Association between TLR2 + 2477G/A polymorphism and bacterial meningitis: a meta-analysis

AbstractToll-like receptor 2 (TLR2) is a key member of TLRs, which is crucial in the initial inflammatory response against bacteria. TLR2, is also the initial barrier against bacterial infection and plays an important role in recognising a variety of bacterial lipoproteins. Several studies have been performed to investigate the TLR2 + 2477G/A polymorphism and bacterial meningitis susceptibility. Unfortunately, the results of previous studies were controversial. Therefore, we performed a meta-analysis to derive a more precise estimation of the association. The association between the TLR2 + 2477G/A polymorphism and bacterial meningitis susceptibility was assessed by odds ratios together with their 95% confidence intervals (CI). Six studies were enrolled in the present meta-analysis. Overall, no significant association between TLR2 + 2477G/A polymorphism and bacterial meningitis risk were found under allele contrast (A vs. G: OR = 1.15, 95% CI = 0.93–1.43, P = 0.202), recessive genetic model (AA vs. AG/GG: OR = 1.12, 95% CI = 0.90–1.41, P = 0.313). The significant association was found between TLR2 + 2477G/A polymorphism and pneumococcal meningitis risk under allele contrast (A vs. G: OR = 1.54, 95% CI = 1.01–2.36, P = 0.046), recessive genetic model (AA vs. AG/GG: OR = 1.63, 95% CI = 1.03–2.57, P = 0.035). We conclude that TLR2 + 2477G/A polymorphism is not associated with meningococcal meningitis risk but contributes an increased risk of pneumococcal meningitis.

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TLR9 Rs352140 polymorphism contributes to a decreased risk of bacterial meningitis: evidence from a meta-analysis

Epidemiology and Infection ◽

10.1017/s0950268820002666 ◽

2020 ◽

Vol 148 ◽

Author(s):

Haiyi Xue ◽

Huan Peng ◽

Jiaoming Li ◽

Mingming Li ◽

Song Lu

Keyword(s):

Bacterial Meningitis ◽

Genetic Model ◽

Meta Analysis ◽

Relevant Literature ◽

Cochrane Library ◽

Case Control Studies ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Increased Risk ◽

The Cochrane Library

Abstract Some studies have suggested that the Toll-like receptor 9 polymorphism (TLR9 rs352140) is closely related to the risk of bacterial meningitis (BM), but this is subject to controversy. This study set out to estimate whether the TLR9 rs352140 polymorphism confers an increased risk of BM. Relevant literature databases were searched including PubMed, Embase, the Cochrane Library and China National Knowledge Infrastructure (CNKI) up to August 2020. Seven case-control studies from four publications were enrolled in the present meta-analysis. Odds ratios (OR) and confidence intervals (95% CI) were calculated to estimate associations between BM risk and the target polymorphism. Significant associations identified were allele contrast (A vs. G: OR 0.66, 95% CI 0.59–0.75, P = 0.000), homozygote comparison (AA vs. AG/GG: OR 0.62, 95% CI 0.49–0.78, P = 0.000), heterozygote comparison (A vs. G: OR 0.74, 95% CI 0.61–0.91, P = 0.005), recessive genetic model (AA vs. AG/GG: OR 0.78, 95% CI 0.65–0.93, P = 0.006) and dominant genetic model (AA vs. AG/GG: OR 0.70, 95% CI 0.57–0.85, P = 0.000). The findings indicate that, in contrast to some studies, the TLR9 rs352140 polymorphism is associated with a decreased risk for BM.

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Associations of CTLA4 Gene Polymorphisms with Graves’ Ophthalmopathy: A Meta-Analysis

International Journal of Genomics ◽

10.1155/2014/537969 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 4

Author(s):

Pengfei Du ◽

Xiaojie Ma ◽

Changjiang Wang

Keyword(s):

Genetic Model ◽

Meta Analysis ◽

Case Control Studies ◽

Graves Ophthalmopathy ◽

Increased Risk ◽

Exon 1 ◽

Ctla4 Gene ◽

Relationship Of ◽

The Relationship ◽

Susceptible Gene

Many studies have established that T-lymphocyte antigen-4 (CTLA4) is a susceptible gene for Graves’ disease (GD). Also many studies showed the association between the CTLA4 exon-1 49A/G polymorphism and the risk of developing Graves’ ophthalmopathy (GO) in GD patients. But those results were inconsistent. In recent years many new studies were published which helped to shed light on the relationship of CTLA4 SNP49 with GO. So we performed the meta-analysis to explore the association between the SNP49 and GO susceptibility in GD patients. Studies up to February 29, 2012, were searched by using PubMed. The odds ratio was used to evaluate the strength of the association. Altogether 12 case-control studies involving 2,505 participants were included in the meta-analysis. Results showed that the G allele was related to the increased risk of GO compared with the A allele under allelic genetic model (OR = 1.14, 95% CI: 1.14–1.72,P=0.001) in European subgroup. No publication bias was detected. Our results showed that the SNP49 polymorphism of CTLA4 gene was related to increased risk of GO.

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Toll-Like Receptor 2 Participates in Mediation of Immune Response in Experimental Pneumococcal Meningitis

The Journal of Immunology ◽

10.4049/jimmunol.170.1.438 ◽

2003 ◽

Vol 170 (1) ◽

pp. 438-444 ◽

Cited By ~ 167

Author(s):

Uwe Koedel ◽

Barbara Angele ◽

Tobias Rupprecht ◽

Hermann Wagner ◽

Andreas Roggenkamp ◽

...

Keyword(s):

Immune Response ◽

Pneumococcal Meningitis ◽

Toll Like Receptor ◽

Toll Like Receptor 2 ◽

Experimental Pneumococcal Meningitis

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Association between IL-13 +1923C/T polymorphism and asthma risk: a meta-analysis based on 26 case-control studies

Bioscience Reports ◽

10.1042/bsr20160505 ◽

2017 ◽

Vol 37 (1) ◽

Cited By ~ 7

Author(s):

Yueli Xu ◽

Junjuan Li ◽

Zhaolei Ding ◽

Juan Li ◽

Bin Li ◽

...

Keyword(s):

Genetic Model ◽

Meta Analysis ◽

Age Groups ◽

Allergic Inflammation ◽

Case Control ◽

Respiratory Disorder ◽

Case Control Studies ◽

Increased Risk ◽

Asthma Patients ◽

Highly Correlated

Asthma is a serious and hereditary respiratory disorder affecting all age groups. Interleukin-13 (IL-13) is a central regulator of allergic inflammation. The purpose of the present study was to estimate the relationship between IL-13 +1923C/T polymorphism and asthma susceptibility. Relevant case-control studies published between January 2000 and July 2016 were searched in the online databases. Review Manage (RevMan) 5.3 was used to conduct the statistical analysis. The pooled odds ratio (OR) with its 95% confidence interval (CI) was employed to calculate the strength of association. A total of 26 articles were retrieved, including 17642 asthma patients and 42402 controls. Overall, our results found that IL-13 +1923C/T polymorphism was significantly associated with increased risk of asthma under each genetic model (P<0.00001). Subgroup analysis by ethnicity showed that alleles and genotypes of this variant correlated with asthma among Asians and Caucasians, but only TT genotype under the homozygote model in Africans. When stratified by age group, this variant highly correlated with asthma in children and moderately in adults. Furthermore, the TT, CT and CC genotypes in asthma group were all significantly associated with increased IgE levels in sera of asthma patients when compared with controls. Our results suggested that IL-13 +1923C/T polymorphism contributed to the development of asthma. Further case-control studies with more ethnicities are still needed.

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Association between vitamin D receptor (VDR) polymorphisms and the risk of multiple sclerosis (MS): an updated meta-analysis

BMC Neurology ◽

10.1186/s12883-019-1577-y ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 7

Author(s):

Danyal Imani ◽

Bahman Razi ◽

Morteza Motallebnezhad ◽

Ramazan Rezaei

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Gene Polymorphisms ◽

Genetic Model ◽

Meta Analysis ◽

Case Control ◽

Case Control Studies ◽

Asian Populations ◽

Increased Risk ◽

Apai Polymorphism

Abstract Background The association between the Vitamin D Receptor (VDR) gene polymorphism and the risk of Multiple sclerosis (MS) has been evaluated in several researches. However, the findings were inconsistent and inconclusive. Therefore, we set out a meta-analysis of all eligible published case-control studies to obtain an exact evaluation of the association between VDR gene polymorphisms and MS. Method All relevant studies reporting the association between the VDR gene FokI (rs2228570), or/and TaqI (rs731236) or/and BsmI (rs1544410) or/and ApaI (rs7975232) polymorphisms and susceptibility to MS published up to May, 2019 were identified by comprehensive systematic search in the electronic database of web of science, Scopus, and PubMed. After that, the strength of association between VDR gene polymorphisms and susceptibility to MS was evaluated by odds ratio (OR) and 95% confidence interval (CI). Results A total of 30 case–control studies were included in the meta-analysis. The overall results suggested a significant association between TaqI polymorphism and MS risk under heterozygote genetic model (OR = 1.27, 95%CI = 1.01–1.59, random effect). Moreover, the pooled results of subgroup analysis declined presence of significant association under all defined genetic model. In subgroup analysis, BsmI polymorphisms was associated with increased risk of MS under recessive model in Asian populations. On the other hand, ApaI polymorphism was associated with decreased risk of MS under recessive and aa vs. AA model in Asian populations. Conclusion This meta-analysis suggested a significant association between TaqI polymorphism and MS susceptibility. Furthermore, BsmI polymorphism was associated with increased risk of MS in Asian populations. In contrast, ApaI polymorphism was associated with decreased risk of MS in Asian populations. Future large-scale studies on gene–environment and gene–gene interactions are required to estimate risk factors and assist early diagnosis of patients at high risk for MS.

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Association Between miR-146a rs2910164 Polymorphism and Breast Cancer Susceptibility: An Updated Meta-analysis of 9545 Cases and 10030 Controls

MicroRNA ◽

10.2174/2211536610666210707113229 ◽

2021 ◽

Vol 10 ◽

Author(s):

Abdolkarim Moazeni-Roodi ◽

Sajjad Aftabi ◽

Sahel Sarabandi ◽

Shima Karami ◽

Mohammad Hashemi ◽

...

Keyword(s):

Breast Cancer ◽

Web Of Science ◽

Genetic Model ◽

Cancer Susceptibility ◽

Quantitative Estimation ◽

Meta Analysis ◽

Breast Cancer Susceptibility ◽

Precise Estimation ◽

Potential Link ◽

Stratified Analysis

Background: Several studies have reported a possible association of the miR-146a rs2910164 polymorphism with Breast Cancer (BC) development. However, the correlation between this polymorphism and susceptibility to BC is under debate. The current meta-analysis was designed and performed to more conclusively evaluate the miR-146a rs2910164 polymorphism and its potential link to BC. Methods: Our team has selected eligible studies (published up to October 2, 2020) from several electronic databases, including Web of Science, PubMed, Scopus and Google Scholar. A total number of 9,545 BC cases and 10,030 controls extracted from 26 eligible articles were included in this study. We utilized pooled Odds Ratios (ORs) as well as 95% confidence intervals (95% CIs) under five genetic models for quantitative estimation of any possible association between miR-146a rs2910164 polymorphism and BC. Results: Based on this meta-analysis, our findings suggest that there is no significant association between miR-146a rs2910164 polymorphism and BC risk. However, stratified analysis revealed that the rs2910164 polymorphism significantly increased the risk of BC in hospital-based studies using the homozygous genetic model (OR=1.37, 95%CI=1.01-1.86, p=0.043, CC vs. GG). Neither Asian nor Caucasian populations showed any significant association between rs2910164 polymorphism and BC susceptibility. Conclusion: In summary, our findings suggest that BC development is not associated with miR-146a rs2910164 polymorphism. However, larger ingenious future investigations might be needed for a more precise estimation of any association between miR-146a rs2910164 polymorphism and BC.

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How many single-nucleotide polymorphisms (SNPs) must be tested in order to prove susceptibility to bacterial meningitis in children? Analysis of 11 SNPs in seven genes involved in the immune response and their effect on the susceptibility to bacterial meningitis in children

Innate Immunity ◽

10.1177/1753425918762038 ◽

2018 ◽

Vol 24 (3) ◽

pp. 163-170 ◽

Cited By ~ 3

Author(s):

Ewelina Gowin ◽

Bogna Świątek-Kościelna ◽

Ewelina Kałużna ◽

Ewa Strauss ◽

Jacek Wysocki ◽

...

Keyword(s):

Immune Response ◽

Single Nucleotide Polymorphisms ◽

Bacterial Meningitis ◽

Pneumococcal Meningitis ◽

Cumulative Effect ◽

Control Group ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Increased Risk ◽

Meningitis In Children

The aim of this study is to describe the prevalence of single single-nucleotide polymorphisms (SNPs) as well as their combinations in genes encoding proteins involved in the immune response in children with bacterial meningitis. The prospective study group consisted of 39 children with bacterial meningitis and 49 family members surveyed between 2012 and 2016. Eleven SNPs in seven genes involved in immune response were analysed. The mean number of minor frequency alleles (MAF) of studied SNPs was lowest in the control group and highest in patients with pneumococcal meningitis. We found that carrying ≥6 MAF of studied SNPs was associated with an increased risk of pneumococcal meningitis. The prevalence of risky variants was noted to be higher in patients with pneumococcal meningitis as compared to the control group. In conclusion, genetic factors are a relevant factor in determining the susceptibility to bacterial meningitis. A statistically significant cumulative effect of mutated variants on increasing the risk of bacterial meningitis was detected. Combining all three SNPs in MBL2 improves the prediction of susceptibility to pneumococcal meningitis. Analysis of risky alleles can help indicate people prone to the disease who are ‘gene-immunocompromised’.

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Toll-like receptor 2 gene polymorphisms and cancer susceptibility: A meta-analysis

Neoplasma ◽

10.4149/neo_2013_060 ◽

2013 ◽

Vol 60 (04) ◽

pp. 459-467 ◽

Cited By ~ 9

Author(s):

X. Wang ◽

J. Li ◽

W. Xie ◽

W. Zhang ◽

Y. Chang

Keyword(s):

Gene Polymorphisms ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Toll Like Receptor ◽

Toll Like Receptor 2

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Diversity of Toll-like Receptor Genes and Helicobacter Pylori Infections: A Meta-Analysis Study

International Journal of Medical Laboratory ◽

10.18502/ijml.v7i2.2910 ◽

2020 ◽

Author(s):

Hamid Vaez ◽

Amirhossein Sahebkar ◽

Asad Mohammadi ◽

Mohsen Arzanlou ◽

Arshid Yousefi-Avarvand ◽

...

Keyword(s):

Helicobacter Pylori ◽

Odds Ratio ◽

Genetic Factors ◽

Meta Analysis ◽

Helicobacter Pylori Infection ◽

Toll Like Receptor ◽

Inclusion Criteria ◽

Increased Risk ◽

Host Genetic ◽

Increased Susceptibility

Background and Aims: Several studies have shown that host genetic factors can be associated with the risk of developing Helicobacter pylori infections. Therefore, we evaluated the most prevalent toll-like receptors (TLRs) polymorphisms in Helicobacter pylori positive subjects and their possible role in susceptibility to Helicobacter pylori infections. Materials and Methods: Using related keywords, an independent search in the electronic databases including PubMed, Scopus, Google Scholar and ISI web of knowledge was performed to collect studies evaluating, until January 15, 2019, polymorphisms in the TLR 1 to 13 genes and their association with susceptibility to Helicobacter pylori infection. A total of 18 articles met our inclusion criteria and thus were included in the meta-analysis. Results: In this meta-analysis, a significantly increased risk of Helicobacter pylori infection was observed in subjects carrying TLR2 rs3804099 (TT vs. CC: odds ratio = 2.209, 95% CI: 1.283-3.804), TLR4 rs4986790 (A allele vs. G allele: odds ratio = 2.987, 95% CI: 1.899-4.697), TLR4 rs4986791 (C allele vs. T allele: odds ratio = 5.469, 95% CI: 13.432-8.713), TLR4 rs4986791 (CC vs. TT: odds ratio = 7.974, 95% CI: 2.682-23.706), TLR4 rs10759932 (TT vs. CC: odds ratio = 3.180, 95% CI: 1.022-9.890), TLR4 rs1927914 (C allele vs. T allele: odds ratio = 8.831, 95% CI: 4.222-18.470), and TLR9 rs352140 (CC vs. CT: odds ratio = 1.878, 95% CI: 1.071-3.290) polymorphisms. Conclusions: This meta-analysis indicated that TLR2 rs3804099, TLR4 rs4986790, TLR4 rs4986791, TLR4 rs10759932, TLR4 rs1927914 and TLR9 rs352140 polymorphisms are associated with increased susceptibility to Helicobacter pylori infections.

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Associations between LPL gene polymorphisms and coronary artery disease: evidence based on an updated and cumulative meta-analysis

Bioscience Reports ◽

10.1042/bsr20171642 ◽

2018 ◽

Vol 38 (2) ◽

Cited By ~ 3

Author(s):

Wen-Qi Ma ◽

Ying Wang ◽

Xi-Qiong Han ◽

Yi Zhu ◽

Nai-Feng Liu

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Gene Polymorphisms ◽

Genetic Model ◽

Meta Analysis ◽

Cochrane Library ◽

Increased Risk ◽

Lpl Gene ◽

Artery Disease ◽

Cad Risk

Lipoprotein lipase (LPL) is widely linked to lipid and lipoprotein metabolism, but its effects on coronary artery disease (CAD) are not clearly elucidated. The aim of the present study was to clarify the association between LPL gene polymorphisms and CAD susceptibility. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated to estimate the strength of the relationship between LPL gene polymorphisms and CAD risk. Comprehensive electronic databases, including PubMed, EMBASE, Web of Science, and the Cochrane Library, were systematically searched. A total of 45 records containing 80 eligible studies were analyzed. The results indicated an increased risk between the LPL D9N polymorphism and susceptibility to CAD in the dominant genetic model (AA + GA vs. GG: OR = 1.46, 95% CI = 1.14–1.87), whereas the LPL HindIII polymorphism showed a protective effect against CAD under all tested models (GG + GT vs. TT: OR = 0.85, 95% CI = 0.75–0.97; GG vs. TT + TG: OR = 0.62, 95% CI = 0.47–0.83; G vs. T: OR = 0.81, 95% CI = 0.71–0.92). No significant association was identified for the LPL N291S and PvuII polymorphisms. Stratification analysis by ethnicity suggested a significant correlation between the LPL S447X polymorphism and CAD susceptibility in Caucasians under the dominant and allele genetic models. In summary, our meta-analysis indicated that the LPL D9N polymorphism was associated with an increased risk of CAD, whereas the S447X and HindIII polymorphisms showed protective effects. There was no association observed between the N291S and PvuII polymorphisms and CAD risk.

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