Obsessive-Compulsive Disorder With and Without Tic Disorder: A Comparative Study From India

CNS Spectrums ◽  
2008 ◽  
Vol 13 (8) ◽  
pp. 705-711 ◽  
Author(s):  
T.S. Jaisoorya ◽  
Y.C. Janardhan Reddy ◽  
S. Srinath ◽  
K. Thennarasu
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Age Of Onset ◽  
Early Age ◽  
Obsessive Compulsive ◽  
The West ◽  
Tic Disorder ◽  
Compulsive Disorder ◽  
Symptom Profile ◽  
Spectrum Disorders ◽  
Motor Tics

ABSTRACTIntroduction: Evidence from phenomenological, family, genetic, and treatment studies from Western centers have suggested that tic-related obsessive-compulsive disorder (OCD) could be different from non-tic-related OCD. This study from India investigated the differences in OCD with and without tics, with respect to sociode-mographics, symptom profile, and comorbidity, including obsessive-compulsive spectrum disorders, to examine whether the clinical profile of tic-related OCD is similar to that reported previously.Methods: Fifty subjects with OCD and tics (chronic motor tics and Tourette syndrome) were compared with 141 OCD subjects without tics.Results: Subjects having OCD with tics tended to be males, and had an earlier onset of illness. They had more of symmetry/aggressive and religious obsessions, and cleaning, ordering/arranging, hoarding, and repeating compulsions and were associated with trichotillomania and hypochondraisis. Stepwise backward (Wald) regression analysis showed that an early age of onset, male gender, aggressive obsessions, cleaning compulsions, and trichotillomania were significantly associated with tic-related OCD.Conclusion: The findings of this study from India are broadly similar to those reported previously from the West indicating the universality of differences in tic- and non-tic-related OCD. Our findings also support the existing evidence that tics contribute to the heterogeneity of OCD.

scholarly journals Cigarette smoking in patients with obsessive compulsive disorder: a report from the International College of Obsessive Compulsive Spectrum Disorders (ICOCS)

CNS Spectrums ◽  
2015 ◽  
Vol 20 (5) ◽  
pp. 469-473 ◽  
Author(s):  
Bernardo Dell’Osso ◽  
Humberto Nicolini ◽  
Nuria Lanzagorta ◽  
Beatrice Benatti ◽  
Gregorio Spagnolin ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Psychiatric Disorders ◽  
Obsessive Compulsive Disorder ◽  
Tourette’S Syndrome ◽  
Obsessive Compulsive ◽  
Cross Sectional ◽  
Tic Disorder ◽  
Compulsive Disorder ◽  
International College ◽  
Spectrum Disorders

Obsessive compulsive disorder (OCD) showed a lower prevalence of cigarette smoking compared to other psychiatric disorders in previous and recent reports. We assessed the prevalence and clinical correlates of the phenomenon in an international sample of 504 OCD patients recruited through the International College of Obsessive Compulsive Spectrum Disorders (ICOCS) network.Cigarette smoking showed a cross-sectional prevalence of 24.4% in the sample, with significant differences across countries. Females were more represented among smoking patients (16% vs 7%; p<.001). Patients with comorbid Tourette’s syndrome (p<.05) and tic disorder (p<.05) were also more represented among smoking subjects. Former smokers reported a higher number of suicide attempts (p<.05).We found a lower cross-sectional prevalence of smoking among OCD patients compared to findings from previous studies in patients with other psychiatric disorders but higher compared to previous and more recent OCD studies. Geographic differences were found and smoking was more common in females and comorbid Tourette’s syndrome/tic disorder.

Age of onset in obsessive–compulsive disorder: admixture analysis with a large sample

2013 ◽  
Vol 44 (1) ◽  
pp. 185-194 ◽  
Author(s):  
G. E. Anholt ◽  
I. M. Aderka ◽  
A. J. L. M. van Balkom ◽  
J. H. Smit ◽  
K. Schruers ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Obsessive Compulsive Disorder ◽  
Age Of Onset ◽  
Late Onset ◽  
Early Age ◽  
Admixture Analysis ◽  
Adhd Symptoms ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Co Morbidity

BackgroundResearch into age of onset in obsessive–compulsive disorder (OCD) has indicated significant differences between patients with early and late onset of the disorder. However, multiple criteria have been used arbitrarily for differentiating between early- and late-onset OCD, rendering inconsistent results that are difficult to interpret.MethodIn the current study, admixture analysis was conducted in a sample of 377 OC patients to determine the number of underlying populations of age of onset and associated demographic and clinical characteristics. Various measures of anxiety, depression, co-morbidity, autism, OCD, tics and attention deficit hyperactivity disorder (ADHD) symptoms were administered.ResultsA bimodal age of onset was established and the best-fitting cut-off score between early and late age of onset was 20 years (early age of onset ⩽19 years). Patients with early age of onset were more likely to be single. Early age of onset patients demonstrated higher levels of OCD severity and increased symptoms on all OCD dimensions along with increased ADHD symptoms and higher rates of bipolar disorder.ConclusionsIt is suggested that 20 years is the recommended cut-off age for the determination of early versus late age of onset in OCD. Early age of onset is associated with a generally graver OCD clinical picture and increased ADHD symptoms and bipolar disorder rates, which may be related to greater functional implications of the disorder. We propose that age of onset could be an important marker for the subtyping of OCD.

Age of Onset for Obsessive-Compulsive Disorder

1990 ◽  
Author(s):  
W. E. Minichiello ◽  
L. Baer ◽  
M. A. Jenike ◽  
A. Holland
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Age Of Onset ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Genetic variability in the serotoninergic system and age of onset in anorexia nervosa and obsessive-compulsive disorder

2019 ◽  
Vol 271 ◽  
pp. 554-558 ◽  
Author(s):  
Maria Teresa Plana ◽  
Teresa Torres ◽  
Natalia Rodríguez ◽  
Daniel Boloc ◽  
Patricia Gassó ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Genetic Variability ◽  
Obsessive Compulsive Disorder ◽  
Age Of Onset ◽  
Serotoninergic System ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Complex phonic tic and disinhibition in Tourette syndrome: case report

2001 ◽  
Vol 59 (3A) ◽  
pp. 587-589 ◽  
Author(s):  
Débora Palmini Maia ◽  
Francisco Cardoso
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Basal Ganglia ◽  
Obsessive Compulsive Disorder ◽  
Tourette Syndrome ◽  
Limbic Cortex ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Behavioral Abnormalities ◽  
Motor Tics

Tourette syndrome (TS) is a neuropsychiatric disorder characterized by a combination of multiple motor tics and at least one phonic tic. TS patients often have associated behavioral abnormalities such as obsessive compulsive disorder, attention deficit and hyperactive disorder. Coprolalia, defined as emission of obscenities or swearing, is one type of complex vocal tic, present in 8% to 26% of patients. The pathophysiology of coprolalia and other complex phonic tics remains ill-defined. We report a patient whose complex phonic tic was characterized by repetitively saying "breast cancer" on seeing the son of aunt who suffered from this condition. The patient was unable to suppress the tic and did not meet criteria for obsessive compulsive disorder. The phenomenology herein described supports the theory that complex phonic tics result from disinhibition of the loop connecting the basal ganglia with the limbic cortex.

scholarly journals Assessment of in Obsessive Compulsive Disorder

2021 ◽  
pp. 105-114
Author(s):  
Sarah Alaa Mohsen ◽  
Fatma Ahmed El Deeb ◽  
Ehab Sayed Ramadan ◽  
Mai Abd El-Raouf Eissa
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Test Performance ◽  
Age Of Onset ◽  
Neuropsychological Test ◽  
Control Group ◽  
Obsessive Compulsive ◽  
Cross Sectional ◽  
Compulsive Disorder ◽  
Group I ◽  
Significant Difference

Background: Obsessive compulsive disorder (OCD) is a common and potentially debilitating disorder. Neuropsychological assessment provides unique complementary information that is critical for evaluating higher cortical abilities. This study aimed to assess the neuropsychological functions in OCD patients which can then point to the brain structures or pathways and to study the correlation between these assessments and different clinical variables. Methods: This cross-sectional case control study had included sixty patients who were divided into two groups, Group I: thirty OCD patients diagnosed by DSM-IV and Group II: thirty healthy controls who were recruited from the community, matched with patients’ age, gender, and education. Results: The age of onset in our study was 19.13 ± 0.35 years, the mean duration was 7.44 ± 3.88 years, 40% of the studied cases had severe OCD symptoms and 33.3% of them were compulsive cleaners. There was a high significant difference between the two groups regarding WCST in favor of the control group. There was a high significant difference between the two groups regarding ROCF where the control group showed better results than the OCD patients. Conclusions: Neuropsychological test performance remains an informative and objective means of investigation, especially when applied to psychiatric disorders. The executive functions in OCD patients were impaired in comparison to the normal study subjects.

scholarly journals Blocking Tics in Gilles de la Tourette Syndrome

2021 ◽  
Vol 12 ◽  
Author(s):  
Justyna Kaczyńska ◽  
Piotr Janik
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Tourette Syndrome ◽  
Age Of Onset ◽  
Severe Form ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Clinical Correlates ◽  
Clinical Associations ◽  
Motor Acts

Introduction: Patients with Gilles de la Tourette syndrome (GTS) may experience blocking tics (BTs) defined as recurrent, brief cessations of motor acts. The aim of this study was to assess the prevalence, age of onset, and clinical correlates of BTs in GTS patients.Materials and Methods: We performed a one-time registration study in a cohort of 195 consecutive GTS patients aged 5–66 years (mean age: 15.0 ± 9.2; 47 females, 24.1%). All patients were personally interviewed and examined.Results: At least one BT occurred at some point in the lifetime of 73 patients (37.4%) with a mean age of onset of 10.4 ± 5.9 years. BTs occurred an average of 4.8 ± 5.3 years after tic onset. The most common BT was cessation of walking (n = 59, 80.8%), followed by speech (n = 19, 26.0%), running (n = 18, 24.7%), and writing (n = 9, 12.3%). Most of the patients (n = 52, 71.2%) reported cessation of only one activity. Clinical associations of BTs included more severe tics, overall greater number of tics, and, to a lesser extent, higher age at evaluation and comorbid obsessive-compulsive disorder.Conclusions: BTs represent complex tics, early and common symptoms of GTS, and are associated with a more severe form of GTS.

PROLACTIN IN CHILDHOOD OBSESSIVE-COMPULSIVE DISORDER: CLINICAL CORRELATES AND RESPONSE TO CLOMIPRAMINE

PEDIATRICS ◽  
1991 ◽  
Vol 88 (5) ◽  
pp. 992-992
Author(s):  
Gregory L. Hanna ◽  
James T. MCCracken ◽  
Dennis P. Cantwell
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Tic Disorder ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Serotonergic Receptors ◽  
Duration Of Illness ◽  
Chronic Tic Disorder ◽  
History Of ◽  
Clomipramine Treatment

Basal prolactin concentrations were measured before treatment in 18 children and adolescents with obsessive-compulsive disorder as well as in 15 of these patients after 4 and 8 weeks of clomipramine treatment. Basal prolactin levels were influenced by a history of chronic tic disorder and by the duration and severity of obsessive-compulsive symptoms. Clomipramine administration significantly increased basal prolactin levels. A slight decline in prolactin levels during the last 4 weeks of clomipramine treatment was positively correlated with a favorable treatment response and negatively correlated with duration of illness. If the changes in prolactin levels observed during clomipramine treatment are due primarily to changes in serotonergic neurotransmission, these data suggest that clomipramine treatment of obsessive-compulsive disorder produces an adaptive decrease in the responsiveness of serotonergic receptors.

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