Dopaminergic imaging: clinical utility now and in the future

2011 ◽  
Vol 23 (S2) ◽  
pp. S32-S40 ◽  
Author(s):  
Zuzana Walker ◽  
Joanne Rodda
Keyword(s):  
Clinical Practice ◽  
Dementia With Lewy Bodies ◽  
Clinical Utility ◽  
Lewy Bodies ◽  
Present Knowledge ◽  
Parkinsonian Syndromes ◽  
The Past ◽  
Future Clinical Practice ◽  
The Future ◽  
Diagnosis Of Dementia

ABSTRACTOver the past ten years, dopaminergic imaging has become increasingly part of the assessment and diagnosis of dementia. There are numerous PET and SPECT ligands available that target different steps in the process of neurotransmission. Abnormalities in dopaminergic imaging measures are consistent features of dementia with Lewy bodies (DLB) and other parkinsonian syndromes, and can be used to facilitate diagnosis, particularly in distinguishing between DLB and Alzheimer's disease. This review summarizes present knowledge in this area and the implications for current and future clinical practice.

Diagnosis of Dementia With Lewy Bodies in Clinical Practice: A Literature Review

2005 ◽  
Vol 13 (1) ◽  
pp. 54-59 ◽  
Author(s):  
Dhiren Singh
Keyword(s):  
Clinical Practice ◽  
Literature Review ◽  
Diagnostic Accuracy ◽  
Neuropsychological Tests ◽  
Dementia With Lewy Bodies ◽  
Literature Search ◽  
Lewy Bodies ◽  
Research Data ◽  
Accurate Diagnosis ◽  
Diagnosis Of Dementia

Objective: To review the research data about dementia with Lewy bodies (DLB) and describe those clinical features and investigations that will enhance more accurate diagnosis in day-to-day practice. Methods: A literature search using MEDLINE, Psychlit, Psychinfo and Cochrane databases was performed. Conclusions: The diagnosis of DLB is important now that treatment is available using cognitive enhancers and because of the risk to patients with DLB who are prescribed neuroleptics. The use of consensus criteria, despite their limitations, and judicious use of ancillary investigations, especially neuroimaging and neuropsychological tests, will enhance diagnostic accuracy.

640 Consensus criteria for the clinical diagnosis of dementia with Lewy bodies (DLB)

1996 ◽  
Vol 17 (4) ◽  
pp. S159
Author(s):  
I.G. McKeith ◽  
R.H. Perry ◽  
E.K. Perry ◽  
P.G. Ince
Keyword(s):  
Clinical Diagnosis ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Diagnosis Of Dementia

An Approach to Establish Antemortem Diagnosis of Dementia with Lewy Bodies

2002 ◽  
pp. 525-528
Author(s):  
Hiroyuki Arai ◽  
Makoto Higuchi ◽  
Nobuyuki Okamura ◽  
Xia Sheng Hu ◽  
Toshifumi Matsui ◽  
...  
Keyword(s):  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Diagnosis Of Dementia

Accuracy of transcranial brain parenchyma sonography in the diagnosis of dementia with Lewy bodies

2016 ◽  
Vol 23 (8) ◽  
pp. 1322-1328 ◽  
Author(s):  
S. Favaretto ◽  
U. Walter ◽  
C. Baracchini ◽  
S. Pompanin ◽  
C. Bussè ◽  
...  
Keyword(s):  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Brain Parenchyma ◽  
Diagnosis Of Dementia ◽  
Brain Parenchyma Sonography

scholarly journals Magnetic Resonance Spectroscopy in the Diagnosis of Dementia with Lewy Bodies

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Radoslaw Magierski ◽  
Tomasz Sobow
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Dementia With Lewy Bodies ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Lewy Bodies ◽  
Resonance Spectroscopy ◽  
Diagnosis Of Dementia

Dementia with Lewy bodies (DLB) is considered to be the second most frequent primary degenerative dementing illness after Alzheimer’s disease (AD). DLB, together with Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD) belong toα-synucleinopathies—a group of neurodegenerative diseases associated with pathological accumulation of theα-synuclein protein. Dementia due to PD and DLB shares clinical symptoms and neuropsychological profiles. Moreover, the core features and additional clinical signs and symptoms for these two very similar diseases are largely the same. Neuroimaging seems to be a promising method in differential diagnosis of dementia studies. The development of imaging methods or other objective measures to supplement clinical criteria for DLB is needed and a method which would accurately facilitate diagnosis of DLB prior to death is still being searched. Proton magnetic resonance spectroscopy (1H-MRS) provides a noninvasive method of assessing anin vivobiochemistry of brain tissue. This review summarizes the main results obtained from the application of neuroimaging techniques in DLB cases focusing on1H-MRS.

scholarly journals Assessment of genetic risk for improved clinical-neuropathological correlations

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Barbara E. Spencer ◽  
Robin G. Jennings ◽  
Chun C. Fan ◽  
James B. Brewer
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Genetic Risk ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Pathological Diagnosis ◽  
Polygenic Score ◽  
Diagnosis Of Dementia

Abstract In the clinical diagnosis of dementia with Lewy bodies, distinction from Alzheimer’s disease is suboptimal and complicated by shared genetic risk factors and frequent co-pathology. In the present study we tested the ability of polygenic scores for Alzheimer’s disease, dementia with Lewy bodies, and Parkinson’s disease to differentiate individuals in a 2713-participant, pathologically defined sample. A dementia with Lewy bodies polygenic score that excluded apolipoprotein E due to its overlap with Alzheimer’s disease risk was specifically associated with at least limbic (transitional) Lewy-related pathology and a pathological diagnosis of dementia with Lewy bodies. An Alzheimer’s disease polygenic score was associated with neuritic plaques and neurofibrillary tangles but not Lewy-related pathology, and was most strongly associated with an Alzheimer’s pathological diagnosis. Our results indicate that an assessment of genetic risk may be useful to clinically distinguish between Alzheimer’s disease and dementia with Lewy bodies. Notably, we found no association with a Parkinson’s disease polygenic score, which aligns with evidence that dementia with Lewy bodies has a distinct genetic signature that can be exploited to improve clinical diagnoses.

scholarly journals Dementia With Lewy Bodies: the Principles of Diagnostics, Treatment, and Management

Medicina ◽  
2012 ◽  
Vol 48 (1) ◽  
pp. 1 ◽  
Author(s):  
Jūratė Macijauskienė ◽  
Vita Lesauskaitė
Keyword(s):  
Dementia With Lewy Bodies ◽  
Management Strategies ◽  
Laboratory Data ◽  
Lewy Bodies ◽  
Corticobasal Degeneration ◽  
Later Life ◽  
Alpha Synuclein ◽  
Diagnostic Features ◽  
Protein Deposits ◽  
Diagnosis Of Dementia

Dementia with Lewy bodies was first recognized as a separate entity about 30 years ago. The prevalence varies from 0% to 5% in the general population, and this disease accounts for 0% to 30.5% of all dementia cases. Dementia with Lewy bodies is considered the second most common cause of degenerative dementia after Alzheimer’s disease. The disease is characterized by alpha-synuclein immunoreactive protein deposits in both neurons and glial cells. The protein deposits are especially prominent in dopaminergic neurons, where they can be detected using conventional histological stains, such as hematoxylin and eosin, and are commonly referred to as Lewy bodies. The diagnosis of dementia with Lewy bodies is based on the presence of dementia as well as 2 of the following 3 core diagnostic features: 1) fluctuating cognition, 2) visual hallucinations, and 3) movement disorder. Diagnostic tests include laboratory data, structural and functional imaging, and electroencephalography. Differential diagnosis of dementia with Lewy bodies focuses on other later life dementia syndromes, other parkinsonian diseases (Parkinson’s disease, progressive supranuclear palsy, corticobasal degeneration), and primary psychiatric illnesses. There is type 1b evidence to support treatment with cholinesterase inhibitors. Glutamatergic and dopaminergic therapies are used as well. Standard neuroleptics are contraindicated, and atypical agents should be used cautiously. Nonpharmacologic measures – therapeutic environment, psychological and social support, physical activity, behavioral management strategies, caregivers’ education and support, and different services – could be suggested.

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