systems ◽  
Electromagnetic Compatibility ◽  
Transportation Systems ◽  
Operating Conditions ◽  
Rolling Stock ◽  
Intrinsic Variability ◽  
Statistical Characterization ◽  
Electromagnetic Emissions

Accurate and comprehensive methods for the assessment of radiated electromagnetic emissions in modern electric transportation systems are a necessity. The characteristics and susceptibility of modern victim signaling and communication radio services, operating within and outside the right-of-way, require an update of the measurement methods integrating or replacing the swept frequency technique with time domain approaches. Applicable standards are the EN 50121 (equivalent to the IEC 62236) and Urban Mass Transport Association (UMTA) with additional specifications from project contracts. This work discusses the standardized methods and settings, and the representative operating conditions, highlighting areas where improvements are possible and opportune (statistical characterization of measurement results, identification and distinction of emissions and line resonances, and narrowband and broadband phenomena). In particular for the Electromagnetic Compatibility (EMC) assessment with new Digital Communication Systems, the characterization of time distribution of spectral properties is discussed, e.g., by means of Amplitude Probability Distribution and including time distribution information. The problem of determination of site and setup uncertainty and repeatability is also discussed, observing on one hand the lack of clear indications in standards and, on the other hand, the non-ideality and intrinsic variability of measurement conditions (e.g., rolling stock operating conditions, synchronization issues, and electric arc intermittence).

scholarly journals Introduction of the Grayscale Median for Ultrasound Tissue Characterization of the Transplanted Kidney

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 390
Author(s):  
Camilo G. Sotomayor ◽  
Stan Benjamens ◽  
Hildebrand Dijkstra ◽  
Derya Yakar ◽  
Cyril Moers ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Tissue Characterization ◽  
Kidney Transplant Recipients ◽  
Systematic Assessment ◽  
Ultrasound Tissue Characterization ◽  
Adult Kidney ◽  
Mersenne Twister ◽  
History Of

Ultrasound examination is advised for early post-kidney transplant assessment. Grayscale median (GSM) quantification is novel in the kidney transplant field, with no systematic assessment previously reported. In this prospective cohort study, we measured the post-operative GSM in a large cohort of adult kidney transplant recipients (KTR) who consecutively underwent Doppler ultrasound directly after transplantation (within 24 h), compared it with GSM in nontransplanted patients, and investigated its association with baseline and follow-up characteristics. B-mode images were used to calculate the GSM in KTR and compared with GSM data in nontransplanted patients, as simulated from summary statistics of the literature using a Mersenne twister algorithm. The association of GSM with baseline and 1-year follow-up characteristics were studied by means of linear regression analyses. In 282 KTR (54 ± 15 years old, 60% male), the median (IQR) GSM was 55 (45–69), ranging from 22 to 124 (coefficient of variation = 7.4%), without differences by type of donation (p = 0.28). GSM in KTR was significantly higher than in nontransplanted patients (p < 0.001), and associated with systolic blood pressure, history of cardiovascular disease, and donor age (std. β = 0.12, −0.20, and 0.13, respectively; p < 0.05 for all). Higher early post-kidney transplant GSM was not associated with 1-year post-kidney transplant function parameters (e.g., measured and estimated glomerular filtration rate). The data provided in this study could be used as first step for further research on the application of early postoperative ultrasound in KTR.

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